| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | 0.168362 |
| PCBP2 | poly(rC) binding protein 2 | 0.12758 |
| VEGFA | vascular endothelial growth factor A | 0.0991399 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0958734 |
| EREG | epiregulin | 0.0884217 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0839276 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0826937 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0799903 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0764536 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0763648 |
| CCNY | cyclin Y | 0.0761704 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0745959 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0734094 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0720906 |
| RPL3 | ribosomal protein L3 | 0.0704097 |
| FLNB | filamin B, beta | 0.0701842 |
| MYO5B | myosin VB | 0.0670608 |
| KRT8 | keratin 8, type II | 0.0660892 |
| PIGR | polymeric immunoglobulin receptor | 0.0659417 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0654515 |
| CALR | calreticulin | 0.0639212 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0629855 |
| ANXA2 | annexin A2 | 0.0629844 |
| RPS18 | ribosomal protein S18 | 0.0601368 |
| KRT18 | keratin 18, type I | 0.0594761 |
| PGK1 | phosphoglycerate kinase 1 | 0.0581832 |
| ANXA11 | annexin A11 | 0.0572299 |
| MCL1 | myeloid cell leukemia 1 | 0.0571632 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0561809 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0555938 |
| TPM3 | tropomyosin 3 | 0.0555187 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0553562 |
| TXNIP | thioredoxin interacting protein | 0.0552361 |
| RNF145 | ring finger protein 145 | 0.0535771 |
| FAM13A | family with sequence similarity 13, member A | 0.0532001 |
| MED13L | mediator complex subunit 13-like | 0.0530651 |
| ENO1 | enolase 1, (alpha) | 0.052006 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0516962 |
| DSPP | dentin sialophosphoprotein | 0.0512368 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0511283 |
| DSCAM | Down syndrome cell adhesion molecule | 0.050945 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.049197 |
| APP | amyloid beta (A4) precursor protein | 0.0488164 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0481978 |
| ASPH | aspartate beta-hydroxylase | 0.0475417 |
| POTEF | POTE ankyrin domain family, member F | 0.046742 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0459853 |
| PKM | pyruvate kinase, muscle | 0.0453468 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.0446278 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0445663 |
| AFDN | afadin, adherens junction formation factor | 0.0441026 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0440534 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0434751 |
| NDRG1 | N-myc downstream regulated 1 | 0.0424156 |
| CTBP2 | C-terminal binding protein 2 | 0.0422976 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0415649 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0398241 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0391085 |
| RCOR1 | REST corepressor 1 | 0.0378686 |
| PTEN | phosphatase and tensin homolog | 0.0377643 |
| TPD52 | tumor protein D52 | 0.0377077 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0377076 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.037494 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0373692 |
| ADD3 | adducin 3 (gamma) | 0.0371877 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0366186 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0364224 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0355982 |
| LDHA | lactate dehydrogenase A | 0.0354879 |
| UBC | ubiquitin C | 0.0352669 |
| SETD5 | SET domain containing 5 | 0.0351642 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.035122 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0348629 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0345448 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0343854 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0334218 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0332531 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0332114 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0331876 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0330786 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0329547 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0328461 |
| DHFR | dihydrofolate reductase | 0.0324648 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0323372 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0315681 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0315484 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0314496 |
| CCNL1 | cyclin L1 | 0.0309062 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0308913 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0305146 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0304945 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | 0.0304852 |
| ATP13A3 | ATPase type 13A3 | 0.0303953 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0302819 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.03023 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 0.0301568 |
| YTHDC1 | YTH domain containing 1 | 0.0301505 |
| COPA | coatomer protein complex, subunit alpha | 0.0301381 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0296133 |
