Menadione_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH13 cadherin 13 0.150913
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.143028
TRIO trio Rho guanine nucleotide exchange factor 0.141243
PLAT plasminogen activator, tissue 0.118398
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.116728
POTEF POTE ankyrin domain family, member F 0.115863
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.102451
AHNAK AHNAK nucleoprotein 0.0986506
DST dystonin 0.0828598
SLC39A11 solute carrier family 39, member 11 0.0828146
IGFBP3 insulin-like growth factor binding protein 3 0.0795234
VIM vimentin 0.0696627
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0642577
FBN1 fibrillin 1 0.0613964
MYOF myoferlin 0.0613108
ZEB1 zinc finger E-box binding homeobox 1 0.0591621
MACF1 microtubule-actin crosslinking factor 1 0.0564774
ASPH aspartate beta-hydroxylase 0.0541709
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0538587
COL5A1 collagen, type V, alpha 1 0.0523505
FN1 fibronectin 1 0.0520812
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.05193
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0516476
PBX3 pre-B-cell leukemia homeobox 3 0.0514379
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0506033
ZFP36L1 ZFP36 ring finger protein-like 1 0.0504698
CALR calreticulin 0.0493719
AKAP12 A kinase (PRKA) anchor protein 12 0.0489752
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0487744
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0477111
ABI3BP ABI family, member 3 (NESH) binding protein 0.0467987
INSIG2 insulin induced gene 2 0.046216
ADAM9 ADAM metallopeptidase domain 9 0.0440659
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0437032
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0425374
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.041472
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0408633
PKM pyruvate kinase, muscle 0.0399454
CCND1 cyclin D1 0.0392066
TPM4 tropomyosin 4 0.03888
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.0387127
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0379928
SPDL1 spindle apparatus coiled-coil protein 1 0.0368234
MMP12 matrix metallopeptidase 12 0.0366513
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0364928
COPA coatomer protein complex, subunit alpha 0.0364812
EGFR epidermal growth factor receptor 0.0361754
AUTS2 autism susceptibility candidate 2 0.0357375
DTNA dystrobrevin, alpha 0.0355706
NEK7 NIMA-related kinase 7 0.0354468
MSI2 musashi RNA-binding protein 2 0.0353203
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0352433
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.035202
PGK1 phosphoglycerate kinase 1 0.0348854
ERBIN erbb2 interacting protein 0.0346973
CANX calnexin 0.0345545
MED13L mediator complex subunit 13-like 0.0343576
CD109 CD109 molecule 0.0343116
DSPP dentin sialophosphoprotein 0.0338982
FNDC3B fibronectin type III domain containing 3B 0.0338812
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0338246
SDK1 sidekick cell adhesion molecule 1 0.0337894
FLT1 fms-related tyrosine kinase 1 0.0336695
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0336448
SPIRE1 spire-type actin nucleation factor 1 0.0335392
INTS6 integrator complex subunit 6 0.0334922
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0331603
LRRC17 leucine rich repeat containing 17 0.032545
ENO1 enolase 1, (alpha) 0.032476
FXR1 fragile X mental retardation, autosomal homolog 1 0.0324491
ADAM17 ADAM metallopeptidase domain 17 0.0322484
NAV2 neuron navigator 2 0.0319416
C1ORF21 chromosome 1 open reading frame 21 0.0318708
MCL1 myeloid cell leukemia 1 0.0316679
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0314887
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0314364
LCOR ligand dependent nuclear receptor corepressor 0.0312882
DLG1 discs, large homolog 1 (Drosophila) 0.0311438
CUX1 cut-like homeobox 1 0.0310365
PDIA6 protein disulfide isomerase family A, member 6 0.0307566
CENPF centromere protein F, 350/400kDa 0.0307428
KRT81 keratin 81, type II 0.0306975
SORBS2 sorbin and SH3 domain containing 2 0.030585
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0303272
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0301597
KMT2E lysine (K)-specific methyltransferase 2E 0.0300923
DGKG diacylglycerol kinase, gamma 90kDa 0.0298037
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.029803
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0298007
TPM1 tropomyosin 1 (alpha) 0.0297419
TTC3 tetratricopeptide repeat domain 3 0.0292489
PICALM phosphatidylinositol binding clathrin assembly protein 0.0290676
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0284851
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0284812
CSTB cystatin B (stefin B) 0.0283231
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0283019
NOTCH2 notch 2 0.0282134
