Meloxicam_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.198362
PDE4D phosphodiesterase 4D, cAMP-specific 0.167548
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.137355
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.108837
PM20D1 peptidase M20 domain containing 1 0.105277
THSD4 thrombospondin, type I, domain containing 4 0.0990153
TXNRD1 thioredoxin reductase 1 0.0985346
SAMD4A sterile alpha motif domain containing 4A 0.0577891
ANKRD11 ankyrin repeat domain 11 0.052771
KYNU kynureninase 0.0507643
FNDC3B fibronectin type III domain containing 3B 0.0501564
DOCK4 dedicator of cytokinesis 4 0.0497866
DST dystonin 0.0497468
ZFAND3 zinc finger, AN1-type domain 3 0.049282
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0473587
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0468378
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0468126
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0465465
SMOC1 SPARC related modular calcium binding 1 0.0464895
CMIP c-Maf inducing protein 0.0464164
DOCK5 dedicator of cytokinesis 5 0.0461481
FAM107B family with sequence similarity 107, member B 0.045997
SVIL supervillin 0.0456757
OSMR oncostatin M receptor 0.0432955
MACF1 microtubule-actin crosslinking factor 1 0.0427128
ASPH aspartate beta-hydroxylase 0.0418485
BICC1 BicC family RNA binding protein 1 0.0413873
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0402532
PTK2 protein tyrosine kinase 2 0.0401515
HDAC9 histone deacetylase 9 0.0398443
RAD51B RAD51 paralog B 0.0382046
TTC28 tetratricopeptide repeat domain 28 0.0367098
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0355044
NTN4 netrin 4 0.0352693
USP34 ubiquitin specific peptidase 34 0.0337229
ERRFI1 ERBB receptor feedback inhibitor 1 0.0336826
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0336145
EFNA5 ephrin-A5 0.0334354
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0332569
PDLIM5 PDZ and LIM domain 5 0.0327721
JMJD1C jumonji domain containing 1C 0.0322952
MAML3 mastermind-like 3 (Drosophila) 0.0318985
GLIS3 GLIS family zinc finger 3 0.0301319
BIRC6 baculoviral IAP repeat containing 6 0.0297965
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0294585
ARHGAP26 Rho GTPase activating protein 26 0.0291274
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.028583
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0282929
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0282614
EXOC6B exocyst complex component 6B 0.0275912
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0273526
NRG1 neuregulin 1 0.027144
WDR43 WD repeat domain 43 0.027106
SMAD2 SMAD family member 2 0.0265199
GLS2 glutaminase 2 (liver, mitochondrial) 0.0263937
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0263448
IGF1R insulin-like growth factor 1 receptor 0.0263359
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0261151
WWOX WW domain containing oxidoreductase 0.0260988
NIPBL Nipped-B homolog (Drosophila) 0.025599
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0253784
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0251473
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0251461
ZBTB20 zinc finger and BTB domain containing 20 0.0246941
SMAD3 SMAD family member 3 0.0245844
DSCAM Down syndrome cell adhesion molecule 0.0245393
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245322
SPIRE1 spire-type actin nucleation factor 1 0.0245006
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0243634
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.024298
WAC WW domain containing adaptor with coiled-coil 0.0242368
SMYD3 SET and MYND domain containing 3 0.023938
PTPRM protein tyrosine phosphatase, receptor type, M 0.0239115
ALCAM activated leukocyte cell adhesion molecule 0.0238696
EGFR epidermal growth factor receptor 0.023849
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0236814
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0235672
ZNF638 zinc finger protein 638 0.0235313
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.023485
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0234317
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0232381
ZEB1 zinc finger E-box binding homeobox 1 0.0231585
AGO2 argonaute RISC catalytic component 2 0.0225809
MSRB3 methionine sulfoxide reductase B3 0.0225213
TPM4 tropomyosin 4 0.022458
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0224125
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0223878
PLEC plectin 0.0223658
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0223111
BICD1 bicaudal D homolog 1 (Drosophila) 0.0222827
AKAP13 A kinase (PRKA) anchor protein 13 0.0219873
PYGL phosphorylase, glycogen, liver 0.021882
DENND4A DENN/MADD domain containing 4A 0.0218643
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0217871
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0215417
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0215044
