Meloxicam_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.170194
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.126531
CEMIP cell migration inducing protein, hyaluronan binding 0.10163
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.100695
GPHN gephyrin 0.0688894
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0663812
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0656757
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0651003
PTMA prothymosin, alpha 0.0585622
PIGR polymeric immunoglobulin receptor 0.0550013
EREG epiregulin 0.0508552
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0502256
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0485849
CANX calnexin 0.0481759
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0474768
AREG amphiregulin 0.0468915
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0463918
EEF2 eukaryotic translation elongation factor 2 0.0463533
DDIT4 DNA-damage-inducible transcript 4 0.0444716
DSPP dentin sialophosphoprotein 0.0442338
LDHA lactate dehydrogenase A 0.0438873
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0415074
EZR ezrin 0.0401516
ANXA11 annexin A11 0.0390873
EPCAM epithelial cell adhesion molecule 0.0390697
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0385996
KRT18 keratin 18, type I 0.0371966
EIF1 eukaryotic translation initiation factor 1 0.0371298
LOC102724023 ES1 protein homolog, mitochondrial 0.0364347
TBC1D5 TBC1 domain family, member 5 0.0364082
KIF5B kinesin family member 5B 0.0359516
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0345429
B2M beta-2-microglobulin 0.0335289
SOX9 SRY (sex determining region Y)-box 9 0.0327017
MLEC malectin 0.0321803
FOXP1 forkhead box P1 0.0319245
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0310626
TNS4 tensin 4 0.0309513
KRT8 keratin 8, type II 0.0304382
INSIG1 insulin induced gene 1 0.0295507
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0291222
AHNAK AHNAK nucleoprotein 0.0289292
ZFP36L2 ZFP36 ring finger protein-like 2 0.028726
TSC22D1 TSC22 domain family, member 1 0.0285503
OAZ1 ornithine decarboxylase antizyme 1 0.0278289
MUC13 mucin 13, cell surface associated 0.0277379
RPLP0 ribosomal protein, large, P0 0.0274018
NFIA nuclear factor I/A 0.0273238
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0271977
CADPS Ca++-dependent secretion activator 0.0267858
ENO1 enolase 1, (alpha) 0.026743
RPS6 ribosomal protein S6 0.0266498
CCND1 cyclin D1 0.0265382
ABR active BCR-related 0.0261277
PLEC plectin 0.0260389
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0259035
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0254512
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0254305
RBM25 RNA binding motif protein 25 0.0253152
NRXN3 neurexin 3 0.0252411
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0251018
PCBP2 poly(rC) binding protein 2 0.0249538
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.024603
RPL7 ribosomal protein L7 0.024401
RPL3 ribosomal protein L3 0.0242648
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0242162
PTPRG protein tyrosine phosphatase, receptor type, G 0.024201
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0241508
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0237757
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.023705
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0236833
FTL ferritin, light polypeptide 0.0236664
GDF15 growth differentiation factor 15 0.0232675
EPHB2 EPH receptor B2 0.0231988
ZBTB20 zinc finger and BTB domain containing 20 0.0230144
RPL7A ribosomal protein L7a 0.0229988
UBC ubiquitin C 0.0229465
FHIT fragile histidine triad 0.022784
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0227248
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0224243
TRIM2 tripartite motif containing 2 0.0223182
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0223032
MACC1 metastasis associated in colon cancer 1 0.022214
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0220478
ARL15 ADP-ribosylation factor-like 15 0.0220319
SERINC5 serine incorporator 5 0.0220266
NARS1 asparaginyl-tRNA synthetase 1 0.0218943
RPS3 ribosomal protein S3 0.0216294
CTBP2 C-terminal binding protein 2 0.0215974
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0215849
NAP1L1 nucleosome assembly protein 1-like 1 0.0212293
EIF5B eukaryotic translation initiation factor 5B 0.0212023
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0211846
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0211267
TNRC18 trinucleotide repeat containing 18 0.0210805
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0210149
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0207893
EIF4A2 eukaryotic translation initiation factor 4A2 0.0207524
SET SET nuclear proto-oncogene 0.0207511
PCDHB16 protocadherin beta 16 0.0205338

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114791
NPSR1 neuropeptide S receptor 1 -0.0968965
TMSB10 thymosin beta 10 -0.0705667
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0688269
