Meloxicam_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.147989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.122763
PLEC plectin 0.0898189
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0611283
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0493255
ERRFI1 ERBB receptor feedback inhibitor 1 0.0448074
ARRDC3 arrestin domain containing 3 0.0443846
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0424168
DDIT4 DNA-damage-inducible transcript 4 0.0418308
MYH9 myosin, heavy chain 9, non-muscle 0.0408962
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0386468
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0318804
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0318081
HMGB2 high mobility group box 2 0.0317503
FN1 fibronectin 1 0.0314419
DSCAM Down syndrome cell adhesion molecule 0.0304746
PCBP2 poly(rC) binding protein 2 0.0301076
TXNRD1 thioredoxin reductase 1 0.0300263
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0296734
ASPH aspartate beta-hydroxylase 0.0295579
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0294719
TPM3 tropomyosin 3 0.0290291
RPL3 ribosomal protein L3 0.0279312
EEF2 eukaryotic translation elongation factor 2 0.0268251
PLAU plasminogen activator, urokinase 0.0265746
LDHA lactate dehydrogenase A 0.0259465
PEG10 paternally expressed 10 0.0221433
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0211331
FUBP1 far upstream element (FUSE) binding protein 1 0.0199718
YTHDC1 YTH domain containing 1 0.0199629
FXR1 fragile X mental retardation, autosomal homolog 1 0.0199374
ANXA1 annexin A1 0.0196469
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0190765
HSPA8 heat shock 70kDa protein 8 0.0188756
CHD1 chromodomain helicase DNA binding protein 1 0.0188748
TNIP1 TNFAIP3 interacting protein 1 0.0185955
RYBP RING1 and YY1 binding protein 0.0185751
KDM3A lysine (K)-specific demethylase 3A 0.0185706
XPO1 exportin 1 0.0181848
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0179971
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0176293
ELL2 elongation factor, RNA polymerase II, 2 0.017262
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0168656
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.016829
NAMPT nicotinamide phosphoribosyltransferase 0.0160915
SOD2 superoxide dismutase 2, mitochondrial 0.0160722
EREG epiregulin 0.0158978
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0157804
CANX calnexin 0.0155692
CAPN2 calpain 2, (m/II) large subunit 0.0155663
FLNA filamin A, alpha 0.0154954
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.015456
DSPP dentin sialophosphoprotein 0.0154503
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0152723
ANXA5 annexin A5 0.0152573
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0152277
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0150726
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0149355
TOP2B topoisomerase (DNA) II beta 180kDa 0.0145787
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0141648
EIF4A2 eukaryotic translation initiation factor 4A2 0.0141286
SDC4 syndecan 4 0.0140138
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0139323
CCNL1 cyclin L1 0.0138249
IRF6 interferon regulatory factor 6 0.0137595
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0136825
OAZ1 ornithine decarboxylase antizyme 1 0.0136316
WNK1 WNK lysine deficient protein kinase 1 0.0135655
MCL1 myeloid cell leukemia 1 0.0134099
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0134076
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0133182
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0132063
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0131722
NUMA1 nuclear mitotic apparatus protein 1 0.0131527
AHDC1 AT hook, DNA binding motif, containing 1 0.0130666
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0129178
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0129035
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0128971
WDR36 WD repeat domain 36 0.0128526
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0127858
BRD2 bromodomain containing 2 0.0126534
GLS2 glutaminase 2 (liver, mitochondrial) 0.0126016
MSMO1 methylsterol monooxygenase 1 0.0125667
H1-4 H1.4 linker histone, cluster member 0.0125066
NUP58 nucleoporin 58 0.012284
ECT2 epithelial cell transforming 2 0.0122524
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0122163
MBNL1 muscleblind-like splicing regulator 1 0.0121905
CCNY cyclin Y 0.0121157
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.011989
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0119654
MATR3 matrin 3 0.0119139
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0118834
RBBP7 retinoblastoma binding protein 7 0.0118474
HLTF helicase-like transcription factor 0.0118068
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0117848
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0116582
