Meloxicam_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPL3 ribosomal protein L3 0.0382955
ANK2 ankyrin 2, neuronal 0.0377889
DSCAM Down syndrome cell adhesion molecule 0.0361466
ZBTB20 zinc finger and BTB domain containing 20 0.0348239
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0320365
EEF2 eukaryotic translation elongation factor 2 0.0291434
EXT1 exostosin glycosyltransferase 1 0.0279382
PTEN phosphatase and tensin homolog 0.0273329
CCNL1 cyclin L1 0.023889
VMP1 vacuole membrane protein 1 0.0233751
EGFR epidermal growth factor receptor 0.0227491
ADAM10 ADAM metallopeptidase domain 10 0.0224737
RTN4 reticulon 4 0.0222859
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0216639
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0214432
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0199508
KDM4C lysine (K)-specific demethylase 4C 0.0198031
TBC1D5 TBC1 domain family, member 5 0.0197552
RUNX1 runt-related transcription factor 1 0.018906
TXNRD1 thioredoxin reductase 1 0.0187525
BCAS3 breast carcinoma amplified sequence 3 0.0179056
METTL15 methyltransferase like 15 0.0178249
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0177588
PSAT1 phosphoserine aminotransferase 1 0.0175912
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0168891
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.016789
PLXNA1 plexin A1 0.016111
N4BP2L2 NEDD4 binding protein 2-like 2 0.0157836
BBS9 Bardet-Biedl syndrome 9 0.0155144
PICALM phosphatidylinositol binding clathrin assembly protein 0.0154547
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0152831
DENND4A DENN/MADD domain containing 4A 0.015245
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0151142
PCBP2 poly(rC) binding protein 2 0.0147133
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0144704
FBXL17 F-box and leucine-rich repeat protein 17 0.0142336
PRKN parkin RBR E3 ubiquitin protein ligase 0.0141972
ADAM9 ADAM metallopeptidase domain 9 0.014113
NUP58 nucleoporin 58 0.0139433
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0138963
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0136276
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0136272
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0136105
SESN2 sestrin 2 0.0134985
SMYD3 SET and MYND domain containing 3 0.0134022
CDK13 cyclin-dependent kinase 13 0.0133875
NCKAP1 NCK-associated protein 1 0.0132575
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0132337
BTBD9 BTB (POZ) domain containing 9 0.0131031
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.012687
NFE2L1 nuclear factor, erythroid 2-like 1 0.0125967
PLK2 polo-like kinase 2 0.0125225
PANK3 pantothenate kinase 3 0.012379
UBE3A ubiquitin protein ligase E3A 0.012334
MCL1 myeloid cell leukemia 1 0.0119952
ANKRD36 ankyrin repeat domain 36 0.0119318
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0118802
MBD5 methyl-CpG binding domain protein 5 0.0118073
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 0.0117513
AMOTL2 angiomotin like 2 0.0117393
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0116706
KDM6A lysine (K)-specific demethylase 6A 0.0115264
KLHDC4 kelch domain containing 4 0.0114343
LOC112694756 uncharaterized LOC112694756 0.0114249
LRRC7 leucine rich repeat containing 7 0.0113446
ARL15 ADP-ribosylation factor-like 15 0.0113082
BRD2 bromodomain containing 2 0.0111256
COG5 component of oligomeric golgi complex 5 0.0111063
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0110741
ACACA acetyl-CoA carboxylase alpha 0.0110151
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0109493
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0108269
JAK1 Janus kinase 1 0.0105145
HDAC4 histone deacetylase 4 0.010388
ETNK1 ethanolamine kinase 1 0.0102874
WDR26 WD repeat domain 26 0.0102409
EXOC6B exocyst complex component 6B 0.0101992
ERI3 ERI1 exoribonuclease family member 3 0.0101643
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0101206
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0100966
GOLT1A golgi transport 1A 0.00996591
ZC3H7B zinc finger CCCH-type containing 7B 0.00990562
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.00985243
VWA8 von Willebrand factor A domain containing 8 0.0098282
TRAPPC9 trafficking protein particle complex 9 0.00976028
SOS2 son of sevenless homolog 2 (Drosophila) 0.0097495
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.00968791
ZNF644 zinc finger protein 644 0.00968152
CD46 CD46 molecule, complement regulatory protein 0.00966407
RHBDD1 rhomboid domain containing 1 0.00964751
GLS2 glutaminase 2 (liver, mitochondrial) 0.00963899
MLEC malectin 0.00958384
CCDC200 coiled-coil domain containing 200 0.00953727
CDK19 cyclin-dependent kinase 19 0.00953208
ARB2A ARB2 cotranscriptional regulator A 0.00944522
ZFAND3 zinc finger, AN1-type domain 3 0.00939318
DCAF8 DDB1 and CUL4 associated factor 8 0.00937673
