Meloxicam_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.179989
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0897235
BCAS3 breast carcinoma amplified sequence 3 0.0607547
LSAMP limbic system-associated membrane protein 0.0603994
LPIN1 lipin 1 0.0579382
THSD4 thrombospondin, type I, domain containing 4 0.0554937
VMP1 vacuole membrane protein 1 0.0543912
NRG1 neuregulin 1 0.0455082
RNF213 ring finger protein 213 0.0438208
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0432567
TPST1 tyrosylprotein sulfotransferase 1 0.0426558
EEF2 eukaryotic translation elongation factor 2 0.042407
FMN1 formin 1 0.0406719
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0401152
CADM2 cell adhesion molecule 2 0.0393669
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0375694
NALF1 NALCN channel auxiliary factor 1 0.0369573
XPO1 exportin 1 0.033304
PICALM phosphatidylinositol binding clathrin assembly protein 0.0331614
GREM2 gremlin 2, DAN family BMP antagonist 0.0324501
PLEC plectin 0.0322255
TRIO trio Rho guanine nucleotide exchange factor 0.0317751
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0311382
PCBP2 poly(rC) binding protein 2 0.0304947
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.0304258
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0300403
FXR1 fragile X mental retardation, autosomal homolog 1 0.0299739
PSD3 pleckstrin and Sec7 domain containing 3 0.0299632
PBX1 pre-B-cell leukemia homeobox 1 0.0290775
PRRC2B proline-rich coiled-coil 2B 0.0282332
PACS1 phosphofurin acidic cluster sorting protein 1 0.0282064
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0282034
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0280398
TXNRD1 thioredoxin reductase 1 0.0278694
PARD3 par-3 family cell polarity regulator 0.0274947
ANKRD17 ankyrin repeat domain 17 0.0271253
RAD23B RAD23 homolog B (S. cerevisiae) 0.0269834
AHRR aryl-hydrocarbon receptor repressor 0.0267309
EXOC4 exocyst complex component 4 0.0266616
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0264878
COL3A1 collagen, type III, alpha 1 0.0260557
R3HDM2 R3H domain containing 2 0.026025
PDZRN3 PDZ domain containing ring finger 3 0.025622
SYT1 synaptotagmin I 0.0254892
PRKCA protein kinase C, alpha 0.0253658
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.025118
NCAM2 neural cell adhesion molecule 2 0.0251148
SRPK2 SRSF protein kinase 2 0.0248808
DGKH diacylglycerol kinase, eta 0.0248729
NEO1 neogenin 1 0.0247656
CNTN4 contactin 4 0.0243779
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.023863
KLHL13 kelch-like family member 13 0.0236374
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0234016
SLIT2 slit homolog 2 (Drosophila) 0.0231985
ANTXR1 anthrax toxin receptor 1 0.0230907
ARHGAP24 Rho GTPase activating protein 24 0.0230735
HSPA8 heat shock 70kDa protein 8 0.0222259
PLPP1 phospholipid phosphatase 1 0.0221544
AUTS2 autism susceptibility candidate 2 0.0221058
ZC3H11A zinc finger CCCH-type containing 11A 0.0219909
NPAS3 neuronal PAS domain protein 3 0.0216196
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0213282
KIF26B kinesin family member 26B 0.0210517
ZFC3H1 zinc finger, C3H1-type containing 0.0209975
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0209502
SLC39A11 solute carrier family 39, member 11 0.020927
CUX1 cut-like homeobox 1 0.0209253
SMAD5 SMAD family member 5 0.020833
CCNG2 cyclin G2 0.0207171
TENM4 teneurin transmembrane protein 4 0.020612
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0205913
PKM pyruvate kinase, muscle 0.0204887
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0203966
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0203167
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0202535
LINGO2 leucine rich repeat and Ig domain containing 2 0.0201166
CHD7 chromodomain helicase DNA binding protein 7 0.0200995
ENAH enabled homolog (Drosophila) 0.0199936
ZFAND3 zinc finger, AN1-type domain 3 0.0198543
PRRC2C proline-rich coiled-coil 2C 0.0198334
TUBB tubulin, beta class I 0.0197949
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.019475
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0194655
USP34 ubiquitin specific peptidase 34 0.0192658
UNC5C unc-5 homolog C (C. elegans) 0.0192142
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0191676
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0191465
INO80 INO80 complex subunit 0.0190444
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0189868
AKAP13 A kinase (PRKA) anchor protein 13 0.0189833
CSMD3 CUB and Sushi multiple domains 3 0.0189621
SH3KBP1 SH3-domain kinase binding protein 1 0.0188189
KCTD3 potassium channel tetramerization domain containing 3 0.0187689
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0187072
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0186743
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0184897
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0184671
RBM8A RNA binding motif protein 8A 0.0184641
