Meloxicam_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0833202
NTM neurotrimin 0.0561163
ADGRV1 adhesion G protein-coupled receptor V1 0.0523912
SHROOM3 shroom family member 3 0.0455087
TSC22D2 TSC22 domain family, member 2 0.0443746
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0432075
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0423424
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.041117
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0383633
TRPS1 trichorhinophalangeal syndrome I 0.0380827
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0357123
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0348485
ZNF608 zinc finger protein 608 0.0335069
WDR43 WD repeat domain 43 0.0326426
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0319133
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0318905
FXR1 fragile X mental retardation, autosomal homolog 1 0.0309354
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0302903
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0285846
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0279892
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.027786
ATG5 autophagy related 5 0.0270145
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0263252
ATAD2B ATPase family, AAA domain containing 2B 0.0260526
RAB8B RAB8B, member RAS oncogene family 0.0260107
RBM39 RNA binding motif protein 39 0.0255564
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.025439
ARHGAP15 Rho GTPase activating protein 15 0.0248086
SRSF11 serine/arginine-rich splicing factor 11 0.0243933
GOLGA4 golgin A4 0.0240618
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0239635
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0239014
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.023548
FAT1 FAT atypical cadherin 1 0.0234849
VMP1 vacuole membrane protein 1 0.0234733
TPM3 tropomyosin 3 0.023018
GASK1B golgi associated kinase 1B 0.0227366
GPC4 glypican 4 0.0225095
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0222633
TOX thymocyte selection-associated high mobility group box 0.021987
RHOH ras homolog family member H 0.021875
MACF1 microtubule-actin crosslinking factor 1 0.0218353
RPL3 ribosomal protein L3 0.0212526
SRSF3 serine/arginine-rich splicing factor 3 0.020759
BLTP1 bridge-like lipid transfer protein family member 1 0.0206576
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0204942
ANKRD33B ankyrin repeat domain 33B 0.0203775
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.0201882
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0201585
UBE3A ubiquitin protein ligase E3A 0.0200733
THBS1 thrombospondin 1 0.0199594
SAMD4A sterile alpha motif domain containing 4A 0.019792
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.0197687
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.019693
RFX7 regulatory factor X, 7 0.0196515
GLO1 glyoxalase I 0.0196358
GLS2 glutaminase 2 (liver, mitochondrial) 0.0196043
UBP1 upstream binding protein 1 (LBP-1a) 0.019546
NBAS neuroblastoma amplified sequence 0.0194178
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0193133
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0192869
NF2 neurofibromin 2 (merlin) 0.0191512
SCFD2 sec1 family domain containing 2 0.0190057
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0189168
ATAD2 ATPase family, AAA domain containing 2 0.0188569
ADAM9 ADAM metallopeptidase domain 9 0.0186541
RFC3 replication factor C (activator 1) 3, 38kDa 0.0185042
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0184098
NFIA nuclear factor I/A 0.0182616
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0182314
WDFY3 WD repeat and FYVE domain containing 3 0.0182245
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0181389
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0181277
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0181234
NUP153 nucleoporin 153kDa 0.0181098
WDR26 WD repeat domain 26 0.0181071
CALCR calcitonin receptor 0.0179637
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0178896
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0178375
CELF2 CUGBP, Elav-like family member 2 0.0178326
FBXW2 F-box and WD repeat domain containing 2 0.0178197
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0177607
HSPA8 heat shock 70kDa protein 8 0.0177479
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0177432
ZFPM2 zinc finger protein, FOG family member 2 0.0176258
PGAP1 post-GPI attachment to proteins 1 0.0176075
MGA MGA, MAX dimerization protein 0.017389
CSNK1G3 casein kinase 1, gamma 3 0.0173816
DROSHA drosha, ribonuclease type III 0.0173721
IPO11 importin 11 0.017369
QKI QKI, KH domain containing, RNA binding 0.0173432
SUN3 Sad1 and UNC84 domain containing 3 0.0173378
SFPQ splicing factor proline/glutamine-rich 0.017296
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.0172654
ANLN anillin, actin binding protein 0.0171909
COLEC11 collectin sub-family member 11 0.0171724
