| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Megestrol_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.17014 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.152765 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.116334 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.107552 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.102625 |
| FNDC3B | fibronectin type III domain containing 3B | 0.102104 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0931794 |
| NAV2 | neuron navigator 2 | 0.0903414 |
| VCAN | versican | 0.0881528 |
| SPAG9 | sperm associated antigen 9 | 0.0759562 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0714255 |
| HDAC9 | histone deacetylase 9 | 0.070062 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0699009 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0647348 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0614447 |
| DST | dystonin | 0.0584916 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0561337 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0534167 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0510936 |
| JMJD1C | jumonji domain containing 1C | 0.0506354 |
| ZNF292 | zinc finger protein 292 | 0.0497654 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0479184 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0470561 |
| TPM4 | tropomyosin 4 | 0.0470156 |
| CENPF | centromere protein F, 350/400kDa | 0.0451244 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0444778 |
| OPTN | optineurin | 0.0425836 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0423119 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0422822 |
| RTN4 | reticulon 4 | 0.0421852 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0416338 |
| ANXA2 | annexin A2 | 0.0394662 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.03938 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0391226 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0388483 |
| CCNL1 | cyclin L1 | 0.0386519 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0382648 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0377207 |
| TXNRD1 | thioredoxin reductase 1 | 0.0375446 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0375341 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0370393 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0356576 |
| ANLN | anillin, actin binding protein | 0.0354843 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0354654 |
| OGA | O-GlcNAcase | 0.0350062 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.034763 |
| FBXO32 | F-box protein 32 | 0.0345461 |
| SQSTM1 | sequestosome 1 | 0.034533 |
| PCBP2 | poly(rC) binding protein 2 | 0.0345288 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0345186 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.03429 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0342156 |
| BICC1 | BicC family RNA binding protein 1 | 0.033859 |
| LDHA | lactate dehydrogenase A | 0.0337363 |
| PHIP | pleckstrin homology domain interacting protein | 0.0335695 |
| WTAP | Wilms tumor 1 associated protein | 0.0334395 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0332453 |
| SFTPA2 | surfactant protein A2 | 0.032903 |
| HELZ | helicase with zinc finger | 0.0326298 |
| POTEF | POTE ankyrin domain family, member F | 0.032611 |
| QKI | QKI, KH domain containing, RNA binding | 0.0324355 |
| MATR3 | matrin 3 | 0.0323986 |
| STAG2 | stromal antigen 2 | 0.0322998 |
| CADM1 | cell adhesion molecule 1 | 0.0314344 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0313198 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.031219 |
| UTRN | utrophin | 0.0312052 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0309042 |
| MKI67 | marker of proliferation Ki-67 | 0.0308857 |
| FLNA | filamin A, alpha | 0.0307995 |
| CALD1 | caldesmon 1 | 0.0304336 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0303758 |
| FNIP1 | folliculin interacting protein 1 | 0.0302629 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0302562 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0299426 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0297413 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0297352 |
| SNX9 | sorting nexin 9 | 0.029695 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0295611 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0294888 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0294698 |
| ARRDC3 | arrestin domain containing 3 | 0.0289393 |
| MYOF | myoferlin | 0.0288419 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.028337 |
| IL6ST | interleukin 6 signal transducer | 0.0278055 |
| YBX1 | Y box binding protein 1 | 0.0276918 |
| MX1 | MX dynamin-like GTPase 1 | 0.0274391 |
| HLA-E | major histocompatibility complex, class I, E | 0.0271511 |
| MSN | moesin | 0.0269002 |
| ENO1 | enolase 1, (alpha) | 0.0265993 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0265851 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0264421 |
| DUSP10 | dual specificity phosphatase 10 | 0.0260495 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0259104 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0258144 |
| PLIN2 | perilipin 2 | 0.0256358 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0256103 |
| AFF4 | AF4/FMR2 family, member 4 | 0.025299 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0250284 |