FGFR1 fibroblast growth factor receptor 1 0.0275708
SNX9 sorting nexin 9 0.0275532
VMP1 vacuole membrane protein 1 0.0273895

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.245821
MT2A metallothionein 2A -0.213741
COL1A2 collagen, type I, alpha 2 -0.119566
CD44 CD44 molecule (Indian blood group) -0.0902998
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0836256
THBS2 thrombospondin 2 -0.07271
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0727015
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0711654
LOX lysyl oxidase -0.0710706
NAP1L1 nucleosome assembly protein 1-like 1 -0.0632272
LOC112694756 uncharaterized LOC112694756 -0.0615703
GLIS3 GLIS family zinc finger 3 -0.0557744
HLA-B major histocompatibility complex, class I, B -0.0555295
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0551586
B2M beta-2-microglobulin -0.0535011
FTH1 ferritin, heavy polypeptide 1 -0.0504363
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0476686
COL3A1 collagen, type III, alpha 1 -0.0453574
MT1X metallothionein 1X -0.0448925
PLAUR plasminogen activator, urokinase receptor -0.0440426
HLA-C major histocompatibility complex, class I, C -0.0439445
GNAS GNAS complex locus -0.0438677
NDRG1 N-myc downstream regulated 1 -0.043723
TMSB4X thymosin beta 4, X-linked -0.0414004
MX2 MX dynamin-like GTPase 2 -0.040413
BSG basigin (Ok blood group) -0.0398127
RPS6 ribosomal protein S6 -0.0397692
RUNX1 runt-related transcription factor 1 -0.0381153
KLF6 Kruppel-like factor 6 -0.03775
STC1 stanniocalcin 1 -0.0375768
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0370533
IFITM1 interferon induced transmembrane protein 1 -0.0370468
S100A4 S100 calcium binding protein A4 -0.0364483
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0355139
PARD3 par-3 family cell polarity regulator -0.0354927
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0352796
MB21D2 Mab-21 domain containing 2 -0.0352516
DPYSL3 dihydropyrimidinase-like 3 -0.0343645
TUBB tubulin, beta class I -0.0334955
ARL4C ADP-ribosylation factor-like 4C -0.0334882
RPS19 ribosomal protein S19 -0.0333695
ZBTB20 zinc finger and BTB domain containing 20 -0.0323512
MAP1B microtubule-associated protein 1B -0.0311814
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0309888
RPS3 ribosomal protein S3 -0.0297004
COL6A2 collagen, type VI, alpha 2 -0.0295216
EIF1 eukaryotic translation initiation factor 1 -0.0295111
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0292564
ADAR adenosine deaminase, RNA-specific -0.0287685
OSMR oncostatin M receptor -0.0285152
SOX9 SRY (sex determining region Y)-box 9 -0.028496
SVIL supervillin -0.0284886
RPL23 ribosomal protein L23 -0.0275764
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0273656
CBX3 chromobox homolog 3 -0.0269994
RPL34 ribosomal protein L34 -0.0269503
NPR2 natriuretic peptide receptor 2 -0.0268392
WWTR1 WW domain containing transcription regulator 1 -0.0266978
CCL5 chemokine (C-C motif) ligand 5 -0.0265775
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G -0.026416
CTSB cathepsin B -0.0262641
RPL26 ribosomal protein L26 -0.026118
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0253564
RPLP1 ribosomal protein, large, P1 -0.0251257
ZFR zinc finger RNA binding protein -0.0250846
HLA-A major histocompatibility complex, class I, A -0.0249356
SEC62 SEC62 homolog (S. cerevisiae) -0.0248756
NBEA neurobeachin -0.0245684
IFI16 interferon, gamma-inducible protein 16 -0.0244384
SMIM44 small integral membrane protein 44 -0.0238057
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0237433
RBM25 RNA binding motif protein 25 -0.0232219
PLXND1 plexin D1 -0.0229366
TAGLN2 transgelin 2 -0.0228265
PLAAT3 phospholipase A and acyltransferase 3 -0.0224294
NKTR natural killer cell triggering receptor -0.0222811
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0222341
TMOD1 tropomodulin 1 -0.0222129
LOXL2 lysyl oxidase-like 2 -0.0222026
FUS FUS RNA binding protein -0.0219994
TRIM56 tripartite motif containing 56 -0.0219547
IFITM3 interferon induced transmembrane protein 3 -0.0218171
FLNA filamin A, alpha -0.021737
PSD3 pleckstrin and Sec7 domain containing 3 -0.0216206
ATP5F1E ATP synthase F1 subunit epsilon -0.0215692
INSR insulin receptor -0.0214032
RPL35A ribosomal protein L35a -0.0209406
RPL18 ribosomal protein L18 -0.0208037
APP amyloid beta (A4) precursor protein -0.0207702
IQSEC1 IQ motif and Sec7 domain 1 -0.0206784
HLA-E major histocompatibility complex, class I, E -0.0205373
MRC2 mannose receptor, C type 2 -0.0203132
ELL2 elongation factor, RNA polymerase II, 2 -0.0202739
TRIM22 tripartite motif containing 22 -0.0199633
COL5A2 collagen, type V, alpha 2 -0.0199455
TRAM2 translocation associated membrane protein 2 -0.0198867
MYADM myeloid-associated differentiation marker -0.0198694
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0197226
GSN gelsolin -0.0196962
RPL12 ribosomal protein L12 -0.0196707