Menadione_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.112348
MTSS1 metastasis suppressor 1 0.0998594
DPYD dihydropyrimidine dehydrogenase 0.0684133
MYOF myoferlin 0.0657724
MEF2A myocyte enhancer factor 2A 0.0607921
SLC35F3 solute carrier family 35, member F3 0.0602666
FLNB filamin B, beta 0.058644
AHNAK AHNAK nucleoprotein 0.0559417
LMO7 LIM domain 7 0.0540776
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0530302
PDLIM5 PDZ and LIM domain 5 0.0529876
RAI14 retinoic acid induced 14 0.0506171
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0496318
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0491283
NRIP1 nuclear receptor interacting protein 1 0.0489141
FOXO1 forkhead box O1 0.0476266
GRB10 growth factor receptor-bound protein 10 0.045751
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0449357
MACF1 microtubule-actin crosslinking factor 1 0.0442033
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0440148
EXT1 exostosin glycosyltransferase 1 0.042246
SULF1 sulfatase 1 0.0419786
PSD3 pleckstrin and Sec7 domain containing 3 0.041861
SMAD3 SMAD family member 3 0.0405753
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0393544
AOPEP aminopeptidase O (putative) 0.0393366
PRELID2 PRELI domain containing 2 0.0392449
MYH9 myosin, heavy chain 9, non-muscle 0.0391856
NEK7 NIMA-related kinase 7 0.0389077
BCAR3 breast cancer anti-estrogen resistance 3 0.038418
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0375822
TRIO trio Rho guanine nucleotide exchange factor 0.0373912
ASPH aspartate beta-hydroxylase 0.0366206
DOCK5 dedicator of cytokinesis 5 0.0366188
FNDC3B fibronectin type III domain containing 3B 0.0361701
NAV2 neuron navigator 2 0.0347649
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.034536
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0342471
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.034119
PTK2 protein tyrosine kinase 2 0.0340698
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.032836
KDM6A lysine (K)-specific demethylase 6A 0.0324235
CEMIP cell migration inducing protein, hyaluronan binding 0.0318408
PICALM phosphatidylinositol binding clathrin assembly protein 0.0316431
RBM39 RNA binding motif protein 39 0.0316302
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0313218
PDE4D phosphodiesterase 4D, cAMP-specific 0.0312961
RIN2 Ras and Rab interactor 2 0.0308441
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0296942
AKAP13 A kinase (PRKA) anchor protein 13 0.0294061
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0289029
OSMR oncostatin M receptor 0.028123
MECOM MDS1 and EVI1 complex locus 0.0280159
ZEB1 zinc finger E-box binding homeobox 1 0.027858
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0278242
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.027652
VCL vinculin 0.027147
ARHGAP29 Rho GTPase activating protein 29 0.0268343
CUL4B cullin 4B 0.0267141
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0266949
SMYD3 SET and MYND domain containing 3 0.0263916
NRCAM neuronal cell adhesion molecule 0.0262667
SBF2 SET binding factor 2 0.0262276
RASAL2 RAS protein activator like 2 0.0260367
NRG1 neuregulin 1 0.0255793
AMOTL1 angiomotin like 1 0.0254074
KIAA1217 KIAA1217 0.0249479
ITGA6 integrin, alpha 6 0.0247406
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0241605
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0237463
CAPRIN2 caprin family member 2 0.0236639
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0235906
ADAM10 ADAM metallopeptidase domain 10 0.0235665
RAD51B RAD51 paralog B 0.0232677
ITCH itchy E3 ubiquitin protein ligase 0.0232443
MYO10 myosin X 0.0229867
CDK6 cyclin-dependent kinase 6 0.0222942
FNIP1 folliculin interacting protein 1 0.0222918
BCL2L1 BCL2-like 1 0.0221492
BMAL2 basic helix-loop-helix ARNT like 2 0.021967
EFNA5 ephrin-A5 0.0218865
RABGAP1L RAB GTPase activating protein 1-like 0.0216136
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0212618
LAMC2 laminin, gamma 2 0.0209765
BZW1 basic leucine zipper and W2 domains 1 0.0209129
TPM3 tropomyosin 3 0.0207449
DOCK4 dedicator of cytokinesis 4 0.0205153
GRK5 G protein-coupled receptor kinase 5 0.0204673
THSD4 thrombospondin, type I, domain containing 4 0.020405
ANO1 anoctamin 1, calcium activated chloride channel 0.0200901
EGFR epidermal growth factor receptor 0.0200771
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0200564
NCOA3 nuclear receptor coactivator 3 0.0200196
USP12 ubiquitin specific peptidase 12 0.0198405
DOCK9 dedicator of cytokinesis 9 0.0197519
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0196727
RNF217 ring finger protein 217 0.0196313
