Menadione_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Menadione_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.153429
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.108241
LMO7 LIM domain 7 0.0925681
EREG epiregulin 0.0903527
LPP LIM domain containing preferred translocation partner in lipoma 0.0754056
ZFAND3 zinc finger, AN1-type domain 3 0.066884
ANKRD11 ankyrin repeat domain 11 0.0637388
RBM39 RNA binding motif protein 39 0.062857
VCL vinculin 0.0544224
RNF145 ring finger protein 145 0.0541263
WAC WW domain containing adaptor with coiled-coil 0.052515
EXT1 exostosin glycosyltransferase 1 0.0498725
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0489605
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0488133
MED13L mediator complex subunit 13-like 0.0475601
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0473092
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0460791
TXNRD1 thioredoxin reductase 1 0.0425808
PUM2 pumilio RNA-binding family member 2 0.0414223
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0408198
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0390838
KRT8 keratin 8, type II 0.0389176
NCKAP1 NCK-associated protein 1 0.0381772
RAB1A RAB1A, member RAS oncogene family 0.0379475
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0378317
KLF5 Kruppel-like factor 5 (intestinal) 0.0363939
NAMPT nicotinamide phosphoribosyltransferase 0.0359304
EIF4A2 eukaryotic translation initiation factor 4A2 0.0342054
WDR43 WD repeat domain 43 0.0338855
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0334048
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0333641
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0333103
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0332938
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.0330796
TMSB4X thymosin beta 4, X-linked 0.0330603
OSBPL10 oxysterol binding protein-like 10 0.0330551
MYO5B myosin VB 0.0328515
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0318022
TFG TRK-fused gene 0.0312894
MYH9 myosin, heavy chain 9, non-muscle 0.0312464
CTNND1 catenin (cadherin-associated protein), delta 1 0.0309567
NEK7 NIMA-related kinase 7 0.0309068
EPS8 epidermal growth factor receptor pathway substrate 8 0.0300024
FUBP1 far upstream element (FUSE) binding protein 1 0.0297858
PUM1 pumilio RNA-binding family member 1 0.0295274
ASPH aspartate beta-hydroxylase 0.0293016
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0288401
HSPA8 heat shock 70kDa protein 8 0.0286401
BZW1 basic leucine zipper and W2 domains 1 0.0285113
RPS24 ribosomal protein S24 0.0284602
TRA2A transformer 2 alpha homolog (Drosophila) 0.028095
MYOF myoferlin 0.028058
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0278113
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0278055
GARS1 glycyl-tRNA synthetase 1 0.027392
IARS1 isoleucyl-tRNA synthetase 1 0.0273156
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0272381
MORF4L1 mortality factor 4 like 1 0.0270732
YME1L1 YME1-like 1 ATPase 0.027037
SLMAP sarcolemma associated protein 0.0267947
PDS5B PDS5 cohesin associated factor B 0.0264816
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0263766
EIF1 eukaryotic translation initiation factor 1 0.0263718
CCNL1 cyclin L1 0.0263454
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0262613
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0262286
RAD21 RAD21 homolog (S. pombe) 0.0261191
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0260971
LCORL ligand dependent nuclear receptor corepressor-like 0.0260867
PNISR PNN-interacting serine/arginine-rich protein 0.025823
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0258181
DSPP dentin sialophosphoprotein 0.025709
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0254557
GRB10 growth factor receptor-bound protein 10 0.0252021
SARNP SAP domain containing ribonucleoprotein 0.0246098
MARCHF6 membrane associated ring-CH-type finger 6 0.0243942
NFE2L2 nuclear factor, erythroid 2-like 2 0.0241651
RHEB Ras homolog enriched in brain 0.0241476
TES testin LIM domain protein 0.0241188
KDM6A lysine (K)-specific demethylase 6A 0.0241039
MPRIP myosin phosphatase Rho interacting protein 0.0240818
KMT2C lysine (K)-specific methyltransferase 2C 0.0238979
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0236688
OSBPL9 oxysterol binding protein-like 9 0.0236511
APP amyloid beta (A4) precursor protein 0.0235643
TMEM45B transmembrane protein 45B 0.0234575
SENP6 SUMO1/sentrin specific peptidase 6 0.0233745
COG5 component of oligomeric golgi complex 5 0.023368
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0233597
PSME4 proteasome (prosome, macropain) activator subunit 4 0.023333
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0232742
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0232633
ANKRD17 ankyrin repeat domain 17 0.0231892
TM9SF3 transmembrane 9 superfamily member 3 0.0231139
TOP2B topoisomerase (DNA) II beta 180kDa 0.0231019
EWSR1 EWS RNA-binding protein 1 0.0230742
AFDN afadin, adherens junction formation factor 0.0229224
