Menadione_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.15139
MEF2A myocyte enhancer factor 2A 0.140511
CXCL8 chemokine (C-X-C motif) ligand 8 0.117258
RUNX2 runt-related transcription factor 2 0.114502
FNDC3B fibronectin type III domain containing 3B 0.0794945
GRB10 growth factor receptor-bound protein 10 0.0774471
RBM39 RNA binding motif protein 39 0.0722454
PSD3 pleckstrin and Sec7 domain containing 3 0.0698042
EREG epiregulin 0.0674499
ATP13A3 ATPase type 13A3 0.0669343
JARID2 jumonji, AT rich interactive domain 2 0.0609737
RICTOR RPTOR independent companion of MTOR, complex 2 0.060666
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.058961
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0589462
TRIO trio Rho guanine nucleotide exchange factor 0.0588362
WAC WW domain containing adaptor with coiled-coil 0.0570833
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0567709
ATXN10 ataxin 10 0.0561326
FAM13A family with sequence similarity 13, member A 0.0535862
USP3 ubiquitin specific peptidase 3 0.0525734
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0509145
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0484668
CD109 CD109 molecule 0.048323
QKI QKI, KH domain containing, RNA binding 0.0467466
VRK2 vaccinia related kinase 2 0.0466548
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.0442436
SIK3 SIK family kinase 3 0.0433763
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0433611
KDM3A lysine (K)-specific demethylase 3A 0.0431845
ZFAND3 zinc finger, AN1-type domain 3 0.0416647
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0413031
IGFBP3 insulin-like growth factor binding protein 3 0.0406026
RNF145 ring finger protein 145 0.0404286
GOLGA4 golgin A4 0.040168
SETD5 SET domain containing 5 0.0397873
RIOK3 RIO kinase 3 0.039629
ZNF292 zinc finger protein 292 0.0393013
HIPK2 homeodomain interacting protein kinase 2 0.0390536
CCNL1 cyclin L1 0.0374696
POTEF POTE ankyrin domain family, member F 0.0372178
UBA6 ubiquitin-like modifier activating enzyme 6 0.0363718
RAB8B RAB8B, member RAS oncogene family 0.0358016
NPAS2 neuronal PAS domain protein 2 0.0354427
LPP LIM domain containing preferred translocation partner in lipoma 0.035001
MYO1B myosin IB 0.03496
NAMPT nicotinamide phosphoribosyltransferase 0.0345313
MB21D2 Mab-21 domain containing 2 0.0342204
NRG1 neuregulin 1 0.0336969
SSBP2 single-stranded DNA binding protein 2 0.0332967
ZFP91 ZFP91 zinc finger protein 0.0331343
CDC73 cell division cycle 73 0.033036
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0327268
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0326946
VEGFA vascular endothelial growth factor A 0.0321084
ANKRD11 ankyrin repeat domain 11 0.0320263
DLG1 discs, large homolog 1 (Drosophila) 0.0317601
NUP58 nucleoporin 58 0.0313393
PDE4D phosphodiesterase 4D, cAMP-specific 0.0312261
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0310968
SNX9 sorting nexin 9 0.030961
SMAD3 SMAD family member 3 0.0309385
AKAP13 A kinase (PRKA) anchor protein 13 0.0302553
FBN1 fibrillin 1 0.0295577
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0294645
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0294527
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0294453
TSC22D2 TSC22 domain family, member 2 0.029443
AHRR aryl-hydrocarbon receptor repressor 0.0293738
DPYD dihydropyrimidine dehydrogenase 0.029238
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0290898
ZC3H12C zinc finger CCCH-type containing 12C 0.0286472
LIMCH1 LIM and calponin homology domains 1 0.0285174
RORA RAR-related orphan receptor A 0.0283032
INSIG1 insulin induced gene 1 0.0281481
SPAG9 sperm associated antigen 9 0.0278872
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0278283
RAI14 retinoic acid induced 14 0.0276789
ADD3 adducin 3 (gamma) 0.0276026
KMT2C lysine (K)-specific methyltransferase 2C 0.0274624
PUM1 pumilio RNA-binding family member 1 0.0272172
BIRC6 baculoviral IAP repeat containing 6 0.0268528
BZW1 basic leucine zipper and W2 domains 1 0.0267957
PARD3 par-3 family cell polarity regulator 0.0265958
ADAM9 ADAM metallopeptidase domain 9 0.0265717
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.026334
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0253604
PDE7B phosphodiesterase 7B 0.0253292
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0251882
TPST1 tyrosylprotein sulfotransferase 1 0.0251451
USP15 ubiquitin specific peptidase 15 0.0250533
PUM2 pumilio RNA-binding family member 2 0.0249386
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0248665
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0248584
ARRDC3 arrestin domain containing 3 0.0247887
THBS1 thrombospondin 1 0.0247428
RBMS1 RNA binding motif, single stranded interacting protein 1 0.02468
