Menadione_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.132311
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.132064
PDE4B phosphodiesterase 4B, cAMP-specific 0.130792
SSBP2 single-stranded DNA binding protein 2 0.0817152
ADAM10 ADAM metallopeptidase domain 10 0.0764884
KMT2E lysine (K)-specific methyltransferase 2E 0.0758989
ECT2 epithelial cell transforming 2 0.0714626
ZNF292 zinc finger protein 292 0.0606887
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0601342
GOLGA4 golgin A4 0.0586544
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0558648
CCNL1 cyclin L1 0.0547726
ZEB1 zinc finger E-box binding homeobox 1 0.0542346
PDE4D phosphodiesterase 4D, cAMP-specific 0.0527311
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0526882
NAMPT nicotinamide phosphoribosyltransferase 0.0519443
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0500413
DSCAM Down syndrome cell adhesion molecule 0.0499789
SOX6 SRY (sex determining region Y)-box 6 0.0499766
CDC73 cell division cycle 73 0.0497375
EZR ezrin 0.0496813
ZFAND3 zinc finger, AN1-type domain 3 0.0493553
PICALM phosphatidylinositol binding clathrin assembly protein 0.0490497
VCL vinculin 0.0484288
TXNRD1 thioredoxin reductase 1 0.0480349
PDGFC platelet derived growth factor C 0.047825
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0468778
WAC WW domain containing adaptor with coiled-coil 0.0459877
SAMD4A sterile alpha motif domain containing 4A 0.0441761
EGFR epidermal growth factor receptor 0.0429407
RBM39 RNA binding motif protein 39 0.0428048
PUM2 pumilio RNA-binding family member 2 0.0420276
MATR3 matrin 3 0.0405695
CSDE1 cold shock domain containing E1, RNA-binding 0.040333
KDM3A lysine (K)-specific demethylase 3A 0.0401986
EVI5 ecotropic viral integration site 5 0.0401589
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0398772
LPP LIM domain containing preferred translocation partner in lipoma 0.0398193
SLC38A2 solute carrier family 38, member 2 0.0392772
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0391714
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0389313
ADAM9 ADAM metallopeptidase domain 9 0.038651
MED13L mediator complex subunit 13-like 0.0381775
GARS1 glycyl-tRNA synthetase 1 0.0380859
NCKAP1 NCK-associated protein 1 0.0379607
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.03774
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0373143
EML4 echinoderm microtubule associated protein like 4 0.0367274
NUP58 nucleoporin 58 0.0357605
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0354623
EPS8 epidermal growth factor receptor pathway substrate 8 0.0349221
TFG TRK-fused gene 0.0343785
JMJD1C jumonji domain containing 1C 0.0343665
FUBP1 far upstream element (FUSE) binding protein 1 0.0341041
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.034063
FBXO11 F-box protein 11 0.0337684
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0336627
HSPA8 heat shock 70kDa protein 8 0.0336013
ECPAS Ecm29 proteasome adaptor and scaffold 0.0322082
PDS5B PDS5 cohesin associated factor B 0.0321668
TNRC6B trinucleotide repeat containing 6B 0.0321178
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0320272
CAMTA1 calmodulin binding transcription activator 1 0.0317953
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0316313
LCORL ligand dependent nuclear receptor corepressor-like 0.0316178
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0313083
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0311528
RTN4 reticulon 4 0.0309523
YAP1 Yes-associated protein 1 0.0308625
TNPO1 transportin 1 0.0306889
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0306015
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.030542
KDM6A lysine (K)-specific demethylase 6A 0.0305241
RUSC2 RUN and SH3 domain containing 2 0.0305029
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0304549
MED13 mediator complex subunit 13 0.0300679
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0300614
QKI QKI, KH domain containing, RNA binding 0.029978
MSI2 musashi RNA-binding protein 2 0.0299435
POU2F1 POU class 2 homeobox 1 0.0296833
STRN3 striatin, calmodulin binding protein 3 0.0295426
RAD23B RAD23 homolog B (S. cerevisiae) 0.0291053
EIF4A2 eukaryotic translation initiation factor 4A2 0.0288334
PGK1 phosphoglycerate kinase 1 0.0287639
TMEM41B transmembrane protein 41B 0.028554
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.028434
PRELID2 PRELI domain containing 2 0.0281729
CPED1 cadherin-like and PC-esterase domain containing 1 0.0277998
TMEM39A transmembrane protein 39A 0.0275199
SFPQ splicing factor proline/glutamine-rich 0.0274505
SUCO SUN domain containing ossification factor 0.0273751
GSK3B glycogen synthase kinase 3 beta 0.0272658
BIRC6 baculoviral IAP repeat containing 6 0.0271869
TXNL1 thioredoxin-like 1 0.0271793
