| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.134942 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.128227 |
| PCBP2 | poly(rC) binding protein 2 | 0.11474 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.113263 |
| PLAT | plasminogen activator, tissue | 0.0765193 |
| COL3A1 | collagen, type III, alpha 1 | 0.0739389 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0719449 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0683845 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0662547 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0655037 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0651367 |
| NRG1 | neuregulin 1 | 0.0649428 |
| SEPTIN9 | septin 9 | 0.0616859 |
| DST | dystonin | 0.0592135 |
| FAM13A | family with sequence similarity 13, member A | 0.0542325 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0542172 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0535035 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0525659 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0514973 |
| SETD5 | SET domain containing 5 | 0.0500558 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0498744 |
| APP | amyloid beta (A4) precursor protein | 0.0492726 |
| PGK1 | phosphoglycerate kinase 1 | 0.0488276 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0472733 |
| DPH6 | diphthamine biosynthesis 6 | 0.0472153 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0454894 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0452294 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.045057 |
| MSI2 | musashi RNA-binding protein 2 | 0.0447566 |
| PKM | pyruvate kinase, muscle | 0.0436488 |
| TRIB2 | tribbles pseudokinase 2 | 0.0432098 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0428381 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0426241 |
| STC1 | stanniocalcin 1 | 0.0413755 |
| PTMA | prothymosin, alpha | 0.0404749 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.040197 |
| RPL3 | ribosomal protein L3 | 0.0398216 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0396751 |
| ENO1 | enolase 1, (alpha) | 0.039454 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0393249 |
| FMN1 | formin 1 | 0.0390033 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0385595 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0384633 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0384345 |
| LSAMP | limbic system-associated membrane protein | 0.0375462 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0365931 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | 0.036311 |
| RPS18 | ribosomal protein S18 | 0.0358952 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0352444 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0347356 |
| PRRC2C | proline-rich coiled-coil 2C | 0.034579 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0344595 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0343288 |
| SET | SET nuclear proto-oncogene | 0.0336011 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0335755 |
| RBM33 | RNA binding motif protein 33 | 0.0328908 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0326766 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0325637 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0324049 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0316363 |
| TPM3 | tropomyosin 3 | 0.0314216 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0312563 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0312289 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.030774 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0307333 |
| ZNF148 | zinc finger protein 148 | 0.0301606 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0297189 |
| HELZ | helicase with zinc finger | 0.0296008 |
| TPR | translocated promoter region, nuclear basket protein | 0.0292412 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0288919 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0286341 |
| GPC5 | glypican 5 | 0.02852 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0284512 |
| LMNA | lamin A/C | 0.0283413 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0282676 |
| VAT1 | vesicle amine transport 1 | 0.028013 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0276954 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0276736 |
| XPO1 | exportin 1 | 0.0275178 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0274701 |
| CCNY | cyclin Y | 0.0272958 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0272189 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0271117 |
| WDR43 | WD repeat domain 43 | 0.0267551 |
| SMAD9 | SMAD family member 9 | 0.0267291 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0266323 |
| VCAN | versican | 0.0265075 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0263475 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0261491 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0260793 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0260504 |
| MCL1 | myeloid cell leukemia 1 | 0.0259505 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0256076 |
| SMAD3 | SMAD family member 3 | 0.0255369 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0254569 |
| ENAH | enabled homolog (Drosophila) | 0.0254464 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0250775 |
| MMP2 | matrix metallopeptidase 2 | 0.0249787 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0249045 |
