| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methotrexate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.11992 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.119423 |
| MCL1 | myeloid cell leukemia 1 | 0.111328 |
| PCBP2 | poly(rC) binding protein 2 | 0.0921232 |
| LAMC2 | laminin, gamma 2 | 0.0910969 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0616138 |
| CES1 | carboxylesterase 1 | 0.0605549 |
| PGK1 | phosphoglycerate kinase 1 | 0.0512952 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0491254 |
| PLEC | plectin | 0.0472292 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0471262 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0469982 |
| CPE | carboxypeptidase E | 0.0468572 |
| NGLY1 | N-glycanase 1 | 0.0449791 |
| LAMB3 | laminin, beta 3 | 0.0449647 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0432556 |
| LDHA | lactate dehydrogenase A | 0.0429673 |
| MKI67 | marker of proliferation Ki-67 | 0.0427396 |
| LAMA4 | laminin, alpha 4 | 0.0408587 |
| SLTM | SAFB-like, transcription modulator | 0.0406939 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0406455 |
| LMO7 | LIM domain 7 | 0.0390109 |
| RPS3 | ribosomal protein S3 | 0.0381897 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0377658 |
| UBC | ubiquitin C | 0.0365477 |
| ADAR | adenosine deaminase, RNA-specific | 0.0349226 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0348817 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0347584 |
| RTN4 | reticulon 4 | 0.0341143 |
| MT2A | metallothionein 2A | 0.0338977 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0331951 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0329589 |
| B2M | beta-2-microglobulin | 0.0325949 |
| DSPP | dentin sialophosphoprotein | 0.0325079 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.032452 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0308162 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0302894 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0299426 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0293484 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0293182 |
| FAM13A | family with sequence similarity 13, member A | 0.0285718 |
| ENO1 | enolase 1, (alpha) | 0.0265249 |
| CTTN | cortactin | 0.0264094 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0264018 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0261253 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0261045 |
| RPL3 | ribosomal protein L3 | 0.0259581 |
| STC1 | stanniocalcin 1 | 0.0258386 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0253494 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0251024 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0250084 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0247416 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0246139 |
| PKM | pyruvate kinase, muscle | 0.0244209 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0243573 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0238752 |
| SMAD3 | SMAD family member 3 | 0.0238525 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0237356 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.023654 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0235938 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.023566 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0235541 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0235499 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0235384 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | 0.0234031 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0229654 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0227832 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0222996 |
| RPS18 | ribosomal protein S18 | 0.0221864 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0221267 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0219721 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0219157 |
| RNF149 | ring finger protein 149 | 0.0219077 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0214706 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0213293 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0212622 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0212323 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0211074 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0210163 |
| CLTC | clathrin, heavy chain (Hc) | 0.020857 |
| JAK1 | Janus kinase 1 | 0.0208434 |
| NDRG1 | N-myc downstream regulated 1 | 0.0208408 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0207288 |
| CAB39 | calcium binding protein 39 | 0.0207241 |
| DHFR | dihydrofolate reductase | 0.0203926 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.020346 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0203434 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0203147 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0202486 |
| TPM3 | tropomyosin 3 | 0.0201448 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.020052 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0200399 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0198412 |
| AREG | amphiregulin | 0.0195738 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0190819 |
| RSF1 | remodeling and spacing factor 1 | 0.0189644 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0189073 |
| APP | amyloid beta (A4) precursor protein | 0.0186251 |
| TMEM167A | transmembrane protein 167A | 0.0184282 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0184041 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.219154 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0936832 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0739099 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0599318 |
| INTS6 | integrator complex subunit 6 | -0.05348 |
| NABP1 | nucleic acid binding protein 1 | -0.0529463 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0512713 |
| ASPH | aspartate beta-hydroxylase | -0.049573 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0472441 |
| MYOF | myoferlin | -0.043103 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0396563 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0368969 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0336246 |
| ACTG1 | actin gamma 1 | -0.0328693 |
| MORF4L2 | mortality factor 4 like 2 | -0.032509 |
| EGR1 | early growth response 1 | -0.0321512 |
| EGFR | epidermal growth factor receptor | -0.0319782 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.031083 |
| H1-0 | H1.0 linker histone | -0.0310492 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0297644 |
| VCL | vinculin | -0.0291483 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0289351 |
| GRAMD1B | GRAM domain containing 1B | -0.0262553 |
| SCEL | sciellin | -0.0256149 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0249648 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0249116 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0242697 |
| HOMER1 | homer scaffolding protein 1 | -0.023922 |
| RNF213 | ring finger protein 213 | -0.0238413 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0237827 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.023448 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0225557 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0224261 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0220798 |
| RPLP1 | ribosomal protein, large, P1 | -0.0220036 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0216529 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0211972 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0210294 |
| FUS | FUS RNA binding protein | -0.0206095 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0205793 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0205547 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0204622 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0201508 |
| SMYD3 | SET and MYND domain containing 3 | -0.0198273 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0197584 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0194034 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0190288 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0182309 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0181113 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0181106 |
| RAD51B | RAD51 paralog B | -0.0180956 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0178657 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0177722 |
| S100A10 | S100 calcium binding protein A10 | -0.0177295 |
| GPHN | gephyrin | -0.017547 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0174357 |
| CCND1 | cyclin D1 | -0.0171689 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0170575 |
| GPC6 | glypican 6 | -0.0170047 |
| PRKCA | protein kinase C, alpha | -0.0167139 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0166508 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0165922 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0164396 |
| ATF6 | activating transcription factor 6 | -0.016417 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0159977 |
| IER3 | immediate early response 3 | -0.0159846 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0158843 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0157365 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.015681 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0156218 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0155465 |
| MYO1E | myosin IE | -0.0153262 |
| KRT86 | keratin 86, type II | -0.015318 |
| CMIP | c-Maf inducing protein | -0.0152933 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0152333 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.014993 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.014846 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0146914 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0142704 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0140493 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0139348 |
| FOXP1 | forkhead box P1 | -0.0139127 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0138243 |
| MAP7 | microtubule-associated protein 7 | -0.0137723 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0137689 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0133524 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0132818 |
| EMP1 | epithelial membrane protein 1 | -0.0132377 |
| GM2A | GM2 ganglioside activator | -0.013103 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0129735 |
| SP100 | SP100 nuclear antigen | -0.0129024 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0128323 |
| FLNA | filamin A, alpha | -0.012779 |
| DENND5B | DENN/MADD domain containing 5B | -0.0127272 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0127244 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0126089 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0119514 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0119321 |
| RYK | receptor-like tyrosine kinase | -0.0119302 |
| KDM3B | lysine (K)-specific demethylase 3B | -0.0119213 |
