| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Menadione perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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193 genes differentially expressed following the Menadione_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.160661 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.159695 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.142115 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.135081 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.121445 |
| GOLGA4 | golgin A4 | 0.110551 |
| EXT1 | exostosin glycosyltransferase 1 | 0.104652 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.104627 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0954109 |
| FTL | ferritin, light polypeptide | 0.0887832 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0816352 |
| PRELID2 | PRELI domain containing 2 | 0.0799737 |
| FNDC3A | fibronectin type III domain containing 3A | 0.074492 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0701531 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0685572 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0673766 |
| RPS8 | ribosomal protein S8 | 0.0620119 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0612807 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0611617 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0610121 |
| CD44 | CD44 molecule (Indian blood group) | 0.0601655 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0599872 |
| MT2A | metallothionein 2A | 0.0579714 |
| NAV2 | neuron navigator 2 | 0.0577096 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0558267 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0549819 |
| RAB10 | RAB10, member RAS oncogene family | 0.0542145 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.054051 |
| ASPH | aspartate beta-hydroxylase | 0.0499841 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0470058 |
| PKM | pyruvate kinase, muscle | 0.0467031 |
| TMSB10 | thymosin beta 10 | 0.0466886 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0465356 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0464849 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.045766 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0454499 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0452452 |
| MEF2A | myocyte enhancer factor 2A | 0.0444376 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.044389 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0442528 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0437415 |
| PGK1 | phosphoglycerate kinase 1 | 0.0431483 |
| RBM39 | RNA binding motif protein 39 | 0.0430476 |
| CD109 | CD109 molecule | 0.041841 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.040678 |
| TJP2 | tight junction protein 2 | 0.0406282 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.04058 |
| SBF2 | SET binding factor 2 | 0.0399114 |
| RPL32 | ribosomal protein L32 | 0.0379364 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0366176 |
| RPLP1 | ribosomal protein, large, P1 | 0.0354621 |
| FLNB | filamin B, beta | 0.0323695 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0320247 |
| RNF24 | ring finger protein 24 | 0.0315298 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0314056 |
| OGA | O-GlcNAcase | 0.0308392 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0307575 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0306885 |
| NAV1 | neuron navigator 1 | 0.0296362 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0290036 |
| RPL12 | ribosomal protein L12 | 0.0278387 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.026793 |
| GPHN | gephyrin | 0.0267251 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0251241 |
| EZR | ezrin | 0.0248883 |
| EGFR | epidermal growth factor receptor | 0.0237718 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0233427 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0222781 |
| RBM25 | RNA binding motif protein 25 | 0.0216321 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0201692 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0198976 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0195032 |
| RPL35A | ribosomal protein L35a | 0.0187846 |
| B2M | beta-2-microglobulin | 0.0181389 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0174068 |
| RPL11 | ribosomal protein L11 | 0.017396 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0169622 |
| NF1 | neurofibromin 1 | 0.016377 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0163545 |
| VIM | vimentin | 0.0156824 |
| PERP | PERP, TP53 apoptosis effector | 0.015668 |
| ATXN1 | ataxin 1 | 0.015097 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0150773 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0146639 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0137884 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0120776 |
| GPC6 | glypican 6 | 0.0114106 |
| SET | SET nuclear proto-oncogene | 0.00939882 |
| MED13L | mediator complex subunit 13-like | 0.00902218 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00849988 |
| PKN2 | protein kinase N2 | 0.00788596 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.00597013 |
| LMNA | lamin A/C | 0.00584409 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.00495766 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.00494054 |
| ANKRD12 | ankyrin repeat domain 12 | 0.00403677 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.00342912 |
| FAT1 | FAT atypical cadherin 1 | 0.00339658 |
| MYOF | myoferlin | 0.00171634 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.00138906 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.286048 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.152945 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.152911 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.151593 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.15134 |
| LMO7 | LIM domain 7 | -0.148351 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.144975 |
| FN1 | fibronectin 1 | -0.140251 |
| PDE10A | phosphodiesterase 10A | -0.114465 |
| MYO1E | myosin IE | -0.113358 |
| GRB10 | growth factor receptor-bound protein 10 | -0.108973 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0993738 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0970462 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0922872 |
| ATOSA | atos homolog A | -0.0824397 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0807911 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0789051 |
| ABHD17C | abhydrolase domain containing 17C | -0.0787307 |
| TXNRD1 | thioredoxin reductase 1 | -0.0766126 |
| KRT17 | keratin 17, type I | -0.0758222 |
| SVIL | supervillin | -0.0715159 |
| JMJD1C | jumonji domain containing 1C | -0.0676523 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.0653351 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0648012 |
| SRPK2 | SRSF protein kinase 2 | -0.061025 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0576858 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0573081 |
| ZNF638 | zinc finger protein 638 | -0.0565606 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0549743 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0542008 |
| CMIP | c-Maf inducing protein | -0.0531017 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0520993 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0517117 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0514851 |
| SEPTIN7 | septin 7 | -0.0507976 |
| SPAG9 | sperm associated antigen 9 | -0.0505204 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0499406 |
| RPS6 | ribosomal protein S6 | -0.0489405 |
| LAMB3 | laminin, beta 3 | -0.0485369 |
| ZNF292 | zinc finger protein 292 | -0.0477648 |
| DST | dystonin | -0.0473578 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0444726 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0441654 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0431373 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0430272 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0427614 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0426949 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0423225 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0417168 |
| ANXA2 | annexin A2 | -0.0408366 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0401724 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0389415 |
| KIF5B | kinesin family member 5B | -0.0364347 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0362093 |
| GOLGB1 | golgin B1 | -0.0353792 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0349266 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0323852 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0311973 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.030403 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0303364 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0300216 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0298502 |
| RPS19 | ribosomal protein S19 | -0.0297592 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0273562 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0263525 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.02575 |
| RPS12 | ribosomal protein S12 | -0.0252609 |
| ERBIN | erbb2 interacting protein | -0.0239101 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0232589 |
| NPTN | neuroplastin | -0.0201009 |
| LDHA | lactate dehydrogenase A | -0.0191243 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0188453 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0180993 |
| RTN4 | reticulon 4 | -0.0179242 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0169308 |
| RPL37A | ribosomal protein L37a | -0.0168409 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0138473 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0132532 |
| PTK2 | protein tyrosine kinase 2 | -0.0121542 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0121445 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0120919 |
| H3-3B | H3.3 histone B | -0.00998791 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.00995239 |
| NDRG1 | N-myc downstream regulated 1 | -0.00940466 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.00882007 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.00757228 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.00603435 |
| PARD3 | par-3 family cell polarity regulator | -0.00448781 |
| RUNX1 | runt-related transcription factor 1 | -0.00351005 |
| RPL23 | ribosomal protein L23 | -0.0028762 |
| PTMA | prothymosin, alpha | -0.00232887 |
| SETD5 | SET domain containing 5 | -0.00115213 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -5.90511E-4 |