| VGLL4 | vestigial-like family member 4 | 0.0246625 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.470659 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.252547 |
| SYT1 | synaptotagmin I | -0.054693 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.049791 |
| RPS24 | ribosomal protein S24 | -0.0478184 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0436635 |
| IER3 | immediate early response 3 | -0.0419697 |
| ACTG1 | actin gamma 1 | -0.0417108 |
| RPS6 | ribosomal protein S6 | -0.0411009 |
| RPL35A | ribosomal protein L35a | -0.0410967 |
| TMSB10 | thymosin beta 10 | -0.0408137 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0399575 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0394818 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0389209 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0378975 |
| PCBP3 | poly(rC) binding protein 3 | -0.0377282 |
| RPS19 | ribosomal protein S19 | -0.0371245 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.037043 |
| NDRG1 | N-myc downstream regulated 1 | -0.0370281 |
| RPLP1 | ribosomal protein, large, P1 | -0.0352622 |
| RPL23 | ribosomal protein L23 | -0.0337984 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0319226 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0317665 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0306699 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0300989 |
| RPLP0 | ribosomal protein, large, P0 | -0.029479 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0286956 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0286772 |
| BPTF | bromodomain PHD finger transcription factor | -0.0278837 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0276775 |
| PCDH9 | protocadherin 9 | -0.0275165 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0271166 |
| S100A10 | S100 calcium binding protein A10 | -0.026345 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0259671 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0258507 |
| S100A6 | S100 calcium binding protein A6 | -0.0258281 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0257348 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0254792 |
| SBF2 | SET binding factor 2 | -0.024969 |
| RPL32 | ribosomal protein L32 | -0.0249433 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0248469 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0246596 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0244774 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0240347 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0234284 |
| RPL34 | ribosomal protein L34 | -0.0233784 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0232103 |
| RPS21 | ribosomal protein S21 | -0.0231868 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | -0.0231669 |
| FTL | ferritin, light polypeptide | -0.0228082 |
| ASPH | aspartate beta-hydroxylase | -0.0226502 |
| RPS29 | ribosomal protein S29 | -0.0225794 |
| DSTN | destrin (actin depolymerizing factor) | -0.0221534 |
| MEF2A | myocyte enhancer factor 2A | -0.021996 |
| OGA | O-GlcNAcase | -0.021651 |
| H3-3B | H3.3 histone B | -0.0215566 |
| CFDP1 | craniofacial development protein 1 | -0.0215314 |
| RPL38 | ribosomal protein L38 | -0.0209826 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | -0.0207381 |
| RPS16 | ribosomal protein S16 | -0.0207304 |
| FNIP1 | folliculin interacting protein 1 | -0.0207033 |
| TNRC6C | trinucleotide repeat containing 6C | -0.0206905 |
| RPS11 | ribosomal protein S11 | -0.0206757 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0205939 |
| ARF4 | ADP-ribosylation factor 4 | -0.0205467 |
| RPS14 | ribosomal protein S14 | -0.0203735 |
| RPS8 | ribosomal protein S8 | -0.0203457 |
| RHOA | ras homolog family member A | -0.0201185 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0199206 |
| RPL26 | ribosomal protein L26 | -0.0198858 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | -0.0198745 |
| RPL19 | ribosomal protein L19 | -0.0195084 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0194786 |
| POGZ | pogo transposable element with ZNF domain | -0.0193927 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0193881 |
| RIC1 | RAB6A GEF complex partner 1 | -0.0192825 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0192501 |
| CDK12 | cyclin-dependent kinase 12 | -0.0190261 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0189875 |
| EXOC4 | exocyst complex component 4 | -0.0186074 |
| S100A9 | S100 calcium binding protein A9 | -0.0185281 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0183735 |
| RIGI | RNA sensor RIG-I | -0.0183427 |
| ZNF407 | zinc finger protein 407 | -0.0183252 |
| LMO7 | LIM domain 7 | -0.0181526 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0180645 |
| MED13 | mediator complex subunit 13 | -0.0180621 |
| RPL28 | ribosomal protein L28 | -0.0178053 |
| MX1 | MX dynamin-like GTPase 1 | -0.0177621 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0176532 |
| SERF2 | small EDRK-rich factor 2 | -0.0175414 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0174605 |
| PFN1 | profilin 1 | -0.0174285 |
| DENND4C | DENN/MADD domain containing 4C | -0.0173443 |
| GAB2 | GRB2-associated binding protein 2 | -0.0172467 |
| RLF | rearranged L-myc fusion | -0.0170147 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0169956 |
| VGF | VGF nerve growth factor inducible | -0.0169566 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.016937 |
| H1-0 | H1.0 linker histone | -0.0168531 |
