| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0790998 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.075914 |
| GOLGA4 | golgin A4 | 0.0736718 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0624617 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0613865 |
| YAP1 | Yes-associated protein 1 | 0.0551825 |
| ZNF292 | zinc finger protein 292 | 0.0540668 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0527367 |
| RBM39 | RNA binding motif protein 39 | 0.0525358 |
| TXNRD1 | thioredoxin reductase 1 | 0.0524052 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0468593 |
| ANXA2 | annexin A2 | 0.0457971 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0456104 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0442037 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0421486 |
| KIF5B | kinesin family member 5B | 0.0396447 |
| SETD5 | SET domain containing 5 | 0.0395159 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0390488 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0383119 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0378155 |
| PKM | pyruvate kinase, muscle | 0.0369961 |
| SMAD3 | SMAD family member 3 | 0.0367415 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0366228 |
| CEP250 | centrosomal protein 250kDa | 0.0364089 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0360407 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0354893 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0350801 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.034876 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0341544 |
| PHIP | pleckstrin homology domain interacting protein | 0.0333632 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0328061 |
| MATR3 | matrin 3 | 0.0326484 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0324539 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0324536 |
| HELZ | helicase with zinc finger | 0.0318933 |
| GOLIM4 | golgi integral membrane protein 4 | 0.031312 |
| DST | dystonin | 0.0309917 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0305694 |
| EFNA5 | ephrin-A5 | 0.0304597 |
| ERBIN | erbb2 interacting protein | 0.030262 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0300526 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0294307 |
| NCKAP1 | NCK-associated protein 1 | 0.0293333 |
| RNF145 | ring finger protein 145 | 0.0290869 |
| TPX2 | TPX2, microtubule-associated | 0.0290446 |
| NIN | ninein (GSK3B interacting protein) | 0.029009 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0285983 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.02851 |
| FMNL2 | formin-like 2 | 0.0284 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0283273 |
| DIAPH3 | diaphanous-related formin 3 | 0.0281185 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0280871 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0280166 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0279657 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0279121 |
| ANLN | anillin, actin binding protein | 0.0272616 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0266978 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0266916 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0265976 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0264759 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0262788 |
| ANXA1 | annexin A1 | 0.0262549 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0261977 |
| CEP295 | centrosomal protein 295kDa | 0.0257856 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0256931 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0256585 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0253956 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0251909 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0251675 |
| ITGB5 | integrin, beta 5 | 0.0251521 |
| MKI67 | marker of proliferation Ki-67 | 0.0250364 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0248372 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0247777 |
| COG5 | component of oligomeric golgi complex 5 | 0.0244329 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0242448 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0239962 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0239477 |
| RPL4 | ribosomal protein L4 | 0.0237424 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.023688 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.02349 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0234603 |
| YBX1 | Y box binding protein 1 | 0.0231497 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0230946 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0229907 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.02294 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0228009 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0227806 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.022775 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0226502 |
| JMJD1C | jumonji domain containing 1C | 0.0224635 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0224634 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0224562 |
| TLK1 | tousled-like kinase 1 | 0.0224157 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.022401 |
| STK24 | serine/threonine kinase 24 | 0.0222643 |
| WBP11 | WW domain binding protein 11 | 0.0220954 |
| TFG | TRK-fused gene | 0.0219968 |
| TMEM245 | transmembrane protein 245 | 0.0219864 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.02195 |
| ECT2 | epithelial cell transforming 2 | 0.0215912 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.169682 |
| TMSB10 | thymosin beta 10 | -0.157292 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0864717 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.082676 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0763583 |
| IGF2 | insulin-like growth factor 2 | -0.0713172 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0649002 |
| PTMA | prothymosin, alpha | -0.0601418 |
| ANGPTL4 | angiopoietin-like 4 | -0.0600291 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0558376 |
| PRSS23 | protease, serine, 23 | -0.0535657 |
| MT2A | metallothionein 2A | -0.053469 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0522342 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0518389 |
| HMGA2 | high mobility group AT-hook 2 | -0.0507365 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.050479 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0491596 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0484049 |
| ATG7 | autophagy related 7 | -0.0468241 |
| VIM | vimentin | -0.0465743 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0459845 |
| PRR16 | proline rich 16 | -0.0455378 |
| INTS6 | integrator complex subunit 6 | -0.0452444 |
| RPL35A | ribosomal protein L35a | -0.0451015 |
| NDRG1 | N-myc downstream regulated 1 | -0.0438706 |
| VCL | vinculin | -0.0437209 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.043432 |
| PURA | purine-rich element binding protein A | -0.0427895 |
| FMN1 | formin 1 | -0.0425429 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0405124 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0397415 |
| PCED1B | PC-esterase domain containing 1B | -0.0376437 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0369016 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0368731 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0364072 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0364005 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0363665 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0359899 |
| SDC4 | syndecan 4 | -0.0353346 |
| ATXN1 | ataxin 1 | -0.0347448 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0345424 |
| PODXL | podocalyxin-like | -0.0343049 |
| HLA-B | major histocompatibility complex, class I, B | -0.0339068 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0335554 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0331253 |
| GPC5 | glypican 5 | -0.0328006 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0326819 |
| RAD51B | RAD51 paralog B | -0.032588 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0324428 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0321154 |
| ATM | ATM serine/threonine kinase | -0.0319198 |
| FLNB | filamin B, beta | -0.0315791 |
| RPL26 | ribosomal protein L26 | -0.0313695 |
| NALCN | sodium leak channel, non selective | -0.0313353 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0311923 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0308316 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0306136 |
| IER3 | immediate early response 3 | -0.0305041 |
| RPL19 | ribosomal protein L19 | -0.0302437 |
| TRIM56 | tripartite motif containing 56 | -0.0301611 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0299231 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0298401 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0298031 |
| AEBP2 | AE binding protein 2 | -0.0293737 |
| RPS13 | ribosomal protein S13 | -0.0291668 |
| PYGL | phosphorylase, glycogen, liver | -0.0289844 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0289197 |
| LMNA | lamin A/C | -0.0288825 |
| RPS3 | ribosomal protein S3 | -0.0284411 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0280549 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0280409 |
| RAI14 | retinoic acid induced 14 | -0.0276811 |
| MCL1 | myeloid cell leukemia 1 | -0.0276713 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0275866 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0272604 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0271741 |
| LDHA | lactate dehydrogenase A | -0.0270512 |
| HLA-C | major histocompatibility complex, class I, C | -0.0269606 |
| AHNAK | AHNAK nucleoprotein | -0.0267306 |
| OSMR | oncostatin M receptor | -0.0266416 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0266046 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0263996 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0263637 |
| GPC6 | glypican 6 | -0.0260882 |
| ASPH | aspartate beta-hydroxylase | -0.0260726 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.026054 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0255825 |
| SEPTIN9 | septin 9 | -0.0250466 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0249396 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0247347 |
| ANKRD11 | ankyrin repeat domain 11 | -0.024622 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0244858 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0241632 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0241159 |
| FBXO11 | F-box protein 11 | -0.0237618 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0234825 |
| CAVIN1 | caveolae associated protein 1 | -0.0233017 |
| PLEK2 | pleckstrin 2 | -0.0231921 |
| PRKCA | protein kinase C, alpha | -0.0231692 |
| MIDN | midnolin | -0.0230864 |
