Methazolamide Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/4100
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Genes

200 proteins with high or low expression in Methazolamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 2.7
POF1B premature ovarian failure, 1B 2.36
AZGP1 alpha-2-glycoprotein 1, zinc-binding 1.26
ENO1 enolase 1, (alpha) 0.67
ZBTB4 zinc finger and BTB domain containing 4 0.58
TPGS2 tubulin polyglutamylase complex subunit 2 0.58
RGN regucalcin 0.55
ALPK3 alpha-kinase 3 0.53
CAPRIN2 caprin family member 2 0.52
EVA1C eva-1 homolog C (C. elegans) 0.51
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.46
ZNF282 zinc finger protein 282 0.43
LRP12 low density lipoprotein receptor-related protein 12 0.42
CCDC112 coiled-coil domain containing 112 0.42
CXXC5 CXXC finger protein 5 0.39
WDR90 WD repeat domain 90 0.38
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.36
ROGDI rogdi homolog (Drosophila) 0.35
CCDC85B coiled-coil domain containing 85B 0.34
SPEG SPEG complex locus 0.34
COMMD6 COMM domain containing 6 0.33
KLC1 kinesin light chain 1 0.32
ADM adrenomedullin 0.31
GABPB2 GA binding protein transcription factor, beta subunit 2 0.31
ARID3B AT rich interactive domain 3B (BRIGHT-like) 0.31
PRIMPOL primase and polymerase (DNA-directed) 0.31
ULK1 unc-51 like autophagy activating kinase 1 0.31
DES desmin 0.3
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 0.3
ZNF525 zinc finger protein 525 0.3
REPS2 RALBP1 associated Eps domain containing 2 0.3
COL13A1 collagen, type XIII, alpha 1 0.29
ITFG2 integrin alpha FG-GAP repeat containing 2 0.29
GPN3 GPN-loop GTPase 3 0.29
DUSP14 dual specificity phosphatase 14 0.29
UBE2B ubiquitin-conjugating enzyme E2B 0.29
RAB11FIP4 RAB11 family interacting protein 4 (class II) 0.29
C11ORF49 chromosome 11 open reading frame 49 0.28
EPHA4 EPH receptor A4 0.27
ARL16 ADP-ribosylation factor-like 16 0.27
ZNF160 zinc finger protein 160 0.27
KMT2B lysine (K)-specific methyltransferase 2B 0.27
ZXDC ZXD family zinc finger C 0.27
RNF185 ring finger protein 185 0.26
SORBS1 sorbin and SH3 domain containing 1 0.26
FAM222B family with sequence similarity 222, member B 0.26
THAP1 THAP domain containing, apoptosis associated protein 1 0.25
MEX3A mex-3 RNA binding family member A 0.25
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.25
DNAH12 dynein, axonemal, heavy chain 12 0.25
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like 0.25
OBSL1 obscurin-like 1 0.25
ELOB elongin B 0.24
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 0.24
PARPBP PARP1 binding protein 0.24
ASTE1 asteroid homolog 1 (Drosophila) 0.24
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.24
CYB5A cytochrome b5 type A (microsomal) 0.23
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.23
COPZ1 coatomer protein complex, subunit zeta 1 0.23
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.23
RAB40C RAB40C, member RAS oncogene family 0.23
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.22
PIP prolactin-induced protein 0.22
CDC34 cell division cycle 34 0.22
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.22
MCTP2 multiple C2 domains, transmembrane 2 0.22
RNF7 ring finger protein 7 0.22
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.22
CCDC138 coiled-coil domain containing 138 0.22
FAM110C family with sequence similarity 110, member C 0.22
CMC1 C-x(9)-C motif containing 1 0.22
ZNF184 zinc finger protein 184 0.22
TMEM102 transmembrane protein 102 0.22
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.21
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.21
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.21
SPATA7 spermatogenesis associated 7 0.21
PRR3 proline rich 3 0.21
KIF27 kinesin family member 27 0.21
PAH phenylalanine hydroxylase 0.21
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.21
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.21
ATG10 autophagy related 10 0.21
NEU3 sialidase 3 (membrane sialidase) 0.21
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.21
PITX1 paired-like homeodomain 1 0.21
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7 0.2
FAM185A family with sequence similarity 185, member A 0.2
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.2
KMT5A lysine methyltransferase 5A 0.2
RNF223 ring finger protein 223 0.2
SYTL2 synaptotagmin-like 2 0.2
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.2
C12ORF4 chromosome 12 open reading frame 4 0.2
SAMD4A sterile alpha motif domain containing 4A 0.2
BACE2 beta-site APP-cleaving enzyme 2 0.2
CEP70 centrosomal protein 70kDa 0.2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.2
KMT5B lysine methyltransferase 5B 0.2

