Menadione_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

130 genes differentially expressed following the Menadione_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.183713
PRKG1 protein kinase, cGMP-dependent, type I 0.148405
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.139831
PTMA prothymosin, alpha 0.125966
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.107717
PTK2 protein tyrosine kinase 2 0.0992946
TMEM87A transmembrane protein 87A 0.0979048
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0936954
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0913415
CXCL8 chemokine (C-X-C motif) ligand 8 0.0890499
ZNF148 zinc finger protein 148 0.0851033
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0843134
UBA6 ubiquitin-like modifier activating enzyme 6 0.0829232
AKAP12 A kinase (PRKA) anchor protein 12 0.0826223
TMEM165 transmembrane protein 165 0.0822981
EPS8 epidermal growth factor receptor pathway substrate 8 0.0778065
SUCO SUN domain containing ossification factor 0.0773779
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0755031
TM9SF3 transmembrane 9 superfamily member 3 0.0748194
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0729629
KMT2C lysine (K)-specific methyltransferase 2C 0.0708039
PTEN phosphatase and tensin homolog 0.0703162
ZSWIM6 zinc finger, SWIM-type containing 6 0.06815
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0681022
DLG1 discs, large homolog 1 (Drosophila) 0.0668813
VMP1 vacuole membrane protein 1 0.0661488
VCL vinculin 0.0601318
ANKRD12 ankyrin repeat domain 12 0.0541895
ZFAND3 zinc finger, AN1-type domain 3 0.0524614
TRA2A transformer 2 alpha homolog (Drosophila) 0.0517456
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0506505
RBM25 RNA binding motif protein 25 0.0504889
B2M beta-2-microglobulin 0.0480523
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0473535
BRWD1 bromodomain and WD repeat domain containing 1 0.0473277
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0469551
LPP LIM domain containing preferred translocation partner in lipoma 0.0452234
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0448749
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0446538
KDM4C lysine (K)-specific demethylase 4C 0.043921
ANKRD11 ankyrin repeat domain 11 0.043421
NUP58 nucleoporin 58 0.0413645
DSCAM Down syndrome cell adhesion molecule 0.0406593
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0398575
MT2A metallothionein 2A 0.0370395
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0359083
RTN4 reticulon 4 0.0348374
ACTN4 actinin, alpha 4 0.0343122
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0338255
PDE4D phosphodiesterase 4D, cAMP-specific 0.033735
ZC3H11A zinc finger CCCH-type containing 11A 0.0332202
FTL ferritin, light polypeptide 0.031552
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0306638
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0306595
EIF1 eukaryotic translation initiation factor 1 0.0304648
XPO1 exportin 1 0.0297957
AKAP9 A kinase (PRKA) anchor protein 9 0.0294986
PRRC2C proline-rich coiled-coil 2C 0.0275278
EGR1 early growth response 1 0.0261536
RBM39 RNA binding motif protein 39 0.0244783
CALR calreticulin 0.0218416
SMYD3 SET and MYND domain containing 3 0.0215522
BIRC6 baculoviral IAP repeat containing 6 0.0209442
SPAG9 sperm associated antigen 9 0.0209212
SQSTM1 sequestosome 1 0.019841
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187616
YME1L1 YME1-like 1 ATPase 0.0184713
TRIO trio Rho guanine nucleotide exchange factor 0.0179672
PRKCA protein kinase C, alpha 0.0134113
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00986323
ZBTB20 zinc finger and BTB domain containing 20 0.00914619
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00896235
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.00851985
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00822223
JMJD1C jumonji domain containing 1C 0.00771041
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00529838
RPL37 ribosomal protein L37 0.00343803
RPS3 ribosomal protein S3 0.00267941
HMGA2 high mobility group AT-hook 2 0.00260484
VIM vimentin 0.00255559
RPLP1 ribosomal protein, large, P1 0.00252142
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 7.66642E-4
ACTG1 actin gamma 1 7.21869E-4

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.235583
PDE10A phosphodiesterase 10A -0.194653
PSD3 pleckstrin and Sec7 domain containing 3 -0.1413
EFNA5 ephrin-A5 -0.131272
EXT1 exostosin glycosyltransferase 1 -0.124803
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.112176
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.106991
FN1 fibronectin 1 -0.0983987
ASPH aspartate beta-hydroxylase -0.0978058
HDLBP high density lipoprotein binding protein -0.0883243
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0829289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0790597
ZNF292 zinc finger protein 292 -0.0748639
RPS6 ribosomal protein S6 -0.0698022
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0679085
TPT1 tumor protein, translationally-controlled 1 -0.0576541
RPL23 ribosomal protein L23 -0.0543637
KMT2E lysine (K)-specific methyltransferase 2E -0.0527742
FNDC3B fibronectin type III domain containing 3B -0.0519536
NF1 neurofibromin 1 -0.0479503
NDRG1 N-myc downstream regulated 1 -0.0478044
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0464292
ZMYND8 zinc finger, MYND-type containing 8 -0.0450143
NIPBL Nipped-B homolog (Drosophila) -0.0442571
RPL26 ribosomal protein L26 -0.0379611
POTEF POTE ankyrin domain family, member F -0.0376511
RPS12 ribosomal protein S12 -0.0366267
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0267872
GOLGA4 golgin A4 -0.0261202
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0255878
USP34 ubiquitin specific peptidase 34 -0.0210969
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0204345
TPM4 tropomyosin 4 -0.0177389
SLC38A1 solute carrier family 38, member 1 -0.0161999
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0143553
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0140003
MYO1E myosin IE -0.0132555
IGF2 insulin-like growth factor 2 -0.0107886
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00915782
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00905841
RICTOR RPTOR independent companion of MTOR, complex 2 -0.00878344
ZNF638 zinc finger protein 638 -0.00614518
IGFBP3 insulin-like growth factor binding protein 3 -0.00375366
LOC102724023 ES1 protein homolog, mitochondrial -0.00237958
TMSB10 thymosin beta 10 -8.4484E-4
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -7.08041E-4
JUN jun proto-oncogene -1.03975E-4