| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.170774 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.126319 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.124097 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.104697 |
| TXNRD1 | thioredoxin reductase 1 | 0.103384 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.10175 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.101344 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0898914 |
| VIM | vimentin | 0.0898757 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0887682 |
| PCBP2 | poly(rC) binding protein 2 | 0.0720842 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0710376 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0703814 |
| POTEF | POTE ankyrin domain family, member F | 0.0698768 |
| RAI1 | retinoic acid induced 1 | 0.0678576 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0669713 |
| PGK1 | phosphoglycerate kinase 1 | 0.0660262 |
| CANX | calnexin | 0.0626309 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0563021 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0534305 |
| EZR | ezrin | 0.051474 |
| APP | amyloid beta (A4) precursor protein | 0.0485842 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0466765 |
| EREG | epiregulin | 0.0460709 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.043806 |
| SPAG9 | sperm associated antigen 9 | 0.0436457 |
| LDHA | lactate dehydrogenase A | 0.0425981 |
| CALR | calreticulin | 0.0409357 |
| PTMA | prothymosin, alpha | 0.040103 |
| RPS18 | ribosomal protein S18 | 0.0398524 |
| RTN4 | reticulon 4 | 0.0390822 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0389031 |
| TMEM41B | transmembrane protein 41B | 0.0388316 |
| UBC | ubiquitin C | 0.0381909 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0377915 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0359838 |
| RPL3 | ribosomal protein L3 | 0.0357099 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0356356 |
| MATR3 | matrin 3 | 0.0351985 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0350392 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0347823 |
| HMGA1 | high mobility group AT-hook 1 | 0.0340248 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0337354 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0334074 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0323147 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0312113 |
| SET | SET nuclear proto-oncogene | 0.030554 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0303617 |
| CENPF | centromere protein F, 350/400kDa | 0.0298561 |
| YBX1 | Y box binding protein 1 | 0.0298372 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0296065 |
| TOP1 | topoisomerase (DNA) I | 0.0289267 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0286398 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0285186 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0285114 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0282987 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0281474 |
| NUP58 | nucleoporin 58 | 0.0277129 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0276687 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.02747 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0273822 |
| GOLGA4 | golgin A4 | 0.0272647 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0271437 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0270949 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0270176 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0269469 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0265859 |
| MSN | moesin | 0.0262863 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.025953 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0254556 |
| AHNAK | AHNAK nucleoprotein | 0.0251762 |
| IPO7 | importin 7 | 0.0251544 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0247298 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0243942 |
| PLK2 | polo-like kinase 2 | 0.0243011 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0239702 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0239403 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0238201 |
| MCL1 | myeloid cell leukemia 1 | 0.0236498 |
| ANXA1 | annexin A1 | 0.023645 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.02353 |
| XPO1 | exportin 1 | 0.0230104 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0229842 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0228832 |
| OGA | O-GlcNAcase | 0.0228777 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0228253 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0227925 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0227394 |
| UPP1 | uridine phosphorylase 1 | 0.0227176 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0227165 |
| TNPO1 | transportin 1 | 0.0227056 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0225547 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0224858 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0222601 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0222373 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0222018 |
| KIF5B | kinesin family member 5B | 0.0221458 |
| AARS1 | alanyl-tRNA synthetase 1 | 0.0220031 |
| WDR45B | WD repeat domain 45B | 0.0217443 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.021623 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.217069 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.153535 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.117554 |
| CADM2 | cell adhesion molecule 2 | -0.113926 |
| CD44 | CD44 molecule (Indian blood group) | -0.101831 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0984737 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0842381 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.083317 |
| DST | dystonin | -0.0819741 |
| HLA-B | major histocompatibility complex, class I, B | -0.0809827 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0704475 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.069524 |
| RIGI | RNA sensor RIG-I | -0.0693092 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0658746 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0657723 |
| RNF213 | ring finger protein 213 | -0.0617277 |
| SP100 | SP100 nuclear antigen | -0.0594691 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0578837 |
| EHBP1 | EH domain binding protein 1 | -0.0556754 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0556707 |
| PDE10A | phosphodiesterase 10A | -0.0536333 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0521914 |
| TNS3 | tensin 3 | -0.0505217 |
| PLSCR1 | phospholipid scramblase 1 | -0.0496911 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.049022 |
| RAD51B | RAD51 paralog B | -0.0480808 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0470145 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0462472 |
| MT2A | metallothionein 2A | -0.0437988 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0424169 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0417484 |
| PRELID2 | PRELI domain containing 2 | -0.0413824 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0384809 |
| EXOC4 | exocyst complex component 4 | -0.0381996 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0378413 |
| HDAC9 | histone deacetylase 9 | -0.0363334 |
| EPHA4 | EPH receptor A4 | -0.0357607 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0352103 |
| PTK2 | protein tyrosine kinase 2 | -0.0335226 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0324808 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0324237 |
| PMP22 | peripheral myelin protein 22 | -0.0323741 |
| SMYD3 | SET and MYND domain containing 3 | -0.0318096 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0315243 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0291039 |
| DPH6 | diphthamine biosynthesis 6 | -0.0289993 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0285143 |
| TRIM56 | tripartite motif containing 56 | -0.0283742 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0275996 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0263573 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0263546 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0260666 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0255998 |
| RPS19 | ribosomal protein S19 | -0.0254763 |
| H1-0 | H1.0 linker histone | -0.0254041 |
| DNER | delta/notch-like EGF repeat containing | -0.0253742 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0253459 |
| RPL36 | ribosomal protein L36 | -0.0249376 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0246548 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.024654 |
| RPL35A | ribosomal protein L35a | -0.024421 |
| RUNX1 | runt-related transcription factor 1 | -0.0243674 |
| EGFR | epidermal growth factor receptor | -0.0238678 |
| EFNA5 | ephrin-A5 | -0.0238418 |
| B2M | beta-2-microglobulin | -0.0235453 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0232518 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0230242 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0228292 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0227578 |
| COL5A2 | collagen, type V, alpha 2 | -0.0226819 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0224465 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0221964 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0219908 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.021975 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0213601 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0212818 |
| CDK6 | cyclin-dependent kinase 6 | -0.0212022 |
| TPRG1 | tumor protein p63 regulated 1 | -0.0206324 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0205626 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | -0.0204744 |
| CMIP | c-Maf inducing protein | -0.0202894 |
| VCL | vinculin | -0.0200771 |
| RPLP1 | ribosomal protein, large, P1 | -0.0200544 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0200353 |
| WDR27 | WD repeat domain 27 | -0.0199544 |
| XAF1 | XIAP associated factor 1 | -0.0199134 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0199068 |
| AEBP2 | AE binding protein 2 | -0.01972 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0195547 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0194933 |
| ECE1 | endothelin converting enzyme 1 | -0.0194233 |
| PRKCE | protein kinase C, epsilon | -0.0191831 |
| SDC4 | syndecan 4 | -0.0191399 |
| HLA-A | major histocompatibility complex, class I, A | -0.0189946 |
| HLA-E | major histocompatibility complex, class I, E | -0.0189894 |
| RPLP2 | ribosomal protein, large, P2 | -0.0189567 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0188225 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0187595 |
| TGM2 | transglutaminase 2 | -0.0187287 |
| OSMR | oncostatin M receptor | -0.0185424 |
