Meloxicam_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.192154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.183528
TXNRD1 thioredoxin reductase 1 0.139303
GRAMD1B GRAM domain containing 1B 0.106288
ERRFI1 ERBB receptor feedback inhibitor 1 0.0640037
IGF1R insulin-like growth factor 1 receptor 0.0587708
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0572242
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0565549
CCDC200 coiled-coil domain containing 200 0.0561175
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0539816
PLEC plectin 0.0531679
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0482468
TFPI2 tissue factor pathway inhibitor 2 0.0466822
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0460345
RIMS2 regulating synaptic membrane exocytosis 2 0.0459716
IFI6 interferon, alpha-inducible protein 6 0.0454283
NIPBL Nipped-B homolog (Drosophila) 0.0422607
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0409686
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0409318
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0404291
SMAD3 SMAD family member 3 0.0392067
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0387966
YBX3 Y box binding protein 3 0.0384256
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0374402
MCL1 myeloid cell leukemia 1 0.0370997
AHNAK AHNAK nucleoprotein 0.0364659
ACTN1 actinin, alpha 1 0.0356927
MACF1 microtubule-actin crosslinking factor 1 0.0353862
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0348878
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0346046
TPM3 tropomyosin 3 0.034298
ELL2 elongation factor, RNA polymerase II, 2 0.033752
SFPQ splicing factor proline/glutamine-rich 0.0324682
TJP1 tight junction protein 1 0.0293485
MYH9 myosin, heavy chain 9, non-muscle 0.0287084
NAMPT nicotinamide phosphoribosyltransferase 0.0282834
SVIL supervillin 0.0279437
CAVIN1 caveolae associated protein 1 0.0276151
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0272847
ICAM1 intercellular adhesion molecule 1 0.0267176
CLIP1 CAP-GLY domain containing linker protein 1 0.0266484
STC1 stanniocalcin 1 0.0263246
RPL3 ribosomal protein L3 0.0263017
TRIP12 thyroid hormone receptor interactor 12 0.0259695
TNRC18 trinucleotide repeat containing 18 0.025754
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.025587
CDK17 cyclin-dependent kinase 17 0.0254634
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0251492
ZFAND3 zinc finger, AN1-type domain 3 0.0250575
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0249935
DSPP dentin sialophosphoprotein 0.0245241
CCND2 cyclin D2 0.0243793
DNAH14 dynein, axonemal, heavy chain 14 0.0239584
TM4SF1 transmembrane 4 L six family member 1 0.023701
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0230139
VCP valosin containing protein 0.0228653
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0227357
BMAL2 basic helix-loop-helix ARNT like 2 0.0226915
YAP1 Yes-associated protein 1 0.0225598
WAC WW domain containing adaptor with coiled-coil 0.022549
ANKRD11 ankyrin repeat domain 11 0.0224615
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0224357
XPO1 exportin 1 0.0223171
FNDC3B fibronectin type III domain containing 3B 0.0220014
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.021924
MAGEA4 melanoma antigen family A4 0.0216576
APLP2 amyloid beta (A4) precursor-like protein 2 0.0215923
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0215522
SERINC3 serine incorporator 3 0.0214616
CD164 CD164 molecule, sialomucin 0.0213368
CTSL cathepsin L 0.021329
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0208812
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0208105
DOCK1 dedicator of cytokinesis 1 0.0207925
EXT1 exostosin glycosyltransferase 1 0.0206958
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0204537
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0204338
TCIM transcriptional and immune response regulator 0.0202948
NFE2L2 nuclear factor, erythroid 2-like 2 0.0202061
ETV3 ets variant 3 0.0201308
TMEM41B transmembrane protein 41B 0.0199419
SFTPA2 surfactant protein A2 0.0199181
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0198895
RABGAP1L RAB GTPase activating protein 1-like 0.0195793
PPME1 protein phosphatase methylesterase 1 0.0195686
ZYX zyxin 0.0195452
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.019526
RUNX1 runt-related transcription factor 1 0.0194183
ZBTB1 zinc finger and BTB domain containing 1 0.0193054
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0192734
ITGA6 integrin, alpha 6 0.0191515
FLNA filamin A, alpha 0.0189739
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0189691
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0188717
UBC ubiquitin C 0.0186686
PATJ PATJ crumbs cell polarity complex component 0.0186558
NBEA neurobeachin 0.0183477
