Meloxicam_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.1293
MYH9 myosin, heavy chain 9, non-muscle 0.0825867
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.068409
COL6A3 collagen, type VI, alpha 3 0.0533965
NAMPT nicotinamide phosphoribosyltransferase 0.050831
GLIS3 GLIS family zinc finger 3 0.0426658
VCAN versican 0.0376488
KYNU kynureninase 0.0370199
FAM20C family with sequence similarity 20, member C 0.03523
BICC1 BicC family RNA binding protein 1 0.0329898
SMAD3 SMAD family member 3 0.0324447
ZBTB38 zinc finger and BTB domain containing 38 0.0316165
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0296511
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0285664
HMGA2 high mobility group AT-hook 2 0.0276341
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0265846
AHNAK AHNAK nucleoprotein 0.0265386
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0257599
MLPH melanophilin 0.0256846
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0247792
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0238739
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0236116
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0233129
VMP1 vacuole membrane protein 1 0.0220379
ZBTB20 zinc finger and BTB domain containing 20 0.0218972
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.021884
TNS3 tensin 3 0.0211153
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0191028
PHF3 PHD finger protein 3 0.0188682
ARRDC3 arrestin domain containing 3 0.0187148
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0186128
PTPRK protein tyrosine phosphatase, receptor type, K 0.0178931
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0178636
ASPH aspartate beta-hydroxylase 0.0176942
PFKP phosphofructokinase, platelet 0.0173707
MCL1 myeloid cell leukemia 1 0.0172726
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0170644
CDH13 cadherin 13 0.0168058
EXT1 exostosin glycosyltransferase 1 0.016731
EHBP1 EH domain binding protein 1 0.0164055
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0161536
TRIP12 thyroid hormone receptor interactor 12 0.0161372
FOXP1 forkhead box P1 0.016104
MACF1 microtubule-actin crosslinking factor 1 0.0160024
VCL vinculin 0.0158823
HDAC9 histone deacetylase 9 0.0156265
PLEC plectin 0.0149121
PTH2R parathyroid hormone 2 receptor 0.0148336
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.014656
INTS6 integrator complex subunit 6 0.01439
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0141564
COL5A1 collagen, type V, alpha 1 0.0138482
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0132739
APP amyloid beta (A4) precursor protein 0.0132289
SMYD3 SET and MYND domain containing 3 0.0132271
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0131633
DPYD dihydropyrimidine dehydrogenase 0.0130225
DST dystonin 0.0129138
PDE10A phosphodiesterase 10A 0.012397
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.012368
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0123394
GOLGB1 golgin B1 0.0122586
RAI14 retinoic acid induced 14 0.0121285
SEPTIN9 septin 9 0.012024
MX1 MX dynamin-like GTPase 1 0.0117547
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0117093
ZMYND8 zinc finger, MYND-type containing 8 0.0116036
MYO9A myosin IXA 0.0115695
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0114687
EXOC6B exocyst complex component 6B 0.0110983
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.011072
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0110516
ETV6 ets variant 6 0.0110001
BCAS3 breast carcinoma amplified sequence 3 0.0109875
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0108971
PHF21A PHD finger protein 21A 0.0108531
ZC3H12B zinc finger CCCH-type containing 12B 0.0108386
MBNL2 muscleblind-like splicing regulator 2 0.0106586
AFF3 AF4/FMR2 family, member 3 0.0105607
AFDN afadin, adherens junction formation factor 0.0105572
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0105286
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0105121
CEP112 centrosomal protein 112kDa 0.0104839
GPC6 glypican 6 0.0104353
INHBA inhibin, beta A 0.0103944
RABGAP1L RAB GTPase activating protein 1-like 0.01034
EXOC4 exocyst complex component 4 0.0102785
SVIL supervillin 0.010251
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0101656
CEP250 centrosomal protein 250kDa 0.0100902
ATM ATM serine/threonine kinase 0.0100509
IGF1R insulin-like growth factor 1 receptor 0.00993192
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0099317
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.00990031
AFAP1 actin filament associated protein 1 0.00983478
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.00975115