MED13 mediator complex subunit 13 0.0184258

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.236567
AKAP12 A kinase (PRKA) anchor protein 12 -0.195359
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160452
FAM13A family with sequence similarity 13, member A -0.0899657
HELZ helicase with zinc finger -0.0821544
FNBP1 formin binding protein 1 -0.0695476
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0693893
WDR45B WD repeat domain 45B -0.0687858
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0667174
FNDC3B fibronectin type III domain containing 3B -0.0640784
MEF2A myocyte enhancer factor 2A -0.0619419
MEIS2 Meis homeobox 2 -0.060693
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0587092
VIM vimentin -0.0547303
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0534165
DTNA dystrobrevin, alpha -0.0510217
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0503887
NDRG1 N-myc downstream regulated 1 -0.050136
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0478394
RTN4 reticulon 4 -0.0430176
MBD5 methyl-CpG binding domain protein 5 -0.0411998
MXI1 MAX interactor 1, dimerization protein -0.0409478
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0408986
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0387423
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0375296
STC1 stanniocalcin 1 -0.0369719
ANGPTL4 angiopoietin-like 4 -0.0364472
PLAT plasminogen activator, tissue -0.0350052
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.034136
PTPRM protein tyrosine phosphatase, receptor type, M -0.0338913
RPL38 ribosomal protein L38 -0.0325982
CDK19 cyclin-dependent kinase 19 -0.0324279
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0323299
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0322345
RPL35A ribosomal protein L35a -0.0312151
S100A6 S100 calcium binding protein A6 -0.031145
RPLP1 ribosomal protein, large, P1 -0.0308615
RPL37A ribosomal protein L37a -0.0308501
TMSB10 thymosin beta 10 -0.0307794
HILPDA hypoxia inducible lipid droplet-associated -0.030739
CENPF centromere protein F, 350/400kDa -0.0307389
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0306915
CCDC47 coiled-coil domain containing 47 -0.0304666
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0298698
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0297512
ZNF292 zinc finger protein 292 -0.0297449
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0293523
LIMCH1 LIM and calponin homology domains 1 -0.0287455
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0281542
RNMT RNA (guanine-7-) methyltransferase -0.0279103
RPL12 ribosomal protein L12 -0.0277768
ELL2 elongation factor, RNA polymerase II, 2 -0.0271301
DST dystonin -0.0268972
TRIB2 tribbles pseudokinase 2 -0.026851
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0267355
RPS19 ribosomal protein S19 -0.0262017
TTC3 tetratricopeptide repeat domain 3 -0.0261867
KDM3A lysine (K)-specific demethylase 3A -0.025967
CANX calnexin -0.0253357
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0252928
MIS18BP1 MIS18 binding protein 1 -0.0252518
DPH6 diphthamine biosynthesis 6 -0.0251229
UBE2O ubiquitin-conjugating enzyme E2O -0.0249597
PGK1 phosphoglycerate kinase 1 -0.0248278
IFI16 interferon, gamma-inducible protein 16 -0.0248044
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0247843
RUNX1 runt-related transcription factor 1 -0.0246734
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0244392
RAB40C RAB40C, member RAS oncogene family -0.0241815
ADGRG6 adhesion G protein-coupled receptor G6 -0.0239018
AFF3 AF4/FMR2 family, member 3 -0.0237504
SEPTIN9 septin 9 -0.0237214
ASPH aspartate beta-hydroxylase -0.0236995
RPL13A ribosomal protein L13a -0.0236841
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0235225
DNMBP dynamin binding protein -0.0234044
NPAS2 neuronal PAS domain protein 2 -0.0233234
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0232856
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.023189
KLF7 Kruppel-like factor 7 (ubiquitous) -0.023183
RPL36 ribosomal protein L36 -0.0231693
PRR11 proline rich 11 -0.0231648
FTL ferritin, light polypeptide -0.0228483
FAM162A family with sequence similarity 162, member A -0.0226688
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0226414
EGFR epidermal growth factor receptor -0.0226135
RPL23 ribosomal protein L23 -0.0225858
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0224991
RNF169 ring finger protein 169 -0.0222974
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0222199
RPL34 ribosomal protein L34 -0.022213
NKTR natural killer cell triggering receptor -0.0221821
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0221488
RPL19 ribosomal protein L19 -0.0220937
KDM4C lysine (K)-specific demethylase 4C -0.0220017
NGLY1 N-glycanase 1 -0.021994
RPL32 ribosomal protein L32 -0.021979
SUCO SUN domain containing ossification factor -0.0219763
RAB7A RAB7A, member RAS oncogene family -0.0218374
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0216816