Meloxicam_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.142866
KDM6A lysine (K)-specific demethylase 6A 0.0585887
AKAP9 A kinase (PRKA) anchor protein 9 0.0555293
SOD2 superoxide dismutase 2, mitochondrial 0.054322
DIAPH3 diaphanous-related formin 3 0.0503018
RNF145 ring finger protein 145 0.0493465
COG5 component of oligomeric golgi complex 5 0.0472674
NAMPT nicotinamide phosphoribosyltransferase 0.0464655
ARRDC3 arrestin domain containing 3 0.0456028
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0449142
SEC31A SEC31 homolog A (S. cerevisiae) 0.0430902
CSDE1 cold shock domain containing E1, RNA-binding 0.040056
ELL2 elongation factor, RNA polymerase II, 2 0.0397783
TNIP1 TNFAIP3 interacting protein 1 0.039409
SPAG9 sperm associated antigen 9 0.0387141
SETD5 SET domain containing 5 0.0372094
SAMD4A sterile alpha motif domain containing 4A 0.0367921
OGA O-GlcNAcase 0.0358948
ITCH itchy E3 ubiquitin protein ligase 0.0357095
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0354096
TENT2 terminal nucleotidyltransferase 2 0.0348676
TRA2A transformer 2 alpha homolog (Drosophila) 0.034665
COG6 component of oligomeric golgi complex 6 0.0345268
GOLGA4 golgin A4 0.0343905
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0341758
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0341352
SDC4 syndecan 4 0.0338495
KIF16B kinesin family member 16B 0.0337265
SCFD2 sec1 family domain containing 2 0.0332798
JMJD1C jumonji domain containing 1C 0.0330389
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.032937
KIF1B kinesin family member 1B 0.0326184
RBMS3 RNA binding motif, single stranded interacting protein 3 0.032388
ANXA5 annexin A5 0.0323189
EXT1 exostosin glycosyltransferase 1 0.0323174
ZCCHC7 zinc finger, CCHC domain containing 7 0.0322947
AVL9 AVL9 homolog (S. cerevisiase) 0.0322921
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.03216
ATP13A3 ATPase type 13A3 0.0319547
SEC24A SEC24 family member A 0.0315253
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0312349
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0312052
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0311618
SMYD3 SET and MYND domain containing 3 0.0309259
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0307542
RBM39 RNA binding motif protein 39 0.0304119
TTC3 tetratricopeptide repeat domain 3 0.0301747
SRRM1 serine/arginine repetitive matrix 1 0.0299143
ZBTB20 zinc finger and BTB domain containing 20 0.0298876
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0295674
WDFY3 WD repeat and FYVE domain containing 3 0.0295209
NCOR1 nuclear receptor corepressor 1 0.0292669
FAF1 Fas (TNFRSF6) associated factor 1 0.0291472
ALCAM activated leukocyte cell adhesion molecule 0.0290785
TMF1 TATA element modulatory factor 1 0.0287494
ATP11B ATPase, class VI, type 11B 0.0284585
COL4A1 collagen, type IV, alpha 1 0.0281655
PTGES2 prostaglandin E synthase 2 0.0277765
MIGA1 mitoguardin 1 0.0268791
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0258711
PRKCA protein kinase C, alpha 0.0258527
ANO10 anoctamin 10 0.0257938
NCKAP1 NCK-associated protein 1 0.0257601
SEC23A Sec23 homolog A (S. cerevisiae) 0.0257249
UBA6 ubiquitin-like modifier activating enzyme 6 0.0256478
MATR3 matrin 3 0.0254459
HBS1L HBS1-like translational GTPase 0.0254366
NUP54 nucleoporin 54kDa 0.0252411
LOC112694756 uncharaterized LOC112694756 0.0251365
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0250394
PLEC plectin 0.0249597
TBC1D23 TBC1 domain family, member 23 0.0247348
WDFY2 WD repeat and FYVE domain containing 2 0.0245888
NUMB numb homolog (Drosophila) 0.0244802
PGK1 phosphoglycerate kinase 1 0.0244134
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0243302
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0240944
NAV1 neuron navigator 1 0.0239649
TXNL1 thioredoxin-like 1 0.0239503
RFC3 replication factor C (activator 1) 3, 38kDa 0.0236632
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0235545
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0233353
PMM2 phosphomannomutase 2 0.023326
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0231079
TFG TRK-fused gene 0.0230727
ARHGAP29 Rho GTPase activating protein 29 0.0230065
AGFG1 ArfGAP with FG repeats 1 0.022833
PHKB phosphorylase kinase, beta 0.0226464
ERBIN erbb2 interacting protein 0.0226309
FBXW11 F-box and WD repeat domain containing 11 0.0226174
POT1 protection of telomeres 1 0.0225579
MED13L mediator complex subunit 13-like 0.0225547
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.02238
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0221579
NBAS neuroblastoma amplified sequence 0.0221403
SKIC3 SKI3 subunit of superkiller complex 0.0221252
AHDC1 AT hook, DNA binding motif, containing 1 0.0220749
BZW1 basic leucine zipper and W2 domains 1 0.0218312
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0216552
