| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PCBP2 | poly(rC) binding protein 2 | 0.181425 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.176174 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.116019 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.111367 |
| RPL3 | ribosomal protein L3 | 0.0583341 |
| RPS18 | ribosomal protein S18 | 0.0501608 |
| TPM3 | tropomyosin 3 | 0.0493477 |
| HMGA1 | high mobility group AT-hook 1 | 0.0443908 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0437465 |
| YBX1 | Y box binding protein 1 | 0.0374541 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0368808 |
| LDHA | lactate dehydrogenase A | 0.035106 |
| PGK1 | phosphoglycerate kinase 1 | 0.0313039 |
| HLA-A | major histocompatibility complex, class I, A | 0.0299134 |
| RPS3 | ribosomal protein S3 | 0.0295178 |
| ENO1 | enolase 1, (alpha) | 0.028155 |
| PLK2 | polo-like kinase 2 | 0.0277579 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0277482 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0275914 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0274684 |
| RPS7 | ribosomal protein S7 | 0.0258095 |
| DHFR | dihydrofolate reductase | 0.0255989 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0253655 |
| POTEF | POTE ankyrin domain family, member F | 0.0253066 |
| AXIN2 | axin 2 | 0.0250955 |
| EZR | ezrin | 0.02493 |
| MED13L | mediator complex subunit 13-like | 0.0239002 |
| HDGF | hepatoma-derived growth factor | 0.0235419 |
| PTMS | parathymosin | 0.0229858 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0229586 |
| CLDND1 | claudin domain containing 1 | 0.0225089 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0224686 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0221068 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0219927 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0210169 |
| ANXA1 | annexin A1 | 0.0204277 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0201603 |
| EPHA6 | EPH receptor A6 | 0.0198582 |
| FAT1 | FAT atypical cadherin 1 | 0.0197607 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0194135 |
| TGM2 | transglutaminase 2 | 0.0193587 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0191996 |
| CEP250 | centrosomal protein 250kDa | 0.0183196 |
| FBL | fibrillarin | 0.018022 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0178319 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.0178286 |
| DBN1 | drebrin 1 | 0.0176929 |
| CDK19 | cyclin-dependent kinase 19 | 0.0175965 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0174691 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0173036 |
| UBC | ubiquitin C | 0.0172844 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0172667 |
| VAT1 | vesicle amine transport 1 | 0.016679 |
| BAG6 | BCL2-associated athanogene 6 | 0.0166485 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | 0.0163032 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0160983 |
| AFDN | afadin, adherens junction formation factor | 0.0154803 |
| HDAC9 | histone deacetylase 9 | 0.0152832 |
| CCNL1 | cyclin L1 | 0.0149725 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0149651 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0149522 |
| USP5 | ubiquitin specific peptidase 5 (isopeptidase T) | 0.0147439 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0146819 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0144466 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0144456 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0144152 |
| PRKCI | protein kinase C, iota | 0.0144118 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0144048 |
| SSRP1 | structure specific recognition protein 1 | 0.0143784 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0142945 |
| MCL1 | myeloid cell leukemia 1 | 0.0142118 |
| RAB11FIP3 | RAB11 family interacting protein 3 (class II) | 0.0140815 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0139205 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0138892 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0138051 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0137982 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0137759 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0135996 |
| RBM4 | RNA binding motif protein 4 | 0.0135656 |
| MKRN1 | makorin ring finger protein 1 | 0.0135582 |
| SCARB1 | scavenger receptor class B, member 1 | 0.0135299 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0135263 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 0.0134919 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0134405 |
| HELB | helicase (DNA) B | 0.0133925 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0133099 |
| MYH14 | myosin, heavy chain 14, non-muscle | 0.0132519 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.013206 |
| MEMO1 | mediator of cell motility 1 | 0.0131821 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0129638 |
| PFDN5 | prefoldin subunit 5 | 0.0129469 |
| INPPL1 | inositol polyphosphate phosphatase-like 1 | 0.0128756 |
| TRIM28 | tripartite motif containing 28 | 0.012812 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.0127749 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0127637 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0127586 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0127134 |
| GPX4 | glutathione peroxidase 4 | 0.0126943 |
| VPS8 | vacuolar protein sorting 8 homolog (S. cerevisiae) | 0.0125942 |
