Meloxicam_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0969806
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0463892
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0408853
PLEC plectin 0.0316279
ANGPTL4 angiopoietin-like 4 0.0298309
TMSB4X thymosin beta 4, X-linked 0.0245911
ARRDC3 arrestin domain containing 3 0.0220625
CCDC200 coiled-coil domain containing 200 0.0213529
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.02098
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0196509
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0181473
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0167488
AREG amphiregulin 0.0165173
SGK1 serum/glucocorticoid regulated kinase 1 0.0154383
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0146873
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0144951
TSC22D1 TSC22 domain family, member 1 0.0144193
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0142056
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0138285
SOD2 superoxide dismutase 2, mitochondrial 0.0137944
DDIT4 DNA-damage-inducible transcript 4 0.0132945
ZDHHC14 zinc finger, DHHC-type containing 14 0.0127631
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0124851
CXCL5 chemokine (C-X-C motif) ligand 5 0.0115171
GCLC glutamate-cysteine ligase, catalytic subunit 0.0113147
RCAN1 regulator of calcineurin 1 0.0111735
CADM2 cell adhesion molecule 2 0.0105477
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.0100185
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00993357
TP63 tumor protein p63 0.00993007
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.00965954
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.00961845
RGS5 regulator of G-protein signaling 5 0.00955081
NFE2L1 nuclear factor, erythroid 2-like 1 0.00951032
LHX1 LIM homeobox 1 0.00949773
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00939916
EREG epiregulin 0.0093842
BIRC3 baculoviral IAP repeat containing 3 0.00934868
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.00918164
HDAC9 histone deacetylase 9 0.0091728
COL17A1 collagen, type XVII, alpha 1 0.00912184
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.00908837
GRIPAP1 GRIP1 associated protein 1 0.00897133
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.00896128
IER2 immediate early response 2 0.00893939
UPP1 uridine phosphorylase 1 0.00877191
ZFP36L1 ZFP36 ring finger protein-like 1 0.0086895
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0086616
AFAP1 actin filament associated protein 1 0.00863731
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.00845447
TNIP1 TNFAIP3 interacting protein 1 0.00845222
F2R coagulation factor II (thrombin) receptor 0.00838646
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.00835108
PLK2 polo-like kinase 2 0.00834246
BBX bobby sox homolog (Drosophila) 0.00829663
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00825642
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00821924
CBX1 chromobox homolog 1 0.00820549
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.00813988
HEXIM1 hexamethylene bis-acetamide inducible 1 0.00811259
DTX3L deltex 3 like, E3 ubiquitin ligase 0.00806944
ATXN1 ataxin 1 0.00788599
GRAMD1B GRAM domain containing 1B 0.00788541
SOX9 SRY (sex determining region Y)-box 9 0.00785546
PRNP prion protein 0.00783384
CTSB cathepsin B 0.00781979
CD164 CD164 molecule, sialomucin 0.00774835
DOK3 docking protein 3 0.00774375
RIGI RNA sensor RIG-I 0.00773347
ILF3 interleukin enhancer binding factor 3, 90kDa 0.00767378
PARP9 poly (ADP-ribose) polymerase family, member 9 0.00764287
RSAD2 radical S-adenosyl methionine domain containing 2 0.00763468
STIP1 stress-induced phosphoprotein 1 0.00759233
FDPS farnesyl diphosphate synthase 0.00722636
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 0.00719109
AFF3 AF4/FMR2 family, member 3 0.00716405
IRAK2 interleukin-1 receptor-associated kinase 2 0.00714143
LMO7 LIM domain 7 0.00713601
UPRT uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) 0.00712215
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0070606
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.00699709
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.00695771
JAG1 jagged 1 0.00694896
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.00693607
ZBTB4 zinc finger and BTB domain containing 4 0.00692732
IFIH1 interferon induced with helicase C domain 1 0.00691149
FN1 fibronectin 1 0.00690801
CXCL3 chemokine (C-X-C motif) ligand 3 0.00689453
IGFBP3 insulin-like growth factor binding protein 3 0.00686994
ACYP2 acylphosphatase 2, muscle type 0.00686033
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.00684614
HBEGF heparin-binding EGF-like growth factor 0.00681711
INSIG1 insulin induced gene 1 0.00681636
CXCL2 chemokine (C-X-C motif) ligand 2 0.00673824
HKDC1 hexokinase domain containing 1 0.00668688
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00668501
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.00665832