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0214889

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.197053
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140364
TMSB10 thymosin beta 10 -0.135603
VIM vimentin -0.133638
TIMP3 TIMP metallopeptidase inhibitor 3 -0.123758
TGFBI transforming growth factor, beta-induced, 68kDa -0.11494
STC1 stanniocalcin 1 -0.0829343
HLA-B major histocompatibility complex, class I, B -0.08013
PKM pyruvate kinase, muscle -0.075959
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0751837
PTMA prothymosin, alpha -0.0701028
FTL ferritin, light polypeptide -0.0670428
MT2A metallothionein 2A -0.0589077
NDRG1 N-myc downstream regulated 1 -0.0549922
LOX lysyl oxidase -0.0493991
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0478651
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0478145
B2M beta-2-microglobulin -0.0465782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.046115
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0439336
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0430394
COL6A2 collagen, type VI, alpha 2 -0.042672
CANX calnexin -0.041295
CALR calreticulin -0.0410013
TPT1 tumor protein, translationally-controlled 1 -0.0399879
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0397217
PRSS23 protease, serine, 23 -0.0386925
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.038175
AKAP12 A kinase (PRKA) anchor protein 12 -0.0377349
ZMYND8 zinc finger, MYND-type containing 8 -0.0371784
IL6 interleukin 6 -0.0360059
RPS27A ribosomal protein S27a -0.0354306
TNS3 tensin 3 -0.0351458
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0350833
POTEF POTE ankyrin domain family, member F -0.034745
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341979
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0341704
CD44 CD44 molecule (Indian blood group) -0.0334411
CMIP c-Maf inducing protein -0.0329878
FTH1 ferritin, heavy polypeptide 1 -0.0322402
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0317571
RUNX1 runt-related transcription factor 1 -0.0294885
RPLP1 ribosomal protein, large, P1 -0.0293296
EIF1 eukaryotic translation initiation factor 1 -0.0285092
JUN jun proto-oncogene -0.0283914
ADM adrenomedullin -0.0280624
RPL37A ribosomal protein L37a -0.0276186
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0274641
MT1X metallothionein 1X -0.0273525
PDE4D phosphodiesterase 4D, cAMP-specific -0.0272364
FKBP10 FK506 binding protein 10, 65 kDa -0.0267196
WWTR1 WW domain containing transcription regulator 1 -0.0266796
MAP4 microtubule-associated protein 4 -0.0266646
LGALS1 lectin, galactoside-binding, soluble, 1 -0.025769
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0255432
STC2 stanniocalcin 2 -0.0255119
ACTG1 actin gamma 1 -0.0254477
F3 coagulation factor III (thromboplastin, tissue factor) -0.0248807
HIPK2 homeodomain interacting protein kinase 2 -0.0243879
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0241383
LOXL2 lysyl oxidase-like 2 -0.023764
COL1A1 collagen, type I, alpha 1 -0.0236578
ENO1 enolase 1, (alpha) -0.0233674
FLNA filamin A, alpha -0.0233554
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.023279
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0229604
MYADM myeloid-associated differentiation marker -0.022936
COL7A1 collagen, type VII, alpha 1 -0.0226466
ASPH aspartate beta-hydroxylase -0.0225038
DPYSL2 dihydropyrimidinase-like 2 -0.02237
RPS19 ribosomal protein S19 -0.0221823
S100A9 S100 calcium binding protein A9 -0.0221275
TRIM56 tripartite motif containing 56 -0.0218928
HLA-C major histocompatibility complex, class I, C -0.0218541
HDAC9 histone deacetylase 9 -0.0217711
RORA RAR-related orphan receptor A -0.0217239
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0216806
KMT2C lysine (K)-specific methyltransferase 2C -0.0215866
KLF6 Kruppel-like factor 6 -0.0215372
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0212934
CRYBG3 beta-gamma crystallin domain containing 3 -0.0212143
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0211472
DTNA dystrobrevin, alpha -0.0210233
ENAH enabled homolog (Drosophila) -0.0210183
COL1A2 collagen, type I, alpha 2 -0.0209771
LMNA lamin A/C -0.0209456
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0206901
FUS FUS RNA binding protein -0.0206853
PDLIM5 PDZ and LIM domain 5 -0.0206013
MYH9 myosin, heavy chain 9, non-muscle -0.0205863
FLOT1 flotillin 1 -0.0204812
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0204643
MAP1B microtubule-associated protein 1B -0.0204326
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0203024
MTDH metadherin -0.0202983
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0202776
RAI14 retinoic acid induced 14 -0.0202652
BRD4 bromodomain containing 4 -0.020189
NALF1 NALCN channel auxiliary factor 1 -0.0201164
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0199289