Menadione_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.148981
POTEF POTE ankyrin domain family, member F 0.100351
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0913089
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0852983
MYOF myoferlin 0.0810494
LPP LIM domain containing preferred translocation partner in lipoma 0.0781557
CXCL8 chemokine (C-X-C motif) ligand 8 0.0755096
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0691682
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.067398
PDLIM5 PDZ and LIM domain 5 0.0664128
SAMD4A sterile alpha motif domain containing 4A 0.0651524
TPM3 tropomyosin 3 0.061804
TXNRD1 thioredoxin reductase 1 0.060569
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0580871
MCL1 myeloid cell leukemia 1 0.0545229
FTH1 ferritin, heavy polypeptide 1 0.0540219
NCEH1 neutral cholesterol ester hydrolase 1 0.0530429
ZFAND3 zinc finger, AN1-type domain 3 0.0528576
GLS2 glutaminase 2 (liver, mitochondrial) 0.0510137
ASPH aspartate beta-hydroxylase 0.0506067
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0474249
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0466937
EXT1 exostosin glycosyltransferase 1 0.0462529
FAM107B family with sequence similarity 107, member B 0.0457773
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0434737
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0421988
KTN1 kinectin 1 (kinesin receptor) 0.0407101
HSPA8 heat shock 70kDa protein 8 0.0406539
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0404691
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0400417
ADAM17 ADAM metallopeptidase domain 17 0.0394
LDHA lactate dehydrogenase A 0.0384558
ELL2 elongation factor, RNA polymerase II, 2 0.0381757
PDIA6 protein disulfide isomerase family A, member 6 0.0372051
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0364391
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0359691
IER3 immediate early response 3 0.0352654
MACF1 microtubule-actin crosslinking factor 1 0.0350637
YME1L1 YME1-like 1 ATPase 0.0346775
FXR1 fragile X mental retardation, autosomal homolog 1 0.0346673
ATXN1 ataxin 1 0.0346005
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0342808
KIF5B kinesin family member 5B 0.0342386
RICTOR RPTOR independent companion of MTOR, complex 2 0.0340378
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0337568
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0334472
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0321164
SNX9 sorting nexin 9 0.032091
FNDC3B fibronectin type III domain containing 3B 0.0311549
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0311484
RUNX1 runt-related transcription factor 1 0.0310893
ERRFI1 ERBB receptor feedback inhibitor 1 0.0310683
SOD2 superoxide dismutase 2, mitochondrial 0.0310555
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0309029
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0306619
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0305072
BIRC3 baculoviral IAP repeat containing 3 0.0300638
NAV3 neuron navigator 3 0.0295774
CD109 CD109 molecule 0.0290579
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0288
VMP1 vacuole membrane protein 1 0.0287311
NUP58 nucleoporin 58 0.0283784
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0282412
DSCAM Down syndrome cell adhesion molecule 0.0281443
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.027995
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0276947
USP34 ubiquitin specific peptidase 34 0.0272426
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0271202
SPIRE1 spire-type actin nucleation factor 1 0.0271005
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0270529
CCNL1 cyclin L1 0.0270025
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0269944
CAMTA1 calmodulin binding transcription activator 1 0.0267958
NAMPT nicotinamide phosphoribosyltransferase 0.0265776
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0262302
NHSL1 NHS-like 1 0.0262053
SEC31A SEC31 homolog A (S. cerevisiae) 0.0261922
SFPQ splicing factor proline/glutamine-rich 0.0261476
CALR calreticulin 0.0254038
ARHGAP26 Rho GTPase activating protein 26 0.0253551
DST dystonin 0.0253262
KIAA0319 KIAA0319 0.025157
SMAD3 SMAD family member 3 0.0248696
MATR3 matrin 3 0.0248266
PDIA3 protein disulfide isomerase family A, member 3 0.0248119
GOLGA4 golgin A4 0.0247127
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0244923
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0239776
RPL3 ribosomal protein L3 0.0239422
ZSWIM6 zinc finger, SWIM-type containing 6 0.0237374
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0236337
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0236076
ASCC3 activating signal cointegrator 1 complex subunit 3 0.023597
PCNX1 pecanex 1 0.0235609
MYH9 myosin, heavy chain 9, non-muscle 0.0235468
COG5 component of oligomeric golgi complex 5 0.0235225
