Melanosome Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. (Gene Ontology, GO_0042470)
External Link http://amigo.geneontology.org/amigo/term/GO:0042470
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Genes

35 proteins localized to the Melanosome cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
MYO5A myosin VA (heavy chain 12, myoxin) 5.0
APOE apolipoprotein E 5.0
CTNS cystinosin, lysosomal cystine transporter 5.0
ERP29 endoplasmic reticulum protein 29 5.0
TPCN2 two pore segment channel 2 5.0
PMEL premelanosome protein 5.0
BACE2 beta-site APP-cleaving enzyme 2 5.0
SGSM2 small G protein signaling modulator 2 5.0
SLC45A2 solute carrier family 45, member 2 5.0
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 5.0
HPS4 Hermansky-Pudlak syndrome 4 5.0
MFSD12 major facilitator superfamily domain containing 12 5.0
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.0
RAB27B RAB27B, member RAS oncogene family 5.0
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 5.0
GPR143 G protein-coupled receptor 143 5.0
TMEM33 transmembrane protein 33 5.0
CTSD cathepsin D 5.0
GCHFR GTP cyclohydrolase I feedback regulator 5.0
OCA2 oculocutaneous albinism II 5.0
RAB27A RAB27A, member RAS oncogene family 4.0
MLANA melan-A 4.0
RAB32 RAB32, member RAS oncogene family 4.0
RAB38 RAB38, member RAS oncogene family 4.0
TYR tyrosinase 4.0
RAB9A RAB9A, member RAS oncogene family 4.0
RAB17 RAB17, member RAS oncogene family 4.0
ATP7A ATPase, Cu++ transporting, alpha polypeptide 4.0
TYRP1 tyrosinase-related protein 1 4.0
DCT dopachrome tautomerase 4.0
SYTL2 synaptotagmin-like 2 4.0
SYTL1 synaptotagmin-like 1 4.0
TH tyrosine hydroxylase 4.0
MREG melanoregulin 3.0
RAB29 RAB29, member RAS oncogene family 3.0