KDM3A lysine (K)-specific demethylase 3A 0.0228495
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0228063
GSK3B glycogen synthase kinase 3 beta 0.0227912

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.22611
NDRG1 N-myc downstream regulated 1 -0.172225
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162877
MUC6 mucin 6, oligomeric mucus/gel-forming -0.129457
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.113635
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0979002
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0815219
FAM13A family with sequence similarity 13, member A -0.0809008
NPSR1 neuropeptide S receptor 1 -0.0789477
ESYT2 extended synaptotagmin-like protein 2 -0.0757211
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0738056
TMSB10 thymosin beta 10 -0.0716416
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0706549
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0702091
RPS6 ribosomal protein S6 -0.0626707
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0617862
TNS4 tensin 4 -0.0609366
ANXA2 annexin A2 -0.0607191
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.059194
CEMIP cell migration inducing protein, hyaluronan binding -0.0580132
GMDS GDP-mannose 4,6-dehydratase -0.0574839
TXNIP thioredoxin interacting protein -0.0465281
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0449868
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0441924
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0435094
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0419966
FAT1 FAT atypical cadherin 1 -0.0415511
PRELID2 PRELI domain containing 2 -0.0403272
ANTXR2 anthrax toxin receptor 2 -0.0391355
S100A6 S100 calcium binding protein A6 -0.0390976
HMGA1 high mobility group AT-hook 1 -0.0389918
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0388711
LDHA lactate dehydrogenase A -0.03807
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0380613
HILPDA hypoxia inducible lipid droplet-associated -0.0371233
CALB1 calbindin 1, 28kDa -0.0371187
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0367958
PGK1 phosphoglycerate kinase 1 -0.0365071
CCNY cyclin Y -0.0346338
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0337486
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0337189
PTPRR protein tyrosine phosphatase, receptor type, R -0.0327912
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0327037
GPHN gephyrin -0.0325532
LOC102724023 ES1 protein homolog, mitochondrial -0.0320841
MLEC malectin -0.0317171
LOC112694756 uncharaterized LOC112694756 -0.0311329
ENO1 enolase 1, (alpha) -0.0305821
VEGFA vascular endothelial growth factor A -0.029974
WDR45B WD repeat domain 45B -0.0297902
MYO1E myosin IE -0.029377
ITGB4 integrin, beta 4 -0.0291148
FERMT1 fermitin family member 1 -0.0290174
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0287034
PDIA3 protein disulfide isomerase family A, member 3 -0.0282565
TRIM2 tripartite motif containing 2 -0.0281049
TPI1 triosephosphate isomerase 1 -0.0278998
AKAP9 A kinase (PRKA) anchor protein 9 -0.0278882
AUTS2 autism susceptibility candidate 2 -0.0277675
CLDN7 claudin 7 -0.0276843
MUC17 mucin 17, cell surface associated -0.02736
RNF43 ring finger protein 43 -0.0273506
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0273032
MACF1 microtubule-actin crosslinking factor 1 -0.0271416
BACE2 beta-site APP-cleaving enzyme 2 -0.0261679
ANXA1 annexin A1 -0.025999
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0259593
ITGA6 integrin, alpha 6 -0.0259044
RPLP1 ribosomal protein, large, P1 -0.0253986
RPL35A ribosomal protein L35a -0.0252435
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0251546
MAML2 mastermind-like 2 (Drosophila) -0.0251396
TBC1D22A TBC1 domain family, member 22A -0.0251216
PTEN phosphatase and tensin homolog -0.025108
INSIG2 insulin induced gene 2 -0.0248585
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.024627
PFN1 profilin 1 -0.0245225
RPL37A ribosomal protein L37a -0.0243633
CADPS Ca++-dependent secretion activator -0.0239947
S100A9 S100 calcium binding protein A9 -0.0239375
EZR ezrin -0.0236149
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0235289
TPT1 tumor protein, translationally-controlled 1 -0.0234615
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0231154
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0231146
BTG1 B-cell translocation gene 1, anti-proliferative -0.0231053
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0226638
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0224349
RPS19 ribosomal protein S19 -0.0219736
PTPRK protein tyrosine phosphatase, receptor type, K -0.021811
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0216105
RPL5 ribosomal protein L5 -0.021609
PERP PERP, TP53 apoptosis effector -0.0210217
RPS8 ribosomal protein S8 -0.0209091
ANKRD12 ankyrin repeat domain 12 -0.0205711
TFF3 trefoil factor 3 (intestinal) -0.0205593
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0203941
CALR calreticulin -0.0201982
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.020165
EXOC1 exocyst complex component 1 -0.0200515