Menadione_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.135772
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.121269
BTBD9 BTB (POZ) domain containing 9 0.111604
MBNL2 muscleblind-like splicing regulator 2 0.0930982
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0775673
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0572676
FNDC3A fibronectin type III domain containing 3A 0.0571289
ZMYM2 zinc finger, MYM-type 2 0.0531862
PDIA3 protein disulfide isomerase family A, member 3 0.0518168
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0512507
TM9SF2 transmembrane 9 superfamily member 2 0.0506752
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0496868
CANX calnexin 0.0489033
IFNGR1 interferon gamma receptor 1 0.0477454
RNF149 ring finger protein 149 0.0474521
PTEN phosphatase and tensin homolog 0.0468659
COG6 component of oligomeric golgi complex 6 0.044711
SEC24D SEC24 family member D 0.0421719
MCTP2 multiple C2 domains, transmembrane 2 0.0407309
BCLAF1 BCL2-associated transcription factor 1 0.040633
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0404665
SREBF2 sterol regulatory element binding transcription factor 2 0.038502
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0383126
TXNIP thioredoxin interacting protein 0.0373398
PTBP3 polypyrimidine tract binding protein 3 0.0370346
TTC3 tetratricopeptide repeat domain 3 0.0368311
GOLGA4 golgin A4 0.0364849
FNDC3B fibronectin type III domain containing 3B 0.0359293
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0354601
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0349797
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0348557
HELZ helicase with zinc finger 0.0347558
EXT1 exostosin glycosyltransferase 1 0.0343655
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0341666
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0335946
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0333247
DSCAM Down syndrome cell adhesion molecule 0.0324104
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0311079
ARRDC3 arrestin domain containing 3 0.0310079
TM9SF3 transmembrane 9 superfamily member 3 0.0302615
NRIP1 nuclear receptor interacting protein 1 0.0302176
TXNRD1 thioredoxin reductase 1 0.0297464
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0297433
USP3 ubiquitin specific peptidase 3 0.0291106
NPEPPS aminopeptidase puromycin sensitive 0.0282435
AHI1 Abelson helper integration site 1 0.0279676
FNIP1 folliculin interacting protein 1 0.0277717
NEBL nebulette 0.0277002
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0273826
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0271892
SUCO SUN domain containing ossification factor 0.0270959
ESRP1 epithelial splicing regulatory protein 1 0.0266579
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0266062
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0264494
RAB1A RAB1A, member RAS oncogene family 0.0263955
SKIC3 SKI3 subunit of superkiller complex 0.0259321
KMT2C lysine (K)-specific methyltransferase 2C 0.0253364
TMEM39A transmembrane protein 39A 0.0252949
SAMD12 sterile alpha motif domain containing 12 0.0252791
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.0252489
RBM26 RNA binding motif protein 26 0.0249719
BIRC6 baculoviral IAP repeat containing 6 0.0248651
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0248422
COPA coatomer protein complex, subunit alpha 0.0248196
USPL1 ubiquitin specific peptidase like 1 0.0246304
ERRFI1 ERBB receptor feedback inhibitor 1 0.024581
PDIA4 protein disulfide isomerase family A, member 4 0.0244349
ZDHHC20 zinc finger, DHHC-type containing 20 0.0243386
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0242641
KDM6A lysine (K)-specific demethylase 6A 0.0238802
YEATS2 YEATS domain containing 2 0.0238782
TSC22D2 TSC22 domain family, member 2 0.0237942
ITCH itchy E3 ubiquitin protein ligase 0.023748
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0237241
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0236204
ESYT2 extended synaptotagmin-like protein 2 0.0234794
ARGLU1 arginine and glutamate rich 1 0.0232606
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0232572
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0232158
CLTC clathrin, heavy chain (Hc) 0.0232123
MEIS2 Meis homeobox 2 0.0231203
TENT2 terminal nucleotidyltransferase 2 0.0231049
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0230165
METTL15 methyltransferase like 15 0.0229796
MON2 MON2 homolog (S. cerevisiae) 0.0229163
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0228523
SBF2 SET binding factor 2 0.0227636
XPO1 exportin 1 0.0227007
KDM3A lysine (K)-specific demethylase 3A 0.0225871
ADAM17 ADAM metallopeptidase domain 17 0.022483
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0223908
EHF ets homologous factor 0.0222816
OGA O-GlcNAcase 0.0220679
TNRC6A trinucleotide repeat containing 6A 0.0220085
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0219876