NBAS neuroblastoma amplified sequence 0.0268476
FAT1 FAT atypical cadherin 1 0.0264909
EXT1 exostosin glycosyltransferase 1 0.0264573
PIAS2 protein inhibitor of activated STAT, 2 0.0264383
DPYD dihydropyrimidine dehydrogenase 0.0264055
POTEF POTE ankyrin domain family, member F 0.0263682

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.298397
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180565
RPS6 ribosomal protein S6 -0.116936
TPT1 tumor protein, translationally-controlled 1 -0.0870692
RPL35A ribosomal protein L35a -0.0838378
RPS8 ribosomal protein S8 -0.0768332
ACTG1 actin gamma 1 -0.0580103
RPS19 ribosomal protein S19 -0.0573377
RPL34 ribosomal protein L34 -0.0545008
RPL9 ribosomal protein L9 -0.0536726
RPS3 ribosomal protein S3 -0.0533272
RPL26 ribosomal protein L26 -0.0499752
RPL37A ribosomal protein L37a -0.0480958
RPLP2 ribosomal protein, large, P2 -0.0476266
RPL36 ribosomal protein L36 -0.0473215
TMSB10 thymosin beta 10 -0.0460865
RPLP1 ribosomal protein, large, P1 -0.0456753
PFN1 profilin 1 -0.0426806
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0421097
RPL19 ribosomal protein L19 -0.042049
RPL32 ribosomal protein L32 -0.0406419
S100A6 S100 calcium binding protein A6 -0.0402898
RPS12 ribosomal protein S12 -0.0386192
RPS27A ribosomal protein S27a -0.038476
RPL31 ribosomal protein L31 -0.0372599
RPS23 ribosomal protein S23 -0.0369816
RPS29 ribosomal protein S29 -0.035847
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0351839
RPL13A ribosomal protein L13a -0.0346775
S100A4 S100 calcium binding protein A4 -0.0333029
MT2A metallothionein 2A -0.0329678
RPL12 ribosomal protein L12 -0.0329362
RPS17 ribosomal protein S17 -0.032788
FTL ferritin, light polypeptide -0.0324464
RPL23 ribosomal protein L23 -0.0324306
RPL35 ribosomal protein L35 -0.0292131
RPL8 ribosomal protein L8 -0.0287024
S100A9 S100 calcium binding protein A9 -0.0284824
RPS14 ribosomal protein S14 -0.0284581
RPL28 ribosomal protein L28 -0.0276385
RPL30 ribosomal protein L30 -0.0275597
RPS11 ribosomal protein S11 -0.0275565
RPS27 ribosomal protein S27 -0.0267338
ARL4C ADP-ribosylation factor-like 4C -0.0258206
VIM vimentin -0.0255094
RPL27A ribosomal protein L27a -0.0251088
RPS25 ribosomal protein S25 -0.0242215
RPS24 ribosomal protein S24 -0.0240722
TUBB tubulin, beta class I -0.0237044
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0237026
RPS13 ribosomal protein S13 -0.0235863
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0234253
RPL11 ribosomal protein L11 -0.023274
RPS16 ribosomal protein S16 -0.0231714
RPL38 ribosomal protein L38 -0.0223798
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0221415
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0219544
CCND1 cyclin D1 -0.0218853
RPL37 ribosomal protein L37 -0.0213554
RPL27 ribosomal protein L27 -0.0211568
RPL18 ribosomal protein L18 -0.0208446
RPL36A ribosomal protein L36a -0.0207778
PRDX2 peroxiredoxin 2 -0.0205489
RPL7A ribosomal protein L7a -0.0202214
NDRG1 N-myc downstream regulated 1 -0.0202082
RPS10 ribosomal protein S10 -0.0201604
FN1 fibronectin 1 -0.0201148
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0200697
NACA nascent polypeptide-associated complex alpha subunit -0.0199586
LOC102724023 ES1 protein homolog, mitochondrial -0.0198612
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0198163
RPS15 ribosomal protein S15 -0.0197443
RPLP0 ribosomal protein, large, P0 -0.0197036
VDAC1 voltage-dependent anion channel 1 -0.0196357
BMP10 bone morphogenetic protein 10 -0.019564
PTPRF protein tyrosine phosphatase, receptor type, F -0.0195401
WSB1 WD repeat and SOCS box containing 1 -0.0188788
ACBD3 acyl-CoA binding domain containing 3 -0.0187678
RPS28 ribosomal protein S28 -0.0184851
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0184632
TUBB4B tubulin, beta 4B class IVb -0.0183018
EIF1 eukaryotic translation initiation factor 1 -0.0182301
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0180367
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0180276
SEC61G Sec61 gamma subunit -0.0175314
IFITM3 interferon induced transmembrane protein 3 -0.0174897
RPL10A ribosomal protein L10a -0.0173597
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0172652
HLA-B major histocompatibility complex, class I, B -0.0171796
HSPB1 heat shock 27kDa protein 1 -0.01693
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0168692
TPM4 tropomyosin 4 -0.0167302
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0167269
RPS21 ribosomal protein S21 -0.0167181
MTDH metadherin -0.0162344
TPI1 triosephosphate isomerase 1 -0.0162162
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0161308
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0161182
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0160296
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0160294