| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | 0.0589541 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0505407 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0368223 |
| COG6 | component of oligomeric golgi complex 6 | 0.0284427 |
| FOXO3 | forkhead box O3 | 0.0258859 |
| DHFR | dihydrofolate reductase | 0.0256814 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0238845 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0234769 |
| FNIP1 | folliculin interacting protein 1 | 0.0226535 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0211513 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0201466 |
| UBAP1 | ubiquitin associated protein 1 | 0.0191576 |
| PDZD8 | PDZ domain containing 8 | 0.0190172 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0185925 |
| TJP2 | tight junction protein 2 | 0.0180978 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0178378 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0177481 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0176636 |
| EREG | epiregulin | 0.0174758 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.0174361 |
| XDH | xanthine dehydrogenase | 0.0173063 |
| CLTC | clathrin, heavy chain (Hc) | 0.0168601 |
| CORO1C | coronin, actin binding protein, 1C | 0.0163471 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0160255 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0156769 |
| SPICE1 | spindle and centriole associated protein 1 | 0.0156612 |
| TNNC1 | troponin C type 1 (slow) | 0.0155436 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.015412 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0150478 |
| DIAPH3 | diaphanous-related formin 3 | 0.0149402 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.0149267 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0148659 |
| KIF16B | kinesin family member 16B | 0.0148639 |
| GOLGA2 | golgin A2 | 0.0143422 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0142666 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.014235 |
| METTL15 | methyltransferase like 15 | 0.0142163 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0140312 |
| SPTLC1 | serine palmitoyltransferase, long chain base subunit 1 | 0.0139886 |
| FNIP2 | folliculin interacting protein 2 | 0.0139414 |
| KYNU | kynureninase | 0.0138765 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0138342 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0137187 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0136983 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0136784 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0132996 |
| FANCI | Fanconi anemia, complementation group I | 0.012922 |
| KAZN | kazrin, periplakin interacting protein | 0.0128675 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0124834 |
| YAP1 | Yes-associated protein 1 | 0.0124321 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0122926 |
| INTS6 | integrator complex subunit 6 | 0.012207 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0121685 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.012123 |
| SLK | STE20-like kinase | 0.0120445 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0120294 |
| GOLGA3 | golgin A3 | 0.0120151 |
| MLPH | melanophilin | 0.0118693 |
| RPS18 | ribosomal protein S18 | 0.0117475 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0117295 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0115172 |
| RC3H2 | ring finger and CCCH-type domains 2 | 0.0114668 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0113256 |
| CWF19L2 | CWF19-like 2, cell cycle control (S. pombe) | 0.0112822 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0112339 |
| PCBP2 | poly(rC) binding protein 2 | 0.0111823 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0111648 |
| TOX3 | TOX high mobility group box family member 3 | 0.0110888 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0110405 |
| RARS2 | arginyl-tRNA synthetase 2, mitochondrial | 0.010922 |
| FRK | fyn-related Src family tyrosine kinase | 0.01088 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0108678 |
| APOL2 | apolipoprotein L, 2 | 0.010758 |
| FAM114A1 | family with sequence similarity 114, member A1 | 0.0107175 |
| DCP2 | decapping mRNA 2 | 0.0105164 |
| COPA | coatomer protein complex, subunit alpha | 0.0104052 |
| UPF2 | UPF2 regulator of nonsense transcripts homolog (yeast) | 0.0103567 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.010199 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0101897 |
| YY1AP1 | YY1 associated protein 1 | 0.0101808 |
| PRKCI | protein kinase C, iota | 0.0101779 |
| LPIN1 | lipin 1 | 0.0101761 |
| MCEE | methylmalonyl CoA epimerase | 0.0101578 |
| MKRN1 | makorin ring finger protein 1 | 0.010155 |
| USP53 | ubiquitin specific peptidase 53 | 0.0100909 |
| TMEM135 | transmembrane protein 135 | 0.0100097 |
| CEP57 | centrosomal protein 57kDa | 0.00998863 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.00998745 |
| DIAPH1 | diaphanous-related formin 1 | 0.00982402 |
| SEC24D | SEC24 family member D | 0.00980597 |
| CFAP44 | cilia and flagella associated protein 44 | 0.00971933 |
| TMEM65 | transmembrane protein 65 | 0.00968563 |
| STX18 | syntaxin 18 | 0.00966097 |
| SMG5 | SMG5 nonsense mediated mRNA decay factor | 0.00962906 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.00959198 |
| BAG6 | BCL2-associated athanogene 6 | 0.00957989 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.00957325 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.00956609 |