SPRY2 sprouty homolog 2 (Drosophila) 0.00665215
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.00659678
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00657633

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.39336
VIM vimentin -0.178701
TMSB10 thymosin beta 10 -0.160573
PTMA prothymosin, alpha -0.110352
MT2A metallothionein 2A -0.108057
DST dystonin -0.104209
UBC ubiquitin C -0.0914462
CD44 CD44 molecule (Indian blood group) -0.0864383
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0823089
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0803381
TM4SF1 transmembrane 4 L six family member 1 -0.0742924
RPS8 ribosomal protein S8 -0.0722141
POTEF POTE ankyrin domain family, member F -0.0672881
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0655052
APP amyloid beta (A4) precursor protein -0.0635364
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0632108
RPS27A ribosomal protein S27a -0.0576385
ACTG1 actin gamma 1 -0.0570652
FMNL2 formin-like 2 -0.0559572
DLG1 discs, large homolog 1 (Drosophila) -0.0544268
JMJD1C jumonji domain containing 1C -0.0520461
RPL26 ribosomal protein L26 -0.0520052
AHNAK AHNAK nucleoprotein -0.0515546
RPL23 ribosomal protein L23 -0.0479756
FNIP1 folliculin interacting protein 1 -0.0478564
FLNB filamin B, beta -0.0476327
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0473188
TRIO trio Rho guanine nucleotide exchange factor -0.0461264
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0457345
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0446697
RPLP2 ribosomal protein, large, P2 -0.043981
ENO1 enolase 1, (alpha) -0.043335
EEF2 eukaryotic translation elongation factor 2 -0.0431017
RPL37A ribosomal protein L37a -0.0429946
RPS12 ribosomal protein S12 -0.041902
RPS6 ribosomal protein S6 -0.041445
CAPRIN2 caprin family member 2 -0.0413717
BIRC6 baculoviral IAP repeat containing 6 -0.0410514
ZFAND3 zinc finger, AN1-type domain 3 -0.0400877
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.03999
RPL12 ribosomal protein L12 -0.0399602
SLC38A2 solute carrier family 38, member 2 -0.0394359
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0394045
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0393805
RPL19 ribosomal protein L19 -0.03834
EHBP1 EH domain binding protein 1 -0.0379757
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0378365
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0377779
RBM25 RNA binding motif protein 25 -0.0376088
SPAG9 sperm associated antigen 9 -0.0375608
RPS23 ribosomal protein S23 -0.0375139
ANKRD11 ankyrin repeat domain 11 -0.0371064
PIAS2 protein inhibitor of activated STAT, 2 -0.0362538
ZMYND8 zinc finger, MYND-type containing 8 -0.0361205
NF1 neurofibromin 1 -0.0359022
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.035821
WSB1 WD repeat and SOCS box containing 1 -0.035345
WWTR1 WW domain containing transcription regulator 1 -0.0353396
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0353357
RPL5 ribosomal protein L5 -0.035208
DENND5A DENN/MADD domain containing 5A -0.0346294
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0345299
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0344077
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0341046
GOLGA4 golgin A4 -0.0339518
RTN4 reticulon 4 -0.0338135
ANKRD12 ankyrin repeat domain 12 -0.0337328
SRPK2 SRSF protein kinase 2 -0.0334465
OGA O-GlcNAcase -0.033407
EZR ezrin -0.0327555
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0323207
BRWD1 bromodomain and WD repeat domain containing 1 -0.0323072
PUM2 pumilio RNA-binding family member 2 -0.0320998
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0320224
TOP1 topoisomerase (DNA) I -0.0318274
USP34 ubiquitin specific peptidase 34 -0.0316806
YBX1 Y box binding protein 1 -0.0315495
CSNK1A1 casein kinase 1, alpha 1 -0.0313689
CMIP c-Maf inducing protein -0.0312689
FBXO11 F-box protein 11 -0.0312664
RAB7A RAB7A, member RAS oncogene family -0.0311412
RPS24 ribosomal protein S24 -0.0306425
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0303189
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.030075
RPL37 ribosomal protein L37 -0.0300478
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0300345
CUL3 cullin 3 -0.0299329
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0296709
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.029663
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0296242
SMYD3 SET and MYND domain containing 3 -0.0291764
TAS2R14 taste receptor, type 2, member 14 -0.0288547
COG5 component of oligomeric golgi complex 5 -0.0285839
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.028232
RPL9 ribosomal protein L9 -0.0281751
RACK1 receptor for activated C kinase 1 -0.0281694
FNDC3B fibronectin type III domain containing 3B -0.0281554
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0280075
ANKHD1 ankyrin repeat and KH domain containing 1 -0.027988
FAF1 Fas (TNFRSF6) associated factor 1 -0.0279495