Meloxicam_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0687084
PLEC plectin 0.0607235
CEMIP cell migration inducing protein, hyaluronan binding 0.0592453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0577148
APLP2 amyloid beta (A4) precursor-like protein 2 0.0503264
MSN moesin 0.0478307
CLU clusterin 0.0431564
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0384028
MYH9 myosin, heavy chain 9, non-muscle 0.0368751
ARRDC3 arrestin domain containing 3 0.0320493
KCTD12 potassium channel tetramerization domain containing 12 0.029757
FOXP1 forkhead box P1 0.0292824
KTN1 kinectin 1 (kinesin receptor) 0.0289726
NCOA3 nuclear receptor coactivator 3 0.0281504
NAMPT nicotinamide phosphoribosyltransferase 0.0263103
KRT17 keratin 17, type I 0.025954
KRT6A keratin 6A, type II 0.0245715
RPL3 ribosomal protein L3 0.0237466
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.023098
NIBAN2 niban apoptosis regulator 2 0.0228032
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0225009
SKAP2 src kinase associated phosphoprotein 2 0.0220431
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0214966
TGM2 transglutaminase 2 0.0212373
SOD2 superoxide dismutase 2, mitochondrial 0.0211695
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0210478
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0208073
STC1 stanniocalcin 1 0.0207863
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0205951
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0201995
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0200194
UBE2H ubiquitin-conjugating enzyme E2H 0.0199906
NBEA neurobeachin 0.0199507
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0199313
RNF19B ring finger protein 19B 0.019597
SLC45A4 solute carrier family 45, member 4 0.0191474
MCL1 myeloid cell leukemia 1 0.0181008
FNDC3B fibronectin type III domain containing 3B 0.018048
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0178576
BRD2 bromodomain containing 2 0.0178335
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0175362
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0174349
CCNL1 cyclin L1 0.0171115
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0168535
TPM3 tropomyosin 3 0.0166913
FLNA filamin A, alpha 0.0166089
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0164318
SEPTIN9 septin 9 0.0160589
NBAS neuroblastoma amplified sequence 0.0160393
EHBP1L1 EH domain binding protein 1-like 1 0.0160183
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.015964
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0159159
FN1 fibronectin 1 0.0158009
PDLIM1 PDZ and LIM domain 1 0.0157139
TBC1D5 TBC1 domain family, member 5 0.0156145
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0155368
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0154373
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0154372
NCOR2 nuclear receptor corepressor 2 0.0151642
ARHGAP23 Rho GTPase activating protein 23 0.0151563
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.015075
PRELID2 PRELI domain containing 2 0.0148763
XPO1 exportin 1 0.0148476
ACBD3 acyl-CoA binding domain containing 3 0.0147937
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0146636
TMEM245 transmembrane protein 245 0.0145943
TNIP1 TNFAIP3 interacting protein 1 0.0145482
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0145348
DSCAM Down syndrome cell adhesion molecule 0.0143765
GRAMD1B GRAM domain containing 1B 0.0143682
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.0141733
TRIP12 thyroid hormone receptor interactor 12 0.01408
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0140681
NUMA1 nuclear mitotic apparatus protein 1 0.013897
FXR1 fragile X mental retardation, autosomal homolog 1 0.0138609
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0138395
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.013821
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0138146
MKRN1 makorin ring finger protein 1 0.0136597
TMF1 TATA element modulatory factor 1 0.0135509
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 0.0135508
BBS9 Bardet-Biedl syndrome 9 0.0134971
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.013255
EEF2 eukaryotic translation elongation factor 2 0.0131274
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0131087
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.012973
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 0.0128609
KIAA1217 KIAA1217 0.0128571
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0128259
ATM ATM serine/threonine kinase 0.0128017
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0128003
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0127877
FAT1 FAT atypical cadherin 1 0.0127381
FLG filaggrin 0.012714
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0126619
