Menadione_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Menadione_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.155424
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.150831
POTEF POTE ankyrin domain family, member F 0.104352
TPM3 tropomyosin 3 0.0899475
ERRFI1 ERBB receptor feedback inhibitor 1 0.0893826
ZCCHC7 zinc finger, CCHC domain containing 7 0.0640307
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0605188
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0565389
CSDE1 cold shock domain containing E1, RNA-binding 0.0557947
TXNRD1 thioredoxin reductase 1 0.0557934
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0543739
BIRC6 baculoviral IAP repeat containing 6 0.053383
BBX bobby sox homolog (Drosophila) 0.0531109
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.053109
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0528611
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0515082
BRD2 bromodomain containing 2 0.0503552
EXT1 exostosin glycosyltransferase 1 0.049691
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0495055
MACF1 microtubule-actin crosslinking factor 1 0.0477848
USP34 ubiquitin specific peptidase 34 0.046465
VMP1 vacuole membrane protein 1 0.0452072
TBC1D5 TBC1 domain family, member 5 0.0450806
IPO7 importin 7 0.0432203
ANO6 anoctamin 6 0.0432133
MED13L mediator complex subunit 13-like 0.0426504
PTK2 protein tyrosine kinase 2 0.0419491
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0415736
RAD51B RAD51 paralog B 0.0407124
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0401709
FNDC3B fibronectin type III domain containing 3B 0.0401538
KDM2A lysine (K)-specific demethylase 2A 0.0393628
PCBP2 poly(rC) binding protein 2 0.0392179
NOTCH2 notch 2 0.0377714
SFPQ splicing factor proline/glutamine-rich 0.036656
TAS2R14 taste receptor, type 2, member 14 0.0361711
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0359911
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0359311
PRELID2 PRELI domain containing 2 0.034866
PDIA3 protein disulfide isomerase family A, member 3 0.0346114
EXOC4 exocyst complex component 4 0.0345727
AEBP2 AE binding protein 2 0.0343059
CSNK1A1 casein kinase 1, alpha 1 0.0335695
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0335487
LPP LIM domain containing preferred translocation partner in lipoma 0.0333277
FNIP1 folliculin interacting protein 1 0.0328672
WNK1 WNK lysine deficient protein kinase 1 0.0328158
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0328119
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.03238
ENO1 enolase 1, (alpha) 0.0321695
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0319199
COPA coatomer protein complex, subunit alpha 0.0314719
ADIPOR2 adiponectin receptor 2 0.0313072
FAM168A family with sequence similarity 168, member A 0.0312162
SENP6 SUMO1/sentrin specific peptidase 6 0.0310961
HSPA8 heat shock 70kDa protein 8 0.03099
NBAS neuroblastoma amplified sequence 0.0308446
PNN pinin, desmosome associated protein 0.0294204
MORF4L2 mortality factor 4 like 2 0.0287006
KTN1 kinectin 1 (kinesin receptor) 0.0285809
CAMTA1 calmodulin binding transcription activator 1 0.0284883
ATXN1 ataxin 1 0.0284112
DST dystonin 0.0281119
FXR1 fragile X mental retardation, autosomal homolog 1 0.027831
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0278253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0276248
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0275189
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0274832
HMGA2 high mobility group AT-hook 2 0.0273046
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0272364
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0270677
NCKAP1 NCK-associated protein 1 0.0270419
MSN moesin 0.0269969
ZBTB1 zinc finger and BTB domain containing 1 0.026812
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0266927
AFF3 AF4/FMR2 family, member 3 0.0266348
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0264059
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0263255
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.02631
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0262346
FMNL2 formin-like 2 0.0262211
ERBIN erbb2 interacting protein 0.0261482
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0261321
GSK3B glycogen synthase kinase 3 beta 0.0261299
ANKRD36 ankyrin repeat domain 36 0.0260749
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0260337
PDIA6 protein disulfide isomerase family A, member 6 0.025952
ZFAND3 zinc finger, AN1-type domain 3 0.0258602
ZBTB20 zinc finger and BTB domain containing 20 0.0258167
RSF1 remodeling and spacing factor 1 0.02579
NF1 neurofibromin 1 0.0257655
USP24 ubiquitin specific peptidase 24 0.0257503
EML4 echinoderm microtubule associated protein like 4 0.0256573
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.0255773
THSD4 thrombospondin, type I, domain containing 4 0.0254377
