| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.184742 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.167135 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.163721 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.16232 |
| LOXL2 | lysyl oxidase-like 2 | 0.156507 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.152427 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.126222 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.119459 |
| FNDC3B | fibronectin type III domain containing 3B | 0.106342 |
| APP | amyloid beta (A4) precursor protein | 0.0982202 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0957802 |
| NAV1 | neuron navigator 1 | 0.0864455 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0820752 |
| CALR | calreticulin | 0.0795812 |
| FBN1 | fibrillin 1 | 0.0785989 |
| LDHA | lactate dehydrogenase A | 0.0739393 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0733749 |
| PCBP2 | poly(rC) binding protein 2 | 0.0727669 |
| POTEF | POTE ankyrin domain family, member F | 0.0711229 |
| TPM3 | tropomyosin 3 | 0.0697241 |
| COL3A1 | collagen, type III, alpha 1 | 0.0694296 |
| SEPTIN9 | septin 9 | 0.0644558 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0638256 |
| SETD5 | SET domain containing 5 | 0.0629833 |
| COL5A1 | collagen, type V, alpha 1 | 0.0615699 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0587037 |
| RUNX1 | runt-related transcription factor 1 | 0.0576028 |
| NAV2 | neuron navigator 2 | 0.0567455 |
| FLNB | filamin B, beta | 0.0565818 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0548075 |
| MSN | moesin | 0.054235 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0541664 |
| TPM4 | tropomyosin 4 | 0.0536451 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0528624 |
| UBC | ubiquitin C | 0.0513023 |
| VIM | vimentin | 0.0504159 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0503385 |
| FLNA | filamin A, alpha | 0.0500469 |
| MYOF | myoferlin | 0.0496353 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0494813 |
| HDAC9 | histone deacetylase 9 | 0.0492558 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0491127 |
| PGK1 | phosphoglycerate kinase 1 | 0.0477716 |
| PFKP | phosphofructokinase, platelet | 0.0473431 |
| MSI2 | musashi RNA-binding protein 2 | 0.0469389 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0466148 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0454117 |
| MCL1 | myeloid cell leukemia 1 | 0.0452489 |
| CD109 | CD109 molecule | 0.0451598 |
| PKM | pyruvate kinase, muscle | 0.0443176 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0441713 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.044109 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0438741 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0431731 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0427244 |
| AHNAK | AHNAK nucleoprotein | 0.0422703 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0422529 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0414079 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0411655 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | 0.040871 |
| PLAT | plasminogen activator, tissue | 0.0407672 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0406543 |
| AUTS2 | autism susceptibility candidate 2 | 0.0404035 |
| ATP13A3 | ATPase type 13A3 | 0.0396722 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0396041 |
| ZNF292 | zinc finger protein 292 | 0.039501 |
| OPTN | optineurin | 0.0388805 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.038629 |
| ENO1 | enolase 1, (alpha) | 0.0384465 |
| NCOR2 | nuclear receptor corepressor 2 | 0.038193 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0381413 |
| FAT1 | FAT atypical cadherin 1 | 0.0377882 |
| CANX | calnexin | 0.0373505 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0372853 |
| CENPF | centromere protein F, 350/400kDa | 0.0369522 |
| SBF2 | SET binding factor 2 | 0.0368712 |
| INSIG2 | insulin induced gene 2 | 0.0368372 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0367833 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0367824 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0366578 |
| TAGLN2 | transgelin 2 | 0.0365268 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0363314 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0361746 |
| COL1A2 | collagen, type I, alpha 2 | 0.0359985 |
| MYADM | myeloid-associated differentiation marker | 0.0345063 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0341968 |
| FNIP1 | folliculin interacting protein 1 | 0.0340617 |
| CDH13 | cadherin 13 | 0.0334884 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0332006 |
| OGA | O-GlcNAcase | 0.0328428 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0327264 |
| NCKAP1 | NCK-associated protein 1 | 0.0326873 |
| FMNL2 | formin-like 2 | 0.0322265 |
| SQSTM1 | sequestosome 1 | 0.0321243 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0320483 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0316992 |
| L1CAM | L1 cell adhesion molecule | 0.0315989 |
| AXL | AXL receptor tyrosine kinase | 0.031426 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0313801 |
| ANO6 | anoctamin 6 | 0.0313261 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.157799 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157013 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.136981 |
