Menadione_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CADM1 cell adhesion molecule 1 0.143732
FNDC3B fibronectin type III domain containing 3B 0.131567
PSD3 pleckstrin and Sec7 domain containing 3 0.125943
COL6A3 collagen, type VI, alpha 3 0.0991291
IGFBP3 insulin-like growth factor binding protein 3 0.0967569
EXT1 exostosin glycosyltransferase 1 0.0943559
VCAN versican 0.0768252
JARID2 jumonji, AT rich interactive domain 2 0.0609748
CDH13 cadherin 13 0.0603144
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0578257
FBN1 fibrillin 1 0.0572388
MYH9 myosin, heavy chain 9, non-muscle 0.0533743
LPP LIM domain containing preferred translocation partner in lipoma 0.0498671
TIMP3 TIMP metallopeptidase inhibitor 3 0.0493564
CLIC4 chloride intracellular channel 4 0.0463625
DOCK5 dedicator of cytokinesis 5 0.0448736
ATP13A3 ATPase type 13A3 0.0447085
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0432778
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.042787
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0423607
CXCL8 chemokine (C-X-C motif) ligand 8 0.0382576
FAT1 FAT atypical cadherin 1 0.0362909
VEGFA vascular endothelial growth factor A 0.0355027
ZBTB20 zinc finger and BTB domain containing 20 0.0352727
DPYD dihydropyrimidine dehydrogenase 0.0352225
ATXN1 ataxin 1 0.0351609
EGFR epidermal growth factor receptor 0.0336768
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0325958
SMYD3 SET and MYND domain containing 3 0.0317989
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0315596
HIPK2 homeodomain interacting protein kinase 2 0.0311999
PDE10A phosphodiesterase 10A 0.0311502
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0310108
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0301172
DST dystonin 0.0293315
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0292187
INHBA inhibin, beta A 0.0284435
MAP1B microtubule-associated protein 1B 0.0281006
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0274229
TENM3 teneurin transmembrane protein 3 0.0272215
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.0269004
EBF1 early B-cell factor 1 0.0268111
RUNX2 runt-related transcription factor 2 0.0267732
PRELID2 PRELI domain containing 2 0.0266848
IL6ST interleukin 6 signal transducer 0.026482
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0264691
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0259154
NAV1 neuron navigator 1 0.0255901
CD109 CD109 molecule 0.0254053
VMP1 vacuole membrane protein 1 0.0251536
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0249858
STC2 stanniocalcin 2 0.0249601
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0247397
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0246679
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0238388
CNTN5 contactin 5 0.023732
TPM4 tropomyosin 4 0.0232422
ADAM12 ADAM metallopeptidase domain 12 0.0231826
MYO10 myosin X 0.0230787
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0226973
GOLGB1 golgin B1 0.0221245
TRIO trio Rho guanine nucleotide exchange factor 0.0218651
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0218411
CMIP c-Maf inducing protein 0.0204792
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0203313
MACF1 microtubule-actin crosslinking factor 1 0.0201438
ASPH aspartate beta-hydroxylase 0.0198762
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.01974
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0197071
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0190181
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0189381
LTBP1 latent transforming growth factor beta binding protein 1 0.0187673
ERRFI1 ERBB receptor feedback inhibitor 1 0.0187087
PTK2 protein tyrosine kinase 2 0.018569
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.018318
PTEN phosphatase and tensin homolog 0.0181264
AKAP9 A kinase (PRKA) anchor protein 9 0.0180611
SBF2 SET binding factor 2 0.018024
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0179602
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0179385
MAML2 mastermind-like 2 (Drosophila) 0.0178416
NALF1 NALCN channel auxiliary factor 1 0.0175129
IL1B interleukin 1, beta 0.017425
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0172713
CHD9 chromodomain helicase DNA binding protein 9 0.0172432
PDLIM5 PDZ and LIM domain 5 0.0170847
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0170745
TRPS1 trichorhinophalangeal syndrome I 0.0170743
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0169357
SPTBN1 spectrin, beta, non-erythrocytic 1 0.016889
PICALM phosphatidylinositol binding clathrin assembly protein 0.0164775
SMAD3 SMAD family member 3 0.0164311
TPST1 tyrosylprotein sulfotransferase 1 0.0163828
FER fer (fps/fes related) tyrosine kinase 0.0163222
