Menadione_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.276304
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.129727
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.121636
MYO6 myosin VI 0.0802233
ASPH aspartate beta-hydroxylase 0.0792505
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0774402
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0676643
ADAM9 ADAM metallopeptidase domain 9 0.0667822
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0665638
MYH9 myosin, heavy chain 9, non-muscle 0.0616104
FNDC3B fibronectin type III domain containing 3B 0.0615868
RNF145 ring finger protein 145 0.0590658
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0578604
TPM3 tropomyosin 3 0.05619
FXR1 fragile X mental retardation, autosomal homolog 1 0.0552189
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.052893
TFG TRK-fused gene 0.0525434
CCNL1 cyclin L1 0.0510424
APLP2 amyloid beta (A4) precursor-like protein 2 0.0503405
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0470571
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0465498
HMGB2 high mobility group box 2 0.044204
COPA coatomer protein complex, subunit alpha 0.0434957
PCBP2 poly(rC) binding protein 2 0.042702
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0418023
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0404091
DSPP dentin sialophosphoprotein 0.0395296
NUP58 nucleoporin 58 0.039469
GRB10 growth factor receptor-bound protein 10 0.0390754
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0390321
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0374852
HSPA8 heat shock 70kDa protein 8 0.0370236
KMT2E lysine (K)-specific methyltransferase 2E 0.0366488
PAPOLA poly(A) polymerase alpha 0.0358259
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0353737
WAC WW domain containing adaptor with coiled-coil 0.0352803
LDHA lactate dehydrogenase A 0.0349087
KDM6A lysine (K)-specific demethylase 6A 0.0341067
CCNB1 cyclin B1 0.0338811
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0338773
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0330646
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0330122
AREG amphiregulin 0.0329319
VEGFA vascular endothelial growth factor A 0.0327894
MSN moesin 0.0326552
ARRDC3 arrestin domain containing 3 0.0324941
YTHDC1 YTH domain containing 1 0.0319624
PUM1 pumilio RNA-binding family member 1 0.0318851
PDIA6 protein disulfide isomerase family A, member 6 0.03161
CANX calnexin 0.0312883
CD109 CD109 molecule 0.0312422
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307721
SEC23A Sec23 homolog A (S. cerevisiae) 0.030519
GPBP1 GC-rich promoter binding protein 1 0.0304583
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0302114
TMF1 TATA element modulatory factor 1 0.0299748
NCKAP1 NCK-associated protein 1 0.0295328
ITCH itchy E3 ubiquitin protein ligase 0.0288318
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0287139
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0286992
RBM39 RNA binding motif protein 39 0.0285093
SLMAP sarcolemma associated protein 0.0283998
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0283176
UBA6 ubiquitin-like modifier activating enzyme 6 0.0280414
ECT2 epithelial cell transforming 2 0.0279685
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0278555
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0274731
MBNL1 muscleblind-like splicing regulator 1 0.0273695
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0273563
CKAP5 cytoskeleton associated protein 5 0.0272093
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0271222
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0261925
HDGF hepatoma-derived growth factor 0.0261292
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0260444
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.025751
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0257507
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0256851
ADGRF1 adhesion G protein-coupled receptor F1 0.0254145
STRN3 striatin, calmodulin binding protein 3 0.0250607
HELZ helicase with zinc finger 0.0248437
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0248135
QKI QKI, KH domain containing, RNA binding 0.0246473
DST dystonin 0.024613
FAM13A family with sequence similarity 13, member A 0.0244291
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0243899
TSC22D2 TSC22 domain family, member 2 0.024283
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0241392
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0241206
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0239483
AKAP13 A kinase (PRKA) anchor protein 13 0.0238767
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0237352
ANLN anillin, actin binding protein 0.023655
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0233598
