Meloxicam_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0646317
GRB10 growth factor receptor-bound protein 10 0.0614577
RICTOR RPTOR independent companion of MTOR, complex 2 0.0596173
SOD2 superoxide dismutase 2, mitochondrial 0.056873
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0488636
OSMR oncostatin M receptor 0.0483474
TRIO trio Rho guanine nucleotide exchange factor 0.0471726
RBM39 RNA binding motif protein 39 0.0456963
FAM20C family with sequence similarity 20, member C 0.0449876
AOPEP aminopeptidase O (putative) 0.0431969
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.041997
HMGA2 high mobility group AT-hook 2 0.0419641
STRN3 striatin, calmodulin binding protein 3 0.0418034
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0415339
ATP13A3 ATPase type 13A3 0.0385246
ANKRD28 ankyrin repeat domain 28 0.0381666
DSCAM Down syndrome cell adhesion molecule 0.0377556
CD109 CD109 molecule 0.0359638
USP3 ubiquitin specific peptidase 3 0.0348686
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0344794
YME1L1 YME1-like 1 ATPase 0.0339081
ADD3 adducin 3 (gamma) 0.033146
SPRED2 sprouty-related, EVH1 domain containing 2 0.0320478
ZEB2 zinc finger E-box binding homeobox 2 0.0313813
KDM3A lysine (K)-specific demethylase 3A 0.0309851
HDLBP high density lipoprotein binding protein 0.0293647
ANXA2 annexin A2 0.0284699
CTNND1 catenin (cadherin-associated protein), delta 1 0.0280974
ARHGAP5 Rho GTPase activating protein 5 0.0279489
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0272661
MARCHF6 membrane associated ring-CH-type finger 6 0.0267802
CD44 CD44 molecule (Indian blood group) 0.0264449
RUNX2 runt-related transcription factor 2 0.0256722
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0250865
WAC WW domain containing adaptor with coiled-coil 0.0250076
USP15 ubiquitin specific peptidase 15 0.0248778
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0245613
SBF2 SET binding factor 2 0.0244311
FOXO3 forkhead box O3 0.0240451
PDLIM5 PDZ and LIM domain 5 0.0236206
SEC23A Sec23 homolog A (S. cerevisiae) 0.0231383
PARD3 par-3 family cell polarity regulator 0.0229939
CNOT2 CCR4-NOT transcription complex, subunit 2 0.022933
SIK3 SIK family kinase 3 0.0227297
NRP1 neuropilin 1 0.0227134
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0226669
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0226416
MON2 MON2 homolog (S. cerevisiae) 0.0226407
PDGFC platelet derived growth factor C 0.0225665
ABI1 abl-interactor 1 0.0223497
NF1 neurofibromin 1 0.0222445
SPAG9 sperm associated antigen 9 0.0217434
AHNAK AHNAK nucleoprotein 0.020745
NCOA7 nuclear receptor coactivator 7 0.0207347
SRP54 signal recognition particle 54kDa 0.020694
EPS8 epidermal growth factor receptor pathway substrate 8 0.0205863
NPC1 Niemann-Pick disease, type C1 0.0205125
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0205043
UBE2H ubiquitin-conjugating enzyme E2H 0.0202233
ZNF207 zinc finger protein 207 0.0199743
CDK17 cyclin-dependent kinase 17 0.0198473
SREBF2 sterol regulatory element binding transcription factor 2 0.0196862
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0192782
POU2F1 POU class 2 homeobox 1 0.0190958
WDR37 WD repeat domain 37 0.0189781
ITCH itchy E3 ubiquitin protein ligase 0.018972
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0188814
SUN1 Sad1 and UNC84 domain containing 1 0.0187926
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0187247
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0187201
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0186002
EHBP1 EH domain binding protein 1 0.0183533
FRMD5 FERM domain containing 5 0.0182678
SMAD3 SMAD family member 3 0.0180432
RB1CC1 RB1-inducible coiled-coil 1 0.0177499
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0175673
BZW1 basic leucine zipper and W2 domains 1 0.0174952
IQGAP1 IQ motif containing GTPase activating protein 1 0.0174336
PUM2 pumilio RNA-binding family member 2 0.0173824
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0173101
SPRED1 sprouty-related, EVH1 domain containing 1 0.017164
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0170982
TTLL10 tubulin tyrosine ligase-like family member 10 0.0168637
NPEPPS aminopeptidase puromycin sensitive 0.0168517
DAAM1 dishevelled associated activator of morphogenesis 1 0.016844
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0166376
CHIC2 cysteine-rich hydrophobic domain 2 0.016557
OGA O-GlcNAcase 0.0162569
COL12A1 collagen, type XII, alpha 1 0.0160821
TNNC1 troponin C type 1 (slow) 0.0160626
RAB27B RAB27B, member RAS oncogene family 0.0160021
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.015957
ETNK1 ethanolamine kinase 1 0.0159084
THBS1 thrombospondin 1 0.0158995
MYOF myoferlin 0.0158519
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0158192