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0171075
SIRT1 sirtuin 1 0.0170666
SRSF7 serine/arginine-rich splicing factor 7 0.0169089
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0168992

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.229282
TMSB10 thymosin beta 10 -0.162894
PTMA prothymosin, alpha -0.154728
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.132515
COL11A1 collagen, type XI, alpha 1 -0.126956
PCDH9 protocadherin 9 -0.113199
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110559
COL3A1 collagen, type III, alpha 1 -0.104384
COL1A2 collagen, type I, alpha 2 -0.091604
GNAS GNAS complex locus -0.083752
PGK1 phosphoglycerate kinase 1 -0.0735113
RPS16 ribosomal protein S16 -0.0696542
PEG10 paternally expressed 10 -0.0686812
PHIP pleckstrin homology domain interacting protein -0.0673948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0671057
TPT1 tumor protein, translationally-controlled 1 -0.0667103
RPS8 ribosomal protein S8 -0.0657212
WSB1 WD repeat and SOCS box containing 1 -0.0652729
TOP2A topoisomerase (DNA) II alpha 170kDa -0.064785
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0646488
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.064065
CADM2 cell adhesion molecule 2 -0.0624961
MDK midkine (neurite growth-promoting factor 2) -0.0616999
PCLO piccolo presynaptic cytomatrix protein -0.0616633
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0614474
ACTG1 actin gamma 1 -0.0592764
RPL35A ribosomal protein L35a -0.0550611
B2M beta-2-microglobulin -0.053414
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0526097
PFN1 profilin 1 -0.0498842
ENO1 enolase 1, (alpha) -0.0497334
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0494885
H1-0 H1.0 linker histone -0.048879
GPC3 glypican 3 -0.048819
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0485099
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.047048
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0467597
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0460306
MYL12B myosin, light chain 12B, regulatory -0.0453911
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0450351
RPS6 ribosomal protein S6 -0.044677
RPL37A ribosomal protein L37a -0.0424763
RPL23 ribosomal protein L23 -0.0421148
RPL31 ribosomal protein L31 -0.0418366
AKAP12 A kinase (PRKA) anchor protein 12 -0.0409397
NCAM2 neural cell adhesion molecule 2 -0.040669
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0398058
RPLP1 ribosomal protein, large, P1 -0.0395516
EIF1 eukaryotic translation initiation factor 1 -0.0391942
RPS21 ribosomal protein S21 -0.0380059
RPS19 ribosomal protein S19 -0.03682
KDM3A lysine (K)-specific demethylase 3A -0.0366784
KPNB1 karyopherin (importin) beta 1 -0.0361284
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.035888
FTL ferritin, light polypeptide -0.0357141
RPL36A ribosomal protein L36a -0.0351324
PRRC2C proline-rich coiled-coil 2C -0.0350556
RPL19 ribosomal protein L19 -0.0349471
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0345829
RPL37 ribosomal protein L37 -0.0343563
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0341453
RPS3 ribosomal protein S3 -0.033953
CNRIP1 cannabinoid receptor interacting protein 1 -0.0333027
RAD51B RAD51 paralog B -0.033236
RPL5 ribosomal protein L5 -0.0330003
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0323703
NIPBL Nipped-B homolog (Drosophila) -0.0319051
SPAG9 sperm associated antigen 9 -0.03187
CAVIN1 caveolae associated protein 1 -0.0316418
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0315071
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0310975
GSE1 Gse1 coiled-coil protein -0.0302871
OGA O-GlcNAcase -0.030286
CALR calreticulin -0.0302523
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0302281
RAD21 RAD21 homolog (S. pombe) -0.030165
KTN1 kinectin 1 (kinesin receptor) -0.0297236
SNX6 sorting nexin 6 -0.0295894
EMP1 epithelial membrane protein 1 -0.0294192
APOE apolipoprotein E -0.0291306
AHNAK AHNAK nucleoprotein -0.0291219
KMT2C lysine (K)-specific methyltransferase 2C -0.0290773
RPS13 ribosomal protein S13 -0.028938
MED13L mediator complex subunit 13-like -0.0288886
RPS27A ribosomal protein S27a -0.0283722
LDHA lactate dehydrogenase A -0.0282942
NXN nucleoredoxin -0.0281148
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.027957
CKAP2 cytoskeleton associated protein 2 -0.0276517
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0275807
BRD4 bromodomain containing 4 -0.0275705
NACA nascent polypeptide-associated complex alpha subunit -0.0273469
RPLP2 ribosomal protein, large, P2 -0.0270616
RPL9 ribosomal protein L9 -0.0270015
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0269486
RPL34 ribosomal protein L34 -0.0267075
BPTF bromodomain PHD finger transcription factor -0.0263709
S100A9 S100 calcium binding protein A9 -0.0262765
HSPB1 heat shock 27kDa protein 1 -0.0260305
S100A10 S100 calcium binding protein A10 -0.025711