MYOF myoferlin 0.0233218
TRIO trio Rho guanine nucleotide exchange factor 0.0233045
PICALM phosphatidylinositol binding clathrin assembly protein 0.0233036
APP amyloid beta (A4) precursor protein 0.0233018
CALR calreticulin 0.0232772
ANXA5 annexin A5 0.0231487
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0231349

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.288507
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.164214
TMSB10 thymosin beta 10 -0.161888
ACTG1 actin gamma 1 -0.159102
FTL ferritin, light polypeptide -0.155322
LAMB3 laminin, beta 3 -0.122964
NDRG1 N-myc downstream regulated 1 -0.121063
TPT1 tumor protein, translationally-controlled 1 -0.111358
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.101977
RPL35A ribosomal protein L35a -0.0889242
RPLP1 ribosomal protein, large, P1 -0.0831686
RPL34 ribosomal protein L34 -0.0830111
FN1 fibronectin 1 -0.0806212
MT2A metallothionein 2A -0.0753742
S100A6 S100 calcium binding protein A6 -0.0704598
HMGA1 high mobility group AT-hook 1 -0.0684513
LAMC2 laminin, gamma 2 -0.0635022
EFNA5 ephrin-A5 -0.0601245
RPS19 ribosomal protein S19 -0.0585122
IFI27 interferon, alpha-inducible protein 27 -0.0548013
RPS8 ribosomal protein S8 -0.0537508
RPL23 ribosomal protein L23 -0.0519105
S100A10 S100 calcium binding protein A10 -0.0478697
SAMD4A sterile alpha motif domain containing 4A -0.0472351
RPL9 ribosomal protein L9 -0.0446479
RPLP2 ribosomal protein, large, P2 -0.0445771
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0444873
LOC112694756 uncharaterized LOC112694756 -0.0438541
ELL2 elongation factor, RNA polymerase II, 2 -0.043196
RPL8 ribosomal protein L8 -0.0431253
IFI6 interferon, alpha-inducible protein 6 -0.0427804
HLA-B major histocompatibility complex, class I, B -0.041047
ISG15 ISG15 ubiquitin-like modifier -0.040665
SDC4 syndecan 4 -0.040576
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0390523
RPL37 ribosomal protein L37 -0.0383996
RPS23 ribosomal protein S23 -0.0380982
RPL11 ribosomal protein L11 -0.0379808
RPL30 ribosomal protein L30 -0.0376815
IFITM3 interferon induced transmembrane protein 3 -0.0371244
PTMA prothymosin, alpha -0.0370709
RPS27A ribosomal protein S27a -0.0364765
EIF1 eukaryotic translation initiation factor 1 -0.0354728
RACK1 receptor for activated C kinase 1 -0.0350435
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.034902
RPS21 ribosomal protein S21 -0.0345945
RPL35 ribosomal protein L35 -0.0341389
RPS29 ribosomal protein S29 -0.0340214
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0340174
S100A9 S100 calcium binding protein A9 -0.0335
RPL32 ribosomal protein L32 -0.0334256
RPL12 ribosomal protein L12 -0.0332105
PLEC plectin -0.0330203
RPS13 ribosomal protein S13 -0.0327364
RPL37A ribosomal protein L37a -0.0310068
PLSCR1 phospholipid scramblase 1 -0.0309055
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0308704
IFI16 interferon, gamma-inducible protein 16 -0.0306723
RPS3 ribosomal protein S3 -0.0306651
HLA-A major histocompatibility complex, class I, A -0.0306066
IFITM1 interferon induced transmembrane protein 1 -0.0306054
RPL38 ribosomal protein L38 -0.0305391
CSTB cystatin B (stefin B) -0.0302932
CTSB cathepsin B -0.0302585
BASP1 brain abundant, membrane attached signal protein 1 -0.0302371
TM4SF1 transmembrane 4 L six family member 1 -0.0300138
DUSP6 dual specificity phosphatase 6 -0.0299435
FTH1 ferritin, heavy polypeptide 1 -0.0296609
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0288335
RPL36 ribosomal protein L36 -0.0286492
TUBB4B tubulin, beta 4B class IVb -0.0277422
SMAD3 SMAD family member 3 -0.0274998
LMNA lamin A/C -0.027157
MAP1B microtubule-associated protein 1B -0.0264974
BLZF1 basic leucine zipper nuclear factor 1 -0.0262765
RPS24 ribosomal protein S24 -0.0261106
GNAS GNAS complex locus -0.0259913
VIM vimentin -0.0256924
SLC38A1 solute carrier family 38, member 1 -0.0252799
KIAA1217 KIAA1217 -0.0251872
FLNA filamin A, alpha -0.0249676
CDCP1 CUB domain containing protein 1 -0.0247341
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0243344
KLF6 Kruppel-like factor 6 -0.0242929
RPS5 ribosomal protein S5 -0.0242501
NPC2 Niemann-Pick disease, type C2 -0.0237553
RPL27A ribosomal protein L27a -0.0237212
ARF1 ADP-ribosylation factor 1 -0.0236617
ATXN1 ataxin 1 -0.023369
PLAUR plasminogen activator, urokinase receptor -0.0232085
RPL26 ribosomal protein L26 -0.0231578
G0S2 G0/G1 switch 2 -0.0229136
RPS16 ribosomal protein S16 -0.0228561
OSMR oncostatin M receptor -0.0227861
RPL19 ribosomal protein L19 -0.0227145
RAB7A RAB7A, member RAS oncogene family -0.0227028
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0226004
RPS27 ribosomal protein S27 -0.0225528
FBXO32 F-box protein 32 -0.0225451
RPS14 ribosomal protein S14 -0.0224983