| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methotrexate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.1739 |
| CENPF | centromere protein F, 350/400kDa | 0.130427 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.106047 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.104477 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0983146 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0811821 |
| ENO1 | enolase 1, (alpha) | 0.0748477 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0731302 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0725371 |
| DSPP | dentin sialophosphoprotein | 0.0714777 |
| CD109 | CD109 molecule | 0.0707706 |
| SMAD3 | SMAD family member 3 | 0.060777 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0587901 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0567312 |
| GPC6 | glypican 6 | 0.053183 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0524259 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0523482 |
| IFI16 | interferon, gamma-inducible protein 16 | 0.0522091 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0512127 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.048588 |
| ZNF292 | zinc finger protein 292 | 0.0483195 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0468115 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0445795 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0436743 |
| FMN1 | formin 1 | 0.0427531 |
| CCNL1 | cyclin L1 | 0.0423667 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0411285 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0384738 |
| PIK3C3 | phosphatidylinositol 3-kinase, catalytic subunit type 3 | 0.0377295 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0375133 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0369623 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0357619 |
| ZNF207 | zinc finger protein 207 | 0.0357265 |
| GNAS | GNAS complex locus | 0.0356658 |
| CDC73 | cell division cycle 73 | 0.0356033 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0355711 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0355058 |
| NLGN1 | neuroligin 1 | 0.0354531 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0342042 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0335446 |
| ERBIN | erbb2 interacting protein | 0.0334358 |
| ARCN1 | archain 1 | 0.0333827 |
| STK24 | serine/threonine kinase 24 | 0.0324091 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0315973 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0312837 |
| BBX | bobby sox homolog (Drosophila) | 0.0312547 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0312175 |
| IGF1R | insulin-like growth factor 1 receptor | 0.030496 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0301563 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0293283 |
| TRRAP | transformation/transcription domain-associated protein | 0.0290588 |
| KIF13B | kinesin family member 13B | 0.0284357 |
| CLMN | calmin (calponin-like, transmembrane) | 0.0283213 |
| RNF149 | ring finger protein 149 | 0.0280502 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.027967 |
| SEPTIN9 | septin 9 | 0.0279387 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0278747 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0275502 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0275373 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0274008 |
| SPPL3 | signal peptide peptidase like 3 | 0.0273027 |
| RAD51B | RAD51 paralog B | 0.0270788 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0268378 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0267559 |
| MAPK1 | mitogen-activated protein kinase 1 | 0.0266932 |
| ARRDC3 | arrestin domain containing 3 | 0.0261041 |
| WDR26 | WD repeat domain 26 | 0.0260118 |
| YAP1 | Yes-associated protein 1 | 0.0256802 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0256528 |
| FMNL2 | formin-like 2 | 0.0256182 |
| BRD4 | bromodomain containing 4 | 0.0255947 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0255401 |
| NPTN | neuroplastin | 0.0255072 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0253544 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0252562 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.025112 |
| TCF12 | transcription factor 12 | 0.0245479 |
| SRPK2 | SRSF protein kinase 2 | 0.0245268 |
| JAK1 | Janus kinase 1 | 0.0244281 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0243847 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0242411 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0242377 |
| AHNAK | AHNAK nucleoprotein | 0.0241699 |
| ACTN4 | actinin, alpha 4 | 0.024158 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0239632 |
| ATXN1 | ataxin 1 | 0.0236193 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0234566 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | 0.0232294 |
| RPLP0 | ribosomal protein, large, P0 | 0.0229437 |
| RUNX1 | runt-related transcription factor 1 | 0.0228331 |
| TPD52 | tumor protein D52 | 0.0225378 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0222869 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0222173 |
| ZFP91 | ZFP91 zinc finger protein | 0.0222108 |
| TMEM131 | transmembrane protein 131 | 0.0220559 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.021967 |
| PTK2 | protein tyrosine kinase 2 | 0.021739 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0215181 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0210794 |