B2M beta-2-microglobulin 0.0182364
KTN1 kinectin 1 (kinesin receptor) 0.0182016
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0180192

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.269681
TMSB10 thymosin beta 10 -0.095822
RPL35A ribosomal protein L35a -0.0689153
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0688109
RPL37A ribosomal protein L37a -0.0616047
VIM vimentin -0.0583543
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0531614
PFN1 profilin 1 -0.0473945
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0472985
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0454946
LDHB lactate dehydrogenase B -0.043159
RPL37 ribosomal protein L37 -0.0420784
PTMA prothymosin, alpha -0.0416391
RPL34 ribosomal protein L34 -0.0410844
TAS2R14 taste receptor, type 2, member 14 -0.0407352
RPL23 ribosomal protein L23 -0.0385409
RPL26 ribosomal protein L26 -0.0385154
RPLP2 ribosomal protein, large, P2 -0.0376814
RAD51B RAD51 paralog B -0.0373661
RPS6 ribosomal protein S6 -0.0368364
RPL12 ribosomal protein L12 -0.0364905
RPL19 ribosomal protein L19 -0.0358167
RPS27 ribosomal protein S27 -0.034571
RPS21 ribosomal protein S21 -0.0343913
POTEF POTE ankyrin domain family, member F -0.0339677
RPL11 ribosomal protein L11 -0.033838
HMGA1 high mobility group AT-hook 1 -0.0329021
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0327589
RPS8 ribosomal protein S8 -0.0324274
NCOR1 nuclear receptor corepressor 1 -0.0321091
RPS12 ribosomal protein S12 -0.0314424
SBF2 SET binding factor 2 -0.031093
RPS3 ribosomal protein S3 -0.0308429
HM13 histocompatibility (minor) 13 -0.0306442
SRRM2 serine/arginine repetitive matrix 2 -0.0301993
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0300471
RPLP1 ribosomal protein, large, P1 -0.0296861
RPL5 ribosomal protein L5 -0.0295861
RPL28 ribosomal protein L28 -0.0295316
ACTG1 actin gamma 1 -0.0293922
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.029231
EGR1 early growth response 1 -0.0291875
MT2A metallothionein 2A -0.0286654
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280579
RPS27A ribosomal protein S27a -0.0277637
RPL13A ribosomal protein L13a -0.0269214
RPS15 ribosomal protein S15 -0.0265698
RPL36 ribosomal protein L36 -0.0262267
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0255238
RPLP0 ribosomal protein, large, P0 -0.025059
SMC4 structural maintenance of chromosomes 4 -0.0247195
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0245334
TOP2A topoisomerase (DNA) II alpha 170kDa -0.02448
SEC31A SEC31 homolog A (S. cerevisiae) -0.0244704
RBM25 RNA binding motif protein 25 -0.0241016
RPL35 ribosomal protein L35 -0.0237872
IGF2 insulin-like growth factor 2 -0.0230135
ATP5F1B ATP synthase F1 subunit beta -0.0229519
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0227969
YBX1 Y box binding protein 1 -0.0225807
RPL31 ribosomal protein L31 -0.0224363
CENPF centromere protein F, 350/400kDa -0.0222299
RPL27 ribosomal protein L27 -0.0222057
RPL32 ribosomal protein L32 -0.0220285
RBM39 RNA binding motif protein 39 -0.0219598
CAMTA1 calmodulin binding transcription activator 1 -0.0219331
RACK1 receptor for activated C kinase 1 -0.0218556
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0215827
RPL9 ribosomal protein L9 -0.0214041
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0213724
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.021311
PHIP pleckstrin homology domain interacting protein -0.0212743
SRSF11 serine/arginine-rich splicing factor 11 -0.0211838
EP400 E1A binding protein p400 -0.0211345
RPS16 ribosomal protein S16 -0.0210257
RPS19 ribosomal protein S19 -0.0210086
RPS24 ribosomal protein S24 -0.0209949
CFDP1 craniofacial development protein 1 -0.0206146
SRP54 signal recognition particle 54kDa -0.0205472
R3HDM1 R3H domain containing 1 -0.0204324
VDAC1 voltage-dependent anion channel 1 -0.0204037
PGK1 phosphoglycerate kinase 1 -0.0198913
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0197803
ATP5F1E ATP synthase F1 subunit epsilon -0.0196544
ANKRD28 ankyrin repeat domain 28 -0.0196325
ANKRD12 ankyrin repeat domain 12 -0.0196025
SLC38A2 solute carrier family 38, member 2 -0.0194402
TPI1 triosephosphate isomerase 1 -0.0193148
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.018988
DENND1A DENN/MADD domain containing 1A -0.0189391
KMT2C lysine (K)-specific methyltransferase 2C -0.0188034
RPS29 ribosomal protein S29 -0.0187628
FTL ferritin, light polypeptide -0.0187404
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.018541
BABAM2 BRISC and BRCA1 A complex member 2 -0.0183857
RPS17 ribosomal protein S17 -0.0183618
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0183567
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0183178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0178627
SEPTIN7 septin 7 -0.0176339