TFG TRK-fused gene 0.025208
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0249276
UBE2H ubiquitin-conjugating enzyme E2H 0.0249129
PKN2 protein kinase N2 0.0248621
CKAP5 cytoskeleton associated protein 5 0.0248584

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.143869
YBX3 Y box binding protein 3 -0.136153
TFPI2 tissue factor pathway inhibitor 2 -0.120563
PTMA prothymosin, alpha -0.1159
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0959204
GRAMD1B GRAM domain containing 1B -0.0861746
RPL35A ribosomal protein L35a -0.07882
RPL23 ribosomal protein L23 -0.0783296
NAP1L1 nucleosome assembly protein 1-like 1 -0.0770995
RPL26 ribosomal protein L26 -0.0713981
RPL37 ribosomal protein L37 -0.0684503
RPL12 ribosomal protein L12 -0.0663583
RPLP1 ribosomal protein, large, P1 -0.0655989
RPS3 ribosomal protein S3 -0.065
TPT1 tumor protein, translationally-controlled 1 -0.0646858
RPS8 ribosomal protein S8 -0.0632545
MT2A metallothionein 2A -0.0616013
RPS21 ribosomal protein S21 -0.0606578
RPS27A ribosomal protein S27a -0.0543923
RPS19 ribosomal protein S19 -0.0525272
RPL37A ribosomal protein L37a -0.051588
RPL36 ribosomal protein L36 -0.0500083
RPL34 ribosomal protein L34 -0.0490879
MYL12B myosin, light chain 12B, regulatory -0.0485849
RPS29 ribosomal protein S29 -0.0464314
RPL9 ribosomal protein L9 -0.0455068
TM4SF1 transmembrane 4 L six family member 1 -0.044215
RPS12 ribosomal protein S12 -0.0441707
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0432512
VIM vimentin -0.0431338
RPL32 ribosomal protein L32 -0.042158
CAVIN1 caveolae associated protein 1 -0.0413019
RPS27 ribosomal protein S27 -0.0407492
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0396174
RPLP0 ribosomal protein, large, P0 -0.0381833
ATP11A ATPase, class VI, type 11A -0.0379065
RPL19 ribosomal protein L19 -0.0372361
RPL31 ribosomal protein L31 -0.0371094
PTPRF protein tyrosine phosphatase, receptor type, F -0.0369416
RPL35 ribosomal protein L35 -0.0356217
RPL5 ribosomal protein L5 -0.0346332
RPL38 ribosomal protein L38 -0.0344962
RPL11 ribosomal protein L11 -0.0344282
IGF1R insulin-like growth factor 1 receptor -0.0343032
RACK1 receptor for activated C kinase 1 -0.0342761
RPS4X ribosomal protein S4, X-linked -0.0342408
WSB1 WD repeat and SOCS box containing 1 -0.0339871
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0339647
RPL13A ribosomal protein L13a -0.032548
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0323907
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0320713
TPI1 triosephosphate isomerase 1 -0.0318076
ACTG1 actin gamma 1 -0.0311275
NCOA7 nuclear receptor coactivator 7 -0.0308494
RPS24 ribosomal protein S24 -0.0306158
GNAS GNAS complex locus -0.0305063
FTL ferritin, light polypeptide -0.0303513
KLF6 Kruppel-like factor 6 -0.0300748
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0298497
RPLP2 ribosomal protein, large, P2 -0.0297053
RPL28 ribosomal protein L28 -0.0295423
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0292734
RPL27 ribosomal protein L27 -0.0292632
RPS10 ribosomal protein S10 -0.0292281
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0286252
ATP5F1E ATP synthase F1 subunit epsilon -0.0282946
FUS FUS RNA binding protein -0.0276644
RPS15 ribosomal protein S15 -0.0276568
BASP1 brain abundant, membrane attached signal protein 1 -0.0273004
RPS20 ribosomal protein S20 -0.0268147
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0267964
LDHB lactate dehydrogenase B -0.0263071
BSG basigin (Ok blood group) -0.0259988
RPL30 ribosomal protein L30 -0.0248904
LOC112694756 uncharaterized LOC112694756 -0.0245598
S100A6 S100 calcium binding protein A6 -0.0244689
NACA nascent polypeptide-associated complex alpha subunit -0.0242292
NSUN6 NOP2/Sun domain family, member 6 -0.0238405
ELL2 elongation factor, RNA polymerase II, 2 -0.0237798
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0237078
RPS14 ribosomal protein S14 -0.0235668
PABPN1 poly(A) binding protein, nuclear 1 -0.0232414
RPS16 ribosomal protein S16 -0.0227838
EIF4A1 eukaryotic translation initiation factor 4A1 -0.022428
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0224142
H3-3B H3.3 histone B -0.0223264
RPL8 ribosomal protein L8 -0.0221451
EIF1 eukaryotic translation initiation factor 1 -0.0221292
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.021695
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0214325
SINHCAF SIN3-HDAC complex associated factor -0.0211497
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0211187
FHL2 four and a half LIM domains 2 -0.020906
ZBTB7A zinc finger and BTB domain containing 7A -0.0205193
RPS5 ribosomal protein S5 -0.0204183
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0203177
PFN1 profilin 1 -0.0202759
H1-0 H1.0 linker histone -0.0202511
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.020088
GSTP1 glutathione S-transferase pi 1 -0.0200468