Menadione_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Menadione perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Menadione_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0970817
NAMPT nicotinamide phosphoribosyltransferase 0.089404
MYH9 myosin, heavy chain 9, non-muscle 0.0732315
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0669729
MEF2A myocyte enhancer factor 2A 0.0609933
ERRFI1 ERBB receptor feedback inhibitor 1 0.06072
ARRDC3 arrestin domain containing 3 0.0525583
CADM1 cell adhesion molecule 1 0.0506538
ELL2 elongation factor, RNA polymerase II, 2 0.049531
ZNF292 zinc finger protein 292 0.0445419
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0435215
CEMIP cell migration inducing protein, hyaluronan binding 0.0432042
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0429685
SEPTIN9 septin 9 0.0414792
MED13L mediator complex subunit 13-like 0.0395557
PRELID2 PRELI domain containing 2 0.0392488
SMAD3 SMAD family member 3 0.0383257
PGK1 phosphoglycerate kinase 1 0.0365464
SUCO SUN domain containing ossification factor 0.0362507
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0361686
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.034889
NRXN3 neurexin 3 0.0344109
ANLN anillin, actin binding protein 0.0341922
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0341766
PSD3 pleckstrin and Sec7 domain containing 3 0.0331294
LGALS3 lectin, galactoside-binding, soluble, 3 0.0309629
FAM13A family with sequence similarity 13, member A 0.030817
PCM1 pericentriolar material 1 0.0303156
SHB Src homology 2 domain containing adaptor protein B 0.0298537
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0291123
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0289512
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0287696
FXR1 fragile X mental retardation, autosomal homolog 1 0.0287541
ITM2B integral membrane protein 2B 0.0284251
TXNRD1 thioredoxin reductase 1 0.028327
CCDC14 coiled-coil domain containing 14 0.0274457
DENND1A DENN/MADD domain containing 1A 0.027351
FTO fat mass and obesity associated 0.0273331
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0267188
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0263076
HOOK2 hook microtubule-tethering protein 2 0.0262485
ZEB1 zinc finger E-box binding homeobox 1 0.0261785
PRRC2C proline-rich coiled-coil 2C 0.0258871
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.025625
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0254612
MTDH metadherin 0.0253389
CDK17 cyclin-dependent kinase 17 0.0253146
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0252818
SEC23A Sec23 homolog A (S. cerevisiae) 0.0251853
SEC24A SEC24 family member A 0.0251627
FAM20C family with sequence similarity 20, member C 0.0250288
FNDC3B fibronectin type III domain containing 3B 0.0250244
OSBPL9 oxysterol binding protein-like 9 0.0248702
PHF21A PHD finger protein 21A 0.0245473
RBM39 RNA binding motif protein 39 0.0242562
USP9X ubiquitin specific peptidase 9, X-linked 0.0239846
RNF213 ring finger protein 213 0.0239518
TM9SF3 transmembrane 9 superfamily member 3 0.0239516
TFG TRK-fused gene 0.0237464
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0235032
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0233409
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0233002
HMGB2 high mobility group box 2 0.023053
DENND4C DENN/MADD domain containing 4C 0.022616
SSBP2 single-stranded DNA binding protein 2 0.0225931
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0225608
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0225225
PUM2 pumilio RNA-binding family member 2 0.022465
NAP1L1 nucleosome assembly protein 1-like 1 0.0222874
HPCAL1 hippocalcin-like 1 0.0222773
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0221551
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0214239
UBAP2L ubiquitin associated protein 2-like 0.0212716
ANKRD11 ankyrin repeat domain 11 0.0212187
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0212101
RPL5 ribosomal protein L5 0.0211145
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0210136
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.02093
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0208388
NFE2L2 nuclear factor, erythroid 2-like 2 0.0206994
CUL3 cullin 3 0.0206416
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0206384
PTPRG protein tyrosine phosphatase, receptor type, G 0.0205401
KMT2E lysine (K)-specific methyltransferase 2E 0.0204783
KDM6A lysine (K)-specific demethylase 6A 0.0204347
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0204045
POU2F1 POU class 2 homeobox 1 0.0203751
RAB8B RAB8B, member RAS oncogene family 0.0203658
GIGYF2 GRB10 interacting GYF protein 2 0.0203114
RBM25 RNA binding motif protein 25 0.0202839
C2ORF42 chromosome 2 open reading frame 42 0.0200569
WDR43 WD repeat domain 43 0.0198054
SAMD4A sterile alpha motif domain containing 4A 0.0197658
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0196874
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0193784
