| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methotrexate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.240275 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.231779 |
| PCBP2 | poly(rC) binding protein 2 | 0.156632 |
| TPM3 | tropomyosin 3 | 0.147394 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.126195 |
| MCL1 | myeloid cell leukemia 1 | 0.100509 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0933837 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0870364 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.072962 |
| RPL3 | ribosomal protein L3 | 0.0692257 |
| RPS18 | ribosomal protein S18 | 0.0680859 |
| ENO1 | enolase 1, (alpha) | 0.0632818 |
| RPS3 | ribosomal protein S3 | 0.0631057 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0627245 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0579794 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0575761 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0537919 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0535813 |
| TPI1 | triosephosphate isomerase 1 | 0.0524261 |
| MSN | moesin | 0.0520703 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0514358 |
| YBX1 | Y box binding protein 1 | 0.0471105 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0463123 |
| HDGF | hepatoma-derived growth factor | 0.0449204 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0445712 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0437589 |
| HMGA1 | high mobility group AT-hook 1 | 0.0412121 |
| LDHA | lactate dehydrogenase A | 0.0405007 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0400212 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.036934 |
| PGK1 | phosphoglycerate kinase 1 | 0.0367239 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.036697 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0359602 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0358809 |
| PFKP | phosphofructokinase, platelet | 0.0350947 |
| PLEC | plectin | 0.0347945 |
| BAG6 | BCL2-associated athanogene 6 | 0.0340168 |
| PTMA | prothymosin, alpha | 0.0334185 |
| KRT18 | keratin 18, type I | 0.0320095 |
| DHFR | dihydrofolate reductase | 0.0317134 |
| POTEF | POTE ankyrin domain family, member F | 0.0315158 |
| KIF5B | kinesin family member 5B | 0.0314226 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0313159 |
| ATXN1 | ataxin 1 | 0.0307543 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0306039 |
| CEP250 | centrosomal protein 250kDa | 0.0298176 |
| SET | SET nuclear proto-oncogene | 0.0297358 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0294151 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0294076 |
| PKM | pyruvate kinase, muscle | 0.0285404 |
| UBC | ubiquitin C | 0.0284929 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0281228 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.02763 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0276233 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0275771 |
| RPS12 | ribosomal protein S12 | 0.0275624 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0275156 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0274613 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0271849 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0266347 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0262816 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0257766 |
| PRELID2 | PRELI domain containing 2 | 0.0256197 |
| SBF2 | SET binding factor 2 | 0.0255339 |
| RBBP4 | retinoblastoma binding protein 4 | 0.0255173 |
| WASF2 | WAS protein family, member 2 | 0.0254263 |
| TPM2 | tropomyosin 2 (beta) | 0.0249993 |
| ADAR | adenosine deaminase, RNA-specific | 0.0249308 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0247051 |
| EPN2 | epsin 2 | 0.0246343 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0245566 |
| ATP13A3 | ATPase type 13A3 | 0.0243615 |
| CEP192 | centrosomal protein 192kDa | 0.0243008 |
| CTTN | cortactin | 0.0240775 |
| RPS7 | ribosomal protein S7 | 0.0239105 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0238324 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0236484 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0235846 |
| GRAMD1B | GRAM domain containing 1B | 0.0233799 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0232553 |
| RSF1 | remodeling and spacing factor 1 | 0.0231316 |
| CCNL1 | cyclin L1 | 0.0229033 |
| CBX5 | chromobox homolog 5 | 0.0228306 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0227477 |
| BRD4 | bromodomain containing 4 | 0.0225295 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0224566 |
| COPA | coatomer protein complex, subunit alpha | 0.0223888 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0223563 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0222659 |
| ZNF148 | zinc finger protein 148 | 0.022056 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0219216 |
| VIM | vimentin | 0.0218761 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0218218 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0216764 |
| CALR | calreticulin | 0.0215234 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.021483 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.021468 |
| RPS4X | ribosomal protein S4, X-linked | 0.0213546 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0213352 |
| DAZAP1 | DAZ associated protein 1 | 0.0211038 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.311807 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.128048 |
