Menadione_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.306622
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.112785
FNDC3B fibronectin type III domain containing 3B 0.101482
ARHGAP32 Rho GTPase activating protein 32 0.090658
MAML2 mastermind-like 2 (Drosophila) 0.0882614
KLHL29 kelch-like family member 29 0.067711
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.063576
MBNL2 muscleblind-like splicing regulator 2 0.0621446
LMO7 LIM domain 7 0.0588573
GOLGA4 golgin A4 0.0538436
ZFAND3 zinc finger, AN1-type domain 3 0.0510589
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0503166
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0500612
LPP LIM domain containing preferred translocation partner in lipoma 0.0478531
FLNB filamin B, beta 0.0476019
ANKRD11 ankyrin repeat domain 11 0.047497
MYOF myoferlin 0.0454805
IARS1 isoleucyl-tRNA synthetase 1 0.0447158
SEC31A SEC31 homolog A (S. cerevisiae) 0.0446151
COG5 component of oligomeric golgi complex 5 0.0429672
TES testin LIM domain protein 0.0428714
ZCCHC7 zinc finger, CCHC domain containing 7 0.0428627
EXT1 exostosin glycosyltransferase 1 0.0421305
NPSR1 neuropeptide S receptor 1 0.0406397
CDK13 cyclin-dependent kinase 13 0.0402229
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0401145
KDM6A lysine (K)-specific demethylase 6A 0.0400185
ITGA6 integrin, alpha 6 0.0396841
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0396789
AREG amphiregulin 0.0388632
VMP1 vacuole membrane protein 1 0.0378976
HM13 histocompatibility (minor) 13 0.0373887
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0365984
MYH9 myosin, heavy chain 9, non-muscle 0.0362642
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0361935
OSBPL10 oxysterol binding protein-like 10 0.03579
BTBD9 BTB (POZ) domain containing 9 0.0357586
DSPP dentin sialophosphoprotein 0.0356752
JMJD1C jumonji domain containing 1C 0.0346545
INTS6 integrator complex subunit 6 0.0346019
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0344954
RBM39 RNA binding motif protein 39 0.0340325
HYOU1 hypoxia up-regulated 1 0.0337267
PICALM phosphatidylinositol binding clathrin assembly protein 0.0337097
ATXN1 ataxin 1 0.03355
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0333558
KMT2C lysine (K)-specific methyltransferase 2C 0.0332914
SAMD12 sterile alpha motif domain containing 12 0.0329821
RUNX1 runt-related transcription factor 1 0.0327057
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0326957
PTPRK protein tyrosine phosphatase, receptor type, K 0.0325482
ERRFI1 ERBB receptor feedback inhibitor 1 0.0323964
FNIP1 folliculin interacting protein 1 0.0322563
CTBP2 C-terminal binding protein 2 0.0321974
PDIA6 protein disulfide isomerase family A, member 6 0.0318985
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0316116
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.031447
SIK3 SIK family kinase 3 0.03143
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0314179
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0313675
GRB10 growth factor receptor-bound protein 10 0.0313502
ZSWIM6 zinc finger, SWIM-type containing 6 0.0310219
DSCAM Down syndrome cell adhesion molecule 0.0307917
EPS8 epidermal growth factor receptor pathway substrate 8 0.0307309
TRIM2 tripartite motif containing 2 0.0306213
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0302045
PUM2 pumilio RNA-binding family member 2 0.0300804
BIRC6 baculoviral IAP repeat containing 6 0.0299295
POTEF POTE ankyrin domain family, member F 0.0297322
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0294629
SOS1 son of sevenless homolog 1 (Drosophila) 0.0293446
ATF7IP2 activating transcription factor 7 interacting protein 2 0.029277
ITCH itchy E3 ubiquitin protein ligase 0.0292357
CDK6 cyclin-dependent kinase 6 0.0291446
FTH1 ferritin, heavy polypeptide 1 0.028948
TJP1 tight junction protein 1 0.0287653
SLC38A2 solute carrier family 38, member 2 0.02811
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0279742
BCL2L1 BCL2-like 1 0.027959
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.027383
FOXO3 forkhead box O3 0.0273244
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0272561
ESRP1 epithelial splicing regulatory protein 1 0.0269841
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0268945
CTNND1 catenin (cadherin-associated protein), delta 1 0.0267897
VCL vinculin 0.0266184
HDAC9 histone deacetylase 9 0.0265668
ARHGAP26 Rho GTPase activating protein 26 0.0263442
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0262463
CLTC clathrin, heavy chain (Hc) 0.0261284
DLC1 DLC1 Rho GTPase activating protein 0.0255082
CADPS2 Ca++-dependent secretion activator 2 0.0253323
MBNL1 muscleblind-like splicing regulator 1 0.0253119
EIF4A2 eukaryotic translation initiation factor 4A2 0.0251568
TSC22D2 TSC22 domain family, member 2 0.0251147
ANXA2 annexin A2 0.0250399
RCOR1 REST corepressor 1 0.0249935