TSC22D1 TSC22 domain family, member 1 0.0195607
RICTOR RPTOR independent companion of MTOR, complex 2 0.0195088
USP9X ubiquitin specific peptidase 9, X-linked 0.0194968

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.215967
NDRG1 N-myc downstream regulated 1 -0.131207
MT2A metallothionein 2A -0.129609
TMSB10 thymosin beta 10 -0.12951
PTMA prothymosin, alpha -0.129244
B2M beta-2-microglobulin -0.111745
RPS6 ribosomal protein S6 -0.102208
RPS8 ribosomal protein S8 -0.0960769
TPT1 tumor protein, translationally-controlled 1 -0.0818534
RPLP1 ribosomal protein, large, P1 -0.0785779
RPS3 ribosomal protein S3 -0.0758194
RPS19 ribosomal protein S19 -0.0750366
S100A10 S100 calcium binding protein A10 -0.0720508
RPL11 ribosomal protein L11 -0.0710624
RPS21 ribosomal protein S21 -0.0699409
IFITM3 interferon induced transmembrane protein 3 -0.0694589
RPLP2 ribosomal protein, large, P2 -0.0694012
RPS13 ribosomal protein S13 -0.0677626
LMNA lamin A/C -0.0662594
FTL ferritin, light polypeptide -0.0661969
HLA-B major histocompatibility complex, class I, B -0.0618292
RPL37 ribosomal protein L37 -0.0611346
RPL37A ribosomal protein L37a -0.0593964
RPS12 ribosomal protein S12 -0.0592096
RPL35A ribosomal protein L35a -0.0588775
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.057893
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0559954
ENO1 enolase 1, (alpha) -0.0547612
RPL23 ribosomal protein L23 -0.0544595
RPL12 ribosomal protein L12 -0.0528039
LOC112694756 uncharaterized LOC112694756 -0.0523497
S100A6 S100 calcium binding protein A6 -0.0521521
S100A2 S100 calcium binding protein A2 -0.0510721
RPS25 ribosomal protein S25 -0.0495922
S100A9 S100 calcium binding protein A9 -0.0488982
RPL8 ribosomal protein L8 -0.0480897
IFITM1 interferon induced transmembrane protein 1 -0.0480271
GNAS GNAS complex locus -0.0480209
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0468749
CLU clusterin -0.0457431
RPL31 ribosomal protein L31 -0.0456859
RPL34 ribosomal protein L34 -0.045276
RPL19 ribosomal protein L19 -0.0451464
RPL36 ribosomal protein L36 -0.0433794
LDHA lactate dehydrogenase A -0.0433068
RPS23 ribosomal protein S23 -0.0426837
RPS27 ribosomal protein S27 -0.0420135
RACK1 receptor for activated C kinase 1 -0.0419564
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0419036
RPS14 ribosomal protein S14 -0.0414684
RPS29 ribosomal protein S29 -0.0411497
ANXA1 annexin A1 -0.0408201
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0395323
EIF1 eukaryotic translation initiation factor 1 -0.0394503
RPL5 ribosomal protein L5 -0.0391639
RPL26 ribosomal protein L26 -0.0376064
S100A11 S100 calcium binding protein A11 -0.0375786
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.037263
RPL32 ribosomal protein L32 -0.0370917
RPS24 ribosomal protein S24 -0.0370029
RPS27A ribosomal protein S27a -0.0369094
RPL27A ribosomal protein L27a -0.0366363
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0360261
CNRIP1 cannabinoid receptor interacting protein 1 -0.03584
NAP1L1 nucleosome assembly protein 1-like 1 -0.0353941
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0352188
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0345408
RPL7A ribosomal protein L7a -0.0341284
RPL30 ribosomal protein L30 -0.0339696
RPL28 ribosomal protein L28 -0.033546
YBX1 Y box binding protein 1 -0.0335185
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0334703
RPL9 ribosomal protein L9 -0.0331686
PGK1 phosphoglycerate kinase 1 -0.0329594
MT1X metallothionein 1X -0.0327572
KRT17 keratin 17, type I -0.0325465
RPL35 ribosomal protein L35 -0.0319382
TAGLN2 transgelin 2 -0.0315799
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0315634
PFN1 profilin 1 -0.0314956
GUK1 guanylate kinase 1 -0.0312432
HLA-A major histocompatibility complex, class I, A -0.0312007
FTH1 ferritin, heavy polypeptide 1 -0.0308441
RPLP0 ribosomal protein, large, P0 -0.0307709
IGF2 insulin-like growth factor 2 -0.0307678
RPS17 ribosomal protein S17 -0.0307246
IFI27 interferon, alpha-inducible protein 27 -0.0304319
RPS16 ribosomal protein S16 -0.0302514
POTEF POTE ankyrin domain family, member F -0.0299756
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0294604
RPS11 ribosomal protein S11 -0.0294467
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0293476
WASF2 WAS protein family, member 2 -0.0293398
IFI6 interferon, alpha-inducible protein 6 -0.0290852
FSCN1 fascin actin-bundling protein 1 -0.0290625
RPS5 ribosomal protein S5 -0.0288828
RPL36A ribosomal protein L36a -0.0288798
RPS4X ribosomal protein S4, X-linked -0.0286194
SQLE squalene epoxidase -0.0283677
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0282665