| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.266494 |
| TXNRD1 | thioredoxin reductase 1 | 0.225049 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.184008 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.129269 |
| POTEF | POTE ankyrin domain family, member F | 0.102565 |
| TPM3 | tropomyosin 3 | 0.101232 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0890759 |
| HDAC9 | histone deacetylase 9 | 0.0708153 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0695978 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0681872 |
| MCL1 | myeloid cell leukemia 1 | 0.0670157 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.066166 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0645228 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0627423 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0619062 |
| MT2A | metallothionein 2A | 0.0595381 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0581318 |
| PCBP2 | poly(rC) binding protein 2 | 0.0562679 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0558541 |
| VIM | vimentin | 0.0539805 |
| RPL3 | ribosomal protein L3 | 0.0524714 |
| ERBIN | erbb2 interacting protein | 0.05098 |
| ENO1 | enolase 1, (alpha) | 0.0507517 |
| RPS18 | ribosomal protein S18 | 0.0500856 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0496953 |
| HMGA1 | high mobility group AT-hook 1 | 0.0496355 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0490005 |
| STC1 | stanniocalcin 1 | 0.0474319 |
| LDHA | lactate dehydrogenase A | 0.0469452 |
| CALR | calreticulin | 0.0456836 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.045578 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0450064 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0449464 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0445445 |
| FAM107B | family with sequence similarity 107, member B | 0.0440064 |
| HDGF | hepatoma-derived growth factor | 0.0438554 |
| WDR43 | WD repeat domain 43 | 0.0435784 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0406238 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0402783 |
| MSN | moesin | 0.039712 |
| APP | amyloid beta (A4) precursor protein | 0.0390036 |
| TPM4 | tropomyosin 4 | 0.038687 |
| PFDN2 | prefoldin subunit 2 | 0.0380667 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0378208 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0374972 |
| CMIP | c-Maf inducing protein | 0.0370506 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.036965 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0369022 |
| PFKP | phosphofructokinase, platelet | 0.0362548 |
| PTMA | prothymosin, alpha | 0.0360201 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0358954 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0356961 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0354618 |
| CANX | calnexin | 0.0352213 |
| NRG1 | neuregulin 1 | 0.0351485 |
| RTN4 | reticulon 4 | 0.0351023 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0339587 |
| KLF6 | Kruppel-like factor 6 | 0.0338668 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0335755 |
| NTN4 | netrin 4 | 0.0331664 |
| LAMB1 | laminin, beta 1 | 0.0328369 |
| MATR3 | matrin 3 | 0.0326137 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0323338 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0312467 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0308593 |
| GTPBP4 | GTP binding protein 4 | 0.0304917 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0300466 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0299448 |
| S100A6 | S100 calcium binding protein A6 | 0.0298948 |
| YBX3 | Y box binding protein 3 | 0.029714 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0296817 |
| RBM25 | RNA binding motif protein 25 | 0.0291967 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0288823 |
| RPS3 | ribosomal protein S3 | 0.0282791 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0277241 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0275337 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0273371 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0272123 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0267117 |
| DHFR | dihydrofolate reductase | 0.0266846 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0266709 |
| SSRP1 | structure specific recognition protein 1 | 0.0265743 |
| RAI1 | retinoic acid induced 1 | 0.0263338 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.026039 |
| SAR1A | secretion associated, Ras related GTPase 1A | 0.0254859 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0246916 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0244828 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0244591 |
| TAGLN2 | transgelin 2 | 0.0241068 |
| SET | SET nuclear proto-oncogene | 0.023906 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0237547 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0236608 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0236149 |
| SMAD3 | SMAD family member 3 | 0.0235992 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0234922 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.023437 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0232887 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0232159 |
| TPI1 | triosephosphate isomerase 1 | 0.0231809 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0231055 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.292729 |
| FTL | ferritin, light polypeptide | -0.104546 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0921634 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0794428 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0788792 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0761908 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0730072 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0600349 |
| TMSB10 | thymosin beta 10 | -0.0582515 |
| IGF2 | insulin-like growth factor 2 | -0.0520156 |
| RPLP1 | ribosomal protein, large, P1 | -0.0493501 |
| ACTG1 | actin gamma 1 | -0.0484479 |
| ZNF207 | zinc finger protein 207 | -0.041594 |
| RPL19 | ribosomal protein L19 | -0.0414696 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0401382 |
| RPS8 | ribosomal protein S8 | -0.0398357 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0393826 |
| IER3 | immediate early response 3 | -0.0387476 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0372194 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0355565 |
| KYNU | kynureninase | -0.0353048 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0351148 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0343152 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0339556 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0335292 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0333971 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0333139 |
| INTS6 | integrator complex subunit 6 | -0.0327286 |
| RPS6 | ribosomal protein S6 | -0.0327282 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0317303 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0314845 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0302029 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0300224 |
| NUMB | numb homolog (Drosophila) | -0.0294073 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0282208 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.028007 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.027757 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0274402 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0272837 |
| HMGA2 | high mobility group AT-hook 2 | -0.0271776 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0268871 |
| VCL | vinculin | -0.0267683 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0265682 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0265214 |
| FUS | FUS RNA binding protein | -0.0264198 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0261907 |
| ZNF292 | zinc finger protein 292 | -0.0257021 |
| EHBP1 | EH domain binding protein 1 | -0.0256433 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0252812 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0252167 |
| DST | dystonin | -0.0250531 |
| CUX1 | cut-like homeobox 1 | -0.0245015 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0243968 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0240149 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0234017 |
| PARD3 | par-3 family cell polarity regulator | -0.0230017 |
| RPL8 | ribosomal protein L8 | -0.0228901 |
| MORF4L2 | mortality factor 4 like 2 | -0.0225869 |
| NF1 | neurofibromin 1 | -0.0224666 |
| FBXO11 | F-box protein 11 | -0.0220815 |
| RPL35A | ribosomal protein L35a | -0.0220509 |
| FNBP1L | formin binding protein 1-like | -0.0219359 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0217355 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.0215323 |
| PRR16 | proline rich 16 | -0.021377 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0213375 |
| RPS15 | ribosomal protein S15 | -0.0211889 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0211506 |
| UBB | ubiquitin B | -0.0208678 |
| PHF3 | PHD finger protein 3 | -0.0208124 |
| RPS20 | ribosomal protein S20 | -0.0207764 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0206665 |
| MXD1 | MAX dimerization protein 1 | -0.0206079 |
| RPL23 | ribosomal protein L23 | -0.0205429 |
| RPL34 | ribosomal protein L34 | -0.020273 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0201937 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0201893 |
| CDK13 | cyclin-dependent kinase 13 | -0.0201774 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0200199 |
| RAD51B | RAD51 paralog B | -0.0200076 |
| RTN3 | reticulon 3 | -0.0198788 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0196719 |
| PCNX4 | pecanex 4 | -0.0193663 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0193161 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0190113 |
| DENND4A | DENN/MADD domain containing 4A | -0.0189081 |
| ATP11A | ATPase, class VI, type 11A | -0.0188017 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0185785 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0182754 |
| S100A10 | S100 calcium binding protein A10 | -0.0182409 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0181285 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0181166 |
| RPL4 | ribosomal protein L4 | -0.0180911 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0180108 |
| UTRN | utrophin | -0.0178758 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0175861 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0175627 |
| NUP98 | nucleoporin 98kDa | -0.0175433 |
| ATXN1 | ataxin 1 | -0.0175043 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0174889 |
