Menadione_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.164521
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0720565
EXT1 exostosin glycosyltransferase 1 0.0713678
NRG1 neuregulin 1 0.0619117
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0563872
MEF2A myocyte enhancer factor 2A 0.0561195
MAP1B microtubule-associated protein 1B 0.0538486
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0486095
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0465075
DSCAM Down syndrome cell adhesion molecule 0.041184
ARMC9 armadillo repeat containing 9 0.0405606
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0404613
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0402956
HELZ helicase with zinc finger 0.0371468
RAD23B RAD23 homolog B (S. cerevisiae) 0.0369419
SSBP2 single-stranded DNA binding protein 2 0.0362278
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0361209
KDM3A lysine (K)-specific demethylase 3A 0.0356031
COL4A5 collagen, type IV, alpha 5 0.0354423
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0349452
TFG TRK-fused gene 0.0343404
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0343201
LPP LIM domain containing preferred translocation partner in lipoma 0.033487
QKI QKI, KH domain containing, RNA binding 0.0334062
MON2 MON2 homolog (S. cerevisiae) 0.0330666
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0325107
NAMPT nicotinamide phosphoribosyltransferase 0.0323654
MARCHF6 membrane associated ring-CH-type finger 6 0.0318195
POTEF POTE ankyrin domain family, member F 0.0313442
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0313081
NPEPPS aminopeptidase puromycin sensitive 0.0307873
EPS8 epidermal growth factor receptor pathway substrate 8 0.0307325
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0307265
PTEN phosphatase and tensin homolog 0.0306329
PTPRE protein tyrosine phosphatase, receptor type, E 0.0303903
KDM6A lysine (K)-specific demethylase 6A 0.0303521
CADM1 cell adhesion molecule 1 0.0302929
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0299676
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0299221
SOS1 son of sevenless homolog 1 (Drosophila) 0.0299032
SEC31A SEC31 homolog A (S. cerevisiae) 0.0296543
CLTC clathrin, heavy chain (Hc) 0.0296324
ENAH enabled homolog (Drosophila) 0.0292932
SLC35F3 solute carrier family 35, member F3 0.029142
ITGA1 integrin, alpha 1 0.0290017
KLHL24 kelch-like family member 24 0.0287377
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.028428
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0278115
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0278075
COL3A1 collagen, type III, alpha 1 0.0277056
TXNRD1 thioredoxin reductase 1 0.0276782
GPC5 glypican 5 0.0275194
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0274718
SIK3 SIK family kinase 3 0.027417
MED13 mediator complex subunit 13 0.0274036
VDAC1 voltage-dependent anion channel 1 0.0267478
MAPK6 mitogen-activated protein kinase 6 0.0267244
BIRC6 baculoviral IAP repeat containing 6 0.026287
OSBPL8 oxysterol binding protein-like 8 0.0262718
MYO6 myosin VI 0.0261939
WAC WW domain containing adaptor with coiled-coil 0.0258909
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0258394
AHRR aryl-hydrocarbon receptor repressor 0.0256474
VCAN versican 0.0255413
MED13L mediator complex subunit 13-like 0.0253802
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0251846
PTK2 protein tyrosine kinase 2 0.0251309
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0250555
IGFBP3 insulin-like growth factor binding protein 3 0.0249376
LIMCH1 LIM and calponin homology domains 1 0.0249088
NUP58 nucleoporin 58 0.024903
RICTOR RPTOR independent companion of MTOR, complex 2 0.0248685
ZEB1 zinc finger E-box binding homeobox 1 0.0248244
SMAD3 SMAD family member 3 0.0245433
MSI2 musashi RNA-binding protein 2 0.0242374
APP amyloid beta (A4) precursor protein 0.024234
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0241327
NCKAP1 NCK-associated protein 1 0.0240584
LSAMP limbic system-associated membrane protein 0.0239497
TLK2 tousled-like kinase 2 0.0239359
COL4A2 collagen, type IV, alpha 2 0.0237973
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0237211
ATXN2 ataxin 2 0.0236208
ZFAND3 zinc finger, AN1-type domain 3 0.0233261
RNF145 ring finger protein 145 0.0232737
GSK3B glycogen synthase kinase 3 beta 0.0232541
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0232253
ZMAT3 zinc finger, matrin-type 3 0.023211
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0232059
ANKRD28 ankyrin repeat domain 28 0.0230714
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0227987
ZBTB20 zinc finger and BTB domain containing 20 0.0224546
CCND1 cyclin D1 0.0222151
SLC38A2 solute carrier family 38, member 2 0.0219435
HSPA8 heat shock 70kDa protein 8 0.0219145
CALU calumenin 0.0217905
