Menadione_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A 0.248249
NAMPT nicotinamide phosphoribosyltransferase 0.154669
CADM1 cell adhesion molecule 1 0.127208
VCAN versican 0.118312
FNDC3B fibronectin type III domain containing 3B 0.0921009
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0887963
DST dystonin 0.0833457
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0819814
MYH9 myosin, heavy chain 9, non-muscle 0.0761543
ZNF292 zinc finger protein 292 0.073529
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0708471
TRIO trio Rho guanine nucleotide exchange factor 0.068588
UGCG UDP-glucose ceramide glucosyltransferase 0.0636763
PDE10A phosphodiesterase 10A 0.0603074
TENT5A terminal nucleotidyltransferase 5A 0.0589851
GOLGA4 golgin A4 0.0586789
SOD2 superoxide dismutase 2, mitochondrial 0.0564881
MXI1 MAX interactor 1, dimerization protein 0.0557084
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0516812
ARRDC3 arrestin domain containing 3 0.0503964
SNX9 sorting nexin 9 0.0481778
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0476414
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0473339
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0438039
EXT1 exostosin glycosyltransferase 1 0.0431336
SDK1 sidekick cell adhesion molecule 1 0.042355
RUNX2 runt-related transcription factor 2 0.0413446
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0408339
ATP13A3 ATPase type 13A3 0.0407155
SPAG9 sperm associated antigen 9 0.0404441
CDH13 cadherin 13 0.0402023
ELL2 elongation factor, RNA polymerase II, 2 0.0389363
HIPK2 homeodomain interacting protein kinase 2 0.0386188
MMP12 matrix metallopeptidase 12 0.0380648
PHF21A PHD finger protein 21A 0.0377636
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370689
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0369419
CEP250 centrosomal protein 250kDa 0.036848
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0354288
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0346716
OGA O-GlcNAcase 0.0329751
NAV2 neuron navigator 2 0.0329334
SLC35F3 solute carrier family 35, member F3 0.0328638
HELZ helicase with zinc finger 0.032536
QKI QKI, KH domain containing, RNA binding 0.0324728
TXNIP thioredoxin interacting protein 0.032102
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0320715
ARF4 ADP-ribosylation factor 4 0.031855
USP9X ubiquitin specific peptidase 9, X-linked 0.0315353
FLOT1 flotillin 1 0.0315173
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0314832
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0305726
PTPRK protein tyrosine phosphatase, receptor type, K 0.0303312
TSC22D2 TSC22 domain family, member 2 0.0302663
STC2 stanniocalcin 2 0.0302277
INSIG1 insulin induced gene 1 0.0301271
NFE2L2 nuclear factor, erythroid 2-like 2 0.0299757
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0292844
ESYT2 extended synaptotagmin-like protein 2 0.0292261
CD109 CD109 molecule 0.0290159
UBE2H ubiquitin-conjugating enzyme E2H 0.0289264
VEGFA vascular endothelial growth factor A 0.0287293
FBXO32 F-box protein 32 0.0284956
XPO1 exportin 1 0.028478
LPP LIM domain containing preferred translocation partner in lipoma 0.0284316
SMYD3 SET and MYND domain containing 3 0.0282349
SERINC1 serine incorporator 1 0.0279941
MYOF myoferlin 0.0279891
ANLN anillin, actin binding protein 0.0274145
TM9SF3 transmembrane 9 superfamily member 3 0.0269105
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0266776
COL8A1 collagen, type VIII, alpha 1 0.026531
JARID2 jumonji, AT rich interactive domain 2 0.0265252
LDHA lactate dehydrogenase A 0.026491
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0261163
RBM39 RNA binding motif protein 39 0.0260366
LCORL ligand dependent nuclear receptor corepressor-like 0.0256579
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0250902
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0250359
SBF2 SET binding factor 2 0.0249942
ARFGEF3 ARFGEF family member 3 0.0247956
FRMPD4 FERM and PDZ domain containing 4 0.0246754
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0246296
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0245785
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0244617
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0244054
TNPO1 transportin 1 0.0243796
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0243743
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.024198
PGK1 phosphoglycerate kinase 1 0.0239476
MARCHF6 membrane associated ring-CH-type finger 6 0.0239061
CANX calnexin 0.023863
CERT1 ceramide transporter 1 0.0237697
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.023759
RB1CC1 RB1-inducible coiled-coil 1 0.0237368
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0237348
SEC63 SEC63 homolog (S. cerevisiae) 0.0235846
THBS1 thrombospondin 1 0.0235733