low expression

Symbol Name Standardized Value
ZNF608 zinc finger protein 608 -0.69
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 -0.64
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal -0.51
STK16 serine/threonine kinase 16 -0.48
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 -0.44
FRMPD1 FERM and PDZ domain containing 1 -0.41
F13A1 coagulation factor XIII, A1 polypeptide -0.4
DOP1A DOP1 leucine zipper like protein A -0.4
ZFHX4 zinc finger homeobox 4 -0.39
GJC1 gap junction protein, gamma 1, 45kDa -0.38
GTF2A1 general transcription factor IIA, 1, 19/37kDa -0.38
MYORG myogenesis regulating glycosidase (putative) -0.38
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal -0.38
MARCKS myristoylated alanine-rich protein kinase C substrate -0.37
FAM189B family with sequence similarity 189, member B -0.37
MAPKBP1 mitogen-activated protein kinase binding protein 1 -0.37
C19ORF25 chromosome 19 open reading frame 25 -0.37
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) -0.36
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.35
ZNF91 zinc finger protein 91 -0.34
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.34
IRF5 interferon regulatory factor 5 -0.33
FN1 fibronectin 1 -0.33
MCFD2 multiple coagulation factor deficiency 2 -0.33
F10 coagulation factor X -0.32
MARCKSL1 MARCKS-like 1 -0.32
FAN1 FANCD2/FANCI-associated nuclease 1 -0.31
APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D -0.31
CCDC158 coiled-coil domain containing 158 -0.3
ZSCAN5A zinc finger and SCAN domain containing 5A -0.29
TMEM219 transmembrane protein 219 -0.29
MED30 mediator complex subunit 30 -0.28
SELENOM selenoprotein M -0.28
CES3 carboxylesterase 3 -0.27
COL7A1 collagen, type VII, alpha 1 -0.27
GREB1 growth regulation by estrogen in breast cancer 1 -0.26
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.26
SULF2 sulfatase 2 -0.26
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -0.26
VWA1 von Willebrand factor A domain containing 1 -0.25
ACIN1 apoptotic chromatin condensation inducer 1 -0.25
NENF neudesin neurotrophic factor -0.24
STOML1 stomatin (EPB72)-like 1 -0.24
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -0.24
ADGRE2 adhesion G protein-coupled receptor E2 -0.23
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -0.23
SREBF1 sterol regulatory element binding transcription factor 1 -0.23
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -0.23
CLK1 CDC-like kinase 1 -0.23
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.22
RGL2 ral guanine nucleotide dissociation stimulator-like 2 -0.22
BBS1 Bardet-Biedl syndrome 1 -0.22
CCDC9 coiled-coil domain containing 9 -0.22
CFD complement factor D (adipsin) -0.22
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) -0.22
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.22
ESAM endothelial cell adhesion molecule -0.22
FBXL4 F-box and leucine-rich repeat protein 4 -0.22
BEND7 BEN domain containing 7 -0.21
TSPAN3 tetraspanin 3 -0.21
POU2F1 POU class 2 homeobox 1 -0.21
ZNF226 zinc finger protein 226 -0.21
WDR25 WD repeat domain 25 -0.21
APOL2 apolipoprotein L, 2 -0.21
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -0.21
ITGA6 integrin, alpha 6 -0.21
ADIRF adipogenesis regulatory factor -0.21
TMEM179B transmembrane protein 179B -0.21
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -0.21
OSCP1 organic solute carrier partner 1 -0.2
MSL3P1 male-specific lethal 3 homolog (Drosophila) pseudogene 1 -0.2
MTMR8 myotubularin related protein 8 -0.2
ZNF518A zinc finger protein 518A -0.2
DEF8 differentially expressed in FDCP 8 homolog (mouse) -0.2
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.2
MAST3 microtubule associated serine/threonine kinase 3 -0.2
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 -0.19
PEA15 phosphoprotein enriched in astrocytes 15 -0.19
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.19
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -0.19
ANAPC16 anaphase promoting complex subunit 16 -0.19
FAM122A family with sequence similarity 122A -0.19
ZNF12 zinc finger protein 12 -0.19
IER5 immediate early response 5 -0.19
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 -0.19
TET3 tet methylcytosine dioxygenase 3 -0.19
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 -0.18
C15ORF61 chromosome 15 open reading frame 61 -0.18
PRICKLE3 prickle homolog 3 (Drosophila) -0.18
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.18
INO80D INO80 complex subunit D -0.18
GLRX5 glutaredoxin 5 -0.18
RHOQ ras homolog family member Q -0.18
NAIF1 nuclear apoptosis inducing factor 1 -0.18
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.18
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.18
NUCB2 nucleobindin 2 -0.18
RPP21 ribonuclease P/MRP 21kDa subunit -0.18
PCLO piccolo presynaptic cytomatrix protein -0.18
LRP11 low density lipoprotein receptor-related protein 11 -0.18