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0116438
SFPQ splicing factor proline/glutamine-rich 0.0116227
TNPO1 transportin 1 0.0116104

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.259766
TMSB10 thymosin beta 10 -0.256004
FTL ferritin, light polypeptide -0.230317
ACTG1 actin gamma 1 -0.199642
PTMA prothymosin, alpha -0.163616
IFI27 interferon, alpha-inducible protein 27 -0.131769
LPP LIM domain containing preferred translocation partner in lipoma -0.10989
POTEF POTE ankyrin domain family, member F -0.0970743
ISG15 ISG15 ubiquitin-like modifier -0.0964941
RPL35A ribosomal protein L35a -0.0900024
RPL34 ribosomal protein L34 -0.0879012
RPLP1 ribosomal protein, large, P1 -0.0858941
S100A10 S100 calcium binding protein A10 -0.0815172
IFI6 interferon, alpha-inducible protein 6 -0.0793701
FBXO32 F-box protein 32 -0.0748955
S100A6 S100 calcium binding protein A6 -0.0748423
RPLP2 ribosomal protein, large, P2 -0.0743364
TPT1 tumor protein, translationally-controlled 1 -0.0721919
LIMCH1 LIM and calponin homology domains 1 -0.0714446
RPS8 ribosomal protein S8 -0.071066
RPS23 ribosomal protein S23 -0.0698009
IFITM3 interferon induced transmembrane protein 3 -0.0657563
RPS19 ribosomal protein S19 -0.0650145
HLA-B major histocompatibility complex, class I, B -0.0638536
RPS29 ribosomal protein S29 -0.0621314
IFITM1 interferon induced transmembrane protein 1 -0.061686
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0614626
RPS6 ribosomal protein S6 -0.0597917
FTH1 ferritin, heavy polypeptide 1 -0.0591979
RPL8 ribosomal protein L8 -0.0588801
CSTB cystatin B (stefin B) -0.0580761
RPS25 ribosomal protein S25 -0.0564104
IGFBP3 insulin-like growth factor binding protein 3 -0.0555804
MDK midkine (neurite growth-promoting factor 2) -0.0538051
EIF1 eukaryotic translation initiation factor 1 -0.0526407
HMGA1 high mobility group AT-hook 1 -0.0526075
LY6E lymphocyte antigen 6 complex, locus E -0.0525446
RPS13 ribosomal protein S13 -0.0524319
RPL32 ribosomal protein L32 -0.0523053
S100A9 S100 calcium binding protein A9 -0.0514697
SOX4 SRY (sex determining region Y)-box 4 -0.0513316
RPS27 ribosomal protein S27 -0.0506025
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0497128
IFI16 interferon, gamma-inducible protein 16 -0.0488113
MT2A metallothionein 2A -0.0483115
RPL12 ribosomal protein L12 -0.0474013
RPL28 ribosomal protein L28 -0.0471717
HLA-A major histocompatibility complex, class I, A -0.0469614
WSB1 WD repeat and SOCS box containing 1 -0.0464241
RNF213 ring finger protein 213 -0.0451399
ENO2 enolase 2 (gamma, neuronal) -0.0446207
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0443728
RPS14 ribosomal protein S14 -0.0443443
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0443425
RPL37 ribosomal protein L37 -0.0443369
RPL23 ribosomal protein L23 -0.0438837
RPL19 ribosomal protein L19 -0.0436157
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0433923
RPS21 ribosomal protein S21 -0.0422521
RPL37A ribosomal protein L37a -0.0417621
HSPB1 heat shock 27kDa protein 1 -0.0415739
RACK1 receptor for activated C kinase 1 -0.0412229
TRIO trio Rho guanine nucleotide exchange factor -0.0411869
MX2 MX dynamin-like GTPase 2 -0.0406139
RPL31 ribosomal protein L31 -0.0399982
RPL36 ribosomal protein L36 -0.0395891
EXT1 exostosin glycosyltransferase 1 -0.0390464
CD2AP CD2-associated protein -0.038794
SAMD4A sterile alpha motif domain containing 4A -0.0387783
RPS16 ribosomal protein S16 -0.037717
KDM5B lysine (K)-specific demethylase 5B -0.0371837
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0371778
FNDC3B fibronectin type III domain containing 3B -0.0369631
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0368164
RPL9 ribosomal protein L9 -0.0368151
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0367726
RAB7A RAB7A, member RAS oncogene family -0.0365214
TOP1 topoisomerase (DNA) I -0.0365152
RPS17 ribosomal protein S17 -0.0364585
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0363062
ALCAM activated leukocyte cell adhesion molecule -0.035747
EFNA5 ephrin-A5 -0.0351788
RPL15 ribosomal protein L15 -0.0345814
BASP1 brain abundant, membrane attached signal protein 1 -0.034288
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0342278
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0336952
RPS27A ribosomal protein S27a -0.0334858
SQSTM1 sequestosome 1 -0.0333838
NPEPPS aminopeptidase puromycin sensitive -0.033217
RBM47 RNA binding motif protein 47 -0.0331636
GNAS GNAS complex locus -0.0331387
RPS3 ribosomal protein S3 -0.0329204
ADAR adenosine deaminase, RNA-specific -0.0325638
NAV2 neuron navigator 2 -0.0325267
TMSB4X thymosin beta 4, X-linked -0.0322313
MYO6 myosin VI -0.0322282
LAMB3 laminin, beta 3 -0.0321042
MYO1E myosin IE -0.0318187
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0316835
C15ORF48 chromosome 15 open reading frame 48 -0.0316044