| LOX | lysyl oxidase | -0.0908439 |
| MT2A | metallothionein 2A | -0.0889617 |
| HLA-B | major histocompatibility complex, class I, B | -0.0721534 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0670562 |
| S100A10 | S100 calcium binding protein A10 | -0.058929 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0527983 |
| CD44 | CD44 molecule (Indian blood group) | -0.0509368 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.041694 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0409479 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0378181 |
| ACTG1 | actin gamma 1 | -0.0373757 |
| RRBP1 | ribosome binding protein 1 | -0.0358523 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0351521 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0319818 |
| GLIS3 | GLIS family zinc finger 3 | -0.0319233 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0308543 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0305802 |
| CAVIN1 | caveolae associated protein 1 | -0.0304238 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0287964 |
| PODXL | podocalyxin-like | -0.0283924 |
| CSTB | cystatin B (stefin B) | -0.0278781 |
| MX2 | MX dynamin-like GTPase 2 | -0.0274825 |
| SP100 | SP100 nuclear antigen | -0.0273522 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0266225 |
| EXOC6B | exocyst complex component 6B | -0.0265647 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.026549 |
| RIGI | RNA sensor RIG-I | -0.0258779 |
| OSMR | oncostatin M receptor | -0.0250617 |
| MT1X | metallothionein 1X | -0.0237261 |
| MEIS2 | Meis homeobox 2 | -0.0236032 |
| VEGFC | vascular endothelial growth factor C | -0.0234109 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0230061 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0228846 |
| RPS24 | ribosomal protein S24 | -0.022456 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0220962 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0216824 |
| RPL36 | ribosomal protein L36 | -0.0215834 |
| RPL28 | ribosomal protein L28 | -0.021576 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0214148 |
| HLA-C | major histocompatibility complex, class I, C | -0.0212807 |
| RPL35A | ribosomal protein L35a | -0.020531 |
| BPTF | bromodomain PHD finger transcription factor | -0.0202699 |
| FUS | FUS RNA binding protein | -0.0202259 |
| IL7R | interleukin 7 receptor | -0.0201816 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.020176 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.019994 |
| STK17A | serine/threonine kinase 17a | -0.0193463 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0185924 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0185502 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0184287 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0183386 |
| PFN1 | profilin 1 | -0.0181651 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0181231 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0177777 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | -0.017656 |
| FBXO11 | F-box protein 11 | -0.0176087 |
| SLC38A1 | solute carrier family 38, member 1 | -0.017449 |
| RPLP1 | ribosomal protein, large, P1 | -0.0171685 |
| JMJD1C | jumonji domain containing 1C | -0.0170998 |
| HMGB1 | high mobility group box 1 | -0.0169992 |
| CDK12 | cyclin-dependent kinase 12 | -0.0168869 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0168119 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0165609 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0164723 |
| S100A4 | S100 calcium binding protein A4 | -0.0164164 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0164012 |
| S100A9 | S100 calcium binding protein A9 | -0.0163833 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.01635 |
| CEP112 | centrosomal protein 112kDa | -0.0162895 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0162372 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0161824 |
| SPAG9 | sperm associated antigen 9 | -0.0161769 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0159993 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0159856 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0159596 |
| RPS19 | ribosomal protein S19 | -0.0159244 |
| RPL34 | ribosomal protein L34 | -0.0158924 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0156992 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0156932 |
| RPL12 | ribosomal protein L12 | -0.0156342 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0154671 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | -0.0154643 |
| RPLP2 | ribosomal protein, large, P2 | -0.015337 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0152618 |
| CENPP | centromere protein P | -0.0151598 |
| ZNF460 | zinc finger protein 460 | -0.0151277 |
| GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -0.0150572 |
| UBXN4 | UBX domain protein 4 | -0.0148604 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.014779 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | -0.0147509 |
| CD99 | CD99 molecule | -0.0147155 |
| PHPT1 | phosphohistidine phosphatase 1 | -0.0147153 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0147136 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0146894 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0146847 |
| NPR2 | natriuretic peptide receptor 2 | -0.0146505 |
| PRSS23 | protease, serine, 23 | -0.0146434 |