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0162972
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0162746
NFE2L2 nuclear factor, erythroid 2-like 2 0.0161676
NBAS neuroblastoma amplified sequence 0.0160727
ITGA11 integrin, alpha 11 0.0160706
CEMIP cell migration inducing protein, hyaluronan binding 0.0160362

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.279464
VIM vimentin -0.242839
MT2A metallothionein 2A -0.230528
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.197039
TMSB10 thymosin beta 10 -0.146568
NDRG1 N-myc downstream regulated 1 -0.126595
PTMA prothymosin, alpha -0.0873646
RPS8 ribosomal protein S8 -0.0804765
FTL ferritin, light polypeptide -0.0735924
RPL35A ribosomal protein L35a -0.0654041
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0558728
RPS6 ribosomal protein S6 -0.0548912
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0524042
COL1A1 collagen, type I, alpha 1 -0.052268
EIF1 eukaryotic translation initiation factor 1 -0.0511326
ACTG1 actin gamma 1 -0.0509002
RPS19 ribosomal protein S19 -0.050423
HLA-B major histocompatibility complex, class I, B -0.0503636
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0486998
MT1X metallothionein 1X -0.0483168
TM4SF1 transmembrane 4 L six family member 1 -0.0482814
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0464137
S100A9 S100 calcium binding protein A9 -0.0453557
RPLP1 ribosomal protein, large, P1 -0.0444694
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0435538
CALR calreticulin -0.0433223
RPL28 ribosomal protein L28 -0.0432424
FN1 fibronectin 1 -0.0431435
RPL8 ribosomal protein L8 -0.0429183
RPL23 ribosomal protein L23 -0.0423723
RPS3 ribosomal protein S3 -0.042073
RPL26 ribosomal protein L26 -0.0416545
CAVIN1 caveolae associated protein 1 -0.0405389
RPL37A ribosomal protein L37a -0.0402045
RPL11 ribosomal protein L11 -0.0391448
RPLP2 ribosomal protein, large, P2 -0.0381068
RPL12 ribosomal protein L12 -0.037202
RPL36 ribosomal protein L36 -0.0370235
B2M beta-2-microglobulin -0.0357058
TPT1 tumor protein, translationally-controlled 1 -0.0350891
RPL19 ribosomal protein L19 -0.0350126
RPL34 ribosomal protein L34 -0.0347696
RPL7 ribosomal protein L7 -0.033719
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0326294
TGFBI transforming growth factor, beta-induced, 68kDa -0.0311689
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0311183
RACK1 receptor for activated C kinase 1 -0.030903
RPL5 ribosomal protein L5 -0.0306442
RPL32 ribosomal protein L32 -0.03036
RPL30 ribosomal protein L30 -0.0303482
RPS21 ribosomal protein S21 -0.0297899
LOC112694756 uncharaterized LOC112694756 -0.0295044
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0291425
WSB1 WD repeat and SOCS box containing 1 -0.0289471
RPS20 ribosomal protein S20 -0.0288627
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0283991
RPS16 ribosomal protein S16 -0.0283779
RPS5 ribosomal protein S5 -0.0283349
ANXA2 annexin A2 -0.0283056
RPS27A ribosomal protein S27a -0.0282825
RPL13A ribosomal protein L13a -0.0270323
EEF2 eukaryotic translation elongation factor 2 -0.0270204
S100A6 S100 calcium binding protein A6 -0.0269414
RPS13 ribosomal protein S13 -0.0269095
LOX lysyl oxidase -0.0269016
ENO1 enolase 1, (alpha) -0.0268149
S100A10 S100 calcium binding protein A10 -0.0265613
RPL37 ribosomal protein L37 -0.0265487
RPLP0 ribosomal protein, large, P0 -0.0258629
NAP1L1 nucleosome assembly protein 1-like 1 -0.0253295
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0247604
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.024509
RPS11 ribosomal protein S11 -0.024394
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0243265
RPL18 ribosomal protein L18 -0.0241717
RPS24 ribosomal protein S24 -0.0241259
ADM adrenomedullin -0.024015
RPS14 ribosomal protein S14 -0.0240107
RPS23 ribosomal protein S23 -0.0239906
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.023943
RPL31 ribosomal protein L31 -0.0234542
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0233607
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0232029
IER3 immediate early response 3 -0.022929
P4HB prolyl 4-hydroxylase, beta polypeptide -0.022648
ICAM1 intercellular adhesion molecule 1 -0.0224803
MYO9B myosin IXB -0.0224305
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0222615
PFN1 profilin 1 -0.0219365
TUBB tubulin, beta class I -0.0219267
LMNA lamin A/C -0.0218937
IFITM3 interferon induced transmembrane protein 3 -0.0218169
PLAUR plasminogen activator, urokinase receptor -0.0217398
RPS12 ribosomal protein S12 -0.0216051
UBC ubiquitin C -0.0214817
TPI1 triosephosphate isomerase 1 -0.0213864
PKM pyruvate kinase, muscle -0.0211985
HILPDA hypoxia inducible lipid droplet-associated -0.0210919
RPS25 ribosomal protein S25 -0.0205207
RPL27 ribosomal protein L27 -0.0202397