Menadione_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.187767
AKAP12 A kinase (PRKA) anchor protein 12 0.158145
FNDC3B fibronectin type III domain containing 3B 0.151985
SOS1 son of sevenless homolog 1 (Drosophila) 0.113069
EHBP1 EH domain binding protein 1 0.113064
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0986528
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0946005
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0910863
DSPP dentin sialophosphoprotein 0.0900873
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0882883
APOB apolipoprotein B 0.0867597
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0831608
SAMD4A sterile alpha motif domain containing 4A 0.0755234
ASPH aspartate beta-hydroxylase 0.0729349
LRMDA leucine rich melanocyte differentiation associated 0.0687105
GMDS GDP-mannose 4,6-dehydratase 0.0646757
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0574694
ATXN1 ataxin 1 0.0574419
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0560611
TRIO trio Rho guanine nucleotide exchange factor 0.0542085
MAML2 mastermind-like 2 (Drosophila) 0.053591
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.053299
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.052947
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0501646
GPC6 glypican 6 0.0491905
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0489558
CANX calnexin 0.041367
TXNRD1 thioredoxin reductase 1 0.0413529
FRMD5 FERM domain containing 5 0.0411565
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0406973
PEG3 paternally expressed 3 0.0404455
DST dystonin 0.0376824
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0376049
ITGA1 integrin, alpha 1 0.0374964
DTNA dystrobrevin, alpha 0.0369832
FMNL2 formin-like 2 0.0363918
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0358699
FBF1 Fas (TNFRSF6) binding factor 1 0.035842
ELL2 elongation factor, RNA polymerase II, 2 0.0356193
RNF213 ring finger protein 213 0.0355585
LPP LIM domain containing preferred translocation partner in lipoma 0.035126
AFDN afadin, adherens junction formation factor 0.0337478
TF transferrin 0.0327612
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.032687
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0326198
SESTD1 SEC14 and spectrin domains 1 0.0318914
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0316076
PARD3 par-3 family cell polarity regulator 0.0314708
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0312266
GLS2 glutaminase 2 (liver, mitochondrial) 0.0302982
NPAS2 neuronal PAS domain protein 2 0.0301017
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0297425
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0289697
RBM39 RNA binding motif protein 39 0.0289515
EPS8 epidermal growth factor receptor pathway substrate 8 0.0289181
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0287335
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0280738
TNS3 tensin 3 0.028056
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0278469
ZBTB20 zinc finger and BTB domain containing 20 0.0278139
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0269556
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0263629
BIRC6 baculoviral IAP repeat containing 6 0.0262275
TTC28 tetratricopeptide repeat domain 28 0.0259405
ADGRG6 adhesion G protein-coupled receptor G6 0.0258708
SOX5 SRY (sex determining region Y)-box 5 0.0258578
ARHGAP21 Rho GTPase activating protein 21 0.0256394
NHSL1 NHS-like 1 0.0254291
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0253208
FAT1 FAT atypical cadherin 1 0.0251959
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.025113
FAM135A family with sequence similarity 135, member A 0.0250521
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0250351
MACF1 microtubule-actin crosslinking factor 1 0.0247806
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0244179
ARL5B ADP-ribosylation factor-like 5B 0.0244152
ZFAND3 zinc finger, AN1-type domain 3 0.024125
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0240267
ANO6 anoctamin 6 0.0239474
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0239075
ACSL4 acyl-CoA synthetase long-chain family member 4 0.023869
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0233238
PUM2 pumilio RNA-binding family member 2 0.0232967
MYO1B myosin IB 0.0232765
RUNX1 runt-related transcription factor 1 0.0230951
GRB10 growth factor receptor-bound protein 10 0.0230772
GK glycerol kinase 0.0230616
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0226804
PHF3 PHD finger protein 3 0.0226661
SDC4 syndecan 4 0.0226419
CNKSR3 CNKSR family member 3 0.0223652
JMJD1C jumonji domain containing 1C 0.0221602