| UTRN | utrophin | 0.0208913 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.085473 |
| TXNRD1 | thioredoxin reductase 1 | -0.0832363 |
| VIM | vimentin | -0.0741162 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.067826 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.065069 |
| TMSB10 | thymosin beta 10 | -0.0584377 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.058284 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0582589 |
| MT2A | metallothionein 2A | -0.0580467 |
| STC1 | stanniocalcin 1 | -0.0550389 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0519206 |
| LAMB3 | laminin, beta 3 | -0.0510831 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0495791 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0494536 |
| NDRG1 | N-myc downstream regulated 1 | -0.0487211 |
| JMJD1C | jumonji domain containing 1C | -0.0480755 |
| IGF2 | insulin-like growth factor 2 | -0.046669 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0465747 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0450357 |
| PKM | pyruvate kinase, muscle | -0.0450127 |
| RPS6 | ribosomal protein S6 | -0.0446082 |
| KYNU | kynureninase | -0.0445839 |
| LOXL2 | lysyl oxidase-like 2 | -0.0440929 |
| GOLGA4 | golgin A4 | -0.0440854 |
| PTMA | prothymosin, alpha | -0.0433243 |
| RPL11 | ribosomal protein L11 | -0.0425904 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0421117 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0418451 |
| EFNA5 | ephrin-A5 | -0.0417709 |
| MED13L | mediator complex subunit 13-like | -0.0396449 |
| KRT17 | keratin 17, type I | -0.039459 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0394488 |
| SMYD3 | SET and MYND domain containing 3 | -0.0390054 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0389648 |
| ANXA2 | annexin A2 | -0.038946 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.038665 |
| RPS16 | ribosomal protein S16 | -0.0383184 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0381271 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0379939 |
| CANX | calnexin | -0.0371873 |
| NF1 | neurofibromin 1 | -0.0366799 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0364399 |
| RACK1 | receptor for activated C kinase 1 | -0.0356411 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0355751 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0352502 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.035233 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0349655 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0341849 |
| RIGI | RNA sensor RIG-I | -0.0341141 |
| RNF145 | ring finger protein 145 | -0.0340848 |
| FBXO11 | F-box protein 11 | -0.033826 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0334455 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0331972 |
| SBF2 | SET binding factor 2 | -0.0329618 |
| CCDC88A | coiled-coil domain containing 88A | -0.0329475 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0327177 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0323368 |
| RPL37A | ribosomal protein L37a | -0.0322423 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0322286 |
| AK1 | adenylate kinase 1 | -0.0318036 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0316795 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0314721 |
| ARF4 | ADP-ribosylation factor 4 | -0.0310278 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.030367 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0303475 |
| LMNA | lamin A/C | -0.0303076 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0302606 |
| ZNF638 | zinc finger protein 638 | -0.030146 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0301312 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0300286 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0300189 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0299717 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0298529 |
| MMP12 | matrix metallopeptidase 12 | -0.0297903 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0297834 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0297345 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0295397 |
| PDE10A | phosphodiesterase 10A | -0.029328 |
| C1D | C1D nuclear receptor corepressor | -0.0292582 |
| CALR | calreticulin | -0.0291843 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0291135 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0288126 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0287273 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.028577 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.028505 |
| RAB10 | RAB10, member RAS oncogene family | -0.0284877 |
| CCND1 | cyclin D1 | -0.0283376 |
| RPLP1 | ribosomal protein, large, P1 | -0.0283328 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0282191 |
| ANO6 | anoctamin 6 | -0.0281976 |
| USP3 | ubiquitin specific peptidase 3 | -0.0279389 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0274888 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0274115 |
| MSN | moesin | -0.0270386 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0269851 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0267409 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0264291 |
| HMGA2 | high mobility group AT-hook 2 | -0.026337 |
| GLIS3 | GLIS family zinc finger 3 | -0.0263232 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0261878 |