| DCTN1 | dynactin 1 | 0.012468 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.287402 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.171737 |
| NLGN1 | neuroligin 1 | -0.170968 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.124811 |
| PCDH7 | protocadherin 7 | -0.101391 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0965063 |
| MMP12 | matrix metallopeptidase 12 | -0.0874993 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0831428 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0808205 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0800485 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0788328 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0718026 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0641265 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0605954 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0599266 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0563197 |
| ACTG1 | actin gamma 1 | -0.0545624 |
| HMGA2 | high mobility group AT-hook 2 | -0.0538589 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0518405 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0517499 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0511965 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0478862 |
| JMJD1C | jumonji domain containing 1C | -0.0472542 |
| EHBP1 | EH domain binding protein 1 | -0.0461825 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0448508 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0438058 |
| ANKRD28 | ankyrin repeat domain 28 | -0.04292 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0393196 |
| TMSB10 | thymosin beta 10 | -0.0387932 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0386137 |
| AREG | amphiregulin | -0.0382029 |
| RPS6 | ribosomal protein S6 | -0.0376303 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0376166 |
| TMEM41B | transmembrane protein 41B | -0.0368789 |
| ZNF804A | zinc finger protein 804A | -0.0358302 |
| RPS24 | ribosomal protein S24 | -0.0354777 |
| NF1 | neurofibromin 1 | -0.0347172 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0343035 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0340021 |
| CANX | calnexin | -0.0338586 |
| CLTC | clathrin, heavy chain (Hc) | -0.0337412 |
| MTAP | methylthioadenosine phosphorylase | -0.0336816 |
| RPL38 | ribosomal protein L38 | -0.0328311 |
| FUS | FUS RNA binding protein | -0.0324935 |
| USP34 | ubiquitin specific peptidase 34 | -0.0323165 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0321449 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0320072 |
| TXNRD1 | thioredoxin reductase 1 | -0.0317405 |
| RPLP0 | ribosomal protein, large, P0 | -0.0317235 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0316897 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0316636 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0312326 |
| TENM3 | teneurin transmembrane protein 3 | -0.0311224 |
| RPLP2 | ribosomal protein, large, P2 | -0.0307166 |
| RSF1 | remodeling and spacing factor 1 | -0.0305271 |
| RPL19 | ribosomal protein L19 | -0.0303294 |
| RPL35A | ribosomal protein L35a | -0.0302838 |
| VIM | vimentin | -0.0300401 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0299234 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0299052 |
| BPTF | bromodomain PHD finger transcription factor | -0.0296788 |
| ZNF207 | zinc finger protein 207 | -0.0296053 |
| RPS8 | ribosomal protein S8 | -0.0291061 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0290881 |
| ASPH | aspartate beta-hydroxylase | -0.0286045 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0285757 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0285228 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0284914 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0280745 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0280267 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0277215 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274594 |
| RPS27A | ribosomal protein S27a | -0.0273209 |
| CEP95 | centrosomal protein 95kDa | -0.0272539 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0270728 |
| LMO7 | LIM domain 7 | -0.0268204 |
| CCDC88A | coiled-coil domain containing 88A | -0.0267741 |
| RPS15 | ribosomal protein S15 | -0.0265931 |
| YAP1 | Yes-associated protein 1 | -0.0265024 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0264878 |
| HMGB1 | high mobility group box 1 | -0.0259571 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0255819 |
| RPL34 | ribosomal protein L34 | -0.0254548 |
| XPO1 | exportin 1 | -0.0253848 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0253283 |
| RPL9 | ribosomal protein L9 | -0.0252767 |
| RBM39 | RNA binding motif protein 39 | -0.0249711 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0248647 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0247382 |
| H1-0 | H1.0 linker histone | -0.0246728 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0245531 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0242959 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0242365 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0241855 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0241494 |
| EXOC4 | exocyst complex component 4 | -0.0241437 |
| KPNB1 | karyopherin (importin) beta 1 | -0.024074 |
| RPL8 | ribosomal protein L8 | -0.024026 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0239353 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0239019 |
