Metformin Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A member of the class of guanidines that is the 1,1-dimethyl derivative of biguanide. (Chemical Entities of Biological Interest Ontology, CHEBI_6801)
External Link http://ctdbase.org/detail.go?type=chem&acc=D008687
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Genes

99 genes/proteins interacting with the chemical Metformin from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACACA acetyl-CoA carboxylase alpha
ACACB acetyl-CoA carboxylase beta
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCND2 cyclin D2
CCNE1 cyclin E1
COX1
CRP C-reactive protein, pentraxin-related
CXCL8 chemokine (C-X-C motif) ligand 8
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
EDN1 endothelin 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ESR1 estrogen receptor 1
FASN fatty acid synthase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA2 forkhead box A2
FSHB follicle stimulating hormone, beta polypeptide
GCG glucagon
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GSK3B glycogen synthase kinase 3 beta
GSR glutathione reductase
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HRH2 histamine receptor H2
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF2 insulin-like growth factor 2
IL1B interleukin 1, beta
IL6 interleukin 6
INS insulin
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
LEP leptin
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK9 mitogen-activated protein kinase 9
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NAMPT nicotinamide phosphoribosyltransferase
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDX1 pancreatic and duodenal homeobox 1
PLAT plasminogen activator, tissue
PPARA peroxisome proliferator-activated receptor alpha
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRL prolactin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBP4 retinol binding protein 4, plasma
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RETN resistin
RPS6 ribosomal protein S6
RUNX2 runt-related transcription factor 2
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2
SP1 Sp1 transcription factor
STAR steroidogenic acute regulatory protein
TDO2 tryptophan 2,3-dioxygenase
TNF tumor necrosis factor