Methotrexate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methotrexate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methotrexate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.0907786
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0882335
FLNB filamin B, beta 0.0881611
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0845443
TRIO trio Rho guanine nucleotide exchange factor 0.0840035
MSN moesin 0.0807405
CLU clusterin 0.0700768
ENO1 enolase 1, (alpha) 0.0697318
SMAD3 SMAD family member 3 0.0658904
MYOF myoferlin 0.0656672
CEMIP cell migration inducing protein, hyaluronan binding 0.0576891
PGK1 phosphoglycerate kinase 1 0.0575545
MEF2A myocyte enhancer factor 2A 0.0570654
PLEC plectin 0.0568224
TGM2 transglutaminase 2 0.0513913
NDRG1 N-myc downstream regulated 1 0.0512264
PCBP2 poly(rC) binding protein 2 0.049654
TPM3 tropomyosin 3 0.0490219
KRT17 keratin 17, type I 0.0486466
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0474563
MCL1 myeloid cell leukemia 1 0.0469556
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0463012
CTNND1 catenin (cadherin-associated protein), delta 1 0.0462121
KIAA1217 KIAA1217 0.0423207
MTSS1 metastasis suppressor 1 0.0418624
KRT6A keratin 6A, type II 0.0418564
NCOR2 nuclear receptor corepressor 2 0.0395512
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0389112
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0386318
DHFR dihydrofolate reductase 0.0382165
KMT2E lysine (K)-specific methyltransferase 2E 0.0379772
LMNA lamin A/C 0.037253
APLP2 amyloid beta (A4) precursor-like protein 2 0.0368868
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0362026
MBNL2 muscleblind-like splicing regulator 2 0.0359957
APP amyloid beta (A4) precursor protein 0.0359796
RPL3 ribosomal protein L3 0.0354696
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0350162
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0345796
FLNA filamin A, alpha 0.0343187
RICTOR RPTOR independent companion of MTOR, complex 2 0.0337038
PRELID2 PRELI domain containing 2 0.0336252
FN1 fibronectin 1 0.033079
EEF2 eukaryotic translation elongation factor 2 0.032942
STC1 stanniocalcin 1 0.0328326
CUL4B cullin 4B 0.0323246
FNDC3B fibronectin type III domain containing 3B 0.0320785
KTN1 kinectin 1 (kinesin receptor) 0.031602
BCL2L1 BCL2-like 1 0.0315722
LOXL2 lysyl oxidase-like 2 0.0313095
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0312343
RNF145 ring finger protein 145 0.0312124
GOLGA4 golgin A4 0.031056
KDM6A lysine (K)-specific demethylase 6A 0.0308674
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0303091
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0301949
OGA O-GlcNAcase 0.0300782
EPHA2 EPH receptor A2 0.0299757
SEPTIN9 septin 9 0.0296746
BHLHE40 basic helix-loop-helix family, member e40 0.0293863
ARRDC3 arrestin domain containing 3 0.0293409
ESYT2 extended synaptotagmin-like protein 2 0.0289166
SLK STE20-like kinase 0.0288134
LDHA lactate dehydrogenase A 0.0284156
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0283255
RPS18 ribosomal protein S18 0.0281796
MBNL1 muscleblind-like splicing regulator 1 0.0281507
CD46 CD46 molecule, complement regulatory protein 0.0271667
RNF19B ring finger protein 19B 0.0271325
EZR ezrin 0.0267869
AKAP13 A kinase (PRKA) anchor protein 13 0.026771
MEGF6 multiple EGF-like-domains 6 0.0267402
ANXA11 annexin A11 0.02646
SH3PXD2A SH3 and PX domains 2A 0.0262939
ITCH itchy E3 ubiquitin protein ligase 0.0262206
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0260936
CEP250 centrosomal protein 250kDa 0.025547
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0253928
HELZ helicase with zinc finger 0.0253674
KRT14 keratin 14, type I 0.0252015
PDLIM1 PDZ and LIM domain 1 0.0251189
KRT5 keratin 5, type II 0.0250582
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0250473
TNIP1 TNFAIP3 interacting protein 1 0.024774
LAMA5 laminin, alpha 5 0.0246503
INSIG2 insulin induced gene 2 0.0242178
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0242027
CD9 CD9 molecule 0.0238307
ZNF292 zinc finger protein 292 0.023643
LUZP1 leucine zipper protein 1 0.0236362
YBX1 Y box binding protein 1 0.0235072
SOX13 SRY (sex determining region Y)-box 13 0.0230377
ARHGAP5 Rho GTPase activating protein 5 0.0229217
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0228099
ANXA2 annexin A2 0.0225988
POTEF POTE ankyrin domain family, member F 0.0224094
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0222078
ADM adrenomedullin 0.0221912
KIF16B kinesin family member 16B 0.0216885
ANKH ANKH inorganic pyrophosphate transport regulator 0.0213329

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.243999
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.219272
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.140105
DPYD dihydropyrimidine dehydrogenase -0.102195