| NUP153 | nucleoporin 153kDa | 0.0250262 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.13273 |
| GLIS3 | GLIS family zinc finger 3 | -0.130407 |
| TMSB10 | thymosin beta 10 | -0.125602 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0916567 |
| VIM | vimentin | -0.0838403 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0753656 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0661698 |
| HLA-B | major histocompatibility complex, class I, B | -0.0657617 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0570979 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0507905 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0499034 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.045694 |
| NDRG1 | N-myc downstream regulated 1 | -0.0452081 |
| HMGA2 | high mobility group AT-hook 2 | -0.0443573 |
| RPS3 | ribosomal protein S3 | -0.0413767 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0410547 |
| RPL37A | ribosomal protein L37a | -0.0385795 |
| RPLP2 | ribosomal protein, large, P2 | -0.0376846 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0375697 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0371684 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0361352 |
| RPL26 | ribosomal protein L26 | -0.0358387 |
| RPL36 | ribosomal protein L36 | -0.0354895 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.035226 |
| COL5A1 | collagen, type V, alpha 1 | -0.0351017 |
| RPS21 | ribosomal protein S21 | -0.0345398 |
| STC1 | stanniocalcin 1 | -0.0342829 |
| MT1X | metallothionein 1X | -0.0333877 |
| FAM20C | family with sequence similarity 20, member C | -0.0330452 |
| RPL9 | ribosomal protein L9 | -0.0325308 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0320141 |
| RPS12 | ribosomal protein S12 | -0.0318302 |
| PDE10A | phosphodiesterase 10A | -0.030579 |
| RPL32 | ribosomal protein L32 | -0.0305671 |
| INTS6 | integrator complex subunit 6 | -0.0304044 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0303781 |
| RPS23 | ribosomal protein S23 | -0.0303699 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0299748 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0297027 |
| RPL31 | ribosomal protein L31 | -0.0283042 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0276678 |
| EGFR | epidermal growth factor receptor | -0.0273894 |
| RPS24 | ribosomal protein S24 | -0.0273691 |
| RPS19 | ribosomal protein S19 | -0.0270075 |
| RPS6 | ribosomal protein S6 | -0.0257976 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0253549 |
| S100A9 | S100 calcium binding protein A9 | -0.0244739 |
| FRMD4A | FERM domain containing 4A | -0.0243357 |
| EHBP1 | EH domain binding protein 1 | -0.0243126 |
| NRN1 | neuritin 1 | -0.0239703 |
| RPS27A | ribosomal protein S27a | -0.0236646 |
| RPL36A | ribosomal protein L36a | -0.0233814 |
| NCKAP5 | NCK-associated protein 5 | -0.0233056 |
| RPL23 | ribosomal protein L23 | -0.0232628 |
| AHNAK | AHNAK nucleoprotein | -0.0230632 |
| HLA-A | major histocompatibility complex, class I, A | -0.0230391 |
| TMEM132D | transmembrane protein 132D | -0.0226561 |
| RPS13 | ribosomal protein S13 | -0.0224596 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0211285 |
| RPLP1 | ribosomal protein, large, P1 | -0.0206971 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0206504 |
| CDH13 | cadherin 13 | -0.020423 |
| RPL38 | ribosomal protein L38 | -0.0203342 |
| RPL12 | ribosomal protein L12 | -0.0203004 |
| RPL34 | ribosomal protein L34 | -0.0201326 |
| RPL11 | ribosomal protein L11 | -0.0197224 |
| DIAPH2 | diaphanous-related formin 2 | -0.0196385 |
| LOX | lysyl oxidase | -0.0196023 |
| THBS2 | thrombospondin 2 | -0.0194818 |
| RAI14 | retinoic acid induced 14 | -0.019452 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | -0.0194057 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0192004 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0188991 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0188514 |
| ASTN2 | astrotactin 2 | -0.018518 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0184703 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.018227 |
| KRT19 | keratin 19, type I | -0.0181314 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0180829 |
| C3 | complement component 3 | -0.0178403 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0177056 |
| RPL35A | ribosomal protein L35a | -0.0174903 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0173779 |
| RPS17 | ribosomal protein S17 | -0.0172708 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0171714 |
| RBBP6 | retinoblastoma binding protein 6 | -0.017159 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0169077 |
| SMYD3 | SET and MYND domain containing 3 | -0.0167307 |
| STK17A | serine/threonine kinase 17a | -0.0166089 |
| TMSB4X | thymosin beta 4, X-linked | -0.0165577 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0164878 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0163399 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0163392 |
| DENND2A | DENN/MADD domain containing 2A | -0.0163391 |
| RPS10 | ribosomal protein S10 | -0.0162427 |
| RPL37 | ribosomal protein L37 | -0.0161714 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0161107 |
| RPL28 | ribosomal protein L28 | -0.016103 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0160688 |
| RPL5 | ribosomal protein L5 | -0.0159801 |
