| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.202882 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.125583 |
| LOXL2 | lysyl oxidase-like 2 | 0.122253 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.113112 |
| ATP13A3 | ATPase type 13A3 | 0.0976672 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0958473 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0846566 |
| SMAD3 | SMAD family member 3 | 0.0755328 |
| STC1 | stanniocalcin 1 | 0.0748057 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0693198 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0640284 |
| APP | amyloid beta (A4) precursor protein | 0.0609009 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0559936 |
| SPAG9 | sperm associated antigen 9 | 0.0491328 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0490788 |
| LDHA | lactate dehydrogenase A | 0.0490424 |
| CALR | calreticulin | 0.0461585 |
| PCBP2 | poly(rC) binding protein 2 | 0.0452553 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0446844 |
| NDRG1 | N-myc downstream regulated 1 | 0.0438062 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0437522 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0414247 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0412343 |
| COL1A2 | collagen, type I, alpha 2 | 0.0412244 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0402687 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0397118 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0391882 |
| ENO1 | enolase 1, (alpha) | 0.0391707 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0381364 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0372615 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0368053 |
| ARRDC3 | arrestin domain containing 3 | 0.0350479 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0334999 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0333888 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0330788 |
| PTK2 | protein tyrosine kinase 2 | 0.0326514 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.032398 |
| COL3A1 | collagen, type III, alpha 1 | 0.0323413 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.031826 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0317538 |
| PLEC | plectin | 0.0316651 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0315517 |
| PKM | pyruvate kinase, muscle | 0.0310461 |
| FMNL2 | formin-like 2 | 0.0309359 |
| SETD5 | SET domain containing 5 | 0.0308364 |
| ANXA2 | annexin A2 | 0.0306746 |
| FAT1 | FAT atypical cadherin 1 | 0.0302754 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0301036 |
| UBC | ubiquitin C | 0.0299486 |
| RLF | rearranged L-myc fusion | 0.0298848 |
| SQLE | squalene epoxidase | 0.0298376 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0297669 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0296601 |
| NAV2 | neuron navigator 2 | 0.0293709 |
| ADM | adrenomedullin | 0.0292377 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0291399 |
| RPL3 | ribosomal protein L3 | 0.028826 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0284403 |
| TPX2 | TPX2, microtubule-associated | 0.0282274 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0280605 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0276984 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0271799 |
| MSN | moesin | 0.026975 |
| GOLGA4 | golgin A4 | 0.0269482 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0260573 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.026007 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0259804 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0253138 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0250409 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.024947 |
| MTSS1 | metastasis suppressor 1 | 0.0249014 |
| POSTN | periostin, osteoblast specific factor | 0.0241302 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0240046 |
| CALU | calumenin | 0.0236068 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0235271 |
| PFKP | phosphofructokinase, platelet | 0.0234943 |
| CENPF | centromere protein F, 350/400kDa | 0.023278 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0228367 |
| TRAM2 | translocation associated membrane protein 2 | 0.0226574 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0226294 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0226132 |
| ZNF292 | zinc finger protein 292 | 0.0222004 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0221797 |
| XPO1 | exportin 1 | 0.0219092 |
| CANX | calnexin | 0.0218614 |
| ECT2 | epithelial cell transforming 2 | 0.0217748 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0209315 |
| MCL1 | myeloid cell leukemia 1 | 0.0207615 |
| RASA2 | RAS p21 protein activator 2 | 0.0206053 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204405 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0204084 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0203236 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0202291 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0201361 |
| RPS18 | ribosomal protein S18 | 0.0201008 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0200817 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0200624 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0200565 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0198519 |
| PGK1 | phosphoglycerate kinase 1 | 0.0195068 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.253653 |
| CDH13 | cadherin 13 | -0.126002 |
| COL1A1 | collagen, type I, alpha 1 | -0.0673131 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0671256 |
| CALD1 | caldesmon 1 | -0.0617919 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0563291 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0556992 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0556481 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0550325 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0533268 |
| TMSB10 | thymosin beta 10 | -0.0521256 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0517476 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0499744 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0494366 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0491512 |
| ACTG1 | actin gamma 1 | -0.0370502 |
| VCL | vinculin | -0.0367302 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0357397 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0349651 |
| RPL35A | ribosomal protein L35a | -0.0343987 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0341984 |
| GLIS3 | GLIS family zinc finger 3 | -0.0337161 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0325572 |
| EGFR | epidermal growth factor receptor | -0.0319265 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0301998 |
| IL6ST | interleukin 6 signal transducer | -0.0294709 |
| IER3 | immediate early response 3 | -0.0294469 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0287397 |
| OSMR | oncostatin M receptor | -0.0285836 |
| GOLGB1 | golgin B1 | -0.02804 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0280161 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.027709 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0276685 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0273747 |
| FBN1 | fibrillin 1 | -0.0273567 |
| CNTN5 | contactin 5 | -0.0271672 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0267981 |
| EGR1 | early growth response 1 | -0.026666 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0264879 |
| ATXN1 | ataxin 1 | -0.025931 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0258874 |
| NEK10 | NIMA-related kinase 10 | -0.0255112 |
| CADM1 | cell adhesion molecule 1 | -0.0254718 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0253856 |
| EPHB1 | EPH receptor B1 | -0.0249131 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.024727 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0247218 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0243109 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0235965 |
| CLMP | CXADR-like membrane protein | -0.0235656 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.023493 |
| NAV1 | neuron navigator 1 | -0.0233552 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0231252 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0230423 |
| DGKI | diacylglycerol kinase, iota | -0.0229102 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0226795 |
| RPL34 | ribosomal protein L34 | -0.0225713 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0225422 |
| IL6 | interleukin 6 | -0.0223857 |
| AFF3 | AF4/FMR2 family, member 3 | -0.022325 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0221983 |
| FTL | ferritin, light polypeptide | -0.0216911 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0215686 |
| RPS6 | ribosomal protein S6 | -0.0211476 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0207426 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0204269 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0203739 |
| ATM | ATM serine/threonine kinase | -0.0202317 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0202141 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0201987 |
| RPS8 | ribosomal protein S8 | -0.0192119 |
| RSU1 | Ras suppressor protein 1 | -0.0192037 |
| FOXP1 | forkhead box P1 | -0.0189616 |
| RPL23 | ribosomal protein L23 | -0.0188984 |
| S100A9 | S100 calcium binding protein A9 | -0.018844 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0187538 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.018753 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0183718 |
| MTDH | metadherin | -0.0183166 |
| EXOC4 | exocyst complex component 4 | -0.0182343 |
| ZNF644 | zinc finger protein 644 | -0.0181621 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.018118 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0180162 |
| RRBP1 | ribosome binding protein 1 | -0.0179328 |
| PRKCA | protein kinase C, alpha | -0.0179301 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0178295 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0176663 |
| HDAC9 | histone deacetylase 9 | -0.0173562 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.017049 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0170089 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0167349 |
| TENM3 | teneurin transmembrane protein 3 | -0.0166859 |
| CUX1 | cut-like homeobox 1 | -0.01666 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0164175 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0162975 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0157911 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0156445 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.015509 |
| NCKAP5 | NCK-associated protein 5 | -0.0154858 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0154852 |
