Megestrol_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Megestrol perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Megestrol_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.120644
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.117479
ADAM10 ADAM metallopeptidase domain 10 0.112864
SOX6 SRY (sex determining region Y)-box 6 0.105573
PDE4B phosphodiesterase 4B, cAMP-specific 0.101375
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0932882
HDAC9 histone deacetylase 9 0.0864903
EZR ezrin 0.0856674
VCL vinculin 0.0847842
PDE4D phosphodiesterase 4D, cAMP-specific 0.0843433
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0819916
PKM pyruvate kinase, muscle 0.0799304
TJP1 tight junction protein 1 0.0767635
NBEA neurobeachin 0.0679455
PRELID2 PRELI domain containing 2 0.0668056
EGFR epidermal growth factor receptor 0.0664631
BMP2K BMP2 inducible kinase 0.0596654
GOLGA4 golgin A4 0.0596195
EEF2 eukaryotic translation elongation factor 2 0.0589121
LDHA lactate dehydrogenase A 0.0535325
RBMS3 RNA binding motif, single stranded interacting protein 3 0.052143
LPP LIM domain containing preferred translocation partner in lipoma 0.0513137
PGK1 phosphoglycerate kinase 1 0.0501351
PDGFC platelet derived growth factor C 0.0488569
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0481201
FLNB filamin B, beta 0.0463179
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0460852
DPYD dihydropyrimidine dehydrogenase 0.0451639
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0443211
TMSB4X thymosin beta 4, X-linked 0.0442268
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0441908
LOXL3 lysyl oxidase-like 3 0.0430062
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0429134
ZEB1 zinc finger E-box binding homeobox 1 0.0424812
ENO1 enolase 1, (alpha) 0.04248
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0422721
POTEF POTE ankyrin domain family, member F 0.0417425
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0408436
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.040688
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0406859
ECT2 epithelial cell transforming 2 0.040454
SLC38A2 solute carrier family 38, member 2 0.0403669
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0397098
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0395333
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0385117
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0381895
TRERF1 transcriptional regulating factor 1 0.0379232
NPAS2 neuronal PAS domain protein 2 0.0375502
PYGB phosphorylase, glycogen; brain 0.0375381
ZNF608 zinc finger protein 608 0.0372663
SSBP2 single-stranded DNA binding protein 2 0.0365295
MKI67 marker of proliferation Ki-67 0.0362867
GCLM glutamate-cysteine ligase, modifier subunit 0.0358047
KIF5B kinesin family member 5B 0.0353135
TMEM65 transmembrane protein 65 0.0350516
AHNAK AHNAK nucleoprotein 0.0328958
ANXA1 annexin A1 0.0322174
TXNIP thioredoxin interacting protein 0.0322043
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.031725
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0314871
SRRM2 serine/arginine repetitive matrix 2 0.0314551
TGFBR3 transforming growth factor, beta receptor III 0.0313906
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0309422
CENPF centromere protein F, 350/400kDa 0.0308309
ZBTB20 zinc finger and BTB domain containing 20 0.0308019
NUP58 nucleoporin 58 0.0307623
ZNF292 zinc finger protein 292 0.0303005
EML4 echinoderm microtubule associated protein like 4 0.0300707
NCKAP1 NCK-associated protein 1 0.0300695
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0300449
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0299951
LOC112694756 uncharaterized LOC112694756 0.0295619
BRWD1 bromodomain and WD repeat domain containing 1 0.0294163
TBC1D5 TBC1 domain family, member 5 0.0292716
SEPTIN11 septin 11 0.0291569
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0288132
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0287247
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0286972
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0286797
RNF145 ring finger protein 145 0.0284844
EVI5 ecotropic viral integration site 5 0.028431
CSDE1 cold shock domain containing E1, RNA-binding 0.0281858
MYO5C myosin VC 0.0279485
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0278433
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0274775
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0271553
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0271516
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0269896
METTL15 methyltransferase like 15 0.0269085
JMJD1C jumonji domain containing 1C 0.0264791
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0261261
ITGA6 integrin, alpha 6 0.0260905
FAM13A family with sequence similarity 13, member A 0.0260577
PLK2 polo-like kinase 2 0.0260303