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0234263
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.023209
TTC3 tetratricopeptide repeat domain 3 0.0228489
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0227933

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.21249
MT2A metallothionein 2A -0.143713
FTL ferritin, light polypeptide -0.136425
PM20D1 peptidase M20 domain containing 1 -0.103198
VIM vimentin -0.0800479
TFPI2 tissue factor pathway inhibitor 2 -0.0714902
RPL23 ribosomal protein L23 -0.0700919
HDAC9 histone deacetylase 9 -0.0665341
IGF2 insulin-like growth factor 2 -0.0533274
RPL36 ribosomal protein L36 -0.0475608
PTMA prothymosin, alpha -0.0473271
BHLHE40 basic helix-loop-helix family, member e40 -0.047226
RPL37A ribosomal protein L37a -0.0424144
THSD4 thrombospondin, type I, domain containing 4 -0.0412223
RPL26 ribosomal protein L26 -0.0392228
RPS19 ribosomal protein S19 -0.0384925
RPLP1 ribosomal protein, large, P1 -0.0371784
BICC1 BicC family RNA binding protein 1 -0.0356268
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0348922
CAVIN1 caveolae associated protein 1 -0.0346691
RPS27A ribosomal protein S27a -0.0344275
RPL35A ribosomal protein L35a -0.031512
RPS3 ribosomal protein S3 -0.0303311
SLC38A2 solute carrier family 38, member 2 -0.0301909
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0296859
RPS29 ribosomal protein S29 -0.0288426
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0287215
FGB fibrinogen beta chain -0.0268891
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0268474
KLF6 Kruppel-like factor 6 -0.0260641
FLNB filamin B, beta -0.0260186
IGFBP4 insulin-like growth factor binding protein 4 -0.0259061
RPL19 ribosomal protein L19 -0.0257799
FGG fibrinogen gamma chain -0.0241154
NEBL nebulette -0.0238873
RAD21 RAD21 homolog (S. pombe) -0.0236503
RPL8 ribosomal protein L8 -0.0235179
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.023476
LMNA lamin A/C -0.0233425
GRAMD1B GRAM domain containing 1B -0.0232138
RPLP2 ribosomal protein, large, P2 -0.0230643
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0229274
BABAM2 BRISC and BRCA1 A complex member 2 -0.0229041
RPL32 ribosomal protein L32 -0.0228367
PDE4D phosphodiesterase 4D, cAMP-specific -0.0228273
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0228141
RPS12 ribosomal protein S12 -0.0222533
SERF2 small EDRK-rich factor 2 -0.0222004
HMGA1 high mobility group AT-hook 1 -0.0218747
ACACA acetyl-CoA carboxylase alpha -0.0216469
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0215222
RPL12 ribosomal protein L12 -0.0214956
RAD51B RAD51 paralog B -0.0214892
RPL18 ribosomal protein L18 -0.0214246
PARD3 par-3 family cell polarity regulator -0.0211372
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0207726
RCC1 regulator of chromosome condensation 1 -0.0203162
KYNU kynureninase -0.0202534
RPL37 ribosomal protein L37 -0.0202452
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0201273
NTM neurotrimin -0.0200307
TPD52 tumor protein D52 -0.0200134
RPS21 ribosomal protein S21 -0.0195896
ROMO1 reactive oxygen species modulator 1 -0.0195021
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0192118
RHOA ras homolog family member A -0.0188556
FGA fibrinogen alpha chain -0.018809
RSL1D1 ribosomal L1 domain containing 1 -0.0186868
TBC1D5 TBC1 domain family, member 5 -0.0186136
RPL34 ribosomal protein L34 -0.0185345
RPL36AL ribosomal protein L36a-like -0.0185251
HMGB1 high mobility group box 1 -0.0184009
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0183999
IST1 increased sodium tolerance 1 homolog (yeast) -0.01819
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0181083
KCTD9 potassium channel tetramerization domain containing 9 -0.017755
RPS14 ribosomal protein S14 -0.0176913
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0176168
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.017596
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0175865
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0175068
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -0.0174325
RNF213 ring finger protein 213 -0.0172024
ACTG1 actin gamma 1 -0.0171374
RPS27 ribosomal protein S27 -0.0168317
EFNA5 ephrin-A5 -0.0167853
MSRB3 methionine sulfoxide reductase B3 -0.0165795
WASF2 WAS protein family, member 2 -0.0164813
COX6C cytochrome c oxidase subunit VIc -0.0161845
MBNL1 muscleblind-like splicing regulator 1 -0.0161833
RPL31 ribosomal protein L31 -0.0161794
NCAPD2 non-SMC condensin I complex, subunit D2 -0.015987
CMIP c-Maf inducing protein -0.0159288
BASP1 brain abundant, membrane attached signal protein 1 -0.0159194
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0156896
AHR aryl hydrocarbon receptor -0.0156023
YBX3 Y box binding protein 3 -0.015577
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0155223
NPR2 natriuretic peptide receptor 2 -0.0154269
COL4A5 collagen, type IV, alpha 5 -0.0154222