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0214805
XPO1 exportin 1 0.021409
BMERB1 bMERB domain containing 1 0.0213836
TNPO1 transportin 1 0.0213181

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.146524
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139234
PTMA prothymosin, alpha -0.087685
PTPRD protein tyrosine phosphatase, receptor type, D -0.0701284
MEIS2 Meis homeobox 2 -0.0623044
RPLP1 ribosomal protein, large, P1 -0.0563424
TRIB2 tribbles pseudokinase 2 -0.0488557
SYT1 synaptotagmin I -0.0485826
RPL19 ribosomal protein L19 -0.0485214
TLE4 transducin-like enhancer of split 4 -0.0483845
RPS6 ribosomal protein S6 -0.0476158
RPL38 ribosomal protein L38 -0.0471478
RPL23 ribosomal protein L23 -0.0471153
DPH6 diphthamine biosynthesis 6 -0.0466327
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0462253
HAND2 heart and neural crest derivatives expressed 2 -0.0409608
COL1A1 collagen, type I, alpha 1 -0.0401014
FMN1 formin 1 -0.0381098
BPTF bromodomain PHD finger transcription factor -0.0348561
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0346875
FNBP1 formin binding protein 1 -0.0346766
DCAF7 DDB1 and CUL4 associated factor 7 -0.0343616
RPL37A ribosomal protein L37a -0.0338532
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0332038
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.032571
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0317787
VIM vimentin -0.03173
RPS12 ribosomal protein S12 -0.0300915
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0299346
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0288175
VEGFA vascular endothelial growth factor A -0.0286646
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0284126
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0283879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0281945
ITPRID2 ITPR interacting domain containing 2 -0.0279631
RPL12 ribosomal protein L12 -0.0277718
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0272046
RPL5 ribosomal protein L5 -0.0270535
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0266526
RPL34 ribosomal protein L34 -0.026498
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.026243
EIF1 eukaryotic translation initiation factor 1 -0.0261425
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0254866
RPS3 ribosomal protein S3 -0.0254247
LPIN1 lipin 1 -0.0253133
TAS2R14 taste receptor, type 2, member 14 -0.0251114
TBX2 T-box 2 -0.024939
RPS19 ribosomal protein S19 -0.0242798
HILPDA hypoxia inducible lipid droplet-associated -0.0240297
CA12 carbonic anhydrase XII -0.0239959
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0239881
RPL36 ribosomal protein L36 -0.0238796
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0238024
CDK19 cyclin-dependent kinase 19 -0.0232347
RPL18 ribosomal protein L18 -0.0231983
HAS2 hyaluronan synthase 2 -0.0231133
TPST1 tyrosylprotein sulfotransferase 1 -0.0231065
RPL7 ribosomal protein L7 -0.0229568
TMSB10 thymosin beta 10 -0.0229521
CENPF centromere protein F, 350/400kDa -0.0228915
CENPE centromere protein E, 312kDa -0.0228846
SMYD3 SET and MYND domain containing 3 -0.0227876
FAM13A family with sequence similarity 13, member A -0.0227098
RPL28 ribosomal protein L28 -0.0226575
XRN1 5'-3' exoribonuclease 1 -0.0226423
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0223401
PLAT plasminogen activator, tissue -0.021913
KIAA1217 KIAA1217 -0.0218165
RAB30 RAB30, member RAS oncogene family -0.0218059
RPL9 ribosomal protein L9 -0.0215686
ADGRB3 adhesion G protein-coupled receptor B3 -0.0214607
ANO6 anoctamin 6 -0.0213498
PCM1 pericentriolar material 1 -0.021286
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0211128
SON SON DNA binding protein -0.0210478
FHIT fragile histidine triad -0.0209128
PHOX2B paired-like homeobox 2b -0.0208615
ANK2 ankyrin 2, neuronal -0.0204246
GLG1 golgi glycoprotein 1 -0.0204037
ANGPTL4 angiopoietin-like 4 -0.0202512
MBTD1 mbt domain containing 1 -0.0201544
RPS27 ribosomal protein S27 -0.0199343
RPL7A ribosomal protein L7a -0.0198977
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0198171
JMJD1C jumonji domain containing 1C -0.0197758
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0197444
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0197371
UNC5C unc-5 homolog C (C. elegans) -0.0197074
AKAP9 A kinase (PRKA) anchor protein 9 -0.0194402
GNAS GNAS complex locus -0.0193448
RPL32 ribosomal protein L32 -0.0188886
NCAM2 neural cell adhesion molecule 2 -0.0186124
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0186014
RPL26 ribosomal protein L26 -0.0185782
RPS8 ribosomal protein S8 -0.0183821
PIBF1 progesterone immunomodulatory binding factor 1 -0.0183716
RPL35A ribosomal protein L35a -0.0182461
DGKD diacylglycerol kinase, delta 130kDa -0.0178682
RNF213 ring finger protein 213 -0.0178563
ENO1 enolase 1, (alpha) -0.0178504