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0126577
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0126172
EHF ets homologous factor 0.0124572
PFKP phosphofructokinase, platelet 0.0124277
CLIC4 chloride intracellular channel 4 0.0122342

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.220392
MT2A metallothionein 2A -0.175362
TMSB10 thymosin beta 10 -0.169613
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.13424
TPT1 tumor protein, translationally-controlled 1 -0.126925
RPS6 ribosomal protein S6 -0.112313
RPS21 ribosomal protein S21 -0.111944
RPS8 ribosomal protein S8 -0.103004
S100A10 S100 calcium binding protein A10 -0.100409
RPLP2 ribosomal protein, large, P2 -0.0995602
RPLP1 ribosomal protein, large, P1 -0.0993147
SLC35F3 solute carrier family 35, member F3 -0.0991756
PTMA prothymosin, alpha -0.0942218
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0879152
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0843699
RPL11 ribosomal protein L11 -0.0815326
TRIO trio Rho guanine nucleotide exchange factor -0.080166
PODXL podocalyxin-like -0.0797944
CD44 CD44 molecule (Indian blood group) -0.0726182
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0704018
CAV1 caveolin 1, caveolae protein, 22kDa -0.0688586
RPS19 ribosomal protein S19 -0.0673929
MTSS1 metastasis suppressor 1 -0.0659859
RASAL2 RAS protein activator like 2 -0.0638262
HLA-B major histocompatibility complex, class I, B -0.0623187
IFITM3 interferon induced transmembrane protein 3 -0.0614857
RPL37 ribosomal protein L37 -0.0611373
RPS13 ribosomal protein S13 -0.0602082
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0598213
LAMC2 laminin, gamma 2 -0.0586062
FLNB filamin B, beta -0.0585477
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0582212
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0581254
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0580487
PGK1 phosphoglycerate kinase 1 -0.0575719
RPS3 ribosomal protein S3 -0.0572169
RPS24 ribosomal protein S24 -0.056939
RPL34 ribosomal protein L34 -0.0559961
RPL35A ribosomal protein L35a -0.054854
RPL37A ribosomal protein L37a -0.0541086
RPL12 ribosomal protein L12 -0.0514549
MEF2A myocyte enhancer factor 2A -0.0510369
RPL23 ribosomal protein L23 -0.0504541
S100A9 S100 calcium binding protein A9 -0.0495793
RPS25 ribosomal protein S25 -0.0495485
RPS27A ribosomal protein S27a -0.0493085
RPS12 ribosomal protein S12 -0.0488611
GNAS GNAS complex locus -0.0481817
RPL30 ribosomal protein L30 -0.0480945
IFITM1 interferon induced transmembrane protein 1 -0.0478085
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.047635
RPL19 ribosomal protein L19 -0.0474059
S100A6 S100 calcium binding protein A6 -0.0470373
TMSB4X thymosin beta 4, X-linked -0.0466291
RPL32 ribosomal protein L32 -0.0465452
VCL vinculin -0.0456561
PRSS23 protease, serine, 23 -0.045525
RPL26 ribosomal protein L26 -0.0455037
AHNAK AHNAK nucleoprotein -0.0451947
RPL36 ribosomal protein L36 -0.0447369
H1-0 H1.0 linker histone -0.0445538
PLS3 plastin 3 -0.0438969
NAV2 neuron navigator 2 -0.0438913
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0434725
RPL5 ribosomal protein L5 -0.0433316
RPL28 ribosomal protein L28 -0.0430715
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0430255
LOC112694756 uncharaterized LOC112694756 -0.0430233
RPL8 ribosomal protein L8 -0.0423188
RPS29 ribosomal protein S29 -0.0422066
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0415617
RPL7A ribosomal protein L7a -0.0412229
RPL35 ribosomal protein L35 -0.0407035
RPS27 ribosomal protein S27 -0.0406775
LDHA lactate dehydrogenase A -0.0397584
FTL ferritin, light polypeptide -0.0393605
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0383698
TM4SF1 transmembrane 4 L six family member 1 -0.0382764
ACTG1 actin gamma 1 -0.0375271
BCAR3 breast cancer anti-estrogen resistance 3 -0.0374123
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0370747
MACF1 microtubule-actin crosslinking factor 1 -0.0370321
ATP5F1E ATP synthase F1 subunit epsilon -0.036922
ALCAM activated leukocyte cell adhesion molecule -0.0369185
RPS20 ribosomal protein S20 -0.0368103
F3 coagulation factor III (thromboplastin, tissue factor) -0.0366065
RPS16 ribosomal protein S16 -0.0364245
IFI16 interferon, gamma-inducible protein 16 -0.0363665
B2M beta-2-microglobulin -0.03605
RPL9 ribosomal protein L9 -0.0360409
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0358181
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0357883
HM13 histocompatibility (minor) 13 -0.0356073
PSD3 pleckstrin and Sec7 domain containing 3 -0.0355777
RACK1 receptor for activated C kinase 1 -0.0352249
RPS14 ribosomal protein S14 -0.035009
MYO10 myosin X -0.0346456
CSTB cystatin B (stefin B) -0.0346276
S100A2 S100 calcium binding protein A2 -0.0343914
RPS23 ribosomal protein S23 -0.0338971