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0876889
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0680864
ALCAM activated leukocyte cell adhesion molecule -0.0623293
SLC35F3 solute carrier family 35, member F3 -0.0530299
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0519308
ABI3BP ABI family, member 3 (NESH) binding protein -0.0490961
TPT1 tumor protein, translationally-controlled 1 -0.0489979
PDE4D phosphodiesterase 4D, cAMP-specific -0.0484669
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0476276
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0475358
MECOM MDS1 and EVI1 complex locus -0.0471515
IGF2 insulin-like growth factor 2 -0.0444908
ANO1 anoctamin 1, calcium activated chloride channel -0.041116
HMGA2 high mobility group AT-hook 2 -0.0390151
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0381763
TMSB10 thymosin beta 10 -0.0378792
HM13 histocompatibility (minor) 13 -0.0368837
PALLD palladin, cytoskeletal associated protein -0.0357723
SULF2 sulfatase 2 -0.0357055
S100A10 S100 calcium binding protein A10 -0.0349184
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0348086
RPS21 ribosomal protein S21 -0.0341563
RIGI RNA sensor RIG-I -0.0339658
EGFR epidermal growth factor receptor -0.0332332
AHNAK AHNAK nucleoprotein -0.033109
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0325533
FNDC3A fibronectin type III domain containing 3A -0.0315393
PRSS23 protease, serine, 23 -0.0310812
INTS6 integrator complex subunit 6 -0.0307885
HLA-B major histocompatibility complex, class I, B -0.0307396
RPLP1 ribosomal protein, large, P1 -0.0306122
RPS6 ribosomal protein S6 -0.0305993
RABGAP1L RAB GTPase activating protein 1-like -0.0289958
RPS8 ribosomal protein S8 -0.0287576
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0287284
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0286233
EXOC6B exocyst complex component 6B -0.0278703
RPLP2 ribosomal protein, large, P2 -0.0277472
SAMD9 sterile alpha motif domain containing 9 -0.0265692
SLC38A2 solute carrier family 38, member 2 -0.0264755
ZMYND8 zinc finger, MYND-type containing 8 -0.0261963
RPL35A ribosomal protein L35a -0.0261191
PDLIM5 PDZ and LIM domain 5 -0.0253905
IARS1 isoleucyl-tRNA synthetase 1 -0.0238136
AGMO alkylglycerol monooxygenase -0.0235743
RPS24 ribosomal protein S24 -0.02355
ZEB1 zinc finger E-box binding homeobox 1 -0.0233032
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0231966
RPL34 ribosomal protein L34 -0.0228404
WARS1 tryptophanyl-tRNA synthetase 1 -0.022447
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0223868
RASAL2 RAS protein activator like 2 -0.0223793
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0213483
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.021266
SP100 SP100 nuclear antigen -0.0212652
RPS25 ribosomal protein S25 -0.0212612
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0211341
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0211212
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0210791
DGKH diacylglycerol kinase, eta -0.0206952
MTAP methylthioadenosine phosphorylase -0.0202372
THBD thrombomodulin -0.0202111
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0198932
ACTG1 actin gamma 1 -0.0198073
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0197975
TMSB4X thymosin beta 4, X-linked -0.0197592
RPL37A ribosomal protein L37a -0.019758
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0194743
GRB10 growth factor receptor-bound protein 10 -0.0193879
UTRN utrophin -0.0193765
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0193139
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0192531
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0190561
SOX5 SRY (sex determining region Y)-box 5 -0.0189225
VDAC1 voltage-dependent anion channel 1 -0.0188956
KLF12 Kruppel-like factor 12 -0.0185952
TXNRD1 thioredoxin reductase 1 -0.0183846
PODXL podocalyxin-like -0.0183484
RPL30 ribosomal protein L30 -0.0182111
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0180587
SULF1 sulfatase 1 -0.0179143
NT5C2 5'-nucleotidase, cytosolic II -0.0178154
RPL23 ribosomal protein L23 -0.0177518
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0175914
CDK6 cyclin-dependent kinase 6 -0.0174487
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0174477
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0174372
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0173854
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0173343
PDIA3 protein disulfide isomerase family A, member 3 -0.0172794
THSD4 thrombospondin, type I, domain containing 4 -0.0169815
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.016977
CNTNAP3 contactin associated protein-like 3 -0.0169552
RRBP1 ribosome binding protein 1 -0.016822
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0167101
OXR1 oxidation resistance 1 -0.0165268