SLC35F5 solute carrier family 35, member F5 0.0193413
WDPCP WD repeat containing planar cell polarity effector 0.0193396
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0192381
CIRSR corepressor of RBPJ and splicing regulator 0.0192107
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.0191152

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.16111
TMSB10 thymosin beta 10 -0.151861
VIM vimentin -0.144606
TGFBI transforming growth factor, beta-induced, 68kDa -0.144397
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104125
MT2A metallothionein 2A -0.0962226
FN1 fibronectin 1 -0.0945079
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0909657
EGFR epidermal growth factor receptor -0.0806932
LOX lysyl oxidase -0.0777114
HLA-B major histocompatibility complex, class I, B -0.0744109
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0742137
MAP1B microtubule-associated protein 1B -0.0679978
F3 coagulation factor III (thromboplastin, tissue factor) -0.0651988
COL6A3 collagen, type VI, alpha 3 -0.0623768
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0603511
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0588386
FTL ferritin, light polypeptide -0.0541985
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0529531
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0516137
CDH13 cadherin 13 -0.0507914
STC1 stanniocalcin 1 -0.0491473
PTMA prothymosin, alpha -0.0482664
LOXL2 lysyl oxidase-like 2 -0.0464071
ENO1 enolase 1, (alpha) -0.0456946
CALU calumenin -0.0452366
CALR calreticulin -0.0450718
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.044609
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0440669
HLA-C major histocompatibility complex, class I, C -0.0433948
AHNAK AHNAK nucleoprotein -0.0427091
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0412033
IL6 interleukin 6 -0.0409061
ACTG1 actin gamma 1 -0.0408379
IGFBP7 insulin-like growth factor binding protein 7 -0.0391864
TPT1 tumor protein, translationally-controlled 1 -0.0378412
SDC4 syndecan 4 -0.0376842
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0373927
MARCKS myristoylated alanine-rich protein kinase C substrate -0.03714
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0365066
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0358694
HLA-A major histocompatibility complex, class I, A -0.0352126
TPM4 tropomyosin 4 -0.0347927
SOD2 superoxide dismutase 2, mitochondrial -0.0339432
RPS6 ribosomal protein S6 -0.0331808
MYADM myeloid-associated differentiation marker -0.0329057
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0325532
MT1X metallothionein 1X -0.0323825
COL1A2 collagen, type I, alpha 2 -0.0320833
TMEM165 transmembrane protein 165 -0.0317702
LDHA lactate dehydrogenase A -0.0316342
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.031619
H3-3B H3.3 histone B -0.0315638
S100A10 S100 calcium binding protein A10 -0.030788
RND3 Rho family GTPase 3 -0.0300034
GNAS GNAS complex locus -0.0299074
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0298606
PKM pyruvate kinase, muscle -0.0293126
NDRG1 N-myc downstream regulated 1 -0.029049
AGO3 argonaute RISC catalytic component 3 -0.0288174
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0288123
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0287771
ZNF395 zinc finger protein 395 -0.0287587
PTPRA protein tyrosine phosphatase, receptor type, A -0.0279974
CANX calnexin -0.0279804
RPS8 ribosomal protein S8 -0.0276464
S100A9 S100 calcium binding protein A9 -0.0276217
FLOT1 flotillin 1 -0.0273875
SEC24D SEC24 family member D -0.027207
TMEM263 transmembrane protein 263 -0.0271221
LOC112694756 uncharaterized LOC112694756 -0.0268166
TTC3 tetratricopeptide repeat domain 3 -0.0268135
CCNI cyclin I -0.026698
ADM adrenomedullin -0.0264778
VCL vinculin -0.0262743
COL6A1 collagen, type VI, alpha 1 -0.0258197
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0258002
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0257801
ZMYND8 zinc finger, MYND-type containing 8 -0.0257709
CAVIN1 caveolae associated protein 1 -0.0254858
VDAC1 voltage-dependent anion channel 1 -0.0251877
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0251131
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0249615
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0247069
B2M beta-2-microglobulin -0.0245802
GARS1 glycyl-tRNA synthetase 1 -0.024564
SEPTIN2 septin 2 -0.0245247
PFN1 profilin 1 -0.0244832
SRSF11 serine/arginine-rich splicing factor 11 -0.0241163
TM4SF1 transmembrane 4 L six family member 1 -0.0237976
RRBP1 ribosome binding protein 1 -0.0237445
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0235875
MAP4 microtubule-associated protein 4 -0.0233787
LMNA lamin A/C -0.0233393
HMGA2 high mobility group AT-hook 2 -0.0233297
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0224192
CAV1 caveolin 1, caveolae protein, 22kDa -0.0221168
GPR173 G protein-coupled receptor 173 -0.0221071
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0220247
BLZF1 basic leucine zipper nuclear factor 1 -0.0220116