COPA coatomer protein complex, subunit alpha 0.0156183
ERRFI1 ERBB receptor feedback inhibitor 1 0.0156075
HELZ helicase with zinc finger 0.0155249
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0154682

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238143
VIM vimentin -0.1862
TMSB10 thymosin beta 10 -0.150204
PDE4D phosphodiesterase 4D, cAMP-specific -0.113472
NDRG1 N-myc downstream regulated 1 -0.108803
STC1 stanniocalcin 1 -0.103466
MT2A metallothionein 2A -0.102583
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101276
FTL ferritin, light polypeptide -0.0997202
SDK1 sidekick cell adhesion molecule 1 -0.0844987
P4HB prolyl 4-hydroxylase, beta polypeptide -0.081164
RPS6 ribosomal protein S6 -0.0809566
PTMA prothymosin, alpha -0.0805043
RPL35A ribosomal protein L35a -0.080023
RPL31 ribosomal protein L31 -0.0766181
AKAP12 A kinase (PRKA) anchor protein 12 -0.0762332
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0720403
RPL37A ribosomal protein L37a -0.0709415
CXCL8 chemokine (C-X-C motif) ligand 8 -0.070356
TPT1 tumor protein, translationally-controlled 1 -0.0700213
B2M beta-2-microglobulin -0.0669796
RPS8 ribosomal protein S8 -0.0613697
ENO1 enolase 1, (alpha) -0.0606989
RPS19 ribosomal protein S19 -0.0602917
RPS12 ribosomal protein S12 -0.0563047
NAP1L1 nucleosome assembly protein 1-like 1 -0.0552279
EIF1 eukaryotic translation initiation factor 1 -0.0536881
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0530771
RPS29 ribosomal protein S29 -0.0521473
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.05128
IFI6 interferon, alpha-inducible protein 6 -0.0497177
RPLP2 ribosomal protein, large, P2 -0.0493249
PKM pyruvate kinase, muscle -0.0487441
CDCP1 CUB domain containing protein 1 -0.0486293
RPL11 ribosomal protein L11 -0.0481659
RPS13 ribosomal protein S13 -0.0480713
NRG1 neuregulin 1 -0.0477732
KTN1 kinectin 1 (kinesin receptor) -0.0476629
TFPI2 tissue factor pathway inhibitor 2 -0.0473075
RPS25 ribosomal protein S25 -0.0467926
CA12 carbonic anhydrase XII -0.0445515
HMGA1 high mobility group AT-hook 1 -0.0444388
ENO2 enolase 2 (gamma, neuronal) -0.0437304
RPLP1 ribosomal protein, large, P1 -0.0430859
RPL36 ribosomal protein L36 -0.0430706
VEGFA vascular endothelial growth factor A -0.0427478
RPL28 ribosomal protein L28 -0.0419548
RPL9 ribosomal protein L9 -0.0410858
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0397981
RPS3 ribosomal protein S3 -0.039514
SQSTM1 sequestosome 1 -0.0393592
RPS11 ribosomal protein S11 -0.039336
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0381087
RPS23 ribosomal protein S23 -0.0380646
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0380029
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0377184
RPS2 ribosomal protein S2 -0.0376766
TM4SF1 transmembrane 4 L six family member 1 -0.0375675
ASPH aspartate beta-hydroxylase -0.0372954
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0371499
RPS27 ribosomal protein S27 -0.0370452
RPL23 ribosomal protein L23 -0.0369245
HLA-B major histocompatibility complex, class I, B -0.036872
IFITM3 interferon induced transmembrane protein 3 -0.0366713
RPL19 ribosomal protein L19 -0.0363255
LDHA lactate dehydrogenase A -0.0360235
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0356008
RPL37 ribosomal protein L37 -0.0355162
BTG1 B-cell translocation gene 1, anti-proliferative -0.0347273
POTEF POTE ankyrin domain family, member F -0.0339914
RPS24 ribosomal protein S24 -0.0339065
PDIA3 protein disulfide isomerase family A, member 3 -0.0335231
HM13 histocompatibility (minor) 13 -0.0332283
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0332124
ANGPTL4 angiopoietin-like 4 -0.0327374
ADM adrenomedullin -0.0325899
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0324775
RPS17 ribosomal protein S17 -0.0324424
RPL5 ribosomal protein L5 -0.0322777
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0321077
S100A10 S100 calcium binding protein A10 -0.032026
PCBP2 poly(rC) binding protein 2 -0.0319512
CDH13 cadherin 13 -0.0317853
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0317758
RPL38 ribosomal protein L38 -0.0315791
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0308399
RPS16 ribosomal protein S16 -0.0307867
TGFB1 transforming growth factor, beta 1 -0.0301209
RPL32 ribosomal protein L32 -0.0296793
RPS21 ribosomal protein S21 -0.029245
RPL7A ribosomal protein L7a -0.0290791
INTS6 integrator complex subunit 6 -0.0290308
S100A6 S100 calcium binding protein A6 -0.0286016
CUX1 cut-like homeobox 1 -0.028574
RPL26 ribosomal protein L26 -0.028263
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0282572
IFI27 interferon, alpha-inducible protein 27 -0.0279114
MAML3 mastermind-like 3 (Drosophila) -0.0277763
RPS10 ribosomal protein S10 -0.0274637
IFI44L interferon-induced protein 44-like -0.0273937