| OSMR | oncostatin M receptor | -0.0700786 |
| SLC38A2 | solute carrier family 38, member 2 | -0.055433 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0537565 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0532042 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0487027 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0480152 |
| FBXO11 | F-box protein 11 | -0.0452382 |
| ACTG1 | actin gamma 1 | -0.0444654 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0441511 |
| NABP1 | nucleic acid binding protein 1 | -0.043325 |
| RPS15 | ribosomal protein S15 | -0.0423608 |
| EGR1 | early growth response 1 | -0.040401 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0402205 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0400108 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0398433 |
| BPTF | bromodomain PHD finger transcription factor | -0.0388568 |
| CDK17 | cyclin-dependent kinase 17 | -0.0385455 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0374693 |
| FUS | FUS RNA binding protein | -0.0372885 |
| GPHN | gephyrin | -0.0357443 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0346864 |
| ZFR | zinc finger RNA binding protein | -0.0337155 |
| PLSCR1 | phospholipid scramblase 1 | -0.0336095 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0334986 |
| IER3 | immediate early response 3 | -0.0334436 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0312679 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0311835 |
| VCL | vinculin | -0.0310627 |
| ATF6 | activating transcription factor 6 | -0.0304626 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0301018 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0296123 |
| IL6ST | interleukin 6 signal transducer | -0.0286529 |
| RPL35A | ribosomal protein L35a | -0.0284152 |
| SRP72 | signal recognition particle 72kDa | -0.0284134 |
| CDK12 | cyclin-dependent kinase 12 | -0.0283623 |
| TXNRD1 | thioredoxin reductase 1 | -0.0282795 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0281491 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0271673 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.026942 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0269399 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0269134 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0267842 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0259443 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0253231 |
| CCDC91 | coiled-coil domain containing 91 | -0.0250633 |
| RPL36A | ribosomal protein L36a | -0.0249276 |
| HMGA2 | high mobility group AT-hook 2 | -0.0246512 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0244794 |
| GPATCH8 | G patch domain containing 8 | -0.0244693 |
| RPS21 | ribosomal protein S21 | -0.0243503 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0242633 |
| JMJD1C | jumonji domain containing 1C | -0.0242033 |
| RAB7A | RAB7A, member RAS oncogene family | -0.024011 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0240075 |
| RIGI | RNA sensor RIG-I | -0.023949 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0237761 |
| HLA-B | major histocompatibility complex, class I, B | -0.0234845 |
| VDAC1 | voltage-dependent anion channel 1 | -0.023412 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0233663 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0233643 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0231085 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0228738 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.02279 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0221225 |
| USP34 | ubiquitin specific peptidase 34 | -0.0218813 |
| EXOC4 | exocyst complex component 4 | -0.0218129 |
| MORF4L2 | mortality factor 4 like 2 | -0.0217156 |
| CLTC | clathrin, heavy chain (Hc) | -0.0215576 |
| YAP1 | Yes-associated protein 1 | -0.021066 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0210378 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0210044 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0209933 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0209224 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0208273 |
| ZNF207 | zinc finger protein 207 | -0.0208267 |
| TUSC3 | tumor suppressor candidate 3 | -0.0205762 |
| STC1 | stanniocalcin 1 | -0.0204897 |
| PHF14 | PHD finger protein 14 | -0.0204749 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.020457 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0204027 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0202793 |
| RPL38 | ribosomal protein L38 | -0.0202657 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0202099 |
| TRIM56 | tripartite motif containing 56 | -0.0201937 |
| PDE10A | phosphodiesterase 10A | -0.0199017 |
| MMP12 | matrix metallopeptidase 12 | -0.0198587 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0198403 |
| RPL26 | ribosomal protein L26 | -0.0197217 |
| EXOC6B | exocyst complex component 6B | -0.019689 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0194085 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0193792 |
| RPL6 | ribosomal protein L6 | -0.0191868 |
| ATG7 | autophagy related 7 | -0.0190438 |
| PHIP | pleckstrin homology domain interacting protein | -0.0190379 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0189569 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0188444 |
| CD2AP | CD2-associated protein | -0.0187828 |
| EHBP1 | EH domain binding protein 1 | -0.0187605 |
