Melanocytic Nevus Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger. (Human Phenotype Ontology, HP_0000995)
External Link https://www.disgenet.org/browser/0/1/0/C0027962
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Genes

273 genes associated with the disease Melanocytic Nevus in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
A2ML1 alpha-2-macroglobulin-like 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADRB2 adrenoceptor beta 2, surface
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
AMACR alpha-methylacyl-CoA racemase
AMN amnion associated transmembrane protein
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARHGAP24 Rho GTPase activating protein 24
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BAD BCL2-associated agonist of cell death
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BIRC7 baculoviral IAP repeat containing 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
CADM1 cell adhesion molecule 1
CARD8 caspase recruitment domain family, member 8
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD163 CD163 molecule
CD34 CD34 molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CLOCK clock circadian regulator
CLPTM1L CLPTM1-like
COIL coilin
COL3A1 collagen, type III, alpha 1
COX2
CREBBP CREB binding protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTSD cathepsin D
CXCL8 chemokine (C-X-C motif) ligand 8
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DCTN4 dynactin 4 (p62)
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DICER1 dicer 1, ribonuclease type III
DMBT1 deleted in malignant brain tumors 1
DNM1 dynamin 1
DPH3 diphthamide biosynthesis 3
DUSP3 dual specificity phosphatase 3
EDN1 endothelin 1
EED embryonic ectoderm development
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERF Ets2 repressor factor
ERVW-1 endogenous retrovirus group W, member 1
ESPN espin
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FGF2 fibroblast growth factor 2 (basic)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FKBP10 FK506 binding protein 10, 65 kDa
G6PD glucose-6-phosphate dehydrogenase
GAB2 GRB2-associated binding protein 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GALK1 galactokinase 1
GH1 growth hormone 1
GJB2 gap junction protein, beta 2, 26kDa
GLB1 galactosidase, beta 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPC3 glypican 3
GSN gelsolin
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HCCS holocytochrome c synthase
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HOXA1 homeobox A1
HPS1 Hermansky-Pudlak syndrome 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSDL1 hydroxysteroid dehydrogenase like 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
HTRA1 HtrA serine peptidase 1
ICAM1 intercellular adhesion molecule 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IGF2 insulin-like growth factor 2
IGFBP7 insulin-like growth factor binding protein 7
IL10 interleukin 10
IL18 interleukin 18
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IRF4 interferon regulatory factor 4
IRF6 interferon regulatory factor 6
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KAT6B K(lysine) acetyltransferase 6B
KDM5B lysine (K)-specific demethylase 5B
KHDC3L KH domain containing 3-like, subcortical maternal complex member
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIF20A kinesin family member 20A
KISS1 KiSS-1 metastasis-suppressor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KLLN killin, p53-regulated DNA replication inhibitor
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT20 keratin 20, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS9 lectin, galactoside-binding, soluble, 9
LRIT1 leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
LRP2 low density lipoprotein receptor-related protein 2
LYST lysosomal trafficking regulator
LZTR1 leucine-zipper-like transcription regulator 1
MAGEA1 melanoma antigen family A1
MAGED4 melanoma antigen family D4
MAGED4B melanoma antigen family D4B
MAOA monoamine oxidase A
MAP2 microtubule-associated protein 2
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCAM melanoma cell adhesion molecule
MCM3AP minichromosome maintenance complex component 3 associated protein
METAP2 methionyl aminopeptidase 2
MIA melanoma inhibitory activity
MIB1 mindbomb E3 ubiquitin protein ligase 1
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLANA melan-A
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MPL MPL proto-oncogene, thrombopoietin receptor
MRAS muscle RAS oncogene homolog
MRPL28 mitochondrial ribosomal protein L28
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH2 mutS homolog 2
MT1A metallothionein 1A
MTAP methylthioadenosine phosphorylase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NES nestin
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGFR nerve growth factor receptor
NID1 nidogen 1
NLRP7 NLR family, pyrin domain containing 7
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP14 NOP14 nucleolar protein
NOS2 nitric oxide synthase 2, inducible
NQO1 NAD(P)H dehydrogenase, quinone 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRF1 nuclear respiratory factor 1
NRP2 neuropilin 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
OCA2 oculocutaneous albinism II
OPN1LW opsin 1 (cone pigments), long-wave-sensitive
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PAM peptidylglycine alpha-amidating monooxygenase
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PAX4 paired box 4
PAX9 paired box 9
PCBP4 poly(rC) binding protein 4
PCNA proliferating cell nuclear antigen
PDE4D phosphodiesterase 4D, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKM pyruvate kinase, muscle
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PLIN2 perilipin 2
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PLXND1 plexin D1
POT1 protection of telomeres 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRAME preferentially expressed antigen in melanoma
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCB protein kinase C, beta
PTAFR platelet-activating factor receptor
PTCH1 patched 1
PTCH2 patched 2
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PYCARD PYD and CARD domain containing
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAG2 recombination activating gene 2
RASA2 RAS p21 protein activator 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM28 RNA binding motif protein 28
RBX1 ring-box 1, E3 ubiquitin protein ligase
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHCE Rh blood group, CcEe antigens
RIT1 Ras-like without CAAX 1
RRAS related RAS viral (r-ras) oncogene homolog
RREB1 ras responsive element binding protein 1
RTL1 retrotransposon-like 1
S100A6 S100 calcium binding protein A6
SASS6 spindle assembly 6 homolog (C. elegans)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SEC23B Sec23 homolog B (S. cerevisiae)
SHCBP1 SHC SH2-domain binding protein 1
SHOX short stature homeobox
SIRT6 sirtuin 6
SLAMF9 SLAM family member 9
SLC12A9 solute carrier family 12, member 9
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLURP1 secreted LY6/PLAUR domain containing 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQSTM1 sequestosome 1
STK11 serine/threonine kinase 11
STS steroid sulfatase (microsomal), isozyme S
SUB1 SUB1 homolog (S. cerevisiae)
SUFU suppressor of fused homolog (Drosophila)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNGAP1 synaptic Ras GTPase activating protein 1
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLR4 toll-like receptor 4
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TSPAN8 tetraspanin 8
TSPO translocator protein (18kDa)
TYR tyrosinase
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XAF1 XIAP associated factor 1
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZHX2 zinc fingers and homeoboxes 2