PLXDC2 plexin domain containing 2 0.0219291
RAI14 retinoic acid induced 14 0.0217758
LPIN2 lipin 2 0.0217202
KDM3A lysine (K)-specific demethylase 3A 0.0217146
ATP10A ATPase, class V, type 10A 0.0216139
INSIG2 insulin induced gene 2 0.0214997
ARHGAP5 Rho GTPase activating protein 5 0.0213948
EXT1 exostosin glycosyltransferase 1 0.0212678

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.266499
MT2A metallothionein 2A -0.170153
C3 complement component 3 -0.159491
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.136773
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121105
APOA2 apolipoprotein A-II -0.0928662
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0916459
RPS6 ribosomal protein S6 -0.0910836
IGF2 insulin-like growth factor 2 -0.0907866
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0862917
RPL37A ribosomal protein L37a -0.0858048
FTL ferritin, light polypeptide -0.0832684
RPS12 ribosomal protein S12 -0.0792903
RPLP1 ribosomal protein, large, P1 -0.0766033
RPS19 ribosomal protein S19 -0.0696846
RPL35A ribosomal protein L35a -0.0695102
TMSB10 thymosin beta 10 -0.065228
RPS8 ribosomal protein S8 -0.0581301
RPL11 ribosomal protein L11 -0.057048
TPT1 tumor protein, translationally-controlled 1 -0.0545127
RPL31 ribosomal protein L31 -0.0518374
RPS3 ribosomal protein S3 -0.0514415
RPL34 ribosomal protein L34 -0.0509672
RPL26 ribosomal protein L26 -0.0506735
RPS27A ribosomal protein S27a -0.0499847
RPL23 ribosomal protein L23 -0.0487748
RPS29 ribosomal protein S29 -0.0474089
RPS24 ribosomal protein S24 -0.0456086
RPS13 ribosomal protein S13 -0.0433109
RPL9 ribosomal protein L9 -0.042571
NKD1 naked cuticle homolog 1 (Drosophila) -0.0412593
APOE apolipoprotein E -0.0399141
RPL12 ribosomal protein L12 -0.0396543
PTMA prothymosin, alpha -0.0390543
RPS14 ribosomal protein S14 -0.0371727
APOA1 apolipoprotein A-I -0.0363028
RPLP2 ribosomal protein, large, P2 -0.0354897
RPL36 ribosomal protein L36 -0.034363
RPS17 ribosomal protein S17 -0.0341243
RACK1 receptor for activated C kinase 1 -0.0339585
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0336002
RPS23 ribosomal protein S23 -0.0326101
EGR1 early growth response 1 -0.031882
RPL37 ribosomal protein L37 -0.0309344
EIF1 eukaryotic translation initiation factor 1 -0.0306736
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0298447
RPL5 ribosomal protein L5 -0.0290105
RPL28 ribosomal protein L28 -0.0284725
RPS10 ribosomal protein S10 -0.0282514
RPS15 ribosomal protein S15 -0.0275857
RPS27 ribosomal protein S27 -0.0274833
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0263126
CST3 cystatin C -0.0262096
HLA-A major histocompatibility complex, class I, A -0.0258411
BCL2L1 BCL2-like 1 -0.0251799
RPL7A ribosomal protein L7a -0.0249855
RPL32 ribosomal protein L32 -0.0247297
GNAS GNAS complex locus -0.0245887
RPL35 ribosomal protein L35 -0.0242952
HMGA1 high mobility group AT-hook 1 -0.0238796
CYB5R3 cytochrome b5 reductase 3 -0.0238392
RPS21 ribosomal protein S21 -0.0238016
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0236254
ACTG1 actin gamma 1 -0.0235899
RPS16 ribosomal protein S16 -0.023563
RPS5 ribosomal protein S5 -0.0235525
RPS11 ribosomal protein S11 -0.0235353
GDF15 growth differentiation factor 15 -0.0233458
AHSG alpha-2-HS-glycoprotein -0.0228907
VCL vinculin -0.0221496
VIM vimentin -0.0217822
NDRG1 N-myc downstream regulated 1 -0.0217465
S100A9 S100 calcium binding protein A9 -0.0213381
ACTN4 actinin, alpha 4 -0.0211749
RPL38 ribosomal protein L38 -0.0211645
RPS25 ribosomal protein S25 -0.0210385
RPL36A ribosomal protein L36a -0.0207939
S100P S100 calcium binding protein P -0.0206573
RPL13A ribosomal protein L13a -0.020381
RPL30 ribosomal protein L30 -0.0200845
IFITM1 interferon induced transmembrane protein 1 -0.0200116
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0198728
ISG15 ISG15 ubiquitin-like modifier -0.0197428
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0197007
RPL19 ribosomal protein L19 -0.0193526
RPL18 ribosomal protein L18 -0.0189165
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.0187011
ATP5F1E ATP synthase F1 subunit epsilon -0.0185966
B2M beta-2-microglobulin -0.0185739
VEGFA vascular endothelial growth factor A -0.0185075
RPLP0 ribosomal protein, large, P0 -0.0184722
RPS20 ribosomal protein S20 -0.0182921
RPL8 ribosomal protein L8 -0.018184
GCC2 GRIP and coiled-coil domain containing 2 -0.0181536
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0180227
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0179443
KTN1 kinectin 1 (kinesin receptor) -0.0177557
IFI6 interferon, alpha-inducible protein 6 -0.0172482
TGFBI transforming growth factor, beta-induced, 68kDa -0.0171742
LCN2 lipocalin 2 -0.0171472