Meloxicam_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Meloxicam perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Meloxicam_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.118496
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0657877
TXNRD1 thioredoxin reductase 1 0.0566994
SMOX spermine oxidase 0.0465095
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0459818
PRRC2C proline-rich coiled-coil 2C 0.0412379
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0410401
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.038377
TMEM156 transmembrane protein 156 0.0380309
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0373602
XPO1 exportin 1 0.035335
CD44 CD44 molecule (Indian blood group) 0.0265916
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0253969
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0248623
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0243621
MCTP2 multiple C2 domains, transmembrane 2 0.0239756
HMGB3 high mobility group box 3 0.0236945
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236916
ETNK1 ethanolamine kinase 1 0.0233893
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0232908
PLEC plectin 0.0232443
VMP1 vacuole membrane protein 1 0.0228124
NUP58 nucleoporin 58 0.0223294
PELI1 pellino E3 ubiquitin protein ligase 1 0.0221671
PNN pinin, desmosome associated protein 0.0218668
PELO pelota homolog (Drosophila) 0.0208002
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0205637
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0204602
EEF2 eukaryotic translation elongation factor 2 0.0203242
ANKRD28 ankyrin repeat domain 28 0.0201675
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0200492
OSMR oncostatin M receptor 0.0197776
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0197385
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0197148
HOMER2 homer scaffolding protein 2 0.0196756
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0196099
ACADVL acyl-CoA dehydrogenase, very long chain 0.0195336
CSDE1 cold shock domain containing E1, RNA-binding 0.0193509
PNISR PNN-interacting serine/arginine-rich protein 0.0193296
CENPF centromere protein F, 350/400kDa 0.0184096
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0183578
PLPP6 phospholipid phosphatase 6 0.018279
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0182583
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.018198
SLC16A6 solute carrier family 16, member 6 0.018032
CCNJL cyclin J-like 0.0179841
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0179587
AHR aryl hydrocarbon receptor 0.0177093
STK24 serine/threonine kinase 24 0.0175961
RPL3 ribosomal protein L3 0.0174842
TGM2 transglutaminase 2 0.0171341
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0169911
SMYD3 SET and MYND domain containing 3 0.0169873
UGCG UDP-glucose ceramide glucosyltransferase 0.0169781
ADAM17 ADAM metallopeptidase domain 17 0.0169328
ARRDC3 arrestin domain containing 3 0.0169189
RB1CC1 RB1-inducible coiled-coil 1 0.0167448
MKRN1 makorin ring finger protein 1 0.0166729
OTUD7B OTU deubiquitinase 7B 0.016671
KSR1 kinase suppressor of ras 1 0.0164889
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0164437
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.016089
ETV6 ets variant 6 0.0160766
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0159807
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0157761
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0157399
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0156845
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0155534
DUSP5 dual specificity phosphatase 5 0.0155039
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0154936
FUBP1 far upstream element (FUSE) binding protein 1 0.0153912
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0153073
SOS1 son of sevenless homolog 1 (Drosophila) 0.0150499
SOD2 superoxide dismutase 2, mitochondrial 0.0150211
SVIL supervillin 0.0149978
CDC27 cell division cycle 27 0.0149391
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0149154
PCBP2 poly(rC) binding protein 2 0.0148889
CDCP1 CUB domain containing protein 1 0.0148483
ATL2 atlastin GTPase 2 0.0147334
TMEM165 transmembrane protein 165 0.0146754
GPR107 G protein-coupled receptor 107 0.0145137
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0144708
ZFR zinc finger RNA binding protein 0.0144476
SMAD3 SMAD family member 3 0.014265
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0142647
WDR43 WD repeat domain 43 0.0140703
NSD1 nuclear receptor binding SET domain protein 1 0.0137219
LMCD1 LIM and cysteine-rich domains 1 0.0137042
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.013612
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0134521
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.0133791
XPO6 exportin 6 0.0133343
IPMK inositol polyphosphate multikinase 0.0132959
UBE2K ubiquitin-conjugating enzyme E2K 0.0132646
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0132519
