| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Megestrol perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Megestrol_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.171472 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.124434 |
| TMEM156 | transmembrane protein 156 | 0.0996236 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0915299 |
| STC2 | stanniocalcin 2 | 0.0774363 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0597418 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0591157 |
| VEGFA | vascular endothelial growth factor A | 0.0572985 |
| FN1 | fibronectin 1 | 0.0548484 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.054112 |
| NRP1 | neuropilin 1 | 0.0501584 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0499232 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0486331 |
| MT2A | metallothionein 2A | 0.048455 |
| SFTPA2 | surfactant protein A2 | 0.0482359 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | 0.0471409 |
| OSMR | oncostatin M receptor | 0.0458657 |
| ANKRD28 | ankyrin repeat domain 28 | 0.043996 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0436479 |
| CEP350 | centrosomal protein 350kDa | 0.0434079 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0420044 |
| AHR | aryl hydrocarbon receptor | 0.0410475 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0409922 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0407839 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.040552 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0404597 |
| HOMER2 | homer scaffolding protein 2 | 0.0401951 |
| ENAH | enabled homolog (Drosophila) | 0.03904 |
| RNF145 | ring finger protein 145 | 0.0386778 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0384736 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0379808 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0378318 |
| GOLGA4 | golgin A4 | 0.0370598 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0355828 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0353343 |
| TPR | translocated promoter region, nuclear basket protein | 0.034814 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0348011 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0347465 |
| IL6ST | interleukin 6 signal transducer | 0.0346872 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0343472 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0340533 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0333748 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0330249 |
| DST | dystonin | 0.0330031 |
| PGK1 | phosphoglycerate kinase 1 | 0.0324423 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0322912 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0320662 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0319981 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0317011 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0311455 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0311017 |
| FRY | furry homolog (Drosophila) | 0.0307709 |
| HDGF | hepatoma-derived growth factor | 0.0306435 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0296313 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0294603 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0293847 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0289724 |
| CAB39 | calcium binding protein 39 | 0.028532 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0281742 |
| SUCO | SUN domain containing ossification factor | 0.0281497 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0280076 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0277169 |
| SVIL | supervillin | 0.0276846 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.02763 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0275888 |
| HELZ | helicase with zinc finger | 0.0272177 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0271541 |
| KIF5B | kinesin family member 5B | 0.0271241 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0270656 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0269755 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0267339 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0266158 |
| FKBP5 | FK506 binding protein 5 | 0.0264714 |
| SH3BP4 | SH3-domain binding protein 4 | 0.026388 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0262584 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0262225 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0260476 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0260286 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0259221 |
| MKI67 | marker of proliferation Ki-67 | 0.0257519 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0253979 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0252946 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0250937 |
| ANGPTL4 | angiopoietin-like 4 | 0.0247911 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0247676 |
| SEPTIN9 | septin 9 | 0.0244806 |
| NXN | nucleoredoxin | 0.0243938 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.024269 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0242038 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0240897 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0240296 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0238586 |
| TXNRD1 | thioredoxin reductase 1 | 0.0237186 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0235232 |
| TGFB2 | transforming growth factor, beta 2 | 0.0232596 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0230362 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0230301 |
| BICC1 | BicC family RNA binding protein 1 | 0.0227919 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0227442 |
| ADD3 | adducin 3 (gamma) | 0.0227345 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.106916 |
| NDRG1 | N-myc downstream regulated 1 | -0.102879 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0882072 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0852494 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0813189 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0778842 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0753417 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0707488 |
| TMSB10 | thymosin beta 10 | -0.0693016 |
| SQSTM1 | sequestosome 1 | -0.0657759 |
| TMSB4X | thymosin beta 4, X-linked | -0.0615986 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0604545 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0585038 |
| AEBP2 | AE binding protein 2 | -0.053153 |
| S100A6 | S100 calcium binding protein A6 | -0.0524906 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0517216 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0508921 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0481257 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0476538 |
| SYT1 | synaptotagmin I | -0.0473384 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0451801 |
| INTS6 | integrator complex subunit 6 | -0.0441201 |
| TENM4 | teneurin transmembrane protein 4 | -0.0431462 |
| HLA-B | major histocompatibility complex, class I, B | -0.0421936 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0414653 |
| HMGA2 | high mobility group AT-hook 2 | -0.0408779 |
| EFNA5 | ephrin-A5 | -0.0364854 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0348583 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0342064 |
| VCL | vinculin | -0.0339263 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0337411 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0330517 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0327494 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0327128 |
| CADM1 | cell adhesion molecule 1 | -0.0323744 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0303534 |
| GPC6 | glypican 6 | -0.0293952 |
| RPS24 | ribosomal protein S24 | -0.0290856 |
| RPL9 | ribosomal protein L9 | -0.0289184 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0286177 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0278341 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0270981 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0269699 |
| IER3 | immediate early response 3 | -0.0266275 |
| SPAG9 | sperm associated antigen 9 | -0.0264339 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0262458 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0261119 |
| AHNAK | AHNAK nucleoprotein | -0.0258373 |
| VIM | vimentin | -0.0253888 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0253206 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0251907 |
| RPS21 | ribosomal protein S21 | -0.0251785 |
| RAI14 | retinoic acid induced 14 | -0.024972 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0249498 |
| GPATCH2L | G patch domain containing 2-like | -0.0249058 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0248175 |
| RPL34 | ribosomal protein L34 | -0.0245085 |
| CRY1 | cryptochrome circadian clock 1 | -0.0239346 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0239266 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0238538 |
| CTSB | cathepsin B | -0.0235476 |
| RANBP17 | RAN binding protein 17 | -0.0233906 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0225982 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0225163 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0216029 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0215728 |
| RPL23 | ribosomal protein L23 | -0.0215481 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0215085 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0213679 |
| TNRC6C | trinucleotide repeat containing 6C | -0.0211224 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0208482 |
| LAMB3 | laminin, beta 3 | -0.0207886 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0207348 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0206818 |
| LOXL2 | lysyl oxidase-like 2 | -0.0204359 |
| MYO1E | myosin IE | -0.0203484 |
| KLF12 | Kruppel-like factor 12 | -0.0202263 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0202172 |
| TSC22D1 | TSC22 domain family, member 1 | -0.020139 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0197032 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.019688 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0196052 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0195143 |
| ASTN2 | astrotactin 2 | -0.0194392 |
| RGS2 | regulator of G-protein signaling 2 | -0.0194268 |
| TGFA | transforming growth factor, alpha | -0.0192622 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0190864 |
| RPS11 | ribosomal protein S11 | -0.0190494 |
| FTL | ferritin, light polypeptide | -0.0189444 |
| MCL1 | myeloid cell leukemia 1 | -0.0187294 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0185957 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0185728 |
| HLA-A | major histocompatibility complex, class I, A | -0.0181659 |
| ADAM8 | ADAM metallopeptidase domain 8 | -0.018018 |
| H1-0 | H1.0 linker histone | -0.0178183 |
| NABP1 | nucleic acid binding protein 1 | -0.0177846 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0176654 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0173659 |
| NBEA | neurobeachin | -0.0170327 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0170216 |