MBD5 methyl-CpG binding domain protein 5 0.00970953
CDK12 cyclin-dependent kinase 12 0.00968097
AMPD3 adenosine monophosphate deaminase 3 0.00966524
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.00963075

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201596
VIM vimentin -0.194192
FTL ferritin, light polypeptide -0.11911
TMSB10 thymosin beta 10 -0.11243
HLA-B major histocompatibility complex, class I, B -0.0924074
RPS6 ribosomal protein S6 -0.0905932
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0677287
MT2A metallothionein 2A -0.0666889
B2M beta-2-microglobulin -0.0656803
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0650664
FTH1 ferritin, heavy polypeptide 1 -0.0630048
RPS12 ribosomal protein S12 -0.0593547
RPS8 ribosomal protein S8 -0.0543096
RPL35A ribosomal protein L35a -0.0532816
RPS19 ribosomal protein S19 -0.0482289
RPLP1 ribosomal protein, large, P1 -0.0471442
RPL23 ribosomal protein L23 -0.0457744
RPLP2 ribosomal protein, large, P2 -0.0457163
RPS3 ribosomal protein S3 -0.0444691
TPT1 tumor protein, translationally-controlled 1 -0.0427277
RPL12 ribosomal protein L12 -0.0424402
ZNF292 zinc finger protein 292 -0.041627
RPL19 ribosomal protein L19 -0.0404236
CADM1 cell adhesion molecule 1 -0.0399199
UGCG UDP-glucose ceramide glucosyltransferase -0.0397715
IER3 immediate early response 3 -0.0390505
ENO1 enolase 1, (alpha) -0.0388226
PGK1 phosphoglycerate kinase 1 -0.0378189
ANXA2 annexin A2 -0.0377258
RAB7A RAB7A, member RAS oncogene family -0.0369538
PTMA prothymosin, alpha -0.0367401
LOC112694756 uncharaterized LOC112694756 -0.0367115
IFITM3 interferon induced transmembrane protein 3 -0.0366029
RPL9 ribosomal protein L9 -0.0357792
RPL36 ribosomal protein L36 -0.0356181
PLIN2 perilipin 2 -0.035587
RPS4X ribosomal protein S4, X-linked -0.035536
RPL37A ribosomal protein L37a -0.0349507
RPS13 ribosomal protein S13 -0.0340566
RPS23 ribosomal protein S23 -0.0340547
RPLP0 ribosomal protein, large, P0 -0.0330901
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0329375
RPL36A ribosomal protein L36a -0.0326311
RPL11 ribosomal protein L11 -0.0319742
EIF1 eukaryotic translation initiation factor 1 -0.0317168
GOLGA4 golgin A4 -0.03171
RACK1 receptor for activated C kinase 1 -0.0311965
HLA-A major histocompatibility complex, class I, A -0.0307215
RPL32 ribosomal protein L32 -0.0297878
RPS24 ribosomal protein S24 -0.0297274
RPS21 ribosomal protein S21 -0.0287039
TSC22D2 TSC22 domain family, member 2 -0.0286589
ADM adrenomedullin -0.0284597
GNAS GNAS complex locus -0.0283906
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0277142
RPS14 ribosomal protein S14 -0.0275768
RPL7A ribosomal protein L7a -0.0274037
S100A9 S100 calcium binding protein A9 -0.0273461
HILPDA hypoxia inducible lipid droplet-associated -0.0272685
RPS10 ribosomal protein S10 -0.027242
HELZ helicase with zinc finger -0.0269183
WSB1 WD repeat and SOCS box containing 1 -0.0258939
RPL28 ribosomal protein L28 -0.0258609
ACTG1 actin gamma 1 -0.0257578
RPL26 ribosomal protein L26 -0.0255095
RPL35 ribosomal protein L35 -0.0252463
RPL31 ribosomal protein L31 -0.0248719
PKM pyruvate kinase, muscle -0.0248482
YBX1 Y box binding protein 1 -0.0248367
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0243325
RPL5 ribosomal protein L5 -0.0241604
ELL2 elongation factor, RNA polymerase II, 2 -0.0239759
RPL37 ribosomal protein L37 -0.0234988
RPS27 ribosomal protein S27 -0.0232958
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0232477
MORF4L2 mortality factor 4 like 2 -0.0227184
RPS20 ribosomal protein S20 -0.0227158
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0226986
PNISR PNN-interacting serine/arginine-rich protein -0.0226661
IFI6 interferon, alpha-inducible protein 6 -0.0225097
RPL7 ribosomal protein L7 -0.0224905
PFN1 profilin 1 -0.0224604
QKI QKI, KH domain containing, RNA binding -0.0224256
RPS29 ribosomal protein S29 -0.0220327
BASP1 brain abundant, membrane attached signal protein 1 -0.021739
RPS25 ribosomal protein S25 -0.0215861
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0214973
RPS27A ribosomal protein S27a -0.0214902
DEK DEK proto-oncogene -0.0214576
NAP1L1 nucleosome assembly protein 1-like 1 -0.0212347
RPL34 ribosomal protein L34 -0.0212341
EGR1 early growth response 1 -0.0211709
IFITM1 interferon induced transmembrane protein 1 -0.0209069
CTSD cathepsin D -0.0208337
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0207454
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0206815
PCBP2 poly(rC) binding protein 2 -0.0203657
HMGA1 high mobility group AT-hook 1 -0.0202144
RPS17 ribosomal protein S17 -0.0202138
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0201777