KDM6A lysine (K)-specific demethylase 6A 0.0131042
FNBP1 formin binding protein 1 0.0130985
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0130893
FAM91A1 family with sequence similarity 91, member A1 0.0129692

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.225636
FN1 fibronectin 1 -0.215078
NRG1 neuregulin 1 -0.208817
HMGA2 high mobility group AT-hook 2 -0.150348
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.118982
TMSB10 thymosin beta 10 -0.112412
PTMA prothymosin, alpha -0.0993479
TRIO trio Rho guanine nucleotide exchange factor -0.0980336
SQSTM1 sequestosome 1 -0.0979968
NDRG1 N-myc downstream regulated 1 -0.088513
VCL vinculin -0.0833152
ASPH aspartate beta-hydroxylase -0.0830052
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0817164
GRB10 growth factor receptor-bound protein 10 -0.076823
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0724437
HLA-B major histocompatibility complex, class I, B -0.0719016
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0674604
RAI14 retinoic acid induced 14 -0.0663875
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0661397
IFI27 interferon, alpha-inducible protein 27 -0.0626107
TPT1 tumor protein, translationally-controlled 1 -0.0605257
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0573856
LIMCH1 LIM and calponin homology domains 1 -0.0567083
ENO2 enolase 2 (gamma, neuronal) -0.0541275
EFNA5 ephrin-A5 -0.0525236
PLIN2 perilipin 2 -0.051471
S100A6 S100 calcium binding protein A6 -0.0503927
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0498892
HILPDA hypoxia inducible lipid droplet-associated -0.0493804
TMSB4X thymosin beta 4, X-linked -0.0475238
CADM1 cell adhesion molecule 1 -0.0468716
LOXL2 lysyl oxidase-like 2 -0.0456543
ACTG1 actin gamma 1 -0.0455259
MRPS6 mitochondrial ribosomal protein S6 -0.0448682
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0445052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0418538
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0413482
GNAS GNAS complex locus -0.0403082
INTS6 integrator complex subunit 6 -0.0401548
TAS2R14 taste receptor, type 2, member 14 -0.0398632
FTL ferritin, light polypeptide -0.0393664
PDLIM5 PDZ and LIM domain 5 -0.0381833
MYOF myoferlin -0.0374694
S100A10 S100 calcium binding protein A10 -0.0374376
STC2 stanniocalcin 2 -0.0373978
WSB1 WD repeat and SOCS box containing 1 -0.0367348
IGFBP3 insulin-like growth factor binding protein 3 -0.0366077
AKAP12 A kinase (PRKA) anchor protein 12 -0.0361053
ITGA1 integrin, alpha 1 -0.0359218
SLC35F3 solute carrier family 35, member F3 -0.0352267
RPL35A ribosomal protein L35a -0.0350677
VIM vimentin -0.0343846
KDM5B lysine (K)-specific demethylase 5B -0.0341252
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0337317
AEBP2 AE binding protein 2 -0.0336914
PALLD palladin, cytoskeletal associated protein -0.0331291
MT2A metallothionein 2A -0.0325149
SYT1 synaptotagmin I -0.0324494
ENO1 enolase 1, (alpha) -0.0319238
FBXO11 F-box protein 11 -0.0319092
MAML2 mastermind-like 2 (Drosophila) -0.0318095
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0315989
RAB7A RAB7A, member RAS oncogene family -0.03149
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0312626
LMNA lamin A/C -0.0307109
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0306404
HMGA1 high mobility group AT-hook 1 -0.0303084
IER3 immediate early response 3 -0.0297318
TENM4 teneurin transmembrane protein 4 -0.0294281
RPL26 ribosomal protein L26 -0.0288152
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0282609
PSD3 pleckstrin and Sec7 domain containing 3 -0.0282311
FTH1 ferritin, heavy polypeptide 1 -0.0281188
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0279409
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0277629
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0276505
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0272347
PKM pyruvate kinase, muscle -0.0270434
DUSP6 dual specificity phosphatase 6 -0.026475
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0261858
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0261259
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0260564
RPS24 ribosomal protein S24 -0.0257544
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0256675
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0256631
OXR1 oxidation resistance 1 -0.0251956
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.02505
PRKCA protein kinase C, alpha -0.0249119
PGK1 phosphoglycerate kinase 1 -0.0244723
FAM13A family with sequence similarity 13, member A -0.0243484
EGR1 early growth response 1 -0.0242127
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0241532
ANXA2 annexin A2 -0.0239961
CTBP2 C-terminal binding protein 2 -0.0239572
JUN jun proto-oncogene -0.0239326
LOX lysyl oxidase -0.0237932
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0237652
SFRP1 secreted frizzled-related protein 1 -0.0234557
AHNAK AHNAK nucleoprotein -0.0230611
TFPI2 tissue factor pathway inhibitor 2 -0.0230011