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0246515
MCU mitochondrial calcium uniporter 0.0244791
MB21D2 Mab-21 domain containing 2 0.0244345

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.198248
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0849406
B2M beta-2-microglobulin -0.0812046
TMC5 transmembrane channel-like 5 -0.0808019
RPS19 ribosomal protein S19 -0.0769229
FTL ferritin, light polypeptide -0.06905
RPLP1 ribosomal protein, large, P1 -0.067375
RPL23 ribosomal protein L23 -0.0651243
S100P S100 calcium binding protein P -0.0549318
LOC112694756 uncharaterized LOC112694756 -0.0547472
NDRG1 N-myc downstream regulated 1 -0.0490314
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0480831
H1-0 H1.0 linker histone -0.0480153
ATF5 activating transcription factor 5 -0.0475158
EIF1 eukaryotic translation initiation factor 1 -0.0457803
S100A6 S100 calcium binding protein A6 -0.045249
PGK1 phosphoglycerate kinase 1 -0.0432396
RRBP1 ribosome binding protein 1 -0.0425123
IFI27 interferon, alpha-inducible protein 27 -0.0424011
RPL35A ribosomal protein L35a -0.0418068
S100A9 S100 calcium binding protein A9 -0.0402122
HLA-A major histocompatibility complex, class I, A -0.0395071
RPS6 ribosomal protein S6 -0.0393539
CLDN4 claudin 4 -0.0383276
RPS3 ribosomal protein S3 -0.0381373
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0380134
TOP2A topoisomerase (DNA) II alpha 170kDa -0.037389
RPL18 ribosomal protein L18 -0.0364398
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0361361
TUBB4B tubulin, beta 4B class IVb -0.0360777
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0348296
RPL35 ribosomal protein L35 -0.0346344
RPL12 ribosomal protein L12 -0.0345999
RPL26 ribosomal protein L26 -0.034589
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0341815
GSTP1 glutathione S-transferase pi 1 -0.0327447
EPCAM epithelial cell adhesion molecule -0.0324466
LMNA lamin A/C -0.0321977
CLDN7 claudin 7 -0.0320994
AGR3 anterior gradient 3 -0.0310459
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.030509
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0292399
S100A10 S100 calcium binding protein A10 -0.028627
NDUFA4 NDUFA4, mitochondrial complex associated -0.0285285
HLA-E major histocompatibility complex, class I, E -0.0282412
RPL32 ribosomal protein L32 -0.0281829
ALDOC aldolase C, fructose-bisphosphate -0.0279057
SEC61G Sec61 gamma subunit -0.0278903
S100A11 S100 calcium binding protein A11 -0.0277355
KRT18 keratin 18, type I -0.0275542
PTMA prothymosin, alpha -0.0273928
IFITM3 interferon induced transmembrane protein 3 -0.0271713
CBX3 chromobox homolog 3 -0.0269201
ZBTB7A zinc finger and BTB domain containing 7A -0.02672
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0266944
EMP1 epithelial membrane protein 1 -0.0265184
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0263048
RPS21 ribosomal protein S21 -0.0259521
RPL8 ribosomal protein L8 -0.0259459
RPS27 ribosomal protein S27 -0.0251347
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0250872
RPL36 ribosomal protein L36 -0.0250092
RPS16 ribosomal protein S16 -0.0250007
RPL28 ribosomal protein L28 -0.0248484
SKAP2 src kinase associated phosphoprotein 2 -0.0248417
PFN1 profilin 1 -0.0248045
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0247894
KRT19 keratin 19, type I -0.0247158
H3-3B H3.3 histone B -0.0244093
RPL19 ribosomal protein L19 -0.0243065
GPX2 glutathione peroxidase 2 -0.024184
IFITM1 interferon induced transmembrane protein 1 -0.0234633
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.023419
RPS29 ribosomal protein S29 -0.0229431
RPS12 ribosomal protein S12 -0.0214166
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0213342
KLF6 Kruppel-like factor 6 -0.0213301
SERF2 small EDRK-rich factor 2 -0.0212043
MYL12B myosin, light chain 12B, regulatory -0.0210824
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0210761
LY6E lymphocyte antigen 6 complex, locus E -0.0209142
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.0208702
COX6C cytochrome c oxidase subunit VIc -0.0205638
ATP5F1E ATP synthase F1 subunit epsilon -0.019955
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0199319
RPL30 ribosomal protein L30 -0.0198351
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0198319
HMGA1 high mobility group AT-hook 1 -0.0196051
RPL34 ribosomal protein L34 -0.0195373
HLA-C major histocompatibility complex, class I, C -0.0194228
RPL27 ribosomal protein L27 -0.0194219
LOC102724023 ES1 protein homolog, mitochondrial -0.0190573
ROMO1 reactive oxygen species modulator 1 -0.0189574
PLSCR1 phospholipid scramblase 1 -0.0189361
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0188548
LYZ lysozyme -0.0187697
CST3 cystatin C -0.0184651
ACACA acetyl-CoA carboxylase alpha -0.0183557
TPI1 triosephosphate isomerase 1 -0.0182706
MKI67 marker of proliferation Ki-67 -0.018205