MACF1 microtubule-actin crosslinking factor 1 0.0258352
PICALM phosphatidylinositol binding clathrin assembly protein 0.0257033
ADAM9 ADAM metallopeptidase domain 9 0.0256493
PDIA3 protein disulfide isomerase family A, member 3 0.0253973
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0251965
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0251007

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.262604
TPT1 tumor protein, translationally-controlled 1 -0.136494
RPL35A ribosomal protein L35a -0.101368
RPL31 ribosomal protein L31 -0.0898368
RPS6 ribosomal protein S6 -0.0840344
RPLP1 ribosomal protein, large, P1 -0.0828966
RPL34 ribosomal protein L34 -0.0767553
RPS23 ribosomal protein S23 -0.0666727
RPL9 ribosomal protein L9 -0.0634142
RPS8 ribosomal protein S8 -0.0619715
RPS13 ribosomal protein S13 -0.0577984
RPL37A ribosomal protein L37a -0.0574201
RPS3 ribosomal protein S3 -0.0568685
RPLP2 ribosomal protein, large, P2 -0.0566118
RPS27A ribosomal protein S27a -0.0565134
RPS25 ribosomal protein S25 -0.0562166
RPL23 ribosomal protein L23 -0.0550515
RPL26 ribosomal protein L26 -0.0541817
RPL19 ribosomal protein L19 -0.0524051
RPS19 ribosomal protein S19 -0.0475775
RPS24 ribosomal protein S24 -0.0469169
RPS29 ribosomal protein S29 -0.0452827
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0431449
RPS21 ribosomal protein S21 -0.0421169
RPL36 ribosomal protein L36 -0.0371793
NAP1L1 nucleosome assembly protein 1-like 1 -0.0352664
RPS12 ribosomal protein S12 -0.0351263
RPL13A ribosomal protein L13a -0.0348682
S100A9 S100 calcium binding protein A9 -0.0339496
RPL30 ribosomal protein L30 -0.0338841
RPL38 ribosomal protein L38 -0.0334236
RPL8 ribosomal protein L8 -0.03285
RPS16 ribosomal protein S16 -0.0325765
RPL11 ribosomal protein L11 -0.0313044
RPL37 ribosomal protein L37 -0.0304937
MYL12B myosin, light chain 12B, regulatory -0.0303964
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0300505
INTS6 integrator complex subunit 6 -0.0298309
RPS27 ribosomal protein S27 -0.0276917
RPL27A ribosomal protein L27a -0.0275937
VIM vimentin -0.0274989
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0269049
RPL32 ribosomal protein L32 -0.026494
RPL12 ribosomal protein L12 -0.0263623
RPLP0 ribosomal protein, large, P0 -0.0263415
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0262465
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0262348
RPS11 ribosomal protein S11 -0.0261453
RPS14 ribosomal protein S14 -0.0261443
FTL ferritin, light polypeptide -0.0261062
RPS15 ribosomal protein S15 -0.0258651
RPL36A ribosomal protein L36a -0.0256279
EIF1 eukaryotic translation initiation factor 1 -0.0253054
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0252861
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0252102
RPS5 ribosomal protein S5 -0.0250607
RPL28 ribosomal protein L28 -0.0246805
RPL7A ribosomal protein L7a -0.0245566
RPS17 ribosomal protein S17 -0.024552
RPL15 ribosomal protein L15 -0.0235825
TMSB10 thymosin beta 10 -0.0235209
WSB1 WD repeat and SOCS box containing 1 -0.0234609
S100A10 S100 calcium binding protein A10 -0.0233445
AEBP2 AE binding protein 2 -0.0231891
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0227504
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0225663
FN1 fibronectin 1 -0.0225485
TBCA tubulin folding cofactor A -0.0224097
HSPB1 heat shock 27kDa protein 1 -0.0223535
BCOR BCL6 corepressor -0.0222659
RPS28 ribosomal protein S28 -0.0221544
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0219981
TUBB4B tubulin, beta 4B class IVb -0.0215756
RPS4X ribosomal protein S4, X-linked -0.0214927
PSD3 pleckstrin and Sec7 domain containing 3 -0.0214387
RPL35 ribosomal protein L35 -0.0213028
RPL5 ribosomal protein L5 -0.0212912
HLA-B major histocompatibility complex, class I, B -0.0210728
RPL27 ribosomal protein L27 -0.0198406
RPS15A ribosomal protein S15a -0.0197655
RACK1 receptor for activated C kinase 1 -0.0197093
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0196772
RPS10 ribosomal protein S10 -0.0196256
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0196115
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.019507
NOP56 NOP56 ribonucleoprotein -0.0189938
FNDC3B fibronectin type III domain containing 3B -0.0189074
RPL10A ribosomal protein L10a -0.0180193
PCNX4 pecanex 4 -0.017924
IFITM3 interferon induced transmembrane protein 3 -0.0178139
AKAP12 A kinase (PRKA) anchor protein 12 -0.0177107
HMGA2 high mobility group AT-hook 2 -0.0171785
RPS20 ribosomal protein S20 -0.0170218
HMGB1 high mobility group box 1 -0.0167908
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0167769
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0163523
COX5A cytochrome c oxidase subunit Va -0.0162546
MCTP1 multiple C2 domains, transmembrane 1 -0.0161816
ATG12 autophagy related 12 -0.0159924
BMP10 bone morphogenetic protein 10 -0.0159808