ESYT2 extended synaptotagmin-like protein 2 -0.0558017
FLNB filamin B, beta -0.0548747
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0541437
NDRG1 N-myc downstream regulated 1 -0.0539416
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0510574
LMO7 LIM domain 7 -0.0507925
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0440065
GREB1L growth regulation by estrogen in breast cancer-like -0.0429125
FTH1 ferritin, heavy polypeptide 1 -0.0425577
MBNL2 muscleblind-like splicing regulator 2 -0.0423734
PSD3 pleckstrin and Sec7 domain containing 3 -0.0421016
SEC31A SEC31 homolog A (S. cerevisiae) -0.0420007
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0419556
USP53 ubiquitin specific peptidase 53 -0.0417874
GRB10 growth factor receptor-bound protein 10 -0.0403474
CALB1 calbindin 1, 28kDa -0.0348623
RAP1B RAP1B, member of RAS oncogene family -0.0346118
GMDS GDP-mannose 4,6-dehydratase -0.0334718
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0334614
MACF1 microtubule-actin crosslinking factor 1 -0.0332768
PDLIM5 PDZ and LIM domain 5 -0.0323933
VCL vinculin -0.0320764
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.030915
EXT1 exostosin glycosyltransferase 1 -0.0290909
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0290817
PTPRR protein tyrosine phosphatase, receptor type, R -0.0287345
SEC24D SEC24 family member D -0.0284795
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0283027
FNDC3B fibronectin type III domain containing 3B -0.0283004
RNF145 ring finger protein 145 -0.0280871
RCOR1 REST corepressor 1 -0.0277196
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0275823
ARHGAP32 Rho GTPase activating protein 32 -0.0269087
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0260826
MED13L mediator complex subunit 13-like -0.0256996
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0256754
ARHGAP21 Rho GTPase activating protein 21 -0.0255792
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.02499
MXD1 MAX dimerization protein 1 -0.0247397
TSC22D2 TSC22 domain family, member 2 -0.024602
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0244566
SPAG9 sperm associated antigen 9 -0.0243821
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0243504
ANTXR2 anthrax toxin receptor 2 -0.0242121
RNF217 ring finger protein 217 -0.0238427
SCFD1 sec1 family domain containing 1 -0.0236501
PARD3 par-3 family cell polarity regulator -0.0230266
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0230221
TTC3 tetratricopeptide repeat domain 3 -0.0230128
IGFL2 IGF-like family member 2 -0.0228978
NBAS neuroblastoma amplified sequence -0.0228134
ALCAM activated leukocyte cell adhesion molecule -0.0221129
NCOR1 nuclear receptor corepressor 1 -0.0220605
LPP LIM domain containing preferred translocation partner in lipoma -0.0219467
GLS2 glutaminase 2 (liver, mitochondrial) -0.0218136
SLC35F3 solute carrier family 35, member F3 -0.0217371
CCNY cyclin Y -0.0217145
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0216336
KLF5 Kruppel-like factor 5 (intestinal) -0.0215791
FOXO1 forkhead box O1 -0.0212125
COG5 component of oligomeric golgi complex 5 -0.0210528
AKAP13 A kinase (PRKA) anchor protein 13 -0.0209886
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0209443
FAM13A family with sequence similarity 13, member A -0.020884
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0207331
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0207202
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0206346
PUM2 pumilio RNA-binding family member 2 -0.0206021
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0205159
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0204693
BTBD9 BTB (POZ) domain containing 9 -0.0202613
GOLGA4 golgin A4 -0.0200511
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0199655
MCTP2 multiple C2 domains, transmembrane 2 -0.0199437
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0199176
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0198353
FNIP1 folliculin interacting protein 1 -0.0196669
EMP1 epithelial membrane protein 1 -0.0196534
MORF4L2 mortality factor 4 like 2 -0.0194743
TFG TRK-fused gene -0.0191449
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0191266
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0190314
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0189264
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0188357
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0187015
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0185554
EGFR epidermal growth factor receptor -0.018543
ARHGAP6 Rho GTPase activating protein 6 -0.0183558
SEC23A Sec23 homolog A (S. cerevisiae) -0.0183531
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0183099
RAB1A RAB1A, member RAS oncogene family -0.0182356
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0182154
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0180044
POF1B premature ovarian failure, 1B -0.017808
TBC1D22A TBC1 domain family, member 22A -0.0177177
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0175358