| TPM4 | tropomyosin 4 | 0.0295572 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.23271 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.132604 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112405 |
| TMSB10 | thymosin beta 10 | -0.0975864 |
| H1-0 | H1.0 linker histone | -0.0700796 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0629133 |
| RPLP1 | ribosomal protein, large, P1 | -0.0625455 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0572818 |
| CD44 | CD44 molecule (Indian blood group) | -0.0564473 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0547201 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0460378 |
| RPS6 | ribosomal protein S6 | -0.0453793 |
| RPS19 | ribosomal protein S19 | -0.0393937 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0373723 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0366333 |
| EPCAM | epithelial cell adhesion molecule | -0.0362902 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0357616 |
| CADPS | Ca++-dependent secretion activator | -0.0352961 |
| RNF43 | ring finger protein 43 | -0.034669 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0334478 |
| RRBP1 | ribosome binding protein 1 | -0.0325645 |
| RPL12 | ribosomal protein L12 | -0.0318865 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.03188 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.030763 |
| AGR2 | anterior gradient 2 | -0.0300374 |
| PCDHB16 | protocadherin beta 16 | -0.029957 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0299318 |
| PFN1 | profilin 1 | -0.0298848 |
| FOXP1 | forkhead box P1 | -0.0291996 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0291122 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0287325 |
| GPHN | gephyrin | -0.0285728 |
| ARF1 | ADP-ribosylation factor 1 | -0.0282055 |
| TNS4 | tensin 4 | -0.0280296 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0270078 |
| LRRK1 | leucine-rich repeat kinase 1 | -0.0268802 |
| POF1B | premature ovarian failure, 1B | -0.0267973 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0264491 |
| RPL34 | ribosomal protein L34 | -0.0260912 |
| RESF1 | retroelement silencing factor 1 | -0.0259991 |
| TFRC | transferrin receptor | -0.0256962 |
| RPL18 | ribosomal protein L18 | -0.0255529 |
| NPSR1 | neuropeptide S receptor 1 | -0.0253196 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0252449 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0251115 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0250602 |
| RPL36 | ribosomal protein L36 | -0.0249263 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0248263 |
| METTL15 | methyltransferase like 15 | -0.0248189 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.024725 |
| DSG2 | desmoglein 2 | -0.0245732 |
| HMGB2 | high mobility group box 2 | -0.0243316 |
| FTL | ferritin, light polypeptide | -0.0242421 |
| RPL32 | ribosomal protein L32 | -0.0240821 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0238204 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0234105 |
| KLF6 | Kruppel-like factor 6 | -0.0234092 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0233923 |
| PHKB | phosphorylase kinase, beta | -0.0225383 |
| HMGB1 | high mobility group box 1 | -0.02225 |
| RPL35 | ribosomal protein L35 | -0.0221786 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0221415 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0220604 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0219574 |
| RPL19 | ribosomal protein L19 | -0.0215819 |
| EXPH5 | exophilin 5 | -0.0214649 |
| PERP | PERP, TP53 apoptosis effector | -0.0213247 |
| RPL8 | ribosomal protein L8 | -0.0211146 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0210764 |
| MT2A | metallothionein 2A | -0.0210548 |
| EMP1 | epithelial membrane protein 1 | -0.0209379 |
| BPTF | bromodomain PHD finger transcription factor | -0.0207458 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0207179 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0205436 |
| RPL28 | ribosomal protein L28 | -0.0205069 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0199806 |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | -0.0199697 |
| MTAP | methylthioadenosine phosphorylase | -0.0198672 |
| PCNX2 | pecanex 2 | -0.0197927 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0197336 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0196351 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0194501 |
| RPL6 | ribosomal protein L6 | -0.019373 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0192927 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0190936 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0190036 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.018948 |
| NFIA | nuclear factor I/A | -0.0188272 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0187792 |
| ANKRD28 | ankyrin repeat domain 28 | -0.01871 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0187002 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0186657 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0185332 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0185032 |
| MT1X | metallothionein 1X | -0.0183589 |
| PKP4 | plakophilin 4 | -0.0183275 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0182475 |
| MYO9A | myosin IXA | -0.0182387 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0181116 |
| TMEM263 | transmembrane protein 263 | -0.0180675 |