NBAS neuroblastoma amplified sequence 0.0218382
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0215133
PUM2 pumilio RNA-binding family member 2 0.0214776
GRK3 G protein-coupled receptor kinase 3 0.0212427
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.0211858

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.124677
B2M beta-2-microglobulin -0.120706
TPT1 tumor protein, translationally-controlled 1 -0.118905
ANXA2 annexin A2 -0.113609
INTS6 integrator complex subunit 6 -0.103916
PTMA prothymosin, alpha -0.101154
EGR1 early growth response 1 -0.0969254
LCN2 lipocalin 2 -0.0949056
RNF213 ring finger protein 213 -0.0848212
IFI6 interferon, alpha-inducible protein 6 -0.0823926
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0805411
SP100 SP100 nuclear antigen -0.079887
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0793144
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0743592
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.069942
HLA-B major histocompatibility complex, class I, B -0.0696978
RIGI RNA sensor RIG-I -0.0692823
MX1 MX dynamin-like GTPase 1 -0.0681543
LMO7 LIM domain 7 -0.0668918
TMSB10 thymosin beta 10 -0.063315
LYZ lysozyme -0.0630943
SQSTM1 sequestosome 1 -0.0628906
C6ORF132 chromosome 6 open reading frame 132 -0.0619586
STS steroid sulfatase (microsomal), isozyme S -0.0618971
RAB7A RAB7A, member RAS oncogene family -0.0611605
MX2 MX dynamin-like GTPase 2 -0.0609612
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0601973
XAF1 XIAP associated factor 1 -0.0561121
AREG amphiregulin -0.0547573
NPSR1 neuropeptide S receptor 1 -0.0545355
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0533002
ACTG1 actin gamma 1 -0.0510046
IFI27 interferon, alpha-inducible protein 27 -0.0510043
JUN jun proto-oncogene -0.0498073
EZR ezrin -0.0494625
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0491665
FTL ferritin, light polypeptide -0.0490786
PLSCR1 phospholipid scramblase 1 -0.0487491
RPL35A ribosomal protein L35a -0.0482323
PLSCR2 phospholipid scramblase 2 -0.0474347
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0468119
LOC102724023 ES1 protein homolog, mitochondrial -0.0466397
VCL vinculin -0.0463321
MT2A metallothionein 2A -0.0455832
PERP PERP, TP53 apoptosis effector -0.0445799
GMDS GDP-mannose 4,6-dehydratase -0.0442417
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0428958
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0417838
RPS6 ribosomal protein S6 -0.0398429
PKM pyruvate kinase, muscle -0.0393014
TSHZ2 teashirt zinc finger homeobox 2 -0.0392896
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0380656
TM4SF1 transmembrane 4 L six family member 1 -0.0379525
IGFBP3 insulin-like growth factor binding protein 3 -0.0367399
EPHB2 EPH receptor B2 -0.036705
MYO1E myosin IE -0.0366184
TMC5 transmembrane channel-like 5 -0.0363106
MCL1 myeloid cell leukemia 1 -0.0362923
RPL23 ribosomal protein L23 -0.0346677
CATSPERB catsper channel auxiliary subunit beta -0.0337777
MAML2 mastermind-like 2 (Drosophila) -0.0328214
S100A6 S100 calcium binding protein A6 -0.0327316
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0327074
PMP22 peripheral myelin protein 22 -0.0327037
ITGA6 integrin, alpha 6 -0.0323422
TM4SF19 transmembrane 4 L six family member 19 -0.0321889
SLC38A1 solute carrier family 38, member 1 -0.0319527
RPLP1 ribosomal protein, large, P1 -0.0318855
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0318483
RABGAP1L RAB GTPase activating protein 1-like -0.0315883
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0314754
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314546
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0306999
IFIH1 interferon induced with helicase C domain 1 -0.0304571
IRS2 insulin receptor substrate 2 -0.0303984
NABP1 nucleic acid binding protein 1 -0.0300105
EFNB2 ephrin-B2 -0.029977
IFITM3 interferon induced transmembrane protein 3 -0.0299593
SLC38A2 solute carrier family 38, member 2 -0.0296875
MUC20 mucin 20, cell surface associated -0.0289638
FOSL1 FOS-like antigen 1 -0.0289058
RPS19 ribosomal protein S19 -0.0287752
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa -0.0286183
TNS4 tensin 4 -0.0284126
S100P S100 calcium binding protein P -0.0281443
BAIAP2L1 BAI1-associated protein 2-like 1 -0.028101
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0279542
TRIO trio Rho guanine nucleotide exchange factor -0.027828
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0276254
VMP1 vacuole membrane protein 1 -0.0268305
ACTN4 actinin, alpha 4 -0.0266867
RPS3 ribosomal protein S3 -0.026591
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0265251
CST3 cystatin C -0.0264145
ZNFX1 zinc finger, NFX1-type containing 1 -0.0263886
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0263827
RPS12 ribosomal protein S12 -0.0259245
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0257755
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0257324
UBAP2 ubiquitin associated protein 2 -0.0256656