KLC1 kinesin light chain 1 0.00937341
NUBPL nucleotide binding protein-like 0.00930692
DNAAF3 dynein, axonemal, assembly factor 3 0.00928515

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.430788
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.234681
PDE4B phosphodiesterase 4B, cAMP-specific -0.136854
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.132116
TPT1 tumor protein, translationally-controlled 1 -0.125146
DLG1 discs, large homolog 1 (Drosophila) -0.102092
RPS6 ribosomal protein S6 -0.0996251
RPS8 ribosomal protein S8 -0.0949539
RPL35A ribosomal protein L35a -0.0922679
AHNAK AHNAK nucleoprotein -0.0896382
MKI67 marker of proliferation Ki-67 -0.0825013
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0785175
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0778231
BMP10 bone morphogenetic protein 10 -0.0759873
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0718604
ACTG1 actin gamma 1 -0.0688601
SOX6 SRY (sex determining region Y)-box 6 -0.0678749
RPLP1 ribosomal protein, large, P1 -0.063995
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0625938
RPL34 ribosomal protein L34 -0.0613426
RPL31 ribosomal protein L31 -0.0608573
S100A6 S100 calcium binding protein A6 -0.0597853
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0584176
NAP1L1 nucleosome assembly protein 1-like 1 -0.0569687
RPLP2 ribosomal protein, large, P2 -0.0561252
RPL19 ribosomal protein L19 -0.0551014
ZEB1 zinc finger E-box binding homeobox 1 -0.0540225
SSBP2 single-stranded DNA binding protein 2 -0.053239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.052589
RPL26 ribosomal protein L26 -0.0525685
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0520301
WSB1 WD repeat and SOCS box containing 1 -0.05147
NFIA nuclear factor I/A -0.051009
LPP LIM domain containing preferred translocation partner in lipoma -0.0509616
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0508845
DIAPH3 diaphanous-related formin 3 -0.0495426
RPS19 ribosomal protein S19 -0.0485206
RPL37A ribosomal protein L37a -0.0479339
RPL12 ribosomal protein L12 -0.0478148
CENPF centromere protein F, 350/400kDa -0.0475093
RPL36 ribosomal protein L36 -0.0470886
HSPB1 heat shock 27kDa protein 1 -0.0469538
TMSB4X thymosin beta 4, X-linked -0.0462729
NAV2 neuron navigator 2 -0.0455628
CCND1 cyclin D1 -0.0450359
PGK1 phosphoglycerate kinase 1 -0.0434281
MT2A metallothionein 2A -0.042506
RPL7A ribosomal protein L7a -0.0409901
FLNB filamin B, beta -0.0409297
RPS13 ribosomal protein S13 -0.0408626
SMC4 structural maintenance of chromosomes 4 -0.0408365
RPL11 ribosomal protein L11 -0.0405971
S100A10 S100 calcium binding protein A10 -0.0405677
GLI3 GLI family zinc finger 3 -0.040462
RPS25 ribosomal protein S25 -0.0404396
RPS24 ribosomal protein S24 -0.0403638
TM4SF1 transmembrane 4 L six family member 1 -0.0400969
ANXA1 annexin A1 -0.0400259
CAMTA1 calmodulin binding transcription activator 1 -0.0397892
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0397733
MYL12B myosin, light chain 12B, regulatory -0.0396669
ENO1 enolase 1, (alpha) -0.0393944
PFN1 profilin 1 -0.0385449
RPS23 ribosomal protein S23 -0.038398
RPS3 ribosomal protein S3 -0.0382141
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0371561
ZMYND8 zinc finger, MYND-type containing 8 -0.036464
RPS27A ribosomal protein S27a -0.0363072
RPLP0 ribosomal protein, large, P0 -0.0358145
S100A4 S100 calcium binding protein A4 -0.0356274
RFC3 replication factor C (activator 1) 3, 38kDa -0.0355414
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0353801
S100A9 S100 calcium binding protein A9 -0.0348035
RPL32 ribosomal protein L32 -0.033861
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0336304
RPS21 ribosomal protein S21 -0.0334205
FTL ferritin, light polypeptide -0.0332561
TJP1 tight junction protein 1 -0.0332535
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0331687
RPL37 ribosomal protein L37 -0.0326799
TMSB10 thymosin beta 10 -0.0325731
RPL5 ribosomal protein L5 -0.0323876
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0323043
RPL9 ribosomal protein L9 -0.0320054
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0319558
UNC13A unc-13 homolog A (C. elegans) -0.0317414
HJURP Holliday junction recognition protein -0.0309455
RPS29 ribosomal protein S29 -0.0309045
RPS11 ribosomal protein S11 -0.0304715
GNAS GNAS complex locus -0.0303911
RPS12 ribosomal protein S12 -0.0303885
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0299711
RPL28 ribosomal protein L28 -0.0293792
RPS27 ribosomal protein S27 -0.029089
KPNB1 karyopherin (importin) beta 1 -0.0283828
LCORL ligand dependent nuclear receptor corepressor-like -0.0283506
FAM162A family with sequence similarity 162, member A -0.0282923
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0282043
ENO2 enolase 2 (gamma, neuronal) -0.0280963
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0279168