| ZFYVE27 | zinc finger, FYVE domain containing 27 | 0.00956283 |
| CCDC14 | coiled-coil domain containing 14 | 0.00954665 |
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | -0.232098 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.197977 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128197 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.121912 |
| RNF213 | ring finger protein 213 | -0.112381 |
| LCN2 | lipocalin 2 | -0.110818 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.108 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106762 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.104624 |
| UBC | ubiquitin C | -0.104013 |
| EZR | ezrin | -0.102768 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0999281 |
| XAF1 | XIAP associated factor 1 | -0.0857393 |
| MX1 | MX dynamin-like GTPase 1 | -0.0857083 |
| RIGI | RNA sensor RIG-I | -0.08539 |
| SQSTM1 | sequestosome 1 | -0.0830958 |
| PTMA | prothymosin, alpha | -0.0828673 |
| JUN | jun proto-oncogene | -0.0814309 |
| MX2 | MX dynamin-like GTPase 2 | -0.0803718 |
| HLA-B | major histocompatibility complex, class I, B | -0.0780204 |
| PKM | pyruvate kinase, muscle | -0.0743081 |
| PERP | PERP, TP53 apoptosis effector | -0.0743041 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0739026 |
| RRBP1 | ribosome binding protein 1 | -0.0726603 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0673288 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0669258 |
| SP100 | SP100 nuclear antigen | -0.0661424 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0656912 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0644933 |
| RPL23 | ribosomal protein L23 | -0.0635596 |
| TMSB10 | thymosin beta 10 | -0.0625098 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0624669 |
| AHNAK | AHNAK nucleoprotein | -0.0611397 |
| ANXA2 | annexin A2 | -0.0611282 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0606905 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0598684 |
| PLSCR1 | phospholipid scramblase 1 | -0.0588301 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.058299 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0574427 |
| LMO7 | LIM domain 7 | -0.0572572 |
| EPCAM | epithelial cell adhesion molecule | -0.0571143 |
| LYZ | lysozyme | -0.0564312 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0563564 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0560142 |
| EGR1 | early growth response 1 | -0.0556936 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0553994 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0543959 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0534951 |
| SSH2 | slingshot protein phosphatase 2 | -0.0532965 |
| ENO1 | enolase 1, (alpha) | -0.052648 |
| ITGA6 | integrin, alpha 6 | -0.0521288 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0506854 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0504267 |
| IRS2 | insulin receptor substrate 2 | -0.0501199 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0494004 |
| TMC5 | transmembrane channel-like 5 | -0.0492655 |
| PRKCA | protein kinase C, alpha | -0.048626 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0466871 |
| VMP1 | vacuole membrane protein 1 | -0.0466531 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0462428 |
| RUNX1 | runt-related transcription factor 1 | -0.0454594 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0447965 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0447618 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.044669 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0446575 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0443035 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.04406 |
| IRF1 | interferon regulatory factor 1 | -0.0438461 |
| MUC13 | mucin 13, cell surface associated | -0.0437038 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0428533 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0427706 |
| FTL | ferritin, light polypeptide | -0.0426471 |
| MSI2 | musashi RNA-binding protein 2 | -0.0413401 |
| MAP7 | microtubule-associated protein 7 | -0.0406356 |
| RPLP1 | ribosomal protein, large, P1 | -0.040357 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | -0.0399073 |
| RPL19 | ribosomal protein L19 | -0.038445 |
| S100A10 | S100 calcium binding protein A10 | -0.0383635 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0382904 |
| TPI1 | triosephosphate isomerase 1 | -0.0381224 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0375615 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0369066 |
| RPS6 | ribosomal protein S6 | -0.0365771 |
| ETV6 | ets variant 6 | -0.0360626 |
| HLA-E | major histocompatibility complex, class I, E | -0.0360249 |
| EPHB2 | EPH receptor B2 | -0.0358501 |
| PMP22 | peripheral myelin protein 22 | -0.0351377 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0350977 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0348634 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0347635 |
| ACTN4 | actinin, alpha 4 | -0.0347123 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0343619 |
| H1-0 | H1.0 linker histone | -0.0343123 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0342912 |
| HLA-C | major histocompatibility complex, class I, C | -0.0342117 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0340459 |
| TRERF1 | transcriptional regulating factor 1 | -0.0337626 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0335763 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0332861 |
| RPL35A | ribosomal protein L35a | -0.0332301 |