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0235063
LAMP2 lysosomal-associated membrane protein 2 0.0234807

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.21416
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153249
TMSB10 thymosin beta 10 -0.141998
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0899161
FTL ferritin, light polypeptide -0.0797844
RPS12 ribosomal protein S12 -0.0742432
RPS6 ribosomal protein S6 -0.0725931
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0719598
HLA-B major histocompatibility complex, class I, B -0.0718897
RPS3 ribosomal protein S3 -0.0704241
RPL23 ribosomal protein L23 -0.0680361
AKAP12 A kinase (PRKA) anchor protein 12 -0.067457
MT2A metallothionein 2A -0.0627009
VCL vinculin -0.062137
CD44 CD44 molecule (Indian blood group) -0.060438
GLIS3 GLIS family zinc finger 3 -0.0587569
RPL37A ribosomal protein L37a -0.0580162
RPS8 ribosomal protein S8 -0.0558333
IGFBP3 insulin-like growth factor binding protein 3 -0.0540784
SLC38A2 solute carrier family 38, member 2 -0.0508111
RPLP1 ribosomal protein, large, P1 -0.049173
RPLP2 ribosomal protein, large, P2 -0.0479171
EGR1 early growth response 1 -0.0478754
PTMA prothymosin, alpha -0.0476248
HMGA2 high mobility group AT-hook 2 -0.0475657
RPL35A ribosomal protein L35a -0.0473719
RPL26 ribosomal protein L26 -0.0458753
HDAC9 histone deacetylase 9 -0.0436865
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0420993
RPL9 ribosomal protein L9 -0.0420725
NABP1 nucleic acid binding protein 1 -0.0413268
EIF1 eukaryotic translation initiation factor 1 -0.0409691
FLNB filamin B, beta -0.0406748
TPT1 tumor protein, translationally-controlled 1 -0.0403021
PALLD palladin, cytoskeletal associated protein -0.040247
PPARD peroxisome proliferator-activated receptor delta -0.038193
RPS14 ribosomal protein S14 -0.0367084
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0365243
RPL19 ribosomal protein L19 -0.0363929
RPL31 ribosomal protein L31 -0.036209
RPS27A ribosomal protein S27a -0.0337863
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0335693
RPL36 ribosomal protein L36 -0.032971
RPS23 ribosomal protein S23 -0.0327718
RPS19 ribosomal protein S19 -0.0326084
RPL36A ribosomal protein L36a -0.0318549
BTG1 B-cell translocation gene 1, anti-proliferative -0.0316759
RPS24 ribosomal protein S24 -0.0316693
IFITM3 interferon induced transmembrane protein 3 -0.0316116
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0313217
RPS13 ribosomal protein S13 -0.0307846
RPL12 ribosomal protein L12 -0.0307372
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0307302
RPL5 ribosomal protein L5 -0.0307014
RACK1 receptor for activated C kinase 1 -0.0302991
RPS29 ribosomal protein S29 -0.030158
HLA-A major histocompatibility complex, class I, A -0.0294467
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0289758
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.028735
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0286982
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0281266
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0277934
LOX lysyl oxidase -0.0274967
RPS17 ribosomal protein S17 -0.0271711
WWTR1 WW domain containing transcription regulator 1 -0.0264871
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0260446
RIGI RNA sensor RIG-I -0.0256156
ACTN4 actinin, alpha 4 -0.0255862
EPAS1 endothelial PAS domain protein 1 -0.0252734
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0251247
RPL28 ribosomal protein L28 -0.0246252
ENO2 enolase 2 (gamma, neuronal) -0.02433
SMAD3 SMAD family member 3 -0.0241865
VMP1 vacuole membrane protein 1 -0.0241377
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0237922
RPL8 ribosomal protein L8 -0.0236891
RAB7A RAB7A, member RAS oncogene family -0.0236711
RPL34 ribosomal protein L34 -0.0236668
RPS16 ribosomal protein S16 -0.023236
GPC6 glypican 6 -0.0232354
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0231318
RPL13A ribosomal protein L13a -0.0230977
RAP1B RAP1B, member of RAS oncogene family -0.0230756
CTSB cathepsin B -0.0230297
NDRG1 N-myc downstream regulated 1 -0.0228762
SOX9 SRY (sex determining region Y)-box 9 -0.0225578
S100A9 S100 calcium binding protein A9 -0.0225322
INTS6 integrator complex subunit 6 -0.0223643
NAP1L1 nucleosome assembly protein 1-like 1 -0.0222924
RPL30 ribosomal protein L30 -0.0222287
EEF2 eukaryotic translation elongation factor 2 -0.0218053
PDLIM5 PDZ and LIM domain 5 -0.0217787
TUT7 terminal uridylyl transferase 7 -0.0217717
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.0217676
RPL32 ribosomal protein L32 -0.0217569
SRSF11 serine/arginine-rich splicing factor 11 -0.0214682
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0213384
EEF1G eukaryotic translation elongation factor 1 gamma -0.0212588
IFI6 interferon, alpha-inducible protein 6 -0.0212232
TBCA tubulin folding cofactor A -0.0211186