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0246667
ECPAS Ecm29 proteasome adaptor and scaffold 0.0246653
SUCO SUN domain containing ossification factor 0.0246365
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0242482

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.313264
VIM vimentin -0.240716
TMSB10 thymosin beta 10 -0.159188
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.103379
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100419
PTMA prothymosin, alpha -0.0796405
UBC ubiquitin C -0.0795171
CD44 CD44 molecule (Indian blood group) -0.0772721
FTL ferritin, light polypeptide -0.0770331
MT2A metallothionein 2A -0.0737606
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0652804
RPLP1 ribosomal protein, large, P1 -0.056452
BASP1 brain abundant, membrane attached signal protein 1 -0.0536204
AHNAK AHNAK nucleoprotein -0.051065
RPL23 ribosomal protein L23 -0.0506932
TM4SF1 transmembrane 4 L six family member 1 -0.0497309
RPS19 ribosomal protein S19 -0.0490643
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0468821
EEF2 eukaryotic translation elongation factor 2 -0.0444487
IFI16 interferon, gamma-inducible protein 16 -0.0435656
RPS8 ribosomal protein S8 -0.0431602
RPS21 ribosomal protein S21 -0.0420762
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0414444
EFNA5 ephrin-A5 -0.0399355
RPL34 ribosomal protein L34 -0.0392904
LOX lysyl oxidase -0.0392078
RPLP2 ribosomal protein, large, P2 -0.0391178
TPT1 tumor protein, translationally-controlled 1 -0.0391088
NCOA7 nuclear receptor coactivator 7 -0.03802
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0377311
OSMR oncostatin M receptor -0.0373612
C15ORF48 chromosome 15 open reading frame 48 -0.037001
PCBP2 poly(rC) binding protein 2 -0.0368423
RPS29 ribosomal protein S29 -0.0366632
CANX calnexin -0.0357529
RPS24 ribosomal protein S24 -0.0342562
ENO1 enolase 1, (alpha) -0.0342253
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0337996
RPL32 ribosomal protein L32 -0.0336977
CALR calreticulin -0.033164
RPS11 ribosomal protein S11 -0.0329863
RPL28 ribosomal protein L28 -0.032972
SOD2 superoxide dismutase 2, mitochondrial -0.0328779
TGM2 transglutaminase 2 -0.0326438
PDIA4 protein disulfide isomerase family A, member 4 -0.0322069
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0315124
HLA-B major histocompatibility complex, class I, B -0.031378
H1-0 H1.0 linker histone -0.031288
MCL1 myeloid cell leukemia 1 -0.0311133
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0309915
RPL12 ribosomal protein L12 -0.0305259
KLF6 Kruppel-like factor 6 -0.0305238
RPL38 ribosomal protein L38 -0.0301903
ACTG1 actin gamma 1 -0.0300357
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0297179
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0296852
ELL2 elongation factor, RNA polymerase II, 2 -0.0293427
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0288929
RPL19 ribosomal protein L19 -0.0287774
RPLP0 ribosomal protein, large, P0 -0.0282989
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0278976
S100A10 S100 calcium binding protein A10 -0.0277903
RPS13 ribosomal protein S13 -0.0276832
RPS27A ribosomal protein S27a -0.0274107
RPL35A ribosomal protein L35a -0.0272981
EIF1 eukaryotic translation initiation factor 1 -0.0263416
RPS16 ribosomal protein S16 -0.0256627
ANGPTL4 angiopoietin-like 4 -0.0255401
RAB27B RAB27B, member RAS oncogene family -0.025498
RPL37A ribosomal protein L37a -0.0251636
ZMYND8 zinc finger, MYND-type containing 8 -0.0248609
S100A6 S100 calcium binding protein A6 -0.0244779
TMSB4X thymosin beta 4, X-linked -0.0243715
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0241708
KIAA1217 KIAA1217 -0.0240723
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0237919
FLNB filamin B, beta -0.0236952
RPL36 ribosomal protein L36 -0.0235323
SLC38A1 solute carrier family 38, member 1 -0.0234347
RPS25 ribosomal protein S25 -0.0234289
ANXA2 annexin A2 -0.023204
FN1 fibronectin 1 -0.02315
SAMD4A sterile alpha motif domain containing 4A -0.0229853
STC1 stanniocalcin 1 -0.0228217
ASPH aspartate beta-hydroxylase -0.0227403
IFI6 interferon, alpha-inducible protein 6 -0.0226728
RPS5 ribosomal protein S5 -0.0217206
BTG1 B-cell translocation gene 1, anti-proliferative -0.0214579
LOC112694756 uncharaterized LOC112694756 -0.0214327
JUN jun proto-oncogene -0.0212967
NAV2 neuron navigator 2 -0.021294
RPS3 ribosomal protein S3 -0.021243
RPL7A ribosomal protein L7a -0.0210924
CCNI cyclin I -0.0209384
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0209095
HDLBP high density lipoprotein binding protein -0.0207856
ANKRD28 ankyrin repeat domain 28 -0.0207532
CSNK1A1 casein kinase 1, alpha 1 -0.0207445
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0206138
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0201474