FMNL2 formin-like 2 0.0214266
RPTOR regulatory associated protein of MTOR, complex 1 0.0212837
LPP LIM domain containing preferred translocation partner in lipoma 0.0212017
RICTOR RPTOR independent companion of MTOR, complex 2 0.0211562

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.191175
TMSB10 thymosin beta 10 -0.175984
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.141641
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12749
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.124333
MT2A metallothionein 2A -0.11394
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0949526
RPL19 ribosomal protein L19 -0.05999
VIM vimentin -0.0548708
PTMA prothymosin, alpha -0.0495847
RPL23 ribosomal protein L23 -0.0478072
FTH1 ferritin, heavy polypeptide 1 -0.042574
RPLP1 ribosomal protein, large, P1 -0.0392229
S100A6 S100 calcium binding protein A6 -0.0341212
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0339636
PFN1 profilin 1 -0.033578
RPL36 ribosomal protein L36 -0.0329929
RPS19 ribosomal protein S19 -0.0315021
TFPI2 tissue factor pathway inhibitor 2 -0.0302016
YBX1 Y box binding protein 1 -0.0301989
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293437
ANXA1 annexin A1 -0.0292605
RPS21 ribosomal protein S21 -0.028142
RPS8 ribosomal protein S8 -0.0280469
ATP5F1E ATP synthase F1 subunit epsilon -0.0230649
RPL8 ribosomal protein L8 -0.0229733
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0226698
SERF2 small EDRK-rich factor 2 -0.0224787
HMGB1 high mobility group box 1 -0.0223278
RPS27A ribosomal protein S27a -0.0221277
MYL12B myosin, light chain 12B, regulatory -0.0213135
RPL35A ribosomal protein L35a -0.0209998
S100A9 S100 calcium binding protein A9 -0.0206225
RPS5 ribosomal protein S5 -0.0206072
P4HB prolyl 4-hydroxylase, beta polypeptide -0.020578
S100A10 S100 calcium binding protein A10 -0.0204773
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0204613
RPL12 ribosomal protein L12 -0.0200686
RPL34 ribosomal protein L34 -0.0200423
RPS3 ribosomal protein S3 -0.0187713
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0186483
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0185398
ACTG1 actin gamma 1 -0.0184431
GSTP1 glutathione S-transferase pi 1 -0.018282
RPL7 ribosomal protein L7 -0.0180616
RPLP0 ribosomal protein, large, P0 -0.0178922
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0177832
LGALS1 lectin, galactoside-binding, soluble, 1 -0.017105
FNBP1L formin binding protein 1-like -0.016971
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0168184
EIF1 eukaryotic translation initiation factor 1 -0.0168124
ANXA2 annexin A2 -0.0167948
HMGA1 high mobility group AT-hook 1 -0.0164298
RBM25 RNA binding motif protein 25 -0.0161347
IER3 immediate early response 3 -0.0161223
RSRC2 arginine/serine-rich coiled-coil 2 -0.0160289
RPL18 ribosomal protein L18 -0.0160014
IFITM3 interferon induced transmembrane protein 3 -0.0159407
STC1 stanniocalcin 1 -0.0157757
JUN jun proto-oncogene -0.0157494
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.015736
RPS6 ribosomal protein S6 -0.0155647
IGF2 insulin-like growth factor 2 -0.0154871
TPT1 tumor protein, translationally-controlled 1 -0.0153678
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0151419
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0149861
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0148878
TAGLN2 transgelin 2 -0.0146764
GNAS GNAS complex locus -0.0144899
RACK1 receptor for activated C kinase 1 -0.0144871
RPS2 ribosomal protein S2 -0.0143667
RPL26 ribosomal protein L26 -0.0142838
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0140878
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0139845
TUBB tubulin, beta class I -0.0139742
RPL35 ribosomal protein L35 -0.0139687
RPL23A ribosomal protein L23a -0.0138132
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.013798
S100A11 S100 calcium binding protein A11 -0.0137806
RPS27 ribosomal protein S27 -0.0136122
C15ORF48 chromosome 15 open reading frame 48 -0.0135504
RPS25 ribosomal protein S25 -0.0134708
RPL32 ribosomal protein L32 -0.0133862
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0132651
RPL37A ribosomal protein L37a -0.0132578
ROMO1 reactive oxygen species modulator 1 -0.0132253
DDIT4 DNA-damage-inducible transcript 4 -0.0132138
RPS20 ribosomal protein S20 -0.0130862
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0130491
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0129176
CNRIP1 cannabinoid receptor interacting protein 1 -0.012702
CAVIN1 caveolae associated protein 1 -0.0126986
PA2G4 proliferation-associated 2G4, 38kDa -0.0126362
TMPO thymopoietin -0.0124666
AZIN1 antizyme inhibitor 1 -0.0123141
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0122508
RPN2 ribophorin II -0.0120893
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0120568
TPI1 triosephosphate isomerase 1 -0.0118037
CALR calreticulin -0.0116762